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24909-91-9 | Pregnane
CAS No: 24909-91-9 Catalog No: AG002PTE MDL No:
Product Description
Catalog Number:
AG002PTE
Chemical Name:
Pregnane
CAS Number:
24909-91-9
Molecular Formula:
C21H36
Molecular Weight:
288.5105
IUPAC Name:
(8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
InChI:
InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3/t15-,16?,17-,18-,19-,20-,21+/m0/s1
InChI Key:
JWMFYGXQPXQEEM-WZBAXQLOSA-N
SMILES:
CC[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2[C@]1(C)CCCC2
Properties
Complexity:
399
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
6
Defined Bond Stereocenter Count:
0
Exact Mass:
288.282g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
0
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
288.519g/mol
Monoisotopic Mass:
288.282g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
0A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
8.4
Literature
| Title | Journal |
|---|---|
| Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents. | Steroids 20121101 |
| Utility of DPX2 cells for predicting CYP3A induction-mediated drug-drug interactions and associated structure-activity relationships. | Drug metabolism and disposition: the biological fate of chemicals 20121101 |
| Targeting the pregnane X receptor in liver injury. | Expert opinion on therapeutic targets 20121101 |
| Dried chicory root modifies the activity and expression of porcine hepatic CYP3A but not 2C--effect of in vitro and in vivo exposure. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121101 |
| Marine sponge steroids as nuclear receptor ligands. | Trends in pharmacological sciences 20121101 |
| Donor ABCB1 variant associates with increased risk for kidney allograft failure. | Journal of the American Society of Nephrology : JASN 20121101 |
| Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury. | Chemico-biological interactions 20121025 |
| Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. | Toxicology 20121009 |
| Pneumococcal nasopharyngeal carriage in infants of mothers immunized with 23V non-conjugate pneumococcal polysaccharide vaccine. | Journal of tropical pediatrics 20121001 |
| Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. | Hepatology (Baltimore, Md.) 20121001 |
| The role of nuclear receptors in the kidney in obesity and metabolic syndrome. | Genes & nutrition 20121001 |
| Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. | The Journal of steroid biochemistry and molecular biology 20121001 |
| Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms. | British journal of pharmacology 20121001 |
| Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. | Toxicological sciences : an official journal of the Society of Toxicology 20121001 |
| Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. | Chemosphere 20121001 |
| D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. | Molecular pharmacology 20121001 |
| Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. | Toxicological sciences : an official journal of the Society of Toxicology 20121001 |
| Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein. | Drug metabolism and disposition: the biological fate of chemicals 20121001 |
| Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice. | Journal of lipid research 20121001 |
| Targeting xenobiotic receptors PXR and CAR for metabolic diseases. | Trends in pharmacological sciences 20121001 |
| Immuno-MS based targeted proteomics: highly specific, sensitive, and reproducible human chorionic gonadotropin determination for clinical diagnostics and doping analysis. | Analytical chemistry 20120918 |
| Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules. | Bioorganic & medicinal chemistry 20120915 |
| Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. | Toxicology and applied pharmacology 20120901 |
| Glucocorticoid receptor-mediated transcriptional regulation of N-acetyltransferase 1 gene through distal promoter. | The AAPS journal 20120901 |
| Hormonal and chemical regulation of paraoxonases in mice. | The Journal of pharmacology and experimental therapeutics 20120901 |
| The potential use of the pregnane X receptor in cardiovascular therapy. | Expert review of cardiovascular therapy 20120901 |
| A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. | International journal of cancer 20120815 |
| Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. | Biochemical pharmacology 20120815 |
| Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. | Toxicology and applied pharmacology 20120815 |
| Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR. | Toxicology letters 20120803 |
| Cytochrome P450 3A expression and function in liver and intestinal mucosa from dexamethasone-treated sheep. | Journal of veterinary pharmacology and therapeutics 20120801 |
| Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. | Hepatology (Baltimore, Md.) 20120801 |
| Influence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats. | Xenobiotica; the fate of foreign compounds in biological systems 20120801 |
| Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. | Biochemical pharmacology 20120801 |
| QSAR model for human pregnane X receptor (PXR) binding: screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity. | Toxicology and applied pharmacology 20120801 |
| Severe hypertriglyceridemia in pregnancy. | The Journal of clinical endocrinology and metabolism 20120801 |
| Alkaloids from Pachysandra terminalis inhibit breast cancer invasion and have potential for development as antimetastasis therapeutic agents. | Journal of natural products 20120727 |
| The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701 |
| FXR and PXR: potential therapeutic targets in cholestasis. | The Journal of steroid biochemistry and molecular biology 20120701 |
| The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes. | Drug and chemical toxicology 20120701 |
| Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. | Drug metabolism and disposition: the biological fate of chemicals 20120701 |
| Role of CAR and PXR in xenobiotic sensing and metabolism. | Expert opinion on drug metabolism & toxicology 20120701 |
| PXR ligand classification model with SFED-weighted WHIM and CoMMA descriptors. | SAR and QSAR in environmental research 20120701 |
| Population pharmacokinetics and pharmacogenetics of everolimus in renal transplant patients. | Clinical pharmacokinetics 20120701 |
| Renal efflux transporter expression in pregnant mice with Type I diabetes. | Toxicology letters 20120620 |
| Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid receptor and pregnane X receptor. | Investigative ophthalmology & visual science 20120608 |
| Effects of pharmaceuticals on the expression of genes involved in detoxification in a carp primary hepatocyte model. | Environmental science & technology 20120605 |
| Selective agonism of human pregnane X receptor by individual ginkgolides. | Drug metabolism and disposition: the biological fate of chemicals 20120601 |
| Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. | Drug metabolism and disposition: the biological fate of chemicals 20120601 |
| Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. | Toxicological sciences : an official journal of the Society of Toxicology 20120601 |
| The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver. | Molecular endocrinology (Baltimore, Md.) 20120601 |
| Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis. | British journal of haematology 20120601 |
| Pregnane X receptor as a target for treatment of inflammatory bowel disorders. | Trends in pharmacological sciences 20120601 |
| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
| Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs. | Vaccine 20120521 |
| The novel antibacterial compound walrycin A induces human PXR transcriptional activity. | Toxicological sciences : an official journal of the Society of Toxicology 20120501 |
| Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. | American journal of physiology. Gastrointestinal and liver physiology 20120501 |
| Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation. | Clinical pharmacology and therapeutics 20120501 |
| Pruritus in chronic cholestatic liver disease. | Clinics in liver disease 20120501 |
| Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation. | Molecular nutrition & food research 20120501 |
| Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases. | Journal of medicinal chemistry 20120426 |
| Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. | Biochemical pharmacology 20120415 |
| Variants of the human NR1I2 (PXR) locus in chronic periodontitis. | Journal of periodontal research 20120401 |
| Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 2. Characterization, using GC-MS and GC-MS/MS, of pregnanes and pregnenes with an oxo- group on the A- or B-ring. | Steroids 20120401 |
| Antiproliferative steroidal glycosides from Digitalis ciliata. | Fitoterapia 20120401 |
| Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. | International immunopharmacology 20120401 |
| Influence of drugs on vitamin D and calcium metabolism. | Dermato-endocrinology 20120401 |
| Characterization of human cytochrome P450 induction by pesticides. | Toxicology 20120329 |
| Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. | Journal of chemical information and modeling 20120326 |
| Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. | Cardiovascular research 20120315 |
| On the environmental stress that reshapes our vessels. | Cardiovascular research 20120315 |
| Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate. | Toxicology 20120311 |
| Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR. | Toxicology 20120311 |
| Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells. | Basic & clinical pharmacology & toxicology 20120301 |
| Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor. | British journal of pharmacology 20120301 |
| Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver. | Drug metabolism and disposition: the biological fate of chemicals 20120301 |
| Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20120301 |
| An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism. | The Journal of pharmacology and experimental therapeutics 20120301 |
| Bisphenol A and its analogues activate human pregnane X receptor. | Environmental health perspectives 20120301 |
| Expression and regulation of human fetal-specific CYP3A7 in mice. | Endocrinology 20120301 |
| BPA and PXR activation: human receptor is affected, mouse receptor is not. | Environmental health perspectives 20120301 |
| Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates. | PLoS genetics 20120301 |
| Molecular dynamics simulations for human CAR inverse agonists. | Journal of chemical information and modeling 20120227 |
| Structure-activity relationship of novel menaquinone-4 analogues: modification of the side chain affects their biological activities. | Journal of medicinal chemistry 20120223 |
| Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei. | The Journal of organic chemistry 20120203 |
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| Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. | Archives of biochemistry and biophysics 20120115 |
| Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction. | Bioorganic & medicinal chemistry 20120115 |
| Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei. | Journal of medicinal chemistry 20120112 |
| Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. | Biochemistry 20120110 |
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| Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. | Gastroenterology 20120101 |
| Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes. | International journal of toxicology 20120101 |
| Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20120101 |
| Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor. | Drug metabolism and pharmacokinetics 20120101 |
| The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. | Pharmacogenetics and genomics 20120101 |
| Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians. | Pharmacogenomics 20120101 |
| Nuclear receptors in nonalcoholic Fatty liver disease. | Journal of lipids 20120101 |
| Immune-related microRNAs are abundant in breast milk exosomes. | International journal of biological sciences 20120101 |
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| Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells. | Marine drugs 20120101 |
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| New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice. | Journal of hepatology 20111001 |
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| [Advances in the research of pregnane X receptor and constitutive androstane receptor]. | Yao xue xue bao = Acta pharmaceutica Sinica 20111001 |
| Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis. | Neuroscience 20110915 |
| Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes. | Stem cell reviews 20110901 |
| Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. | Molecular pharmacology 20110901 |
| Influence of gender, feeding regimen, and exposure duration on gene expression associated with xenobiotic metabolism in fathead minnows (Pimephales promelas). | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901 |
| Deficiency of PXR decreases atherosclerosis in apoE-deficient mice. | Journal of lipid research 20110901 |
| Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. | Drug metabolism and disposition: the biological fate of chemicals 20110901 |
| Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix. | Journal of ethnopharmacology 20110901 |
| Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. | The Journal of antimicrobial chemotherapy 20110901 |
| The pregnane X receptor agonist St John's Wort has no effects on the pharmacokinetics and pharmacodynamics of repaglinide. | Clinical pharmacokinetics 20110901 |
| Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. | Inflammatory bowel diseases 20110901 |
| Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. | PLoS genetics 20110901 |
| [Research progress of zebrafish used in drug metabolism]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110901 |
| Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. | Toxicology letters 20110828 |
| 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | Frontiers in neuroendocrinology 20110801 |
| Nuclear receptor PXR, transcriptional circuits and metabolic relevance. | Biochimica et biophysica acta 20110801 |
| Tacrolimus dosing in Chinese renal transplant recipients: a population-based pharmacogenetics study. | European journal of clinical pharmacology 20110801 |
| The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes. | Pharmaceutical research 20110801 |
| Down-regulation of ATP-binding cassette C2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379. | Molecular pharmacology 20110801 |
| Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: breaking paradigms. | Cytokine 20110801 |
| Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. | The Journal of clinical investigation 20110801 |
| Pregnane derivatives from Potentilla evestita. | Natural product communications 20110801 |
| (Z)-3α-(1,3-Dioxoisoindolin-2-yl)-17(20)-pregnene. | Acta crystallographica. Section E, Structure reports online 20110801 |
| Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors. | Cancer biology & therapy 20110715 |
| Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity. | Journal of medicinal chemistry 20110714 |
| Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K. | Journal of medicinal chemistry 20110714 |
| Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells. | Toxicology 20110711 |
| Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. | Organic & biomolecular chemistry 20110707 |
| Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. | Life sciences 20110704 |
| Post-translational modification of pregnane x receptor. | Pharmacological research 20110701 |
| From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. | Biochemical pharmacology 20110701 |
| In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. | Molecular pharmacology 20110701 |
| The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes. | Xenobiotica; the fate of foreign compounds in biological systems 20110701 |
| Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. | Journal of neurochemistry 20110701 |
| Role of Class II nuclear receptors in liver carcinogenesis. | Anti-cancer agents in medicinal chemistry 20110701 |
| Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia. | Current molecular medicine 20110701 |
| Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta. | Placenta 20110701 |
| Effect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice. | European journal of pharmacology 20110625 |
| Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists. | Journal of medicinal chemistry 20110623 |
| Identification of novel pregnane X receptor activators from traditional Chinese medicines. | Journal of ethnopharmacology 20110614 |
| Association of steroid and xenobiotic receptor (SXR) and multidrug resistance 1 (MDR1) gene expression with survival among patients with invasive bladder carcinoma. | BJU international 20110601 |
| Pregnane X receptor- and CYP3A4-humanized mouse models and their applications. | British journal of pharmacology 20110601 |
| The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers. | Toxicology in vitro : an international journal published in association with BIBRA 20110601 |
| New pregnane saponins from Ecdysanthera rosea and their cytotoxicity. | Fitoterapia 20110601 |
| Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy. | Seizure 20110601 |
| PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. | Gastroenterology 20110601 |
| Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20110601 |
| Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. | Molecular pharmacology 20110601 |
| Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3. | Hepatology (Baltimore, Md.) 20110601 |
| B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. | Molecular endocrinology (Baltimore, Md.) 20110601 |
| Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals. | The Journal of antimicrobial chemotherapy 20110601 |
| Transgenic animal models in toxicology: historical perspectives and future outlook. | Toxicological sciences : an official journal of the Society of Toxicology 20110601 |
| Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease. | Frontiers in bioscience (Landmark edition) 20110601 |
| Pregnane and pregnane tetraglycoside from Marsdenia roylei. | Natural product research 20110601 |
| Pleiotropic functions of the organic solute transporter Ostα-Ostβ. | Digestive diseases (Basel, Switzerland) 20110601 |
| Bile acids regulate cardiovascular function. | Clinical and translational science 20110601 |
| Effect of endocrine disruptor pesticides: a review. | International journal of environmental research and public health 20110601 |
| Frequency of genetic polymorphisms of PXR gene in the Brazilian population. | Clinics (Sao Paulo, Brazil) 20110601 |
| [Human pregnane X receptor-mediated transcriptional regulation of CYP3A4 by extracts of 7 traditional Chinese medicines]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601 |
| 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. | Toxicology letters 20110530 |
| Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. | Clinical cancer research : an official journal of the American Association for Cancer Research 20110515 |
| CYP17 inhibitors for prostate cancer therapy. | The Journal of steroid biochemistry and molecular biology 20110501 |
| Pregnane steroidal glycosides and their cytostatic activities. | Glycobiology 20110501 |
| Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes. | Biotechnology journal 20110501 |
| NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. | Pharmacological research 20110501 |
| Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20110501 |
| Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens. | Steroids 20110501 |
| Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids. | Chemosphere 20110501 |
| Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment. | Toxicology and applied pharmacology 20110501 |
| Acid epimerization of 20-keto pregnane glycosides is determined by 2D-NMR spectroscopy. | Journal of biomolecular NMR 20110501 |
| Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. | Drug metabolism reviews 20110501 |
| Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors. | Journal of medicinal chemistry 20110428 |
| Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). | Toxicology letters 20110425 |
| Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition. | Toxicology letters 20110425 |
| The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. | Journal of natural products 20110425 |
| Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. | Xenobiotica; the fate of foreign compounds in biological systems 20110401 |
| Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice. | The Journal of pharmacology and experimental therapeutics 20110401 |
| Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20110401 |
