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Home > Imidazoles > 25433-13-0
25433-13-0 | 2H-Imidazole-2-thione,1,3-dihydro-1-methyl-5-phenyl-
CAS No: 25433-13-0 Catalog No: AG006UUZ MDL No:MFCD01429053
Product Description
Catalog Number:
AG006UUZ
Chemical Name:
2H-Imidazole-2-thione,1,3-dihydro-1-methyl-5-phenyl-
CAS Number:
25433-13-0
Molecular Formula:
C10H10N2S
Molecular Weight:
190.2648
MDL Number:
MFCD01429053
IUPAC Name:
3-methyl-4-phenyl-1H-imidazole-2-thione
InChI:
InChI=1S/C10H10N2S/c1-12-9(7-11-10(12)13)8-5-3-2-4-6-8/h2-7H,1H3,(H,11,13)
InChI Key:
XGMUOBZHQAVQNX-UHFFFAOYSA-N
SMILES:
Cn1c(S)ncc1c1ccccc1
Properties
Complexity:
241
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
190.056g/mol
Formal Charge:
0
Heavy Atom Count:
13
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
190.264g/mol
Monoisotopic Mass:
190.056g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
47.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6
Literature
| Title | Journal |
|---|---|
| Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization. | Molecules (Basel, Switzerland) 20121022 |
| Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*. | Critical care medicine 20120301 |
| Another potential therapeutic agent for the management of critically ill patients with sepsis syndrome: same old story, same old result?*. | Critical care medicine 20120301 |
| Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages. | The Journal of endocrinology 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis. | European journal of pharmacology 20100915 |
| Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole. | The Journal of endocrinology 20100101 |
| Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090615 |
| Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. | Molecular endocrinology (Baltimore, Md.) 20050501 |
| Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells. | Journal of immunology (Baltimore, Md. : 1950) 20040801 |
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