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CAS No: 259869-55-1 Catalog No: AG002RB2 MDL No:
Title | Journal |
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Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | Oncotarget 20160920 |
CB2 receptor activation ameliorates the proinflammatory activity in acute lung injury induced by paraquat. | BioMed research international 20140101 |
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. | Journal of medicinal chemistry 20131114 |
Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. | Pharmacological research 20130201 |
Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT(2A) and dopamine D₂ receptors in rat prefrontal cortex. | Journal of psychopharmacology (Oxford, England) 20121001 |
Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists. | Journal of medicinal chemistry 20120614 |
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold. | European journal of medicinal chemistry 20120601 |
The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. | European heart journal 20120401 |
Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321 |
Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis. | Toxicology and applied pharmacology 20120115 |
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice. | Journal of neuroinflammation 20120101 |
Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. | Journal of medicinal chemistry 20111027 |
Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice. | European journal of pharmacology 20111001 |
Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. | Bioorganic & medicinal chemistry 20110915 |
Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. | Nature neuroscience 20110901 |
Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways. | British journal of pharmacology 20110801 |
The endocannabinoid system in rat gliosomes and its role in the modulation of glutamate release. | Cellular and molecular life sciences : CMLS 20110301 |
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. | European journal of medicinal chemistry 20110201 |
Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. | Blood 20110120 |
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice. | PloS one 20110101 |
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology. | Journal of biomolecular screening 20101201 |
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor. | Bioorganic & medicinal chemistry 20101115 |
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. | Hepatology (Baltimore, Md.) 20100901 |
Emerging targets in osteoporosis disease modification. | Journal of medicinal chemistry 20100610 |
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100301 |
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. | Inflammatory bowel diseases 20091101 |
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. | Molecular cancer therapeutics 20091101 |
Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242. | British journal of pharmacology 20090901 |
Functional CB2 type cannabinoid receptors at CNS synapses. | Neuropharmacology 20090901 |
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. | Journal of medicinal chemistry 20090625 |
CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion. | Journal of molecular and cellular cardiology 20090501 |
CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. | Glia 20090201 |
Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. | PloS one 20090101 |
The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801 |
Cannabinoid CB(1) receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle. | European journal of pharmacology 20080317 |
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. | Cancer research 20080315 |
Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. | The Journal of pharmacology and experimental therapeutics 20080201 |
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? | Neuropharmacology 20080101 |
Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. | Journal of neuroimmunology 20080101 |
Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux. | European journal of pharmacology 20071114 |
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice. | Behavioural pharmacology 20071101 |
Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality. | Journal of medicinal chemistry 20071101 |
Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. | Journal of leukocyte biology 20070901 |
Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations. | Pharmacological research 20070901 |
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells. | Experimental cell research 20070815 |
Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. | International immunopharmacology 20070301 |
Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. | Journal of medicinal chemistry 20061005 |
Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. | American journal of physiology. Gastrointestinal and liver physiology 20060801 |
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. | Journal of medicinal chemistry 20060112 |
The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. | Life sciences 20060102 |
Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. | Pain 20051205 |
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. | The European journal of neuroscience 20050701 |
Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. | British journal of pharmacology 20050601 |
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223 |
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. | The European journal of neuroscience 20041101 |
Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | Cancer research 20040815 |
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. | Cancer immunology, immunotherapy : CII 20040801 |
Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test. | Anesthesiology 20030901 |
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. | British journal of pharmacology 20030901 |
Topically administered CB(2)-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits. | Life sciences 20030103 |
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. | The Journal of clinical investigation 20030101 |
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. | Cancer research 20010801 |
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. | Expert opinion on investigational drugs 20000701 |
3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. | Bioorganic & medicinal chemistry 19991201 |
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