| The impact of cholesterol and its metabolites on drug metabolism. | Expert opinion on drug metabolism & toxicology 20110401 |
| Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1. | Bioorganic & medicinal chemistry letters 20110401 |
| Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. | Critical reviews in toxicology 20110401 |
| [Comparison of human chorionic gonadotropin (Pregnyl 10 000 IU i.m.) versus GnRH agonist (triptorelin 0,2 mg s.c.) for final oocytes maturation in the same egg donors--clinical and embryological characteristics]. | Ceska gynekologie 20110401 |
| Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. | Biochemical and biophysical research communications 20110318 |
| Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. | Molecular and cellular endocrinology 20110301 |
| Gestational and pregnane X receptor-mediated regulation of placental ATP-binding cassette drug transporters in mice. | Drug metabolism and disposition: the biological fate of chemicals 20110301 |
| Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. | The Journal of pharmacology and experimental therapeutics 20110301 |
| Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR. | Biochemical pharmacology 20110301 |
| Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants. | Clinical pharmacology and therapeutics 20110301 |
| Pregnane progestin contraception in systemic lupus erythematosus: a longitudinal study of 187 patients. | Contraception 20110301 |
| [Mechanism for subcellular localization of nuclear receptor CAR]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110301 |
| Xenosensors CAR and PXR at work: impact on statin metabolism. | Current drug metabolism 20110301 |
| The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. | The Journal of pharmacy and pharmacology 20110301 |
| Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. | Toxicology 20110227 |
| Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration. | The Journal of biological chemistry 20110204 |
| Pregnane X receptor-mediated induction of Cyp3a by black cohosh. | Xenobiotica; the fate of foreign compounds in biological systems 20110201 |
| Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. | Insect molecular biology 20110201 |
| Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. | Drug metabolism and disposition: the biological fate of chemicals 20110201 |
| Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells. | British journal of cancer 20110201 |
| Regulation of hepatic cytochromes p450 by lipids and cholesterol. | Current drug metabolism 20110201 |
| Steroid regulation of drug-metabolizing cytochromes P450. | Current drug metabolism 20110201 |
| Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome p450 enzymes. | Current drug metabolism 20110201 |
| [The relationship between pregnane X receptor and multidrug resistance in tumor]. | Sheng li ke xue jin zhan [Progress in physiology] 20110201 |
| The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles - a randomized controlled study. | Archives of medical science : AMS 20110201 |
| AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. | The Journal of biological chemistry 20110128 |
| Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110118 |
| Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease. | World journal of gastroenterology 20110114 |
| Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity. | Journal of medicinal chemistry 20110113 |
| Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. | Neurotoxicity research 20110101 |
| Interplay between cholesterol and drug metabolism. | Biochimica et biophysica acta 20110101 |
| Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk. | Breast cancer research and treatment 20110101 |
| Content variations of the tomato saponin esculeoside A in various processed tomatoes. | Journal of natural medicines 20110101 |
| Microbial transformation of 3β-acetoxypregna-5,16-diene-20-one by Penicillium citrinum. | Steroids 20110101 |
| Correlation between PXR and ABCG2 patterns of mRNA expression in a MCF7 breast carcinoma cell derivative upon induction by proinflammatory cytokines. | DNA and cell biology 20110101 |
| Functional analysis of genetic variations in the 5'-flanking region of the human MDR1 gene. | Molecular genetics and metabolism 20110101 |
| Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. | Diabetes 20110101 |
| Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. | Drug metabolism and disposition: the biological fate of chemicals 20110101 |
| Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. | British journal of pharmacology 20110101 |
| Identification of clinically used drugs that activate pregnane X receptors. | Drug metabolism and disposition: the biological fate of chemicals 20110101 |
| Kavalactone pharmacophores for major cellular drug targets. | Mini reviews in medicinal chemistry 20110101 |
| Molecular mechanisms of drug transporter regulation. | Handbook of experimental pharmacology 20110101 |
| Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. | Journal of pharmacological and toxicological methods 20110101 |
| Identification of urinary biomarkers of colon inflammation in IL10-/- mice using Short-Column LCMS metabolomics. | Journal of biomedicine & biotechnology 20110101 |
| Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study. | Environmental health : a global access science source 20110101 |
| Inflammatory pseudo-tumor of the liver: a rare pathological entity. | World journal of surgical oncology 20110101 |
| A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. | PloS one 20110101 |
| Essential metabolites of Mycobacterium tuberculosis and their mimics. | mBio 20110101 |
| Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes. | BMC medicine 20110101 |
| The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. | BMC biochemistry 20110101 |
| A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile. | PloS one 20110101 |
| Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett's oesophagus. | Histopathology 20110101 |
| Using nuclear receptor activity to stratify hepatocarcinogens. | PloS one 20110101 |
| Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. | BMC cancer 20110101 |
| Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds. | PloS one 20110101 |
| Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. | PloS one 20110101 |
| Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. | Fluids and barriers of the CNS 20110101 |
| Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats. | Mediators of inflammation 20110101 |
| Therapy with sodium stibogluconate in stearylamine-bearing liposomes confers cure against SSG-resistant Leishmania donovani in BALB/c mice. | PloS one 20110101 |
| Biological and genetic factors associated with ABCB1 and pregnane-X-receptor expressions in peripheral blood mononuclear cells in the STANISLAS cohort. | Drug metabolism and drug interactions 20110101 |
| [Hydroxylation of steroids by Curvalaria lunata mycelium in the presence of methyl-beta-cyclodextrine]. | Prikladnaia biokhimiia i mikrobiologiia 20110101 |
| Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. | PloS one 20110101 |
| The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. | Journal of carcinogenesis 20110101 |
| Effect of screening and management of diabetes during pregnancy on stillbirths. | BMC public health 20110101 |
| Anchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein. | International journal of molecular sciences 20110101 |
| A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. | BMC systems biology 20110101 |
| Current and emerging drugs for the treatment of inflammatory bowel disease. | Drug design, development and therapy 20110101 |
| Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. | PloS one 20110101 |
| Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics. | Cancer management and research 20110101 |
| Expression of OATP family members in hormone-related cancers: potential markers of progression. | PloS one 20110101 |
| Concurrent analysis of choice and control in childbirth. | BMC pregnancy and childbirth 20110101 |
| Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial. | Reproductive biology and endocrinology : RB&E 20110101 |
| Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver. | PloS one 20110101 |
| Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. | Molecular cancer 20110101 |
| Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. | Frontiers in physiology 20110101 |
| Nonalcoholic Fatty liver disease: focus on lipoprotein and lipid deregulation. | Journal of lipids 20110101 |
| Proteomic analysis of polypeptides captured from blood during extracorporeal albumin dialysis in patients with cholestasis and resistant pruritus. | PloS one 20110101 |
| Clinical therapeutics in pregnancy. | Journal of biomedicine & biotechnology 20110101 |
| Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes. | Environmental toxicology and pharmacology 20110101 |
| Hepatic expression of multidrug resistance protein 2 in biliary atresia. | Comparative hepatology 20110101 |
| Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. | PloS one 20110101 |
| A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis. | BMC systems biology 20110101 |
| Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells. | BMC systems biology 20110101 |
| Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. | Lipids in health and disease 20110101 |
| Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. | PloS one 20110101 |
| Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? | Journal of thyroid research 20110101 |
| Regulation of microRNA expression and function by nuclear receptor signaling. | Cell & bioscience 20110101 |
| P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice. | PloS one 20110101 |
| [Transformation of delta4-3-ketosteroids by free and immobilized cells of Rhodococcus erythropolis actinobacterium]. | Prikladnaia biokhimiia i mikrobiologiia 20110101 |
| Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers. | BMC biotechnology 20110101 |
| Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma. | BMC gastroenterology 20110101 |
| Functional evaluation of genetic and environmental regulators of p450 mRNA levels. | PloS one 20110101 |
| Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes. | Frontiers in molecular neuroscience 20110101 |
| A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue. | BMC systems biology 20110101 |
| Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review. | Frontiers in psychiatry 20110101 |
| Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression. | Journal of nutritional science and vitaminology 20110101 |
| A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy. | Molecular vision 20110101 |
| [All signs of metabolic syndrome in the hypertensive ISIAH rats are associated with increased activity of transcription factors PPAR, LXR, PXR, and CAR in the liver]. | Biomeditsinskaia khimiia 20110101 |
| Maternal Deaths in a Tertiary Health Care Centre of Odisha: An In-depth Study Supplemented by Verbal Autopsy. | Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine 20110101 |
| Natriuretic and saluretic effects of Hemidesmus indicus R. Br. root extracts in rats. | Indian journal of pharmacology 20110101 |
| Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients. | PloS one 20110101 |
| Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. | Frontiers in neuroscience 20110101 |
| Quantitative determination of pregnanes from aerial parts of Caralluma species using HPLC-UV and identification by LC-ESI-TOF. | Journal of AOAC International 20110101 |
| What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS). | Fibrogenesis & tissue repair 20110101 |
| Regulation of bilirubin clearance by ligand-activated transcription factors of the endo- and xenobiotic metabolism system. | Frontiers in pharmacology 20110101 |
| A cell-based protein-protein interaction method using a permuted luciferase reporter. | Current chemical genomics 20110101 |
| Role of aldo-keto reductase enzymes in mediating the timing of parturition. | Frontiers in pharmacology 20110101 |
| Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. | Frontiers in neuroscience 20110101 |
| MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors. | International journal of breast cancer 20110101 |
| Network-based functional enrichment. | BMC bioinformatics 20110101 |
| Neuroprotective actions of neurosteroids. | Frontiers in endocrinology 20110101 |
| Guggulsterone-mediated enhancement of radiosensitivity in human tumor cell lines. | Frontiers in oncology 20110101 |
| Measurement of steroid concentrations in brain tissue: methodological considerations. | Frontiers in endocrinology 20110101 |
| Neurosteroids and GABA-A Receptor Function. | Frontiers in endocrinology 20110101 |
| Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. | Frontiers in endocrinology 20110101 |
| Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans. | Journal of acquired immune deficiency syndromes (1999) 20101215 |
| Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. | Chemico-biological interactions 20101205 |
| Pregnane alkaloids from Pachysandra axillaris. | Steroids 20101201 |
| Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes. | Journal of thrombosis and haemostasis : JTH 20101201 |
| The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. | Biochemical pharmacology 20101201 |
| Endocrine profiling and prioritization of environmental chemicals using ToxCast data. | Environmental health perspectives 20101201 |
| Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders. | Molecular and cellular biochemistry 20101201 |
| Nanosilver particle effects on drug metabolism in vitro. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption. | The Journal of endocrinology 20101201 |
| Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Pregnane X receptor as a therapeutic target to inhibit androgen activity. | Endocrinology 20101201 |
| Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells. | Experimental & molecular medicine 20101130 |
| Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism. | Toxicology 20101109 |
| Effects of matrine and oxymatrine on catalytic activity of cytochrome p450s in rats. | Basic & clinical pharmacology & toxicology 20101101 |
| Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells. | Pharmacological research 20101101 |
| Pregnane X receptor is SUMOylated to repress the inflammatory response. | The Journal of pharmacology and experimental therapeutics 20101101 |
| Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1. | Hepatology (Baltimore, Md.) 20101101 |
| Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. | The Annals of pharmacotherapy 20101101 |
| Current in vitro high throughput screening approaches to assess nuclear receptor activation. | Current drug metabolism 20101101 |
| [The influence of a standardized soybean extract (Glycine max) on the expression level of CYP3A enzymes and pregnane X receptor in in vivo model]. | Ginekologia polska 20101101 |
| Overcoming drug resistance by regulating nuclear receptors. | Advanced drug delivery reviews 20101030 |
| Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. | Advanced drug delivery reviews 20101030 |
| Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23. | Biochemical pharmacology 20101015 |
| Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009 |
| Reflections on my career in analytical chemistry and biochemistry. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20101008 |
| Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction. | Bulletin of mathematical biology 20101001 |
| Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database. | Environmental health perspectives 20101001 |
| Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
| Cross-talk between androgen receptor and pregnane and xenobiotic receptor reveals existence of a novel modulatory action of anti-androgenic drugs. | Biochemical pharmacology 20101001 |
| Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. | Archives of toxicology 20101001 |
| Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation. | Molecular pharmacology 20101001 |
| Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. | The Journal of pharmacology and experimental therapeutics 20101001 |
| Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
| Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation. | Human reproduction (Oxford, England) 20101001 |
| Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). | Aquatic toxicology (Amsterdam, Netherlands) 20101001 |
| [Advances on pregnane X receptor]. | Sheng li ke xue jin zhan [Progress in physiology] 20101001 |
| Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism. | Bioinformatics (Oxford, England) 20100915 |
| PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. | Cancer chemotherapy and pharmacology 20100901 |
| Neurosteroid biosynthetic pathway changes in substantia nigra and caudate nucleus in Parkinson's disease. | Brain pathology (Zurich, Switzerland) 20100901 |
| Comparison of metabolism of vitamins D2 and D3 in children with nutritional rickets. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100901 |
| Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20100901 |
| Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes. | Toxicology letters 20100901 |
| Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. | Drug metabolism and disposition: the biological fate of chemicals 20100901 |
| Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20100901 |
| Postprandial plasma bile acid responses in normal weight and obese subjects. | Annals of clinical biochemistry 20100901 |
| Interaction between warfarin and the herbal product Shengmai-yin: a case report of intracerebral hematoma. | Yonsei medical journal 20100901 |
| Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100901 |
| Treatment outcome of women with a single ovary undergoing in vitro fertilisation cycles. | Singapore medical journal 20100901 |
| Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways. | European journal of pharmacology 20100825 |
| Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes. | International journal of pharmaceutics 20100816 |
| Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator. | Aquatic toxicology (Amsterdam, Netherlands) 20100815 |
| Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. | Journal of lipid research 20100801 |
| Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. | Toxicological sciences : an official journal of the Society of Toxicology 20100801 |
| Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines. | Bioorganic & medicinal chemistry letters 20100801 |
| Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro. | Hepatology (Baltimore, Md.) 20100801 |
| Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209. | The Journal of toxicological sciences 20100801 |
| Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100711 |
| Biological analysis of endocrine-disrupting compounds in Tunisian sewage treatment plants. | Archives of environmental contamination and toxicology 20100701 |
| In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. | Drug metabolism and disposition: the biological fate of chemicals 20100701 |
| The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. | Drug metabolism and disposition: the biological fate of chemicals 20100701 |
| Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. | Toxicological sciences : an official journal of the Society of Toxicology 20100701 |
| EMAS position statement: managing obese postmenopausal women. | Maturitas 20100701 |
| Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin-induced diabetic rats. | The Journal of pharmacy and pharmacology 20100701 |
| Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. | Toxicology and applied pharmacology 20100615 |
| Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. | British journal of cancer 20100608 |
| Self-organizing molecular field analysis on pregnane derivatives as human steroidal 5alpha-reductase inhibitors. | Steroids 20100601 |
| Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20100601 |
| Explaining variability in ciclosporin exposure in adult kidney transplant recipients. | European journal of clinical pharmacology 20100601 |
| Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants. | Experimental biology and medicine (Maywood, N.J.) 20100601 |
| The PXR is a drug target for chronic inflammatory liver disease. | The Journal of steroid biochemistry and molecular biology 20100531 |
| The alternatively spliced murine pregnane X receptor isoform, mPXR(delta171-211) exhibits a repressive action. | The international journal of biochemistry & cell biology 20100501 |
| Induced spawning and embryonic development of Liza ramada reared in freshwater ponds. | Animal reproduction science 20100501 |
| Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. | Molecular pharmacology 20100501 |
| Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism. | Journal of clinical pharmacology 20100501 |
| Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol? | Molecular nutrition & food research 20100501 |
| Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers. | Clinical chemistry and laboratory medicine 20100501 |
| The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies. | Toxicology mechanisms and methods 20100501 |
| A role for the pregnane X receptor in flucloxacillin-induced liver injury. | Hepatology (Baltimore, Md.) 20100501 |
| Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis. | Seminars in liver disease 20100501 |
| A new pregnane steroid from Poria cum radix pini. | Journal of Asian natural products research 20100501 |
| Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer. | Pathology international 20100501 |
| Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. | Expert opinion on drug discovery 20100501 |
| Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin. | Chemico-biological interactions 20100429 |
| Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs). | Molecular endocrinology (Baltimore, Md.) 20100401 |
| Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction. | Drug metabolism and disposition: the biological fate of chemicals 20100401 |
| Persistent organic pollutant exposure leads to insulin resistance syndrome. | Environmental health perspectives 20100401 |
| Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20100401 |
| Activation of xenobiotic receptors: driving into the nucleus. | Expert opinion on drug metabolism & toxicology 20100401 |
| In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine. | Cancer chemotherapy and pharmacology 20100401 |
| Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). | Endocrinology 20100401 |
| Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II. | Clinical pharmacokinetics 20100401 |
| In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. | Environmental health perspectives 20100401 |
| Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding. | Biochemical and biophysical research communications 20100319 |
| PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. | Toxicology and applied pharmacology 20100315 |
| Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM(2.5) organic extract from Puerto Rico. | Toxicology and applied pharmacology 20100315 |
| Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. | Toxicology letters 20100315 |
| Modulation of T lymphocyte function by the pregnane X receptor. | Journal of immunology (Baltimore, Md. : 1950) 20100315 |
| Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20100301 |
| Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20100301 |
| Genetic predictors of interindividual variability in hepatic CYP3A4 expression. | The Journal of pharmacology and experimental therapeutics 20100301 |
| The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy. | Alimentary pharmacology & therapeutics 20100301 |
| Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice. | Drug metabolism and disposition: the biological fate of chemicals 20100301 |
| Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro. | Toxicology letters 20100301 |
| The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability. | Pharmacogenetics and genomics 20100301 |
| SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. | Bioorganic & medicinal chemistry letters 20100301 |
| Nuclear receptor-mediated regulation of carboxylesterase expression and activity. | Expert opinion on drug metabolism & toxicology 20100301 |
| [Woman with surgical reconstruction of anal atresia who realized pregnancy with in vitro fertilisation]. | Vojnosanitetski pregled 20100301 |
| New pregnane and steroidal glycosides from Tribulus terrestris L. | Journal of Asian natural products research 20100301 |
| Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines. | European journal of pharmacology 20100225 |
| Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis. | Liver international : official journal of the International Association for the Study of the Liver 20100201 |
| CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. | The Journal of pharmacology and experimental therapeutics 20100201 |
| Steroid and xenobiotic receptor in human esophageal squamous cell carcinoma: a potent prognostic factor. | Cancer science 20100201 |
| Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. | Toxicological sciences : an official journal of the Society of Toxicology 20100201 |
| An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45. | Cellular and molecular life sciences : CMLS 20100201 |
| The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. | Laboratory investigation; a journal of technical methods and pathology 20100201 |
| Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers. | The American journal of pathology 20100201 |
| Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism. | Xenobiotica; the fate of foreign compounds in biological systems 20100201 |
| Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. | Environmental health perspectives 20100201 |
| Two new terpenoids from Trichilia quadrijuga (Meliaceae). | Natural product communications 20100201 |
| Learning from the pregnane X receptor: how to fight one aggressor with two strategies. | Liver international : official journal of the International Association for the Study of the Liver 20100201 |
| Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene. | Biochemical pharmacology 20100115 |
| Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers. | Environmental pollution (Barking, Essex : 1987) 20100101 |
| Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20100101 |
| Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2. | Pharmacogenetics and genomics 20100101 |
| The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease. | Pharmacogenetics and genomics 20100101 |
| Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples. | Analytical and bioanalytical chemistry 20100101 |
| A synergism model for PPARalpha and PXR agonist effects on HDL-cholesterol and apoA1. | Frontiers in bioscience (Elite edition) 20100101 |
| Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. | Acta pharmacologica Sinica 20100101 |
| Global gene expression analysis in the livers of rat offspring perinatally exposed to low doses of 2,2',4,4'-tetrabromodiphenyl ether. | Environmental health perspectives 20100101 |
| Modulation of cytokine expression in human myeloid dendritic cells by environmental endocrine-disrupting chemicals involves epigenetic regulation. | Environmental health perspectives 20100101 |
| Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida. | Reproductive biology and endocrinology : RB&E 20100101 |
| Increased ubiquitination of multidrug resistance 1 by ginsenoside Rd. | Nutrition and cancer 20100101 |
| Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70. | Journal of clinical biochemistry and nutrition 20100101 |
| Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. | BMC medicine 20100101 |
| Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. | Molecular cancer 20100101 |
| [7alpha-hydroxylation of steroid 5-olefins by mold fungi]. | Prikladnaia biokhimiia i mikrobiologiia 20100101 |
| Impact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes. | Drug metabolism letters 20100101 |
| Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. | BMC evolutionary biology 20100101 |
| Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice. | PloS one 20100101 |
| Immature oocytes in 'apparent empty follicle syndrome': a case report. | Case reports in medicine 20100101 |
| [Bioconversion of C19- and C21-steroids with parent and mutant strains of Curvularia lunata]. | Prikladnaia biokhimiia i mikrobiologiia 20100101 |
| Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. | PloS one 20100101 |
| Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. | BMC evolutionary biology 20100101 |
| Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | Current chemical genomics 20100101 |
| Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts. | Biological & pharmaceutical bulletin 20100101 |
| MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia. | Molecular cancer 20100101 |
| Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. | Journal of ovarian research 20100101 |
| Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas. | Journal of oncology 20100101 |
| Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. | BMC gastroenterology 20100101 |
| Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. | BMC biochemistry 20100101 |
| Altered retinoic acid metabolism in diabetic mouse kidney identified by O isotopic labeling and 2D mass spectrometry. | PloS one 20100101 |
| The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation. | PloS one 20100101 |
| Gene activation regresses atherosclerosis, promotes health, and enhances longevity. | Lipids in health and disease 20100101 |
| Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage Embryos. | Obstetrics and gynecology international 20100101 |
| Metabonomic studies on human hepatocyte in primary culture. | Methods in molecular biology (Clifton, N.J.) 20100101 |
| Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. | BMC cancer 20100101 |
| Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin. | Journal of inflammation (London, England) 20100101 |
| Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? | Molecular neurodegeneration 20100101 |
| Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. | PPAR research 20100101 |
| Sex-different hepaticglycogen content and glucose output in rats. | BMC biochemistry 20100101 |
| Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis. | PloS one 20100101 |
| Developmental effects of perfluorononanoic Acid in the mouse are dependent on peroxisome proliferator-activated receptor-alpha. | PPAR research 20100101 |
| Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects. | PPAR research 20100101 |
| The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. | PloS one 20100101 |
| Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats. | Journal of toxicology and environmental health. Part A 20100101 |
| Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. | BMC genomics 20100101 |
| Promotion of tumor development in prostate cancer by progerin. | Cancer cell international 20100101 |
| Age and sex dependent changes in liver gene expression during the life cycle of the rat. | BMC genomics 20100101 |
| Lipid based therapy for ulcerative colitis-modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation. | International journal of molecular sciences 20100101 |
| Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo. | BMC genomics 20100101 |
| Design principles of nuclear receptor signaling: how complex networking improves signal transduction. | Molecular systems biology 20100101 |
| Eukaryotic signaling pathways targeted by Salmonella effector protein AvrA in intestinal infection in vivo. | BMC microbiology 20100101 |
| A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity. | PloS one 20100101 |
| Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α. | PPAR research 20100101 |
| Deciphering the nuclear bile acid receptor FXR paradigm. | Nuclear receptor signaling 20100101 |
| Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver. | Frontiers in pharmacology 20100101 |
| A comprehensive review on Nymphaea stellata: A traditionally used bitter. | Journal of advanced pharmaceutical technology & research 20100101 |
| The structural basis of pregnane X receptor binding promiscuity. | Biochemistry 20091208 |
| In silico predication of nuclear hormone receptors for organic pollutants by homology modeling and molecular docking. | Toxicology letters 20091201 |
| Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes. | Toxicology letters 20091201 |
| Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. | The American journal of pathology 20091201 |
| Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity. | Xenobiotica; the fate of foreign compounds in biological systems 20091201 |
| [Vitamin K function mediated by activation of steroid and xenobiotic receptor]. | Clinical calcium 20091201 |
| 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | International journal of clinical pharmacology and therapeutics 20091201 |
| Clotrimazole protects the liver against normothermic ischemia-reperfusion injury in rats. | Transplantation proceedings 20091201 |
| Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. | PLoS computational biology 20091201 |
| Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells. | The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20091201 |
| Expression, function and regulation of mouse cytochrome P450 enzymes: comparison with human P450 enzymes. | Current drug metabolism 20091201 |
| Investigation of the CYP2C9 induction profile in human hepatocytes by combining experimental and modelling approaches. | Current drug metabolism 20091201 |
| Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats. | European journal of pharmacology 20091125 |
| Synthesis of pregnane derivatives, their cytotoxicity on LNCap and PC-3 cells, and screening on 5alpha-reductase inhibitory activity. | Molecules (Basel, Switzerland) 20091117 |
| Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20091101 |
| Lithocholate--a promising non-calcaemic calcitriol surrogate for promoting human osteoblast maturation upon biomaterials. | Steroids 20091101 |
| Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. | Basic & clinical pharmacology & toxicology 20091101 |
| Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. | Xenobiotica; the fate of foreign compounds in biological systems 20091101 |
| Xenobiotic-sensing nuclear receptors CAR and PXR as drug targets in cholestatic liver disease. | Current drug targets 20091101 |
| Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms. | Current drug metabolism 20091101 |
| Novel C-6 substituted and unsubstituted pregnane derivatives as 5alpha-reductase inhibitors and their effect on hamster flank organs diameter size. | Steroids 20091001 |
| Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. | Molecular aspects of medicine 20091001 |
| Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice. | Journal of lipid research 20091001 |
| Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20091001 |
| A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein. | The Journal of pharmacology and experimental therapeutics 20091001 |
| Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR). | Toxicology 20091001 |
| Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine. | Environmental health perspectives 20091001 |
| Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. | Journal of medicinal chemistry 20090910 |
| Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. | Toxicology and applied pharmacology 20090901 |
| Prediction model and prognostic index to estimate clinically relevant pelvic organ prolapse in a general female population. | International urogynecology journal and pelvic floor dysfunction 20090901 |
| Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor. | Drug metabolism and disposition: the biological fate of chemicals 20090901 |
| Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. | Drug metabolism and disposition: the biological fate of chemicals 20090901 |
| The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor. | Molecular pharmacology 20090901 |
| The role of transporters in the pharmacokinetics of orally administered drugs. | Pharmaceutical research 20090901 |
| Primary biliary cirrhosis. | Seminars in immunopathology 20090901 |
| Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines. | The AAPS journal 20090901 |
| Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6. | Current drug metabolism 20090901 |
| Structure, function, regulation and polymorphism of human cytochrome P450 2A6. | Current drug metabolism 20090901 |
| Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. | Environmental health perspectives 20090901 |
| Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells. | Interdisciplinary toxicology 20090901 |
| Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. | Pharmaceutical research 20090801 |
| Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. | Toxicological sciences : an official journal of the Society of Toxicology 20090801 |
| Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. | Drug metabolism and disposition: the biological fate of chemicals 20090801 |
| Involvement of Vitamin D receptor in the intestinal induction of human ABCB1. | Drug metabolism and disposition: the biological fate of chemicals 20090801 |
| Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. | Hepatology (Baltimore, Md.) 20090801 |
| Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. | Expert opinion on drug metabolism & toxicology 20090801 |
| Metabolites from an endophytic fungus sphaceloma sp. LN-15 isolated from the leaves of Melia azedarach. | Lipids 20090801 |
| PXR and CAR in energy metabolism. | Trends in endocrinology and metabolism: TEM 20090801 |
| Open labeled, uncontrolled pharmacokinetic study of a single intramuscular hCG dose in healthy male volunteers. | International journal of clinical pharmacology and therapeutics 20090801 |
| Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells. | Environmental health perspectives 20090801 |
| Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor. | Drug metabolism and disposition: the biological fate of chemicals 20090701 |
| In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective. | Drug metabolism and disposition: the biological fate of chemicals 20090701 |
| Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. | Toxicological sciences : an official journal of the Society of Toxicology 20090701 |
| Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers. | Xenobiotica; the fate of foreign compounds in biological systems 20090701 |
| Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. | Xenobiotica; the fate of foreign compounds in biological systems 20090701 |
| Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients. | Journal of pediatric gastroenterology and nutrition 20090701 |
| Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. | Biopharmaceutics & drug disposition 20090701 |
| Effects of Oxidized Frying Oil on Proteins Related to alpha-Tocopherol Metabolism in Rat Liver. | Journal of clinical biochemistry and nutrition 20090701 |
| Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes. | Environmental health perspectives 20090701 |
| Regulation of drug resistance by human pregnane X receptor in breast cancer. | Cancer biology & therapy 20090701 |
| Pregnane X receptor: a double-edged sword. | Chinese medical journal 20090605 |
| Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. | Cancer chemotherapy and pharmacology 20090601 |
| Lipid-activated transcription factors control bile acid glucuronidation. | Molecular and cellular biochemistry 20090601 |
| Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. | Reproductive toxicology (Elmsford, N.Y.) 20090601 |
| The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. | Drug metabolism and disposition: the biological fate of chemicals 20090601 |
| Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells. | Molecular pharmacology 20090601 |
| Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells. | Drug metabolism and disposition: the biological fate of chemicals 20090601 |
| A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte. | Hepatology (Baltimore, Md.) 20090601 |
| Multiplexing a high-throughput liability assay to leverage efficiencies. | Assay and drug development technologies 20090601 |
| Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs. | Pharmacogenomics 20090601 |
| Statin regulation of CYP3A4 and CYP3A5 expression. | Pharmacogenomics 20090601 |
| 16α,17α-Ep-oxy-5α-hydr-oxy-6β-nitrooxy-20-oxopregnan-3β-yl acetate. | Acta crystallographica. Section E, Structure reports online 20090601 |
| Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. | Toxicology and applied pharmacology 20090515 |
| Modeling kinetics of subcellular disposition of chemicals. | Chemical reviews 20090513 |
| Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512 |
| Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. | Journal of lipid research 20090501 |
| Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064. | American journal of physiology. Gastrointestinal and liver physiology 20090501 |
| The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions. | Clinica chimica acta; international journal of clinical chemistry 20090501 |
| Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. | Drug metabolism and disposition: the biological fate of chemicals 20090501 |
| 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. | Journal of neurochemistry 20090501 |
| Farnesoid X receptor agonists in biliary tract disease. | Current opinion in gastroenterology 20090501 |
| The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. | Bioorganic & medicinal chemistry letters 20090501 |
| Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma. | Current eye research 20090501 |
| 6beta-Hydroxy-5beta-methyl-20-oxo-19-norpregn-9(10)-en-3beta-yl acetate. | Acta crystallographica. Section C, Crystal structure communications 20090501 |
