CAS 2447-54-3 | [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl- | CAS Number 2447-54-3

Title	Journal
Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds.	Chemico-biological interactions 20150305
Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.	The Journal of pharmacology and experimental therapeutics 20140301
NQO1 involves in the imine bond reduction of sanguinarine and recombinant adeno-associated virus mediated NQO1 overexpression decreases sanguinarine-induced cytotoxicity in rat BRL cells.	Toxicology letters 20140210
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.	Chemico-biological interactions 20130905
Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction.	Toxicology letters 20130704
Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells.	Phytochemistry 20130701
Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis.	Oncology reports 20121201
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.	Bioorganic & medicinal chemistry letters 20121201
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.	Bioorganic & medicinal chemistry 20121115
In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi.	Molecules (Basel, Switzerland) 20121102
Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901
The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages.	European journal of pharmacology 20120815
Molecular basis for differential glycine transporters sensitivity to sanguinarine.	Toxicology letters 20120803
Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20120715
Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA.	ACS chemical biology 20120615
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.	Journal of medicinal chemistry 20120524
Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids.	Phytochemistry 20120501
The interaction of telomeric DNA and C-myc22 G-quadruplex with 11 natural alkaloids.	Nucleic acid therapeutics 20120401
High-throughput library screening identifies two novel NQO1 inducers in human lung cells.	American journal of respiratory cell and molecular biology 20120301
Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.	Fitoterapia 20120301
The sequential exposure to jasmonate, salicylic acid and yeast extract promotes sanguinarine accumulation in Argemone mexicana cell cultures.	Biotechnology letters 20120201
Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.	Oncotarget 20120201
Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats.	Neuroscience letters 20120111
Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion.	The Prostate 20120101
Antitumor effects of the benzophenanthridine alkaloid sanguinarine in a rat syngeneic model of colorectal cancer.	Anti-cancer drugs 20120101
Bioactive isoquinoline alkaloids from Corydalis saxicola.	Planta medica 20120101
Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway.	International journal of toxicology 20120101
Biological activities of nitidine, a potential anti-malarial lead compound.	Malaria journal 20120101
Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.	Frontiers in microbiology 20120101
Establishment of a sanguinarine-producing cell suspension culture of Argemone mexicana L (Papaveraceae): induction of alkaloid accumulation.	Methods in molecular biology (Clifton, N.J.) 20120101
A comparative evaluation of atrigel delivery system (10% doxycycline hyclate) Atridox with scaling and root planing and combination therapy in treatment of periodontitis: A clinical study.	Journal of Indian Society of Periodontology 20120101
Clinical effect of miswak as an adjunct to tooth brushing on gingivitis.	Journal of Indian Society of Periodontology 20120101
Biophysical characterization of the strong stabilization of the RNA triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) alkyl ether berberine analogs.	PloS one 20120101
Binding of the anticancer alkaloid sanguinarine with tRNA(phe): spectroscopic and calorimetric studies.	Journal of biomolecular structure & dynamics 20120101
Alkaloids isolated from natural herbs as the anticancer agents.	Evidence-based complementary and alternative medicine : eCAM 20120101
Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.	Methods in enzymology 20120101
Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.	Medicinal research reviews 20111101
Chiral HPLC studies on chemical behavior of 6-methoxydihydrosanguinarine in alcoholic solvent system.	Journal of pharmaceutical and biomedical analysis 20111101
Alkaloids from Papaver coreanum.	Natural product communications 20111101
Sanguinarine is an allosteric activator of AMP-activated protein kinase.	Biochemical and biophysical research communications 20110923
Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts.	Toxicology letters 20110910
Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line.	Anticancer research 20110901
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.	The Journal of organic chemistry 20110819
Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.	Journal of chromatography. A 20110805
In vitro potentiation of ampicillin, oxacillin, norfloxacin, ciprofloxacin, and vancomycin by sanguinarine against methicillin-resistant Staphylococcus aureus.	Foodborne pathogens and disease 20110801
Natural products in caries research: current (limited) knowledge, challenges and future perspective.	Caries research 20110701
The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.	The Journal of toxicological sciences 20110601
Palladium-catalyzed tandem reaction to construct benzo[c]phenanthridine: application to the total synthesis of benzo[c]phenanthridine alkaloids.	Organic & biomolecular chemistry 20110507
X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).	Chemical communications (Cambridge, England) 20110507
Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters.	Neurochemistry international 20110501
Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution.	Journal of separation science 20110501
Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501
Structural modification of sanguinarine and chelerythrine and their antibacterial activity.	Natural product research 20110501
Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde.	Molecules (Basel, Switzerland) 20110420
Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study.	Biochimica et biophysica acta 20110401
Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status.	Journal of dermatological science 20110401
In vitro and in vivo evaluation of sanguinarine liposomes prepared by a remote loading method with three different ammonium salts.	Die Pharmazie 20110401
[Study on the alkaloids from the stem of Zanthoxylum dissitum].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401
Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana.	Archives of biochemistry and biophysics 20110301
The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro.	European journal of pharmacology 20110301
Inclusion complex formation of sanguinarine alkaloid with cucurbit[7]uril: inhibition of nucleophilic attack and photooxidation.	Organic & biomolecular chemistry 20110221
[Study on liver injury of Oncomelania hupensis caused by Eomecon chinanthe sanguinarine].	Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201
