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2466-09-3 | Diphosphoric acid
CAS No: 2466-09-3 Catalog No: AG002OZI MDL No:MFCD00011343
Product Description
Catalog Number:
AG002OZI
Chemical Name:
Diphosphoric acid
CAS Number:
2466-09-3
Molecular Formula:
H4O7P2
Molecular Weight:
177.9751
MDL Number:
MFCD00011343
IUPAC Name:
phosphono dihydrogen phosphate
InChI:
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
InChI Key:
XPPKVPWEQAFLFU-UHFFFAOYSA-N
SMILES:
OP(=O)(OP(=O)(O)O)O
EC Number:
219-574-0
UNII:
4E862E7GRQ
NSC Number:
289196
Properties
Complexity:
147
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
177.943g/mol
Formal Charge:
0
Heavy Atom Count:
9
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
177.973g/mol
Monoisotopic Mass:
177.943g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.2
Literature
| Title | Journal |
|---|---|
| Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively 'Freeze' the pre-translocated complex during the polymerization catalytic cycle. | Bioorganic & medicinal chemistry 20180501 |
| Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. | Toxicology in vitro : an international journal published in association with BIBRA 20160401 |
| First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. | Journal of medicinal chemistry 20150611 |
| A pyrophosphatase activity associated with purified HIV-1 particles. | Biochimie 20121201 |
| Selective pyrophosphate recognition by cyclic peptide receptors in physiological saline. | Chemistry, an Asian journal 20121101 |
| Cell type-specific effects of Adenosine 5'-triphosphate and pyrophosphate on the antitumor activity of doxorubicin. | Cancer science 20121001 |
| Novel pyrophosphate-forming acetate kinase from the protist Entamoeba histolytica. | Eukaryotic cell 20121001 |
| Gram-scale chemical synthesis of 2'-deoxynucleoside-5'-o-triphosphates. | Current protocols in nucleic acid chemistry 20120601 |
| Imino-phenolic-pyridyl conjugates of calix[4]arene (L1 and L2) as primary fluorescence switch-on sensors for Zn2+ in solution and in HeLa cells and the recognition of pyrophosphate and ATP by [ZnL2]. | Inorganic chemistry 20120507 |
| Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function. | Proteins 20120401 |
| Catalysis and sulfa drug resistance in dihydropteroate synthase. | Science (New York, N.Y.) 20120302 |
| A new proofreading mechanism for lesion bypass by DNA polymerase-λ. | EMBO reports 20120101 |
| Regulation of pyrophosphate levels by H+-PPase is central for proper resumption of early plant development. | Plant signaling & behavior 20120101 |
| Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5'NT/CD73 in metastasis as potential prognostic factor. | PloS one 20120101 |
| Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii. | The Biochemical journal 20111201 |
| Binaphthol-derived bisphosphoric acids serve as efficient organocatalysts for highly enantioselective 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient olefins. | Journal of the American Chemical Society 20110831 |
| Silver(I) pyrophosphonates: structural, photoluminescent and thermal expansion studies. | Dalton transactions (Cambridge, England : 2003) 20110628 |
| Oxidative degradation of dipeptide (glycyl-glycine) by water-soluble colloidal manganese dioxide in the aqueous and micellar media. | Colloids and surfaces. B, Biointerfaces 20110101 |
| A supramolecular sensing platform for phosphate anions and an anthrax biomarker in a microfluidic device. | International journal of molecular sciences 20110101 |
| Automatic policing of biochemical annotations using genomic correlations. | Nature chemical biology 20100101 |
| Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. | PloS one 20100101 |
| Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors. | Biochemistry. Biokhimiia 20080601 |
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | Journal of medicinal chemistry 20080410 |
| Molecular commonality detection using an artificial enzyme membrane for in situ one-stop biosurveillance. | Analytical chemistry 20070801 |
| Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. | Nature chemical biology 20070801 |
| The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. | The Journal of biological chemistry 20070202 |
| Photo-induced chemiluminometric determination of Karbutilate in a continuous-flow multicommutation assembly. | Journal of pharmaceutical and biomedical analysis 20070117 |
| Structure of synthetic calcium hydroxyapatite particles modified with pyrophosphoric acid. | Journal of colloid and interface science 20050315 |
| Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. | Antimicrobial agents and chemotherapy 20050101 |
| Surface modification of calcium hydroxyapatite with pyrophosphoric acid. | Journal of colloid and interface science 20040115 |
| Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate. | Biochemical pharmacology 19981215 |
| Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance. | Biochemical pharmacology 19931214 |
| Nucleoside triphosphates promote the transformation of Ah receptor to its DNA-binding form. | The Biochemical journal 19910301 |
| PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase. | Antimicrobial agents and chemotherapy 19860501 |
| Antiviral effects of phosphonoformate (PFA, foscarnet sodium). | Pharmacology & therapeutics 19820101 |
| Pyrophosphate analogues as inhibitors of herpes simplex virus type 1 DNA polymerase. | Biochimica et biophysica acta 19800328 |
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