| [Induction of rat hepatic cytochrome P-450 3A by zolmitriptan mediated with pregnane X receptor]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090501 |
| 3β,12β,14α-Trihydroxy-pregnan-20-one. | Acta crystallographica. Section E, Structure reports online 20090501 |
| Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. | The Journal of biological chemistry 20090403 |
| Xenobiotic action on steroid hormone synthesis and sulfonation the example of lead and polychlorinated biphenyls. | International archives of occupational and environmental health 20090401 |
| Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. | Pharmaceutical research 20090401 |
| Hybrid scoring and classification approaches to predict human pregnane X receptor activators. | Pharmaceutical research 20090401 |
| Bile Acid sulfation: a pathway of bile acid elimination and detoxification. | Toxicological sciences : an official journal of the Society of Toxicology 20090401 |
| Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. | Drug metabolism and disposition: the biological fate of chemicals 20090401 |
| Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. | The Journal of pharmacology and experimental therapeutics 20090401 |
| Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. | Drug metabolism and disposition: the biological fate of chemicals 20090401 |
| A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. | Drug metabolism and disposition: the biological fate of chemicals 20090401 |
| Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients. | Therapeutic drug monitoring 20090401 |
| Candidate gene copy number analysis by PCR and multicapillary electrophoresis. | Electrophoresis 20090401 |
| Intestinal flora induces the expression of Cyp3a in the mouse liver. | Xenobiotica; the fate of foreign compounds in biological systems 20090401 |
| Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats. | Die Pharmazie 20090401 |
| In vitro cytochrome p450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: possible occurrence of this metabolite in vivo. | International journal of molecular sciences 20090401 |
| Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. | Assay and drug development technologies 20090401 |
| Current Screens Based on the AlphaScreen Technology for Deciphering Cell Signalling Pathways. | Current genomics 20090401 |
| Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. | Aging 20090401 |
| Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner. | The Journal of biological chemistry 20090313 |
| PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090302 |
| PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. | Biochimica et biophysica acta 20090301 |
| Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. | Biochemical pharmacology 20090215 |
| Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? | Clinical reviews in allergy & immunology 20090201 |
| Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | Journal of lipid research 20090201 |
| Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent. | Drug metabolism and disposition: the biological fate of chemicals 20090201 |
| Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. | Molecular pharmacology 20090201 |
| Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. | Molecular pharmacology 20090201 |
| Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons. | Steroids 20090201 |
| New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects. | The Journal of steroid biochemistry and molecular biology 20090201 |
| Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. | British journal of clinical pharmacology 20090201 |
| Kupe virus, a new virus in the family bunyaviridae, genus nairovirus, kenya. | Emerging infectious diseases 20090201 |
| Analysis of endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray. | Environmental health perspectives 20090201 |
| Global gene expression changes including drug metabolism and disposition induced by three-dimensional culture of HepG2 cells-Involvement of microtubules. | Biochemical and biophysical research communications 20090116 |
| PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA. | Chemico-biological interactions 20090115 |
| Enhanced actions of insulin-like growth factor-I and interferon-alpha co-administration in experimental cirrhosis. | Liver international : official journal of the International Association for the Study of the Liver 20090101 |
| The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. | The British journal of nutrition 20090101 |
| Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | The Biochemical journal 20090101 |
| Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090101 |
| Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. | Drug metabolism and disposition: the biological fate of chemicals 20090101 |
| Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. | Archives of biochemistry and biophysics 20090101 |
| Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups. | Toxicological sciences : an official journal of the Society of Toxicology 20090101 |
| Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. | Critical care medicine 20090101 |
| Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction. | Pharmacogenetics and genomics 20090101 |
| Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. | BMC cancer 20090101 |
| Nuclear receptors as therapeutic targets in cholestatic liver diseases. | British journal of pharmacology 20090101 |
| Total fertilization failure and idiopathic subfertility. | Reproductive biology and endocrinology : RB&E 20090101 |
| Impact of GnRH ovarian stimulation protocols on intracytoplasmic sperm injection outcomes. | Reproductive biology and endocrinology : RB&E 20090101 |
| Pregnane X receptor and its potential role in drug resistance in cancer treatment. | Recent patents on anti-cancer drug discovery 20090101 |
| Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. | Biopharmaceutics & drug disposition 20090101 |
| Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice. | Molecular pharmaceutics 20090101 |
| Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. | Journal of biochemical and molecular toxicology 20090101 |
| The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | Nuclear receptor signaling 20090101 |
| Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio. | Frontiers in bioscience (Landmark edition) 20090101 |
| Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria. | Malaria journal 20090101 |
| Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes. | Reproductive biology and endocrinology : RB&E 20090101 |
| Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction. | Drug metabolism letters 20090101 |
| Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. | Nuclear receptor signaling 20090101 |
| The cytochrome P450 (CYP) gene superfamily in Daphnia pulex. | BMC genomics 20090101 |
| Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics. | Comparative hepatology 20090101 |
| [Antidepressants during pregnancy and lactation]. | Tijdschrift voor psychiatrie 20090101 |
| A novel approach to investigate the subcellular distribution of nuclear receptors in vivo. | Nuclear receptor signaling 20090101 |
| Protein expression analysis of inflammation-related colon carcinogenesis. | Journal of carcinogenesis 20090101 |
| Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. | Current medicinal chemistry 20090101 |
| Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor. | Endocrine journal 20090101 |
| Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms. | Molecular pharmaceutics 20090101 |
| Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora. | Drug metabolism and pharmacokinetics 20090101 |
| Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier. | BMC molecular biology 20090101 |
| Naturally occurring C-terminal splice variants of nuclear receptors. | Nuclear receptor signaling 20090101 |
| The health of Arab-Americans living in the United States: a systematic review of the literature. | BMC public health 20090101 |
| Does the clock make the poison? Circadian variation in response to pesticides. | PloS one 20090101 |
| Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs. | PPAR research 20090101 |
| Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers. | BMC genomics 20090101 |
| Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR. | Molecular pharmaceutics 20090101 |
| [Nuclear receptors and metabolism of xenobiotics]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101 |
| Ximaosteroids A-D, new steroids from the Hainan soft coral Scleronephthya sp. | Steroids 20090101 |
| Circadian dysregulation disrupts bile acid homeostasis. | PloS one 20090101 |
| Intestinal microbiota regulate xenobiotic metabolism in the liver. | PloS one 20090101 |
| Lipid alterations in experimental murine colitis: role of ceramide and imipramine for matrix metalloproteinase-1 expression. | PloS one 20090101 |
| Prognostic and therapeutic potential of nuclear receptors in head and neck squamous cell carcinomas. | Journal of oncology 20090101 |
| Gestational choriocarcinoma diagnosed with spontaneous splenic rupture after pregnancy induced by in vitro fertilization: a case report. | Cases journal 20090101 |
| Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles. | PloS one 20090101 |
| Immobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial. | BMJ (Clinical research ed.) 20090101 |
| A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans. | PPAR research 20090101 |
| Tacrolimus population pharmacokinetic-pharmacogenetic analysis and Bayesian estimation in renal transplant recipients. | Clinical pharmacokinetics 20090101 |
| iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells. | Molecular cancer 20090101 |
| Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | PloS one 20090101 |
| A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival. | BMC medical genomics 20090101 |
| Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae). | BMC genomics 20090101 |
| Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance. | Cardiovascular diabetology 20090101 |
| American palm ethnomedicine: a meta-analysis. | Journal of ethnobiology and ethnomedicine 20090101 |
| [Modulation of nuclear receptor action and regulation of medicines biotransformation]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101 |
| FSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development. | International journal of pediatric endocrinology 20090101 |
| PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. | PPAR research 20090101 |
| Studies of Antiviral Activity and Cytotoxicity of Wrightia tinctoria and Morinda citrifolia. | Indian journal of pharmaceutical sciences 20090101 |
| [Application of Pregnyl during the first trimester of the pregnancy]. | Akusherstvo i ginekologiia 20090101 |
| Induction of drug metabolism: species differences and toxicological relevance. | Toxicology 20081230 |
| Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. | Journal of medicinal chemistry 20081225 |
| Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents. | World journal of gastroenterology 20081214 |
| Effects of synthetic polycyclic musks on estrogen receptor, vitellogenin, pregnane X receptor, and cytochrome P450 3A gene expression in the livers of male medaka (Oryzias latipes). | Aquatic toxicology (Amsterdam, Netherlands) 20081211 |
| Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: evidence for an involvement of the glucocorticoid receptor. | Toxicology 20081205 |
| Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. | Archives of toxicology 20081201 |
| Bile acids and signal transduction: role in glucose homeostasis. | Cellular signalling 20081201 |
| Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. | Toxicological sciences : an official journal of the Society of Toxicology 20081201 |
| Structural basis of human pregnane X receptor activation by the hops constituent colupulone. | Molecular pharmacology 20081201 |
| Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice. | Toxicology and applied pharmacology 20081201 |
| A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
| Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. | Xenobiotica; the fate of foreign compounds in biological systems 20081201 |
| Effects of intrauterine undernutrition on the expression of CYP3A23/3A1, PXR, CAR and HNF4alpha in neonate rats. | Biopharmaceutics & drug disposition 20081201 |
| Molecular mechanisms underlying St. John's wort drug interactions. | Current drug metabolism 20081201 |
| Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain. | Environmental health perspectives 20081201 |
| ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. | Journal of neurochemistry 20081201 |
| Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy. | Hepatology international 20081201 |
| Novel microtubule-targeting agents - the epothilones. | Biologics : targets & therapy 20081201 |
| Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis. | Transplantation 20081115 |
| Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. | Cancer research 20081115 |
| Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. | The Journal of biological chemistry 20081107 |
| Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. | Toxicological sciences : an official journal of the Society of Toxicology 20081101 |
| Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. | The Journal of pharmacology and experimental therapeutics 20081101 |
| Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. | Toxicological sciences : an official journal of the Society of Toxicology 20081101 |
| Identification of Ginkgo biloba as a novel activator of pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
| Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081101 |
| Silvaglins and related 2,3-secodammarane derivatives - unusual types of triterpenes from Aglaia silvestris. | Phytochemistry 20081101 |
| PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients. | Clinical cancer research : an official journal of the American Association for Cancer Research 20081101 |
| Ischemic cerebral infarction in an infant following gonadotropin treatment for undescended testes. | Journal of child neurology 20081101 |
| PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. | Pharmacogenomics 20081101 |
| Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. | Environmental health perspectives 20081101 |
| Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. | Toxicology 20081030 |
| Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells. | Biochemical and biophysical research communications 20081024 |
| Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. | Toxicology and applied pharmacology 20081015 |
| Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. | Journal of medicinal chemistry 20081009 |
| Influence of CYP3A5, ABCB1 and NR1I2 polymorphisms on prednisolone pharmacokinetics in renal transplant recipients. | Steroids 20081001 |
| Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20081001 |
| Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). | Biochemical pharmacology 20081001 |
| Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy. | Xenobiotica; the fate of foreign compounds in biological systems 20081001 |
| Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague-Dawley and Wistar rats. | The Journal of toxicological sciences 20081001 |
| Nuclear receptors of the enteric tract: guarding the frontier. | Nutrition reviews 20081001 |
| A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. | The Journal of clinical investigation 20080902 |
| Induction of human UGT1A1 by a complex of dexamethasone-GR dependent on proximal site and independent of PBREM. | Molecular biology reports 20080901 |
| Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach. | Inflammatory bowel diseases 20080901 |
| Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells. | Carcinogenesis 20080901 |
| Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3. | Steroids 20080901 |
| Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. | Molecular pharmacology 20080901 |
| Computational discovery of novel low micromolar human pregnane X receptor antagonists. | Molecular pharmacology 20080901 |
| Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis. | European journal of clinical pharmacology 20080901 |
| Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers. | Biochemical pharmacology 20080901 |
| Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080901 |
| CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. | Current drug metabolism 20080901 |
| Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism. | Current drug metabolism 20080901 |
| New insights on the xenobiotic-sensing nuclear receptors in liver diseases--CAR and PXR--. | Current drug metabolism 20080901 |
| Is there a place for postmenopausal hormone therapy use in women with lupus? | Panminerva medica 20080901 |
| Rexinoids modulate steroid and xenobiotic receptor activity by increasing its protein turnover in a calpain-dependent manner. | The Journal of biological chemistry 20080808 |
| The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20080801 |
| The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. | Molecular pharmacology 20080801 |
| A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. | Drug metabolism and disposition: the biological fate of chemicals 20080801 |
| Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. | American journal of physiology. Cell physiology 20080801 |
| Nuclear receptor drug discovery. | Current opinion in chemical biology 20080801 |
| Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: extrapolation to human CYP3A4 induction potential. | Drug metabolism letters 20080801 |
| 6β-Chloro-5α-hydr-oxy-20-oxopregnan-3β-yl acetate. | Acta crystallographica. Section E, Structure reports online 20080801 |
| Hoodigogenin A from Hoodia gordonii. | Acta crystallographica. Section E, Structure reports online 20080801 |
| Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). | Bioorganic & medicinal chemistry letters 20080715 |
| PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine. | Biochemical and biophysical research communications 20080711 |
| Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. | Journal of agricultural and food chemistry 20080709 |
| Molecular characterization of cytochrome P450 1A and 3A and the effects of perfluorooctanoic acid on their mRNA levels in rare minnow (Gobiocypris rarus) gills. | Aquatic toxicology (Amsterdam, Netherlands) 20080707 |
| Evolution of the bile salt nuclear receptor FXR in vertebrates. | Journal of lipid research 20080701 |
| Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage. | Toxicological sciences : an official journal of the Society of Toxicology 20080701 |
| Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability. | Protein engineering, design & selection : PEDS 20080701 |
| Machine learning methods and docking for predicting human pregnane X receptor activation. | Chemical research in toxicology 20080701 |
| Mechanism for conversion of spirosolane derivative into pregnane. | Chemical & pharmaceutical bulletin 20080701 |
| Active nuclear receptors exhibit highly correlated AF-2 domain motions. | PLoS computational biology 20080701 |
| The pregnane X receptor: from bench to bedside. | Expert opinion on drug metabolism & toxicology 20080701 |
| Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. | Environmental health perspectives 20080701 |
| Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment. | Toxicology letters 20080630 |
| Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. | Chemico-biological interactions 20080617 |
| Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. | Naunyn-Schmiedeberg's archives of pharmacology 20080601 |
| Novel CYP2C9 promoter variants and assessment of their impact on gene expression. | Molecular pharmacology 20080601 |
| CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist. | The Journal of pharmacology and experimental therapeutics 20080601 |
| Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. | Pediatric research 20080601 |
| Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes. | Molecular nutrition & food research 20080601 |
| Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of Tanzanian plant extracts traditionally used for treatment of fungal infections. | Basic & clinical pharmacology & toxicology 20080601 |
| Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. | Toxicological sciences : an official journal of the Society of Toxicology 20080601 |
| Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
| Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
| Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
| Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080601 |
| Review article: cytochrome P450 enzyme, and transport protein mediated herb-drug interactions in renal transplant patients: grapefruit juice, St John's Wort - and beyond! | Nephrology (Carlton, Vic.) 20080601 |
| A gut feeling of the PXR, PPAR and NF-kappaB connection. | Journal of internal medicine 20080601 |
| Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential. | Anti-cancer agents in medicinal chemistry 20080601 |