Human telomere d[(TTAGGG)4] undergoes a conformational transition to the Na+-form upon binding with sanguinarine in presence of K+.	Biochemical and biophysical research communications 20110107
Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.	Evidence-based complementary and alternative medicine : eCAM 20110101
Photoreduction and ketone-sensitized reduction of alkaloids.	Photochemistry and photobiology 20110101
Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed.	PloS one 20110101
A 'reverse pharmacology' approach for developing an anti-malarial phytomedicine.	Malaria journal 20110101
Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin.	PloS one 20110101
Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.	Evidence-based complementary and alternative medicine : eCAM 20110101
Targeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-β-D-glucoside and daunomycin binding to tRNA(phe).	PloS one 20110101
Photooxidation of alkaloids: considerable quantum yield enhancement by rose bengal-sensitized singlet molecular oxygen generation.	Photochemistry and photobiology 20110101
Effect of DNA groove binder distamycin A upon chromatin structure.	PloS one 20110101
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.	PloS one 20110101
Attenuation of cytotoxic natural product DNA intercalating agents by caffeine.	Scientia pharmaceutica 20110101
Binding of tetracycline and chlortetracycline to the enzyme trypsin: spectroscopic and molecular modeling investigations.	PloS one 20110101
'Science means learning to say-I don't know': An interview with Dr. Ashok D.B. Vaidya.	Journal of Ayurveda and integrative medicine 20110101
Potentiation of tumour promotion by topical application of argemone oil/isolated sanguinarine alkaloid in a model of mouse skin carcinogenesis.	Chemico-biological interactions 20101205
Phytochemical and antimicrobial characterization of Macleaya cordata herb.	Fitoterapia 20101201
Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition.	Fitoterapia 20101201
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents.	European journal of medicinal chemistry 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.	Bioorganic & medicinal chemistry letters 20101101
Fluorescence of sanguinarine: spectral changes on interaction with amino acids.	Physical chemistry chemical physics : PCCP 20101007
Effect of sanguinarine from the leaves of Macleaya cordata against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idella).	Parasitology research 20101001
An Internet misadventure: bloodroot salve toxicity.	Journal of alternative and complementary medicine (New York, N.Y.) 20101001
In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees.	Veterinary microbiology 20100928
Extractions of isoquinoline alkaloids with butanol and octanol.	Fitoterapia 20100901
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.	Cancer metastasis reviews 20100901
Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways.	Biochemical and biophysical research communications 20100827
In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus.	Veterinary parasitology 20100804
Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica.	Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721
Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.	Journal of pharmaceutical and biomedical analysis 20100708
Fusarium oxysporum homogenates and jasmonate induce limited sanguinarine accumulation in Argemone mexicana cell cultures.	Biotechnology letters 20100701
Binding of the anticancer alkaloid sanguinarine to double stranded RNAs: insights into the structural and energetics aspects.	Molecular bioSystems 20100701
A study on separation and extraction of four main alkaloids in Macleaya cordata (Willd) R. Br. with strip dispersion hybrid liquid membrane.	Journal of separation science 20100701
Interaction of sanguinarine and its dihydroderivative with the Na+/K+-ATPase. Complex view on the old problem.	Toxicology letters 20100616
Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.	The Journal of biological chemistry 20100611
[Identification of differentially expressed proteins in the liver of Oncomelania snails induced by Eomecon chinanthe sanguinarine].	Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20100601
Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells.	Toxicology in vitro : an international journal published in association with BIBRA 20100401
Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection.	Journal of separation science 20100401
Sanguinarine suppresses prostate tumor growth and inhibits survivin expression.	Genes & cancer 20100301
Study on the inclusion interaction of cucurbit[n]urils with sanguinarine by spectrofluorimetry and its analytical application.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100201
Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC.	Journal of pharmaceutical and biomedical analysis 20100105
Skin tumor promotion by argemone oil/alkaloid in mice: evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101
ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation.	Breast cancer research : BCR 20100101
The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro.	Anticancer research 20100101
Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems.	PloS one 20100101
BIAdb: a curated database of benzylisoquinoline alkaloids.	BMC pharmacology 20100101
Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.	Bioscience, biotechnology, and biochemistry 20100101
Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae).	BMC plant biology 20100101
A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection.	BMC plant biology 20100101
Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.	Journal of nucleic acids 20100101
Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures.	Plant physiology and biochemistry : PPB 20100101
Genetic evidence for inhibition of bacterial division protein FtsZ by berberine.	PloS one 20100101
[Comparative substrate-inhibitor analysis of liver monoamine oxidases of minks].	Zhurnal evoliutsionnoi biokhimii i fiziologii 20100101
Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures.	BMC plant biology 20100101
Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.	PloS one 20100101
A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine.	PloS one 20100101
Cytotoxic activity of proteins isolated from extracts of Corydalis cava tubers in human cervical carcinoma HeLa cells.	BMC complementary and alternative medicine 20100101
Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines.	Cancer chemotherapy and pharmacology 20091201
Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma.	Biochemical pharmacology 20091201
Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens.	Natural product communications 20091101
Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.	Anticancer research 20091101
Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: effect of P450 inducers on its toxicity.	Toxicology mechanisms and methods 20091001
Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates.	Journal of ethnopharmacology 20090925
Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms.	Analytical and bioanalytical chemistry 20090901
Fluorescence properties of selected benzo[c]phenantridine alkaloids and studies of their interaction with CT DNA.	Analytical and bioanalytical chemistry 20090601
Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells.	Toxicology in vitro : an international journal published in association with BIBRA 20090601
Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells.	Chemico-biological interactions 20090515
Food contamination.	Disease-a-month : DM 20090501
Effect of argemone oil and argemone alkaloid, sanguinarine on Sertoli-germ cell coculture.	Toxicology letters 20090425
Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.	Journal of chromatography. A 20090313
Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion.	Toxicology in vitro : an international journal published in association with BIBRA 20090301
Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin.	Chemistry & biology 20090227
Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics.	Molecular & cellular proteomics : MCP 20090101
Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.	BMC complementary and alternative medicine 20090101
Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.	BMC neuroscience 20090101
Structural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteins.	PloS one 20090101
PCNA damage caused by antineoplastic drugs.	Biochemical pharmacology 20081215
Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects.	Biochemical pharmacology 20081201
Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201
A concerted mechanism for berberine bridge enzyme.	Nature chemical biology 20081201
Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.	Journal of medicinal chemistry 20081113
Ligand binding to tandem G quadruplexes from human telomeric DNA.	Chembiochem : a European journal of chemical biology 20081103
Induction of hepatotoxicity by sanguinarine is associated with oxidation of protein thiols and disturbance of mitochondrial respiration.	Journal of applied toxicology : JAT 20081101
Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei).	Molecules (Basel, Switzerland) 20081003
Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA.	Analytical and bioanalytical chemistry 20081001
Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms.	Planta medica 20081001
Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis.	Archives of biochemistry and biophysics 20080901
Cancer is a preventable disease that requires major lifestyle changes.	Pharmaceutical research 20080901
The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701
Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL.	Journal of cellular biochemistry 20080601
Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20080601
Separation of sanguinarine and chelerythrine in Macleaya cordata (Willd) R. Br. based on methyl acrylate-co-divinylbenzene macroporous adsorbents.	Journal of chromatography. A 20080523
Synergistic effects of sequential treatment with methyl jasmonate, salicylic acid and yeast extract on benzophenanthridine alkaloid accumulation and protein expression in Eschscholtzia californica suspension cultures.	Journal of biotechnology 20080520
A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids.	Toxicology letters 20080401
Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature.	Journal of cutaneous pathology 20080401
Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells.	Archives of biochemistry and biophysics 20080315
Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines.	Chemico-biological interactions 20080310
Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects.	Toxicology in vitro : an international journal published in association with BIBRA 20080301
Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells.	Cell biology international 20080201
Differential induction of protein expression and benzophenanthridine alkaloid accumulation in Eschscholtzia californica suspension cultures by methyl jasmonate and yeast extract.	Journal of microbiology and biotechnology 20080201
Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine.	Cell biology and toxicology 20080101
Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures.	BMC plant biology 20080101
Sanguinarine.	Cardiovascular therapeutics 20080101
Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.	Chemotherapy 20080101
Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway.	Chemotherapy 20080101
Strategies for prostate cancer prevention: Review of the literature.	Indian journal of urology : IJU : journal of the Urological Society of India 20080101
Interaction of sanguinarine alkaloid, isolated from argemone oil, with hepatic cytochrome p450 in rats.	Toxicology mechanisms and methods 20080101
Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholtzia californica suspension cultures.	Biotechnology letters 20071201
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins.	PLoS genetics 20071201
Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives.	Medicinal research reviews 20070901
Quaternary benzo[c]phenanthridine alkaloids--novel cell permeant and red fluorescing DNA probes.	Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070901
Specific binding and self-structure induction to poly(A) by the cytotoxic plant alkaloid sanguinarine.	Biochimica et biophysica acta 20070901
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.	Anti-cancer drugs 20070901
Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.	Pharmacological research 20070901
Administration of Ratanhia-based herbal oral care products for the prophylaxis of oral mucositis in cancer chemotherapy patients: a clinical trial.	Evidence-based complementary and alternative medicine : eCAM 20070901
Metabolic engineering in isoquinoline alkaloid biosynthesis.	Current pharmaceutical biotechnology 20070801
Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells.	Transgenic research 20070601
The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis.	The Journal of reproduction and development 20070601
HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae.	Journal of pharmaceutical and biomedical analysis 20070509
Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins.	Cancer letters 20070508
Disposition of sanguinarine in the rat.	Xenobiotica; the fate of foreign compounds in biological systems 20070501
Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.	Cancer research 20070415
Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.	Atherosclerosis 20070401
Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism.	Planta 20070401
Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).	Journal of agricultural and food chemistry 20070221
Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.	The FEBS journal 20070201
Metabolism of sanguinarine: the facts and the myths.	Current drug metabolism 20070201
Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine-induced apoptosis and oncosis.	Toxicologic pathology 20070201
Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.	Toxicology and applied pharmacology 20070115
Sanguinarine inhibits VEGF-induced Akt phosphorylation.	Annals of the New York Academy of Sciences 20070101
Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix.	BioFactors (Oxford, England) 20070101
Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: implications for prevention of skin cancer.	Photochemistry and photobiology 20070101
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.	Journal of molecular biology 20061201
Protective effect of bioantioxidants on argemone oil/sanguinarine alkaloid induced genotoxicity in mice.	Cancer letters 20061128
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine.	Cell biology and toxicology 20061101
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?	Applied microbiology and biotechnology 20061101
Simultaneous analysis of alkaloids from Zanthoxylum nitidum by high performance liquid chromatography-diode array detector-electrospray tandem mass spectrometry.	Journal of pharmaceutical and biomedical analysis 20060918
Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.	Toxicology letters 20060910
Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: analyses in rat hepatoma cell line H4IIE.luc.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901
DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.	Bioorganic & medicinal chemistry 20060815
A simple and sensitive method of nonaqueous capillary electrophoresis with laser-induced native fluorescence detection for the analysis of chelerythrine and sanguinarine in Chinese herbal medicines.	Talanta 20060815
Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells.	Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801
Sanguinarine downregulates AT1a gene expression in a hypertensive rat model.	Journal of cardiovascular pharmacology 20060801
Safety evaluation studies on argemone oil through dietary exposure for 90days in rats.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060701
Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid.	Biochimica et biophysica acta 20060701
Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis.	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20060701
Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine.	Cancer letters 20060608
Development of a kinetic metabolic model: application to Catharanthus roseus hairy root.	Bioprocess and biosystems engineering 20060501
The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.	The FEBS journal 20060501
The plant alkaloid Sanguinarine affects swine granulosa cell activity.	Reproductive toxicology (Elmsford, N.Y.) 20060401
Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.	Cancer research 20060401
Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060201
Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells.	Chemico-biological interactions 20060201
Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes.	Molecular cancer therapeutics 20060201
Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.	Plant, cell & environment 20060201
A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.	BMC cancer 20060101
Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.	BMC cell biology 20060101
Biosynthesis of antitumoral and bactericidal sanguinarine.	Journal of biomedicine & biotechnology 20060101
Analysis of secondary metabolites from eschscholtzia californica by high-performance liquid chromatography.	Phytochemical analysis : PCA 20060101
[Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101
Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine in fruits of Macleaya cordata by microwave-assisted solvent extraction and HPLC-ESI/MS.	Phytochemical analysis : PCA 20060101
Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins.	Nucleic acids symposium series (2004) 20060101
Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines.	Anticancer research 20060101
Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling.	Biochemistry 20051220
Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice.	International journal of cancer 20051210
A rapid and reliable solid-phase extraction method for high-performance liquid chromatographic analysis of opium alkaloids from papaver plants.	Chemical & pharmaceutical bulletin 20051101
Randomized controlled clinical trials on agents used for chemical plaque control.	International journal of dental hygiene 20051101
Effects of the limited analyte solubility on its mobility and zone shape: electrophoretic behavior of sanguinarine and chelerythrine around pH 7.	Electrophoresis 20050901
Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.	Toxicology letters 20050814
Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.	Toxicology letters 20050728
Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro.	International dental journal 20050601
Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine.	Journal of enzyme inhibition and medicinal chemistry 20050601
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.	The Journal of biological chemistry 20050513
Capillary zone electrophoretic studies of interactions of some quaternary isoquinoline alkaloids with DNA constituents and DNA.	Electrophoresis 20050501
Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment.	Plant physiology 20050501
In situ extraction strategy affects benzophenanthridine alkaloid production fluxes in suspension cultures of Eschscholtzia californica.	Biotechnology and bioengineering 20050205
Immunohistochemical assessment of Viadent-associated leukoplakia.	Oral oncology 20050201
In vivo DNA damaging potential of sanguinarine alkaloid, isolated from argemone oil, using alkaline Comet assay in mice.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101
Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.	BMC neuroscience 20050101
Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarine: a study on cardiotoxicity of sanguinarine.	Journal of biomedical science 20050101
[Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101
[Effect of alkaloid sanguinarine and a pharmaceutical preparation ukrain on modulation of vesicular membrane fusion and actin cytoskeleton of macrophages].	Tsitologiia 20050101
Unequivocal evidence of genotoxic potential of argemone oil in mice.	International journal of cancer 20041210
Aggregation and other intermolecular interactions of biological buffers observed by capillary electrophoresis and UV photometry.	Journal of chromatography. A 20041008
Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.	The Plant journal : for cell and molecular biology 20041001
Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.	Biochemical pharmacology 20040915
Sanguinarine: an evaluation of in vivo cytogenetic activity.	Mutation research 20040912
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.	Molecular cancer therapeutics 20040801
Involvement of cytochrome P450 1A in sanguinarine detoxication.	Toxicology letters 20040715
Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.	British journal of pharmacology 20040701
Capillary electrophoretic studies of acid-base properties of sanguinarine and chelerythrine alkaloids.	Journal of chromatography. A 20040618