| The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. | Current drug metabolism 20080601 |
| Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. | Pharmacological reviews 20080601 |
| Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. | The AAPS journal 20080601 |
| Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor. | Endocrine 20080601 |
| Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor. | European journal of pharmacology 20080531 |
| Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
| Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
| Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
| Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. | British journal of pharmacology 20080501 |
| Nuclear receptors and inflammatory diseases. | Experimental biology and medicine (Maywood, N.J.) 20080501 |
| Ligand specificity and evolution of liver X receptors. | The Journal of steroid biochemistry and molecular biology 20080501 |
| Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. | Current neurovascular research 20080501 |
| [Transcriptional regulation of cytochrome P450 3A4 by four kinds of traditional Chinese medicines]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501 |
| Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. | European journal of pharmacology 20080414 |
| Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. | The Journal of biological chemistry 20080411 |
| A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB? | Toxicology 20080403 |
| Drug resistance: the fight against fungi. | Nature 20080403 |
| A nuclear receptor-like pathway regulating multidrug resistance in fungi. | Nature 20080403 |
| PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. | The pharmacogenomics journal 20080401 |
| The antiapoptotic role of pregnane X receptor in human colon cancer cells. | Molecular endocrinology (Baltimore, Md.) 20080401 |
| Pregnane X receptor is essential for normal progression of liver regeneration. | Hepatology (Baltimore, Md.) 20080401 |
| Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. | Molecular pharmacology 20080401 |
| A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis. | Steroids 20080401 |
| Terpenoids from the stems of Cipadessa baccifera. | Journal of natural products 20080401 |
| Structural elucidation of limonoids and steroids from Trichilia connaroides. | Phytochemistry 20080401 |
| N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists. | Bioorganic & medicinal chemistry 20080401 |
| Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes. | Pharmacogenetics and genomics 20080401 |
| Peroxisome proliferator-activated receptor-gamma agonists and diabetes: current evidence and future perspectives. | Vascular health and risk management 20080401 |
| [Coexpression of PXRLBD with SRC88 and construction of equilibrium dialysis model of screening PXR ligands]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080401 |
| Rapid structural determination of modified pregnane glycosides from Cynanchum forrestii by liquid chromatography-diode-array detection/electrospray ionization multi-stage tandem mass spectrometry. | Analytica chimica acta 20080324 |
| Effect of ergot alkaloids associated with fescue toxicosis on hepatic cytochrome P450 and antioxidant proteins. | Toxicology and applied pharmacology 20080315 |
| Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. | Drug metabolism and disposition: the biological fate of chemicals 20080301 |
| A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20080301 |
| [[Inflammation and drug metabolism: NF-kappB and the CAR and PXR xeno-receptors]. | Medecine sciences : M/S 20080301 |
| Urinary concentrations of triclosan in the U.S. population: 2003-2004. | Environmental health perspectives 20080301 |
| Catecholamines induce an inflammatory response in human hepatocytes. | Critical care medicine 20080301 |
| Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | The AAPS journal 20080301 |
| Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. | The Journal of pharmacology and experimental therapeutics 20080201 |
| o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. | Toxicological sciences : an official journal of the Society of Toxicology 20080201 |
| Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. | The Journal of pharmacology and experimental therapeutics 20080201 |
| Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20080201 |
| Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. | British journal of pharmacology 20080201 |
| Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa. | Therapeutic drug monitoring 20080201 |
| Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. | Gastroenterology 20080201 |
| The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. | PLoS genetics 20080201 |
| Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies. | British journal of cancer 20080115 |
| A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity. | Bioorganic & medicinal chemistry letters 20080115 |
| Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | Breast cancer research and treatment 20080101 |
| The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. | Annual review of pharmacology and toxicology 20080101 |
| Flavaglines and triterpenoids from the leaves of Aglaia forbesii. | Phytochemistry 20080101 |
| The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. | The Biochemical journal 20080101 |
| Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier. | Neurochemistry international 20080101 |
| Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression. | Drug metabolism and disposition: the biological fate of chemicals 20080101 |
| Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. | Drug metabolism and disposition: the biological fate of chemicals 20080101 |
| Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. | Drug metabolism and disposition: the biological fate of chemicals 20080101 |
| HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. | Drug metabolism and disposition: the biological fate of chemicals 20080101 |
| Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. | Toxicological sciences : an official journal of the Society of Toxicology 20080101 |
| PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks. | Molecular pharmaceutics 20080101 |
| Regulation of transporters by nuclear hormone receptors: implications during inflammation. | Molecular pharmaceutics 20080101 |
| Steroid and xenobiotic receptor mediates a novel vitamin K2 signaling pathway in osteoblastic cells. | Journal of bone and mineral metabolism 20080101 |
| Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. | Xenobiotica; the fate of foreign compounds in biological systems 20080101 |
| Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. | Molecular pharmaceutics 20080101 |
| Metabolism of conjugated sterols in eggplant. Part 1. UDP-glucose : sterol glucosyltransferase. | Acta biochimica Polonica 20080101 |
| Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report. | Annals of clinical microbiology and antimicrobials 20080101 |
| Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development. | Nuclear receptor signaling 20080101 |
| The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. | Drug metabolism and pharmacokinetics 20080101 |
| Interplay of pregnane X receptor with other nuclear receptors on gene regulation. | Drug metabolism and pharmacokinetics 20080101 |
| Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver. | Drug metabolism and pharmacokinetics 20080101 |
| Evolution of pharmacologic specificity in the pregnane X receptor. | BMC evolutionary biology 20080101 |
| Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations. | Pharmacology 20080101 |
| Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports. | Journal of medical case reports 20080101 |
| A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model. | BMC bioinformatics 20080101 |
| Association of ABCB1 genetic variants with renal function in Africans and in Caucasians. | BMC medical genomics 20080101 |
| Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency. | Neuroendocrinology 20080101 |
| Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. | BMC cancer 20080101 |
| Expression of cytochrome P450 and transcription factors during in vitro differentiation of mouse embryonic stem cells into hepatocytes. | Drug metabolism and pharmacokinetics 20080101 |
| Experiences of abortion: a narrative review of qualitative studies. | BMC health services research 20080101 |
| Clinically relevant safety issues associated with St. John's wort product labels. | BMC complementary and alternative medicine 20080101 |
| Relevant approach to assess performances of wastewater biosolids composting in terms of micropollutants removal. | Water science and technology : a journal of the International Association on Water Pollution Research 20080101 |
| An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution. | BMC evolutionary biology 20080101 |
| Tests for predicting complications of pre-eclampsia: a protocol for systematic reviews. | BMC pregnancy and childbirth 20080101 |
| Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner. | BMC genomics 20080101 |
| Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection. | Virology journal 20080101 |
| TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining. | BMC complementary and alternative medicine 20080101 |
| Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. | BMC genomics 20080101 |
| Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis. | BMC genomics 20080101 |
| A new pregnane steroid from the stems of Caralluma umbellata. | Journal of Asian natural products research 20080101 |
| [New perspectives in the use of human hepatocytes in the preclinical drug development process]. | Annales pharmaceutiques francaises 20080101 |
| targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. | BMC systems biology 20080101 |
| [Ovulation induction in high risk IVF patients: GnRH-agonist, diminished dose of urinary or recombinant chorion gonadotropin]. | Akusherstvo i ginekologiia 20080101 |
| Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. | Drug metabolism and drug interactions 20080101 |
| Selective single blastocyst transfer study: 604 cases in 6 years. | Journal of human reproductive sciences 20080101 |
| Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20071201 |
| Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20071201 |
| Role of the PXR gene locus in inflammatory bowel diseases. | Inflammatory bowel diseases 20071201 |
| Development of in vitro methods to predict induction of CYP1A2 and CYP3A4 in humans. | Assay and drug development technologies 20071201 |
| Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. | Clinical cancer research : an official journal of the American Association for Cancer Research 20071201 |
| Health impacts of estrogens in the environment, considering complex mixture effects. | Environmental health perspectives 20071201 |
| Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review. | Environmental health perspectives 20071201 |
| Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. | Current Alzheimer research 20071201 |
| A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese. | Current drug metabolism 20071201 |
| Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs. | Current drug metabolism 20071201 |
| Molecular mechanisms of cytochrome p450 induction: potential for drug-drug interactions. | Current protein & peptide science 20071201 |
| Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. | Journal of medicinal chemistry 20071129 |
| Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. | Biochemical pharmacology 20071115 |
| Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. | Free radical biology & medicine 20071115 |
| Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene. | The Biochemical journal 20071101 |
| Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. | Molecular endocrinology (Baltimore, Md.) 20071101 |
| Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20071101 |
| The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. | Molecular pharmacology 20071101 |
| Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. | Molecular and cellular biology 20071101 |
| Human pregnane X receptor and resistance to chemotherapy in prostate cancer. | Cancer research 20071101 |
| Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells. | Biological & pharmaceutical bulletin 20071101 |
| [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. | Clinical calcium 20071101 |
| [Molecular mechanism of vitamin K and its regulators in bone metabolism]. | Clinical calcium 20071101 |
| Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults. | Toxicology and applied pharmacology 20071015 |
| Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors. | Pharmacology & therapeutics 20071001 |
| Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. | Drug metabolism and disposition: the biological fate of chemicals 20071001 |
| Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. | Molecular pharmacology 20071001 |
| Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone. | Drug metabolism and disposition: the biological fate of chemicals 20071001 |
| The identification and simultaneous quantification of neuroactive androstane steroids and their polar conjugates in the serum of adult men, using gas chromatography-mass spectrometry. | Steroids 20071001 |
| Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia. | Genomics 20071001 |
| 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. | Pharmacogenetics and genomics 20071001 |
| Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. | Journal of molecular endocrinology 20071001 |
| Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy. | The Journal of endocrinology 20071001 |
| Nuclear hormone receptors and intestinal inflammation. | Gastroenterology 20071001 |
| [Advances on pregnane X receptor]. | Sheng li ke xue jin zhan [Progress in physiology] 20071001 |
| Inhibitory effect of Egyptian propolis on Fasciola gigantica eggs with reference to its effect on Clostridium oedematiens and correlation to chemical composition. | Pakistan journal of biological sciences : PJBS 20071001 |
| Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. | Clinical pharmacology and therapeutics 20070901 |
| Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats. | Drug metabolism and disposition: the biological fate of chemicals 20070901 |
| Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to 'in vivo' biological activity. | Molecular pharmacology 20070901 |
| Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. | Molecular pharmacology 20070901 |
| Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor. | Drug metabolism and disposition: the biological fate of chemicals 20070901 |
| The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. | Molecular endocrinology (Baltimore, Md.) 20070901 |
| Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. | Pediatric research 20070901 |
| Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070901 |
| Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses. | Pharmacogenomics 20070901 |
| Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. | Environmental toxicology and pharmacology 20070901 |
| Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR. | World journal of gastroenterology 20070821 |
| Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. | Biochemical and biophysical research communications 20070817 |
| The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20070801 |
| Alterations in xenobiotic metabolism in the long-lived Little mice. | Aging cell 20070801 |
| Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20070801 |
| Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort. | Naunyn-Schmiedeberg's archives of pharmacology 20070801 |
| Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes. | Drug metabolism and pharmacokinetics 20070801 |
| Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. | Drug metabolism and pharmacokinetics 20070801 |
| Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
| Rifaximin is a gut-specific human pregnane X receptor activator. | The Journal of pharmacology and experimental therapeutics 20070701 |
| The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. | Molecular endocrinology (Baltimore, Md.) 20070701 |
| Expeditious and convenient synthesis of pregnanes and its glycosides as potential anti-dyslipidemic and anti-oxidant agents. | Bioorganic & medicinal chemistry 20070701 |
| Targeting farnesoid X receptor for liver and metabolic disorders. | Trends in molecular medicine 20070701 |
| Efficient conversion of tomatidine into neuritogenic pregnane derivative. | Chemical & pharmaceutical bulletin 20070701 |
| Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. | Inflammatory bowel diseases 20070601 |
| Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity. | Toxicological sciences : an official journal of the Society of Toxicology 20070601 |
| Identification of NR1I2 genetic variation using resequencing. | European journal of clinical pharmacology 20070601 |
| Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. | British journal of pharmacology 20070601 |
| Artificial insemination in the anoestrous and the postpartum white rhinoceros using GnRH analogue to induce ovulation. | Theriogenology 20070601 |
| The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. | Cancer treatment reviews 20070601 |
| Systemic lupus erythematosus and hormone replacement therapy. | Menopause international 20070601 |
| Genomic profiling in nuclear receptor-mediated toxicity. | Toxicologic pathology 20070601 |
| New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues. | Mini reviews in medicinal chemistry 20070601 |
| Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells. | Endocrine-related cancer 20070601 |
| The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. | Chemico-biological interactions 20070520 |
| Nuclear receptors and susceptibility to chemical exposure in aquatic organisms. | Environment international 20070501 |
| Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070501 |
| Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. | Pflugers Archiv : European journal of physiology 20070501 |
| Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues. | Endocrinology 20070501 |
| Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. | Drug metabolism and disposition: the biological fate of chemicals 20070501 |
| Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. | Drug metabolism and disposition: the biological fate of chemicals 20070501 |
| The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. | Toxicological sciences : an official journal of the Society of Toxicology 20070501 |
| Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. | Molecular endocrinology (Baltimore, Md.) 20070501 |
| T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. | FEBS letters 20070501 |
| Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1. | Pharmacogenetics and genomics 20070501 |
| Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070501 |
| Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line. | Journal of cardiovascular pharmacology 20070501 |
| Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070415 |
| Estrogens and antiestrogens activate hPXR. | Toxicology letters 20070405 |
| Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. | American journal of physiology. Gastrointestinal and liver physiology 20070401 |
| Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. | Environmental health perspectives 20070401 |
| Decreased PXR and CAR inhibit transporter and CYP mRNA Levels in the liver and intestine of mice with collagen-induced arthritis. | Xenobiotica; the fate of foreign compounds in biological systems 20070401 |
| Coordinated defence and the liver. | Clinical medicine (London, England) 20070401 |
| The utility of stable cell lines to assess species differences in PXR transactivation. | Drug metabolism letters 20070401 |
| Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. | The Journal of biological chemistry 20070330 |
| Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes. | Cell biology and toxicology 20070301 |
| Association of warfarin dose with genes involved in its action and metabolism. | Human genetics 20070301 |
| Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. | Bioorganic & medicinal chemistry 20070301 |
| Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay. | Journal of biomolecular screening 20070301 |
| Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. | Cancer 20070301 |
| CAR and PXR: the xenobiotic-sensing receptors. | Steroids 20070301 |
| Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070301 |
| Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison. | Mammalian genome : official journal of the International Mammalian Genome Society 20070301 |
| Chemopreventive herbal anti-oxidants: current status and future perspectives. | Journal of clinical biochemistry and nutrition 20070301 |
| Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study. | Circulation 20070220 |
| Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits. | Life sciences 20070213 |
| Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system. | The Journal of organic chemistry 20070202 |
| The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. | Drug metabolism and disposition: the biological fate of chemicals 20070201 |
| Effects of alterations in CAR on bilirubin detoxification in mouse collagen-induced arthritis. | Drug metabolism and disposition: the biological fate of chemicals 20070201 |
| Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor. | Hypertension (Dallas, Tex. : 1979) 20070201 |
| Effects of budesonide on P-glycoprotein expression in intestinal cell lines. | British journal of pharmacology 20070201 |
| Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. | Free radical biology & medicine 20070201 |
| Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. | Journal of animal physiology and animal nutrition 20070201 |
| A steroid hormone that extends the lifespan of Caenorhabditis elegans. | Aging cell 20070201 |
| Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach. | Xenobiotica; the fate of foreign compounds in biological systems 20070201 |
| Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. | Oncogene 20070111 |
| Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. | Journal of molecular graphics & modelling 20070101 |
| Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. | Molecular endocrinology (Baltimore, Md.) 20070101 |
| Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20070101 |
| In silico prediction of pregnane X receptor activators by machine learning approaches. | Molecular pharmacology 20070101 |
| Gender dictates the nuclear receptor-mediated regulation of CYP3A44. | Drug metabolism and disposition: the biological fate of chemicals 20070101 |
| The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. | Molecular pharmacology 20070101 |
| Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane. | Drug metabolism and disposition: the biological fate of chemicals 20070101 |
| Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. | The Journal of pharmacology and experimental therapeutics 20070101 |
| Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6J mouse liver. | Archives of biochemistry and biophysics 20070101 |
| Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors. | The international journal of biochemistry & cell biology 20070101 |
| Pregnane X receptor: promiscuous regulator of detoxification pathways. | The international journal of biochemistry & cell biology 20070101 |
| Effect of maternal calcium intake during pregnancy on children's blood pressure: a systematic review of the literature. | BMC pediatrics 20070101 |
| Evolution and medicine: the long reach of 'Dr. Darwin'. | Philosophy, ethics, and humanities in medicine : PEHM 20070101 |
| Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis. | Journal of biosciences 20070101 |
| A review of the methodological features of systematic reviews in maternal medicine. | BMC medicine 20070101 |
| MATLIGN: a motif clustering, comparison and matching tool. | BMC bioinformatics 20070101 |
| Circulating levels of pregnanolone isomers during the third trimester of human pregnancy. | The Journal of steroid biochemistry and molecular biology 20070101 |
| Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver--a role for growth hormone in alternative exon usage. | BMC molecular biology 20070101 |
| Disparate effects of p24alpha and p24delta on secretory protein transport and processing. | PloS one 20070101 |
| Pregnane glycosides from Solanum nigrum. | Journal of Asian natural products research 20070101 |
| CYP3A4 and pregnane X receptor humanized mice. | Journal of biochemical and molecular toxicology 20070101 |
| Mechanisms of cytochrome P450 induction. | Journal of biochemical and molecular toxicology 20070101 |
| Gene expression profiles in testis of pigs with extreme high and low levels of androstenone. | BMC genomics 20070101 |
| Functional evolution of the vitamin D and pregnane X receptors. | BMC evolutionary biology 20070101 |
| Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention. | Nutrition and cancer 20070101 |
| Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent. | BMC cancer 20070101 |
| Suppression of peroxisomal enzyme activities and cytochrome P450 4A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. | PPAR research 20070101 |
| [Steroid and xenobiotic receptor (SXR), multidrug resistance gene (MDR1) and GSTs, SULTs and CYP polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors]. | Actas urologicas espanolas 20070101 |
| Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice. | Nutrition research and practice 20070101 |
| Molecular changes to HeLa cells on continuous exposure to cisplatin or paclitaxel. | Cancer chemotherapy and pharmacology 20061201 |
| Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. | Toxicological sciences : an official journal of the Society of Toxicology 20061201 |
| The impact of pregnane X receptor activation on liver fibrosis. | Biochemical Society transactions 20061201 |
| Pregnane X receptor and natural products: beyond drug-drug interactions. | Expert opinion on drug metabolism & toxicology 20061201 |
| International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. | Pharmacological reviews 20061201 |
| Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells. | Endocrine 20061201 |
| Nuclear receptor and target gene mRNA abundance in duodenum and colon of dogs with chronic enteropathies. | Domestic animal endocrinology 20061101 |
| Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. | Cancer science 20061101 |
| Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. | Drug metabolism and disposition: the biological fate of chemicals 20061101 |
| Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis. | Gut 20061101 |
| Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity. | Journal of clinical pharmacology 20061101 |
| Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers. | Environmental health perspectives 20061101 |
| Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. | Clinical pharmacology and therapeutics 20061101 |
| Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients. | Clinical pharmacology and therapeutics 20061101 |
| [Genetic and epigenetic alteration in cancer]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20061101 |
| Response to Zhou et al. Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital. | The Journal of clinical investigation 20061002 |
| Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic. | Carcinogenesis 20061001 |
| Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4alpha expression. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. | Molecular pharmacology 20061001 |
| Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| Hyperforin. | Phytochemistry 20061001 |
| Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. | Toxicology and applied pharmacology 20060915 |
| Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. | The Journal of biological chemistry 20060908 |
| P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile. | Drug metabolism and disposition: the biological fate of chemicals 20060901 |
| In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin. | European journal of clinical investigation 20060901 |
| Xenobiotic receptor meets NF-kappaB, a collision in the small bowel. | Cell metabolism 20060901 |
| [Protective effects of vitamin K against osteoporosis and its pleiotropic actions]. | Clinical calcium 20060901 |
| Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors. | Pharmaceutical research 20060901 |
| Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis. | Gastroenterology 20060901 |
| The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells. | The Journal of endocrinology 20060901 |
| New pregnane steroids from Turraea pubescens. | Steroids 20060801 |
| Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. | The Journal of clinical investigation 20060801 |
| Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines. | Pharmacogenetics and genomics 20060801 |
| Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. | Current drug metabolism 20060801 |
| Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies. | Mini reviews in medicinal chemistry 20060801 |
| Human PXR forms a tryptophan zipper-mediated homodimer. | Biochemistry 20060718 |
| Pregnane X receptor is a target of farnesoid X receptor. | The Journal of biological chemistry 20060714 |
| Ontogeny of mRNA abundance of nuclear receptors and nuclear receptor target genes in young cattle. | Domestic animal endocrinology 20060701 |
| Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. | Molecular pharmacology 20060701 |
| Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
| Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. | Toxicological sciences : an official journal of the Society of Toxicology 20060701 |
| Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR. | Hepatology (Baltimore, Md.) 20060701 |
| Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro. | Gastroenterology 20060701 |
| Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. | The Journal of biological chemistry 20060630 |
| Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations. | Aquatic toxicology (Amsterdam, Netherlands) 20060630 |
| Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. | The Journal of biological chemistry 20060623 |
| Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. | The Journal of biological chemistry 20060616 |
| Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. | Biochemical pharmacology 20060614 |
| Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy. | American journal of physiology. Endocrinology and metabolism 20060601 |
| Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20060601 |
| The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20060601 |
| Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. | Toxicological sciences : an official journal of the Society of Toxicology 20060601 |
| Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. | The Journal of clinical investigation 20060601 |
| CYP induction-mediated drug interactions: in vitro assessment and clinical implications. | Pharmaceutical research 20060601 |
| The persistent DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr. | Environmental toxicology and chemistry 20060601 |
| Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GR. | Molecular biology reports 20060601 |
| Functional evolution of the pregnane X receptor. | Expert opinion on drug metabolism & toxicology 20060601 |
| Two new pregnane glycosides from soft coral Cladiella krempfi. | Journal of Asian natural products research 20060601 |
| Ovulation, pregnancy, placentation and husbandry in the African elephant (Loxodonta africana). | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20060529 |
| A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. | The Journal of biological chemistry 20060526 |
| Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide. | Cellular signalling 20060501 |
| Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex. | Molecular pharmacology 20060501 |
| Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20060501 |
| Cholestasis and cholestatic syndromes. | Current opinion in gastroenterology 20060501 |
| Screening for polymorphisms in the PXR gene in a Dutch population. | European journal of clinical pharmacology 20060501 |
| Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia. | Phytochemistry 20060501 |
| Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. | Basic & clinical pharmacology & toxicology 20060501 |
| Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. | Clinical pharmacology and therapeutics 20060501 |
| [Roles of nuclear receptors in the gene expression of drug-metabolizing enzymes under various physiological conditions]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060501 |
| Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. | Current drug metabolism 20060501 |
| Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. | Current drug metabolism 20060501 |
| Lipopolysaccharide downregulates the expressions of intestinal pregnane X receptor and cytochrome P450 3a11. | European journal of pharmacology 20060424 |
| Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina. | Neuropeptides 20060401 |
| MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. | Clinical pharmacology and therapeutics 20060401 |
| Molecular cloning and regulation of porcine SULT2A1: relationship between SULT2A1 expression and sulfoconjugation of androstenone. | Journal of molecular endocrinology 20060401 |
| Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction. | Drug metabolism and pharmacokinetics 20060401 |
| Endocrine disrupting contaminants--beyond the dogma. | Environmental health perspectives 20060401 |
| Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. | The Journal of pharmacology and experimental therapeutics 20060301 |
| The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice. | Drug metabolism and disposition: the biological fate of chemicals 20060301 |
| [Role of PXR and CAR in cholestasis]. | The Korean journal of hepatology 20060301 |
| Nuclear receptors, bile-acid detoxification, and cholestasis. | Lancet (London, England) 20060211 |
| Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. | Molecular endocrinology (Baltimore, Md.) 20060201 |
| Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration. | The Journal of pharmacology and experimental therapeutics 20060201 |
| Steroidal glycosides from the underground parts of Solanum sodomaeum. | Chemical & pharmaceutical bulletin 20060201 |
| Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin. | Current drug metabolism 20060201 |
| Preclinical pharmacokinetics: an approach towards safer and efficacious drugs. | Current drug metabolism 20060201 |
| The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. | Gastroenterology 20060201 |
| Cytotoxic constituents from Solanum lyratum. | Archives of pharmacal research 20060201 |
| Faecal steroid metabolites for non-invasive assessment of reproduction in common warthogs (Phacochoerus africanus), red river hogs (Potamochoerus porcus) and babirusa (Babyrousa babyrussa). | Animal reproduction science 20060101 |
| Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). | Molecular pharmacology 20060101 |
| Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans. | Pharmaceutical research 20060101 |
| Identification of regulatory sites in the human PXR (NR1I2) promoter region. | Molecular and cellular biochemistry 20060101 |
| Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. | Cancer research 20060101 |
| The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar). | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060101 |
| A paracrine component of salient symptoms of depression in Cushing's of diencephalic origin, and in perimenstrual syndromes: a hypothesis. | Medical hypotheses 20060101 |
| Significance of the minor cytochrome P450 3A isoforms. | Clinical pharmacokinetics 20060101 |
| Cytotoxic pregnane steroids from the formosan soft coral Stereonephthya crystalliana. | Journal of natural products 20060101 |
| [Human pregnane X receptor-mediated transcriptional regulation of cytochrome P450 3A4 by some phytochemicals]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060101 |
| [Kaempferol activates human steroid and xenobiotic receptor-mediated cytochrome P450 3A4 transcription]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060101 |
| Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. | Annals of clinical microbiology and antimicrobials 20060101 |
| BIPAD: a web server for modeling bipartite sequence elements. | BMC bioinformatics 20060101 |
| Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice. | BMC cancer 20060101 |
| An integrated biological approach to nuclear receptor signaling in physiological control and disease. | Critical reviews in eukaryotic gene expression 20060101 |
| How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome. | Lipids in health and disease 20060101 |
| [The induction of CYP3A regulated by pregnane X receptor and its significance in drug metabolism]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060101 |
| Transcriptional regulation of the human pregnane-X receptor. | Drug metabolism reviews 20060101 |
| Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). | Drug metabolism reviews 20060101 |
| The biological actions of dehydroepiandrosterone involves multiple receptors. | Drug metabolism reviews 20060101 |
| Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. | BMC genetics 20060101 |
| Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors. | Molecular pharmaceutics 20060101 |
| Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. | Molecular pharmaceutics 20060101 |
| Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. | Molecular pharmaceutics 20060101 |
| Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101 |
| Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet. | Nutrition & metabolism 20060101 |
| Genome-wide approaches for identification of nuclear receptor target genes. | Nuclear receptor signaling 20060101 |
| PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. | Drug metabolism reviews 20060101 |
| Antiepileptic drugs and bone metabolism. | Nutrition & metabolism 20060101 |
| Prediction of pre-eclampsia: a protocol for systematic reviews of test accuracy. | BMC pregnancy and childbirth 20060101 |
| Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. | Molecular cancer 20060101 |
| The nuclear receptor transcriptional coregulator RIP140. | Nuclear receptor signaling 20060101 |
| Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo. | Xenobiotica; the fate of foreign compounds in biological systems 20060101 |
| Nuclear receptors CAR and PXR in the regulation of hepatic metabolism. | Xenobiotica; the fate of foreign compounds in biological systems 20060101 |
| Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1). | Journal of biochemical and molecular toxicology 20060101 |
| (Far) Outside the box: genomic approach to acute porphyria. | Physiological research 20060101 |
| Study of the Urinary Ratio of 6 beta-Hydroxycortisol/Cortisol as a Biomarker of CYP3A4 Activity in Egyptian Patients with Chronic Liver Diseases. | Biomarker insights 20060101 |
| Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis. | Biochimica et biophysica acta 20051215 |
| Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). | Toxicology and applied pharmacology 20051201 |
| The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. | Molecular endocrinology (Baltimore, Md.) 20051201 |
| Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. | Drug metabolism and disposition: the biological fate of chemicals 20051201 |
| Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. | Molecular pharmacology 20051201 |
| Orphan nuclear receptors adopted by crystallography. | Current opinion in structural biology 20051201 |
| Cytochrome P450 3A expression and activity in the rabbit lacrimal gland: glucocorticoid modulation and the impact on androgen metabolism. | Investigative ophthalmology & visual science 20051201 |
| Functional interactions between P-glycoprotein and CYP3A in drug metabolism. | Expert opinion on drug metabolism & toxicology 20051201 |
| Chronic ethanol exposure downregulates hepatic expression of pregnane X receptor and P450 3A11 in female ICR mice. | Toxicology 20051115 |
| Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. | The Journal of biological chemistry 20051111 |
| Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. | American journal of physiology. Gastrointestinal and liver physiology 20051101 |
| Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051101 |
| Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. | Journal of dairy science 20051101 |
| [Methodology of the inquiry MISSION (menopause, breast cancer risk, morbidity and prevalence)]. | Journal de gynecologie, obstetrique et biologie de la reproduction 20051101 |
| In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. | Toxicology 20051015 |
| P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. | American journal of physiology. Regulatory, integrative and comparative physiology 20051001 |
| Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile. | Arteriosclerosis, thrombosis, and vascular biology 20051001 |
| A role for the pregnane X receptor in high-density lipoprotein metabolism. | Arteriosclerosis, thrombosis, and vascular biology 20051001 |
| Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization. | Cell research 20051001 |
| Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases. | Current opinion in investigational drugs (London, England : 2000) 20051001 |
| Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. | Biochemical pharmacology 20050915 |
| The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. | The Journal of pharmacology and experimental therapeutics 20050901 |
| Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. | Drug metabolism and disposition: the biological fate of chemicals 20050901 |
| Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. | Molecular pharmacology 20050901 |
| Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver. | Toxicological sciences : an official journal of the Society of Toxicology 20050901 |
| Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula. | British journal of pharmacology 20050901 |
| Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. | Epilepsy & behavior : E&B 20050901 |
| Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050901 |
| P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy. | Current cancer drug targets 20050901 |
| CAR and PXR: xenosensors of endocrine disrupters? | Chemico-biological interactions 20050815 |
| Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. | Biochimica et biophysica acta 20050815 |
| Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. | The Journal of pharmacology and experimental therapeutics 20050801 |
| Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta. | Toxicology 20050801 |
| A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. | Molecular pharmacology 20050801 |
| Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses. | Toxicological sciences : an official journal of the Society of Toxicology 20050801 |
| New pregnane glycosides from Caralluma dalzielii. | Steroids 20050801 |
| CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. | Hepatology (Baltimore, Md.) 20050801 |
| Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. | Hepatology (Baltimore, Md.) 20050801 |
| C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age. | Ageing research reviews 20050801 |
| Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. | Current drug metabolism 20050801 |
| Regulation of sulfotransferases by xenobiotic receptors. | Current drug metabolism 20050801 |
| Animal models of xenobiotic receptors. | Current drug metabolism 20050801 |
| Structure and function of the human nuclear xenobiotic receptor PXR. | Current drug metabolism 20050801 |
| Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. | Current drug metabolism 20050801 |
| Beyond CAR and PXR. | Current drug metabolism 20050801 |
| Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? | Alcohol (Fayetteville, N.Y.) 20050801 |
| Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase. | Journal of medicinal chemistry 20050714 |
| Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. | Molecular endocrinology (Baltimore, Md.) 20050701 |
| Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques. | Molecular & cellular proteomics : MCP 20050701 |
| Neurosteroids: endogenous regulators of the GABA(A) receptor. | Nature reviews. Neuroscience 20050701 |
| Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. | Cancer biology & therapy 20050701 |
| Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. | Biochemical and biophysical research communications 20050617 |
| Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. | The Biochemical journal 20050601 |
| Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. | Molecular pharmacology 20050601 |
| Nuclear receptors and drug disposition gene regulation. | Journal of pharmaceutical sciences 20050601 |
| A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression. | Biological chemistry 20050601 |
| Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices. | Combinatorial chemistry & high throughput screening 20050601 |
| Induction of PXR-mediated metabolism by beta-carotene. | Biochimica et biophysica acta 20050530 |
| Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. | The Biochemical journal 20050501 |
| The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. | Molecular endocrinology (Baltimore, Md.) 20050501 |
| Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. | Molecular endocrinology (Baltimore, Md.) 20050501 |
| Fecal steroid analysis of female giraffe (Giraffa camelopardalis) reproductive condition and the impact of endocrine status on daily time budgets. | General and comparative endocrinology 20050501 |
| Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. | Biochemical pharmacology 20050501 |
| Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects. | Pharmacogenetics and genomics 20050501 |
| 5' diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site. | Molecular and cellular biochemistry 20050501 |
| CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs. | Life sciences 20050415 |
| Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin. | European journal of pharmacology 20050404 |
| Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. | Molecular pharmacology 20050401 |
| Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats. | Toxicological sciences : an official journal of the Society of Toxicology 20050401 |
| Physiological, pharmacological and clinical features of the multidrug resistance protein 2. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050401 |
| [PPARs as molecular targets for drug discovery]. | Nihon rinsho. Japanese journal of clinical medicine 20050401 |
| Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy? | American journal of obstetrics and gynecology 20050401 |
| Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. | The Journal of biological chemistry 20050311 |
| Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. | Molecular pharmacology 20050301 |
| A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20050301 |
| Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. | Biochemical pharmacology 20050301 |
| CARs and drugs: a risky combination. | Endocrinology 20050301 |
| Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. | Hepatology (Baltimore, Md.) 20050301 |
| Induction of phase I, II and III drug metabolism/transport by xenobiotics. | Archives of pharmacal research 20050301 |
| A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. | The AAPS journal 20050301 |
| Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. | Molecular and cellular endocrinology 20050227 |
| Novel pathways of bile acid metabolism involving CYP3A4. | Biochimica et biophysica acta 20050221 |
| Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis. | Journal of molecular biology 20050218 |
| Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice. | Free radical biology & medicine 20050215 |
| Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development. | American journal of physiology. Gastrointestinal and liver physiology 20050201 |
| The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20050201 |
| Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. | Journal of lipid research 20050201 |
| Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity. | Journal of molecular modeling 20050201 |
| Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. | Archives of biochemistry and biophysics 20050201 |
| The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA. | European journal of medicinal chemistry 20050201 |
| Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors. | Journal of pharmacological sciences 20050201 |
| Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. | Archives of biochemistry and biophysics 20050115 |
| Regulation of CYP3A genes in the human respiratory tract. | Chemico-biological interactions 20050115 |
| Impact of African herbal medicines on antiretroviral metabolism. | AIDS (London, England) 20050103 |
| Stay tuned to PXR: an orphan actor that may not be D-structive only to bone. | The Journal of clinical investigation 20050103 |
| Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. | The Journal of clinical investigation 20050103 |
| Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. | American journal of physiology. Gastrointestinal and liver physiology 20050101 |
| High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. | Drug metabolism and disposition: the biological fate of chemicals 20050101 |
| Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. | Journal of lipid research 20050101 |
| Melatonin attenuates lipopolysaccharide-induced down-regulation of pregnane X receptor and its target gene CYP3A in mouse liver. | Journal of pineal research 20050101 |
| Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. | Hepatology (Baltimore, Md.) 20050101 |
| Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. | Hepatology (Baltimore, Md.) 20050101 |
| Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort. | Journal of biochemical and molecular toxicology 20050101 |
| Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. | Pharmaceutical research 20050101 |
| Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes. | The pharmacogenomics journal 20050101 |
| Electrospray ionization mass spectrometry for identification and structural characterization of pregnane glycosides. | Rapid communications in mass spectrometry : RCM 20050101 |
| The identification of ligand features essential for PXR activation by pharmacophore modeling. | Journal of chemical information and modeling 20050101 |
| Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050101 |
| African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology. | Nutrition journal 20050101 |
| [Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification]. | Medecine sciences : M/S 20050101 |
| Regulation of gene transcription by botanicals: novel regulatory mechanisms. | Annual review of nutrition 20050101 |
| Pregnane X receptor: predicting and preventing drug interactions. | Thrombosis research 20050101 |
| Tandem machine learning for the identification of genes regulated by transcription factors. | BMC bioinformatics 20050101 |
| Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). | Nuclear receptor 20050101 |
| Risk factors for adverse perinatal outcomes in imprisoned pregnant women: a systematic review. | BMC public health 20050101 |
| Clinical benefit of metaphase I oocytes. | Reproductive biology and endocrinology : RB&E 20050101 |
| UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. | Methods in enzymology 20050101 |
| Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor. | Methods in enzymology 20050101 |
| Pregnane X receptor-mediated transcription. | Methods in enzymology 20050101 |
| A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. | Biochemical pharmacology 20041215 |
| Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor. | European journal of nutrition 20041201 |
| Effect of pregnancy and 5alpha-pregnan-3alpha-ol-20-one on atrial receptor afferent discharge in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20041201 |
| Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20041201 |
| Enhanced acetaminophen toxicity by activation of the pregnane X receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20041201 |
| In silico tools to aid risk assessment of endocrine disrupting chemicals. | Toxicology 20041201 |
| CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. | Current drug metabolism 20041201 |
| Prenatal DDT exposure in relation to anthropometric and pubertal measures in adolescent males. | Environmental health perspectives 20041201 |
| [Observational study of criteria involved in the choice of hormone replacement therapy (HRT), when initiated and subsequently adapted]. | Gynecologie, obstetrique & fertilite 20041201 |
| Vitamin E mediates cell signaling and regulation of gene expression. | Annals of the New York Academy of Sciences 20041201 |
| Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids. | The Journal of steroid biochemistry and molecular biology 20041201 |
| Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. | The Journal of biological chemistry 20041119 |
| The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. | The Journal of biological chemistry 20041119 |
| Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation. | The Journal of biological chemistry 20041105 |
| Modified oligonucleotides containing lithocholic acid in their backbones: their enhanced cellular uptake and their mimicking of hairpin structures. | Chembiochem : a European journal of chemical biology 20041105 |
| Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. | Drug metabolism and disposition: the biological fate of chemicals 20041101 |
| Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. | Journal of clinical pharmacology 20041101 |
| Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. | The Journal of biological chemistry 20041022 |
| Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response. | American journal of physiology. Endocrinology and metabolism 20041001 |
| Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | Drug metabolism and disposition: the biological fate of chemicals 20041001 |
| Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. | Pharmacogenetics 20041001 |
| Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | The British journal of dermatology 20041001 |
| Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. | Antiviral therapy 20041001 |
| Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. | Drug metabolism reviews 20041001 |
| In silico search for single nucleotide polymorphisms in genes important in vitamin E homeostasis. | IUBMB life 20041001 |
| PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. | Toxicology and applied pharmacology 20040915 |
| Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. | Toxicology and applied pharmacology 20040915 |
| Regulation of the cytochrome P450 2A genes. | Toxicology and applied pharmacology 20040915 |
| Regulation of NAD(P)H:quininone oxidoreductase by glucocorticoids. | Toxicology and applied pharmacology 20040915 |
| The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). | The Journal of biological chemistry 20040910 |
| Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes. | Cancer chemotherapy and pharmacology 20040901 |
| PXR and the regulation of apoA1 and HDL-cholesterol in rodents. | Pharmacological research 20040901 |
| Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues. | Drug metabolism and disposition: the biological fate of chemicals 20040901 |
| Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. | Molecular pharmacology 20040901 |
| Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. | Clinical pharmacology and therapeutics 20040901 |
| Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays. | Journal of biomolecular screening 20040901 |
| Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20040801 |
| Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20040801 |
| CAR: detailing new models. | Trends in pharmacological sciences 20040801 |
| Biotransformation of hydrocortisone by a natural isolate of Nostoc muscorum. | Phytochemistry 20040801 |
| Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. | The Journal of biological chemistry 20040709 |
| Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver. | Free radical biology & medicine 20040701 |
| Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. | Gastroenterology 20040701 |
| A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction. | Toxicology 20040601 |
| Tamoxifen: a novel treatment for primary biliary cirrhosis? | Liver international : official journal of the International Association for the Study of the Liver 20040601 |
| Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. | Pharmacology, biochemistry, and behavior 20040601 |
| Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. | Drug discovery today 20040515 |
| The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. | British journal of anaesthesia 20040501 |
| Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. | Drug metabolism and disposition: the biological fate of chemicals 20040501 |
| Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. | Molecular pharmacology 20040501 |
| Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | Molecular pharmacology 20040501 |
| ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. | Biochemical and biophysical research communications 20040423 |
| Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. | Chemico-biological interactions 20040415 |
| Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. | Physiological genomics 20040413 |
| Key structural features of ligands for activation of human pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20040401 |
| Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. | Drug metabolism and pharmacokinetics 20040401 |
| Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors. | The Journal of biological chemistry 20040326 |
| Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. | Drug metabolism and disposition: the biological fate of chemicals 20040301 |
| Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. | Drug metabolism and disposition: the biological fate of chemicals 20040301 |
| Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. | Molecular pharmacology 20040301 |
| Vitamin E, nuclear receptors and xenobiotic metabolism. | Archives of biochemistry and biophysics 20040301 |
| CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. | Clinical pharmacology and therapeutics 20040301 |
| The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. | Biochemical pharmacology 20040301 |
| Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20040201 |
| Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). | Environmental health perspectives 20040201 |
| The danger of extrapolation. Humans and rodents differ in response to PCBs. | Environmental health perspectives 20040201 |
| Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential. | Expert opinion on therapeutic targets 20040201 |
| Herbal modulation of P-glycoprotein. | Drug metabolism reviews 20040201 |
| Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. | Molecular endocrinology (Baltimore, Md.) 20040101 |
| Effects of triaryl phosphates on mouse and human nuclear receptors. | Biochemical pharmacology 20040101 |
| Enterohepatic bile salt transporters in normal physiology and liver disease. | Gastroenterology 20040101 |
| The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes. | Drug metabolism and disposition: the biological fate of chemicals 20040101 |
| CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20040101 |
| Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. | Drug metabolism and disposition: the biological fate of chemicals 20040101 |
| Pregnane- and furostane-type oligoglycosides from the seeds of Allium tuberosum. | Chemical & pharmaceutical bulletin 20040101 |
| Identification of amino acids in rat pregnane X receptor that determine species-specific activation. | Molecular pharmacology 20040101 |
| CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. | The pharmacogenomics journal 20040101 |
| Effects of a single injection of hCG or GnRH agonist on day 12 post mating on fetal growth and reproductive performance of sheep. | Animal reproduction science 20040101 |
| Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR). | Mechanisms of ageing and development 20040101 |
| Induction of cytochromes P450. | Current topics in medicinal chemistry 20040101 |
| Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization. | Pediatric research 20031201 |
| Novel PPARgamma-dependent and independent effects for thiazolidinediones. | Current opinion in lipidology 20031201 |
| Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate. | Epilepsia 20031201 |
| Induction of drug metabolism: the role of nuclear receptors. | Pharmacological reviews 20031201 |
| Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. | Current drug metabolism 20031201 |
| Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor. | Toxicology and applied pharmacology 20031115 |
| Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. | The Journal of biological chemistry 20031114 |
| Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. | The Journal of biological chemistry 20031107 |
| Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia. | British journal of pharmacology 20031101 |
| Induction of ABCC3 (MRP3) by pregnane X receptor activators. | Drug metabolism and disposition: the biological fate of chemicals 20031101 |
| Androgens and antiandrogens. | Annals of the New York Academy of Sciences 20031101 |
| Regulation of drug and bile salt transporters in liver and intestine. | Drug metabolism reviews 20031101 |
| Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. | The Journal of biological chemistry 20031010 |
| A natural product ligand of the oxysterol receptor, liver X receptor. | The Journal of pharmacology and experimental therapeutics 20031001 |
| ABC transporter regulation by bile acids: where PXR meets FXR. | Journal of hepatology 20031001 |
| Sex is a major determinant of CYP3A4 expression in human liver. | Hepatology (Baltimore, Md.) 20031001 |
| Prediction of human drug metabolizing enzyme induction. | Current drug metabolism 20031001 |
| Ascochlorin derivatives as ligands for nuclear hormone receptors. | Journal of medicinal chemistry 20030911 |
| Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20030901 |
| The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity. | Molecular endocrinology (Baltimore, Md.) 20030901 |
| Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901 |
| Expression and potential roles of pregnane X receptor in endometrial cancer. | The Journal of clinical endocrinology and metabolism 20030901 |
| Neurosteroid modulation of GABAA receptors. | Progress in neurobiology 20030901 |
| In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. | Drug news & perspectives 20030901 |
| Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. | Journal of molecular biology 20030822 |
| Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. | Molecular pharmacology 20030801 |
| The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor. | Molecular pharmacology 20030801 |
| Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. | Hepatology (Baltimore, Md.) 20030801 |
| Cytotoxic activity of steroidal glycosides from solanum plants. | Biological & pharmaceutical bulletin 20030801 |
| The toxicogenomics of nuclear receptor agonists. | Current opinion in chemical biology 20030801 |
| Chemical complementation: small-molecule-based genetic selection in yeast. | Biochemical and biophysical research communications 20030704 |
| Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. | Molecular endocrinology (Baltimore, Md.) 20030701 |
| CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. | Drug metabolism and disposition: the biological fate of chemicals 20030701 |
| Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. | Drug metabolism and disposition: the biological fate of chemicals 20030701 |
| Transgenic mouse models of human CYP3A4 gene regulation. | Molecular pharmacology 20030701 |
| Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. | Molecular pharmacology 20030701 |
| Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells. | Xenobiotica; the fate of foreign compounds in biological systems 20030701 |
| Attenuation of the effect of progesterone and 4'-chlordiazepam on stress-induced immune responses by bicuculline. | Indian journal of physiology and pharmacology 20030701 |
| Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA. | Biochemical and biophysical research communications 20030620 |
| Vitamin E and drug metabolism. | Biochemical and biophysical research communications 20030606 |
| Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep. | Pediatric research 20030601 |
| Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. | Endocrinology 20030601 |
| Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20030601 |
| Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. | Hepatology (Baltimore, Md.) 20030601 |
| In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. | Biochemical pharmacology 20030601 |
| Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica. | Chemical & pharmaceutical bulletin 20030601 |
| Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid. | Molecular and cellular biochemistry 20030601 |
| Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. | The Journal of biological chemistry 20030516 |
| Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. | The Journal of biological chemistry 20030509 |
| Regulation of drug transporter gene expression by nuclear receptors. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis. | Archives of biochemistry and biophysics 20030501 |
| Quantitation of CYP2B6, constitutive androstane receptor, and pregnane X receptor mRNA levels. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| Nuclear receptors orchestrate detoxification pathways. | Developmental cell 20030501 |
| Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A. | Shock (Augusta, Ga.) 20030501 |
| Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. | Biochemical and biophysical research communications 20030425 |
| A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. | The Journal of biological chemistry 20030418 |
| Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. | Proceedings of the National Academy of Sciences of the United States of America 20030401 |
| Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19. | Pharmacogenetics 20030401 |
| The role of the enterohepatic circulation of bile salts and nuclear hormone receptors in the regulation of cholesterol homeostasis: Bile salts as ligands for nuclear hormone receptors. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030401 |
| Repression of farnesoid X receptor during the acute phase response. | The Journal of biological chemistry 20030314 |
| CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. | Hepatology (Baltimore, Md.) 20030301 |
| Predicting inductive drug-drug interactions. | Pharmacogenomics 20030301 |
| Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. | Molecular pharmacology 20030301 |
| Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile. | Archives of toxicology 20030301 |
| 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. | Biochemistry 20030218 |
| Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. | Biochimica et biophysica acta 20030217 |
| Functional and structural comparison of PXR and CAR. | Biochimica et biophysica acta 20030217 |
| The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. | Biochimica et biophysica acta 20030217 |
| The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. | Nature medicine 20030201 |
| Interactions of herbs with cytochrome P450. | Drug metabolism reviews 20030201 |
| Vitamin E activates gene expression via the pregnane X receptor. | Biochemical pharmacology 20030115 |
| Pregnane X receptor-dependent and -independent effects of 2-acetylaminofluorene on cytochrome P450 3A23 expression and liver cell proliferation. | Biochemical and biophysical research communications 20030110 |
| Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. | Biochimica et biophysica acta 20030110 |
| Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR). | Journal of cellular physiology 20030101 |
| Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. | Drug metabolism and disposition: the biological fate of chemicals 20030101 |
| Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Nuclear receptors and the control of metabolism. | Annual review of physiology 20030101 |
| Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. | The Journal of pharmacy and pharmacology 20030101 |
| Steroid and xenobiotic receptor (SXR) is a key system for the acquisition of cisplatin resistance in endometrial cancer cells. | The Journal of international medical research 20030101 |
| Drug-activated nuclear receptors CAR and PXR. | Annals of medicine 20030101 |
| An in vitro bioassay for xenobiotics using the SXR-driven human CYP3A4/lacZ reporter gene. | International journal of toxicology 20030101 |
| Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery. | American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20030101 |
| Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter. | Journal of human genetics 20030101 |
| Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. | Clinical pharmacokinetics 20030101 |
| Involvement of GABA-A receptor chloride channel complex in isolation stress-induced free choice ethanol consumption in rats. | Indian journal of experimental biology 20030101 |
| Practical uses for ecdysteroids in mammals including humans: an update. | Journal of insect science (Online) 20030101 |
| The varied roles of nuclear receptors during vertebrate embryonic development. | Nuclear receptor signaling 20030101 |
| Receptor-dependent regulation of the CYP3A4 gene. | Toxicology 20021227 |
| Coordinating clearance - the many phases of PXR! | Trends in pharmacological sciences 20021201 |
| A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. | Pharmaceutical research 20021201 |
| The increasing importance of genetic variation in drug discovery and development. | Current opinion in molecular therapeutics 20021201 |
| PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. | Biochemical pharmacology 20021115 |
| Identification of the novel splicing variants for the hPXR in human livers. | Biochemical and biophysical research communications 20021101 |
| Effects of level of feeding and progesterone dose on plasma and faecal progesterone in ovariectomised cows. | Animal reproduction science 20021016 |
| Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. | Drug metabolism and disposition: the biological fate of chemicals 20021001 |
| A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. | The Journal of pharmacology and experimental therapeutics 20021001 |
| Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation. | European journal of biochemistry 20021001 |
| Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. | Current drug metabolism 20021001 |
| The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. | Endocrine reviews 20021001 |
| Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. | The Journal of biological chemistry 20020906 |
| Insights from a three-dimensional model into ligand binding to constitutive active receptor. | Drug metabolism and disposition: the biological fate of chemicals 20020901 |
| Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20020901 |
| Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. | Drug metabolism and disposition: the biological fate of chemicals 20020901 |
| Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. | Molecular pharmacology 20020901 |
| Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. | Molecular pharmacology 20020901 |
| Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. | Molecular pharmacology 20020901 |
| Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. | European journal of pharmacology 20020823 |
| Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. | The Journal of biological chemistry 20020816 |
| Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. | Molecular pharmacology 20020801 |
| Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors. | Molecular pharmacology 20020801 |
| Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. | The Journal of pharmacology and experimental therapeutics 20020801 |
| In vitro studies of tibolone in breast cells. | Fertility and sterility 20020801 |
| Pregnane and pregnane glycosides from the Malagasy plant, Cynanchum aphyllum. | Chemical & pharmaceutical bulletin 20020801 |
| Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response. | British journal of cancer 20020729 |
| Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. | The Journal of biological chemistry 20020712 |
| Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine. | The Journal of biological chemistry 20020705 |
| CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20020701 |
| The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20020701 |
| Tissue distribution and chemical induction of multiple drug resistance genes in rats. | Drug metabolism and disposition: the biological fate of chemicals 20020701 |
| Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone. | Life sciences 20020607 |
| Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. | Gastroenterology 20020601 |
| Redundant pathways for negative feedback regulation of bile acid production. | Developmental cell 20020601 |
| [Nuclear receptor and inflammation]. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20020601 |
| A natural product that lowers cholesterol as an antagonist ligand for FXR. | Science (New York, N.Y.) 20020531 |
| Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. | The Journal of biological chemistry 20020524 |
| Vitamin D receptor as an intestinal bile acid sensor. | Science (New York, N.Y.) 20020517 |
| Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20020501 |
| Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. | Drug metabolism and disposition: the biological fate of chemicals 20020501 |
| Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. | Molecular endocrinology (Baltimore, Md.) 20020501 |
| Pharmaceutical use of mouse models humanized for the xenobiotic receptor. | Drug discovery today 20020501 |
| Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. | Biochemical and biophysical research communications 20020426 |
| How to calculate the dose of chemotherapy. | British journal of cancer 20020422 |
| Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. | Molecular pharmacology 20020401 |
| PXR, CAR and drug metabolism. | Nature reviews. Drug discovery 20020401 |
| Evaluation of the analgesic effect of neurosteroids and their possible mechanism of action. | Indian journal of physiology and pharmacology 20020401 |
| Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| Organic anion transporting polypeptides, cholestasis, and nuclear receptors. | Hepatology (Baltimore, Md.) 20020301 |
| Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. | Journal of lipid research 20020301 |
| Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. | Toxicology 20020227 |
| The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201 |
| The PXR crystal structure: the end of the beginning. | Trends in pharmacological sciences 20020201 |
| Steroid hormone receptors and dietary ligands: a selected review. | The Proceedings of the Nutrition Society 20020201 |
| Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. | The Journal of biological chemistry 20020125 |
| Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. | The Journal of biological chemistry 20020104 |
| A pharmacophore for human pregnane X receptor ligands. | Drug metabolism and disposition: the biological fate of chemicals 20020101 |
| Ligands have various potential effects on the degradation of pregnane X receptor by proteasome. | Endocrinology 20020101 |
| Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. | The Journal of pharmacology and experimental therapeutics 20020101 |
| Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense. | Hepatology (Baltimore, Md.) 20020101 |
| BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. | Journal of lipid research 20020101 |
| Regulation of cyp3a gene transcription by the pregnane x receptor. | Annual review of pharmacology and toxicology 20020101 |
| [Analysis of the mechanisms of the drug-drug interaction from a view of pharmacogenomics]. | Nihon rinsho. Japanese journal of clinical medicine 20020101 |
| Synthesis and pharmacological evaluation of new 16-methyl pregnane derivatives. | Chemical & pharmaceutical bulletin 20020101 |
| Structural insights into the promiscuity and function of the human pregnane X receptor. | Current opinion in drug discovery & development 20020101 |
| [Regulation of cytochrome P-450 (CYP) genes by nuclear receptors]. | Nihon eiseigaku zasshi. Japanese journal of hygiene 20020101 |
| Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. | Journal of cellular biochemistry 20020101 |
| Regulation of hepatic drug metabolism: role of the nuclear receptors PXR and CAR. | Seminars in liver disease 20020101 |
| Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. | The pharmacogenomics journal 20020101 |
| [Contraception at 40]. | Gynecologie, obstetrique & fertilite 20020101 |
| The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. | Cell biology and toxicology 20020101 |
| Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates. | Methods in enzymology 20020101 |
| The nuclear receptor PXR: a master regulator of 'homeland' defense. | Critical reviews in eukaryotic gene expression 20020101 |
| Nuclear receptor regulation of genes involved in bile acid metabolism. | Critical reviews in eukaryotic gene expression 20020101 |
| Hepatobiliary transport of bile acids and organic anions. | Journal of hepato-biliary-pancreatic surgery 20020101 |
| [Treatment with human chorion-gonadotropin (pregnyl) of patients with vaginal bleeding in the first trimester of pregnancy]. | Akusherstvo i ginekologiia 20020101 |
| Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain. | Genome biology 20020101 |
| Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression. | Lipids in health and disease 20020101 |
| Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes. | Journal of pharmacological and toxicological methods 20020101 |
| [The role of nuclear receptors in cytochrome P-450 induction by xenochemicals]. | Roczniki Panstwowego Zakladu Higieny 20020101 |
| Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. | Molecular pharmacology 20011201 |
| Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. | European journal of biochemistry 20011201 |
| Nuclear receptors and lipid physiology: opening the X-files. | Science (New York, N.Y.) 20011130 |
| 3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex. | Brain research. Developmental brain research 20011126 |
| Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
| Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
| Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
| Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
| Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. | Medicinal research reviews 20011101 |
| New steroids from Solenostemma argel leaves. | Fitoterapia 20011101 |
| Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. | Brain research. Brain research reviews 20011101 |
| Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. | The Journal of biological chemistry 20011019 |
| Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20011001 |
| Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. | Molecular pharmacology 20011001 |
| Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. | European journal of endocrinology 20011001 |
| Polymorphisms in promiscuous PXR: an explanation for interindividual differences in drug clearance? | Pharmacogenetics 20011001 |
| The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. | Pharmacogenetics 20011001 |
| Chemical characterization of naturally weathered oil residues in arid terrestrial environment in Al-Alamein, Egypt. | Environment international 20011001 |
| Faecal oestrogens and progesterone metabolites in mares of different breeds during the last trimester of pregnancy. | Reproduction in domestic animals = Zuchthygiene 20011001 |
| Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. | The Journal of biological chemistry 20010907 |
| Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. | Molecular pharmacology 20010901 |
| Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. | Molecular pharmacology 20010901 |
| Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. | Molecular endocrinology (Baltimore, Md.) 20010901 |
| The PXR ligand-binding domain: how to be picky and promiscuous at the same time. | Trends in pharmacological sciences 20010901 |
| Gene induction by Phenobarbital: an update on an old question that receives key novel answers. | Pharmacology & toxicology 20010901 |
| The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes. | Molecular pharmacology 20010801 |
| [Syphilis in pregnancy women]. | Zhonghua fu chan ke za zhi 20010801 |
| Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010701 |
| Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep. | Neuroscience letters 20010622 |
| The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. | Science (New York, N.Y.) 20010622 |
| Effect of 5 alpha-pregnan-3 alpha-ol-20-one on nitric oxide biosynthesis and plasma volume in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20010601 |
| Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. | Chemico-biological interactions 20010516 |
| Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. | The Journal of biological chemistry 20010504 |
| Cyp3A regulation: from pharmacology to nuclear receptors. | Drug metabolism and disposition: the biological fate of chemicals 20010501 |
| Promiscuous regulator of xenobiotic removal. | Nature medicine 20010501 |
| The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. | Nature medicine 20010501 |
| Evaluation of new pregnane derivatives as 5alpha-reductase inhibitor. | Chemical & pharmaceutical bulletin 20010501 |
| Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics. | The Journal of biological chemistry 20010420 |
| A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography. | Phytochemistry 20010401 |
| Induction of CYP2C genes in human hepatocytes in primary culture. | Drug metabolism and disposition: the biological fate of chemicals 20010301 |
| The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. | Molecular and cellular endocrinology 20010214 |
| [Peroxisome proliferator-activated receptor (PPAR)]. | Nihon rinsho. Japanese journal of clinical medicine 20010201 |
| Pharmacology. How the body's 'garbage disposal' may inactivate drugs. | Science (New York, N.Y.) 20010105 |
| Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. | Annual review of pharmacology and toxicology 20010101 |
| [Why aren't Leydig cell tumors of the ovary diagnosed in time?]. | Medicinski pregled 20010101 |
| Neurosteroid modulation of recombinant and synaptic GABAA receptors. | International review of neurobiology 20010101 |
| Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. | European journal of medicinal chemistry 20010101 |
| Cycloartanes, protolimonoids, a pregnane and a new ergostane from Trichilia reticulata. | Natural product letters 20010101 |
| Regulation of drug transport by new xenobiotic receptors. | The pharmacogenomics journal 20010101 |
| The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. | Molecular endocrinology (Baltimore, Md.) |
| Evolutionary history and functional characterization of the amphibian xenosensor CAR. | Molecular endocrinology (Baltimore, Md.) |
| Editorial: molecular endocrinology articles in the spotlight for June 2012. | Molecular endocrinology (Baltimore, Md.) |
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