Suppression of angiogenesis by the plant alkaloid, sanguinarine.	Biochemical and biophysical research communications 20040430
Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans.	International journal of antimicrobial agents 20040401
Natural antimycobacterial metabolites: current status.	Phytochemistry 20040401
Hairy root induction of Papaver somniferum var. album, a difficult-to-transform plant, by A rhizogenes LBA 9402.	Planta 20040301
Quantitative liquid chromatographic determination of sanguinarine in cell culture medium and in rat urine and plasma.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125
Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism.	Chemico-biological interactions 20040115
Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101
[Biosynthesis of poppy isoquinoline alkaloids in nature and in vitro culture. 2. Bracteum poppy (Papaver bracteatum Lindl.)].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101
Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.	Toxicology letters 20031215
Local anti-infective therapy: pharmacological agents. A systematic review.	Annals of periodontology 20031201
Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031125
A tale of three cell types: alkaloid biosynthesis is localized to sieve elements in opium poppy.	The Plant cell 20031101
Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy.	Phytochemistry 20030901
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes.	Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion.	Cancer chemotherapy and pharmacology 20030601
Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures.	Journal of biomolecular structure & dynamics 20030401
In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.	Phytotherapy research : PTR 20030301
Achiral and chiral determination of benzophenanthridine alkaloids from methanol extracts of Hylomecon species by high performance liquid chromatography.	Archives of pharmacal research 20030201
In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor.	European journal of pharmacology 20030105
Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids.	Plant molecular biology 20030101
Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines.	Physiological research 20030101
Argemone oil induced cellular damage in the reproductive tissues of transgenic Drosophila melanogaster: protective role of 70 kDa heat shock protein.	Journal of biochemical and molecular toxicology 20030101
Sensitivity of lysosomal enzymes to the plant alkaloid sanguinarine: comparison with other SH-specific agents.	Cell biology international 20030101
[Biosynthesis of poppy isoquinoline alkaloids in nature and in vitro culture. 1. Opium poppy (Papaver somniferum L.)].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101
[Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their derivative drugs].	Tsitologiia 20030101
Influence of DNA structures on the conversion of sanguinarine alkanolamine form to iminium form.	Journal of biomolecular structure & dynamics 20021201
Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis.	Biological & pharmaceutical bulletin 20021201
Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.	Planta medica 20020901
DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique.	Chemico-biological interactions 20020815
[Effect of a fungal elicitor on levels of sanguinarine and polyphenoloxidase activity in a suspension culture of Papaver somniferum L].	Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20020701
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.	The Journal of biological chemistry 20020419
The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death.	Biochemical pharmacology 20020415
Epidemic dropsy: observations on pathophysiology and clinical features during the Delhi epidemic of 1998.	Tropical doctor 20020401
Interaction of sanguinarine with double stranded RNA structures.	Indian journal of biochemistry & biophysics 20020401
Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV.	Phytotherapy research : PTR 20020201
Capillary electrophoresis of phytochemical substances.	Journal of pharmaceutical and biomedical analysis 20020201
Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy.	Plant physiology 20020201
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.	Journal of ethnopharmacology 20020101
Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice.	BMC complementary and alternative medicine 20020101
[Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood].	Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101
The association between Viadent use and oral leukoplakia--results of a matched case-control study.	Journal of public health dentistry 20020101
White patch of maxillary vestibule. Sanguinarine-associated leukoplakia.	General dentistry 20020101
Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids.	Toxicology letters 20011215
The association between Viadent use and oral leukoplakia.	Epidemiology (Cambridge, Mass.) 20011101
In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.	Planta medica 20011001
Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant.	Planta 20011001
Argemone mexicana and epidemic dropsy: phytopharmacology and putative sequelae and therapy.	The Journal of the Association of Physicians of India 20011001
Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death.	Experimental and molecular pathology 20010801
Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain.	Phytotherapy research : PTR 20010301
Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1.	Planta medica 20010301
Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps.	Naunyn-Schmiedeberg's archives of pharmacology 20010201
Benzo[c]phenanthridine bases and their antituberculosis activity.	Medicinal research reviews 20010101
Mechanisms underlying the induction of vasorelaxation in rat thoracic aorta by sanguinarine.	Japanese journal of pharmacology 20010101
Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.	Cell biology and toxicology 20010101
Molecular aspects on the interaction of sanguinarine with B-form, Z-form and HL-form DNA structures.	Indian journal of biochemistry & biophysics 20010101
Sanguinarine induces bimodal cell death in K562 but not in high Bcl-2-expressing JM1 cells.	Pathology, research and practice 20010101
Role of Bcl-2 family proteins and caspase-3 in sanguinarine-induced bimodal cell death.	Cell biology and toxicology 20010101
[The inhibition enzymatic hydrolysis of acetylthiocholine by acetylcholinesterase using principal alkaloids isolated from celandine and macleya and their derivatives].	Tsitologiia 20010101
Isoquinoline alkaloid production by transformed cultures of Papaver somniferum.	Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20010101
Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity.	General dentistry 20010101
Alkaloid biosynthesis in Papaver sp. cells in culture and during organogenesis.	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20010101
Relationship between oral pain and ethanol concentration in mouthrinses.	Journal of periodontal research 19950501
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.	Journal of natural products 19910101

Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells.

Phytochemistry 20130701

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis.

Oncology reports 20121201

Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.

Bioorganic & medicinal chemistry letters 20121201

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Bioorganic & medicinal chemistry 20121115

In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi.

Molecules (Basel, Switzerland) 20121102

Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages.

European journal of pharmacology 20120815

Molecular basis for differential glycine transporters sensitivity to sanguinarine.

Toxicology letters 20120803

Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20120715

Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA.

ACS chemical biology 20120615

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids.

Phytochemistry 20120501

The interaction of telomeric DNA and C-myc22 G-quadruplex with 11 natural alkaloids.

Nucleic acid therapeutics 20120401

High-throughput library screening identifies two novel NQO1 inducers in human lung cells.

American journal of respiratory cell and molecular biology 20120301

Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.

Fitoterapia 20120301

The sequential exposure to jasmonate, salicylic acid and yeast extract promotes sanguinarine accumulation in Argemone mexicana cell cultures.

Biotechnology letters 20120201

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

Oncotarget 20120201

Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats.

Neuroscience letters 20120111

Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion.

The Prostate 20120101

Antitumor effects of the benzophenanthridine alkaloid sanguinarine in a rat syngeneic model of colorectal cancer.

Anti-cancer drugs 20120101

Bioactive isoquinoline alkaloids from Corydalis saxicola.

Planta medica 20120101

Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway.

International journal of toxicology 20120101

Biological activities of nitidine, a potential anti-malarial lead compound.

Malaria journal 20120101

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Frontiers in microbiology 20120101

Establishment of a sanguinarine-producing cell suspension culture of Argemone mexicana L (Papaveraceae): induction of alkaloid accumulation.

Methods in molecular biology (Clifton, N.J.) 20120101

A comparative evaluation of atrigel delivery system (10% doxycycline hyclate) Atridox with scaling and root planing and combination therapy in treatment of periodontitis: A clinical study.

Journal of Indian Society of Periodontology 20120101

Clinical effect of miswak as an adjunct to tooth brushing on gingivitis.

Journal of Indian Society of Periodontology 20120101

Biophysical characterization of the strong stabilization of the RNA triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) alkyl ether berberine analogs.

PloS one 20120101

Binding of the anticancer alkaloid sanguinarine with tRNA(phe): spectroscopic and calorimetric studies.

Journal of biomolecular structure & dynamics 20120101

Alkaloids isolated from natural herbs as the anticancer agents.

Evidence-based complementary and alternative medicine : eCAM 20120101

Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.

Methods in enzymology 20120101

Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.

Medicinal research reviews 20111101

Chiral HPLC studies on chemical behavior of 6-methoxydihydrosanguinarine in alcoholic solvent system.

Journal of pharmaceutical and biomedical analysis 20111101

Alkaloids from Papaver coreanum.

Natural product communications 20111101

Sanguinarine is an allosteric activator of AMP-activated protein kinase.

Biochemical and biophysical research communications 20110923

Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts.

Toxicology letters 20110910

Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line.

Anticancer research 20110901

Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

The Journal of organic chemistry 20110819

Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.

Journal of chromatography. A 20110805

In vitro potentiation of ampicillin, oxacillin, norfloxacin, ciprofloxacin, and vancomycin by sanguinarine against methicillin-resistant Staphylococcus aureus.

Foodborne pathogens and disease 20110801

Natural products in caries research: current (limited) knowledge, challenges and future perspective.

Caries research 20110701

The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.

The Journal of toxicological sciences 20110601

Palladium-catalyzed tandem reaction to construct benzo[c]phenanthridine: application to the total synthesis of benzo[c]phenanthridine alkaloids.

Organic & biomolecular chemistry 20110507

X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).

Chemical communications (Cambridge, England) 20110507

Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters.

Neurochemistry international 20110501

Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution.

Journal of separation science 20110501

Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

Structural modification of sanguinarine and chelerythrine and their antibacterial activity.

Natural product research 20110501

Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde.

Molecules (Basel, Switzerland) 20110420

Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study.

Biochimica et biophysica acta 20110401

Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status.

Journal of dermatological science 20110401

In vitro and in vivo evaluation of sanguinarine liposomes prepared by a remote loading method with three different ammonium salts.

Die Pharmazie 20110401

[Study on the alkaloids from the stem of Zanthoxylum dissitum].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana.

Archives of biochemistry and biophysics 20110301

The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro.

European journal of pharmacology 20110301

Inclusion complex formation of sanguinarine alkaloid with cucurbit[7]uril: inhibition of nucleophilic attack and photooxidation.

Organic & biomolecular chemistry 20110221

[Study on liver injury of Oncomelania hupensis caused by Eomecon chinanthe sanguinarine].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

Human telomere d[(TTAGGG)4] undergoes a conformational transition to the Na+-form upon binding with sanguinarine in presence of K+.

Biochemical and biophysical research communications 20110107

Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.

Evidence-based complementary and alternative medicine : eCAM 20110101

Photoreduction and ketone-sensitized reduction of alkaloids.

Photochemistry and photobiology 20110101

Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed.

PloS one 20110101

A 'reverse pharmacology' approach for developing an anti-malarial phytomedicine.

Malaria journal 20110101

Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin.

PloS one 20110101

Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.

Evidence-based complementary and alternative medicine : eCAM 20110101

Targeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-β-D-glucoside and daunomycin binding to tRNA(phe).

PloS one 20110101

Photooxidation of alkaloids: considerable quantum yield enhancement by rose bengal-sensitized singlet molecular oxygen generation.

Photochemistry and photobiology 20110101

Effect of DNA groove binder distamycin A upon chromatin structure.

PloS one 20110101

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.

PloS one 20110101

Attenuation of cytotoxic natural product DNA intercalating agents by caffeine.

Scientia pharmaceutica 20110101

Binding of tetracycline and chlortetracycline to the enzyme trypsin: spectroscopic and molecular modeling investigations.

PloS one 20110101

'Science means learning to say-I don't know': An interview with Dr. Ashok D.B. Vaidya.

Journal of Ayurveda and integrative medicine 20110101

Potentiation of tumour promotion by topical application of argemone oil/isolated sanguinarine alkaloid in a model of mouse skin carcinogenesis.

Chemico-biological interactions 20101205

Phytochemical and antimicrobial characterization of Macleaya cordata herb.

Fitoterapia 20101201

Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition.

Fitoterapia 20101201

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents.

European journal of medicinal chemistry 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Fluorescence of sanguinarine: spectral changes on interaction with amino acids.

Physical chemistry chemical physics : PCCP 20101007

Effect of sanguinarine from the leaves of Macleaya cordata against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idella).

Parasitology research 20101001

An Internet misadventure: bloodroot salve toxicity.

Journal of alternative and complementary medicine (New York, N.Y.) 20101001

In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees.

Veterinary microbiology 20100928

Extractions of isoquinoline alkaloids with butanol and octanol.

Fitoterapia 20100901

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.

Cancer metastasis reviews 20100901

Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways.

Biochemical and biophysical research communications 20100827

In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus.

Veterinary parasitology 20100804

Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica.

Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721

Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20100708

Fusarium oxysporum homogenates and jasmonate induce limited sanguinarine accumulation in Argemone mexicana cell cultures.

Biotechnology letters 20100701

Binding of the anticancer alkaloid sanguinarine to double stranded RNAs: insights into the structural and energetics aspects.

Molecular bioSystems 20100701

A study on separation and extraction of four main alkaloids in Macleaya cordata (Willd) R. Br. with strip dispersion hybrid liquid membrane.

Journal of separation science 20100701

Interaction of sanguinarine and its dihydroderivative with the Na+/K+-ATPase. Complex view on the old problem.

Toxicology letters 20100616

Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.

The Journal of biological chemistry 20100611

[Identification of differentially expressed proteins in the liver of Oncomelania snails induced by Eomecon chinanthe sanguinarine].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20100601

Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells.

Toxicology in vitro : an international journal published in association with BIBRA 20100401

Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection.

Journal of separation science 20100401

Sanguinarine suppresses prostate tumor growth and inhibits survivin expression.

Genes & cancer 20100301

Study on the inclusion interaction of cucurbit[n]urils with sanguinarine by spectrofluorimetry and its analytical application.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100201

Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC.

Journal of pharmaceutical and biomedical analysis 20100105

Skin tumor promotion by argemone oil/alkaloid in mice: evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation.

Breast cancer research : BCR 20100101

The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro.

Anticancer research 20100101

Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems.

PloS one 20100101

BIAdb: a curated database of benzylisoquinoline alkaloids.

BMC pharmacology 20100101

Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.

Bioscience, biotechnology, and biochemistry 20100101

Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae).

BMC plant biology 20100101

A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection.

BMC plant biology 20100101

Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.

Journal of nucleic acids 20100101

Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures.

Plant physiology and biochemistry : PPB 20100101

Genetic evidence for inhibition of bacterial division protein FtsZ by berberine.

PloS one 20100101

[Comparative substrate-inhibitor analysis of liver monoamine oxidases of minks].

Zhurnal evoliutsionnoi biokhimii i fiziologii 20100101

Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures.

BMC plant biology 20100101

Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.

PloS one 20100101

A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine.

PloS one 20100101

Cytotoxic activity of proteins isolated from extracts of Corydalis cava tubers in human cervical carcinoma HeLa cells.

BMC complementary and alternative medicine 20100101

Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines.

Cancer chemotherapy and pharmacology 20091201

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma.

Biochemical pharmacology 20091201

Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens.

Natural product communications 20091101

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.

Anticancer research 20091101

Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: effect of P450 inducers on its toxicity.

Toxicology mechanisms and methods 20091001

Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates.

Journal of ethnopharmacology 20090925

Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms.

Analytical and bioanalytical chemistry 20090901

Fluorescence properties of selected benzo[c]phenantridine alkaloids and studies of their interaction with CT DNA.

Analytical and bioanalytical chemistry 20090601

Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20090601

Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells.

Chemico-biological interactions 20090515

Food contamination.

Disease-a-month : DM 20090501

Effect of argemone oil and argemone alkaloid, sanguinarine on Sertoli-germ cell coculture.

Toxicology letters 20090425

Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.

Journal of chromatography. A 20090313

Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion.

Toxicology in vitro : an international journal published in association with BIBRA 20090301

Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin.

Chemistry & biology 20090227

Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics.

Molecular & cellular proteomics : MCP 20090101

Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.

BMC complementary and alternative medicine 20090101

Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

BMC neuroscience 20090101

Structural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteins.

PloS one 20090101

PCNA damage caused by antineoplastic drugs.

Biochemical pharmacology 20081215

Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects.

Biochemical pharmacology 20081201

Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

A concerted mechanism for berberine bridge enzyme.

Nature chemical biology 20081201

Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

Journal of medicinal chemistry 20081113

Ligand binding to tandem G quadruplexes from human telomeric DNA.

Chembiochem : a European journal of chemical biology 20081103

Induction of hepatotoxicity by sanguinarine is associated with oxidation of protein thiols and disturbance of mitochondrial respiration.

Journal of applied toxicology : JAT 20081101

Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei).

Molecules (Basel, Switzerland) 20081003

Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA.

Analytical and bioanalytical chemistry 20081001

Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms.

Planta medica 20081001

Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis.

Archives of biochemistry and biophysics 20080901

Cancer is a preventable disease that requires major lifestyle changes.

Pharmaceutical research 20080901

The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL.

Journal of cellular biochemistry 20080601

Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20080601

Separation of sanguinarine and chelerythrine in Macleaya cordata (Willd) R. Br. based on methyl acrylate-co-divinylbenzene macroporous adsorbents.

Journal of chromatography. A 20080523

Synergistic effects of sequential treatment with methyl jasmonate, salicylic acid and yeast extract on benzophenanthridine alkaloid accumulation and protein expression in Eschscholtzia californica suspension cultures.

Journal of biotechnology 20080520

A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids.

Toxicology letters 20080401

Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature.

Journal of cutaneous pathology 20080401

Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells.

Archives of biochemistry and biophysics 20080315

Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines.

Chemico-biological interactions 20080310

Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects.

Toxicology in vitro : an international journal published in association with BIBRA 20080301

Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells.

Cell biology international 20080201

Differential induction of protein expression and benzophenanthridine alkaloid accumulation in Eschscholtzia californica suspension cultures by methyl jasmonate and yeast extract.

Journal of microbiology and biotechnology 20080201

Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine.

Cell biology and toxicology 20080101

Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures.

BMC plant biology 20080101

Sanguinarine.

Cardiovascular therapeutics 20080101

Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.

Chemotherapy 20080101

Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway.

Chemotherapy 20080101

Strategies for prostate cancer prevention: Review of the literature.

Indian journal of urology : IJU : journal of the Urological Society of India 20080101

Interaction of sanguinarine alkaloid, isolated from argemone oil, with hepatic cytochrome p450 in rats.

Toxicology mechanisms and methods 20080101

Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholtzia californica suspension cultures.

Biotechnology letters 20071201

Conserved regulation of MAP kinase expression by PUF RNA-binding proteins.

PLoS genetics 20071201

Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives.

Medicinal research reviews 20070901

Quaternary benzo[c]phenanthridine alkaloids--novel cell permeant and red fluorescing DNA probes.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070901

Specific binding and self-structure induction to poly(A) by the cytotoxic plant alkaloid sanguinarine.

Biochimica et biophysica acta 20070901

Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.

Anti-cancer drugs 20070901

Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.

Pharmacological research 20070901

Administration of Ratanhia-based herbal oral care products for the prophylaxis of oral mucositis in cancer chemotherapy patients: a clinical trial.

Evidence-based complementary and alternative medicine : eCAM 20070901

Metabolic engineering in isoquinoline alkaloid biosynthesis.

Current pharmaceutical biotechnology 20070801

Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells.

Transgenic research 20070601

The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis.

The Journal of reproduction and development 20070601

HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae.

Journal of pharmaceutical and biomedical analysis 20070509

Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins.

Cancer letters 20070508

Disposition of sanguinarine in the rat.

Xenobiotica; the fate of foreign compounds in biological systems 20070501

Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.

Cancer research 20070415

Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.

Atherosclerosis 20070401

Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism.

Planta 20070401

Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Journal of agricultural and food chemistry 20070221

Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.

The FEBS journal 20070201

Metabolism of sanguinarine: the facts and the myths.

Current drug metabolism 20070201

Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine-induced apoptosis and oncosis.

Toxicologic pathology 20070201

Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.

Toxicology and applied pharmacology 20070115

Sanguinarine inhibits VEGF-induced Akt phosphorylation.

Annals of the New York Academy of Sciences 20070101

Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix.

BioFactors (Oxford, England) 20070101

Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: implications for prevention of skin cancer.

Photochemistry and photobiology 20070101

Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.

Journal of molecular biology 20061201

Protective effect of bioantioxidants on argemone oil/sanguinarine alkaloid induced genotoxicity in mice.

Cancer letters 20061128

The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine.

Cell biology and toxicology 20061101

The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

Applied microbiology and biotechnology 20061101

Simultaneous analysis of alkaloids from Zanthoxylum nitidum by high performance liquid chromatography-diode array detector-electrospray tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20060918

Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.

Toxicology letters 20060910

Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: analyses in rat hepatoma cell line H4IIE.luc.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901

DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.

Bioorganic & medicinal chemistry 20060815

A simple and sensitive method of nonaqueous capillary electrophoresis with laser-induced native fluorescence detection for the analysis of chelerythrine and sanguinarine in Chinese herbal medicines.

Talanta 20060815

Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801

Sanguinarine downregulates AT1a gene expression in a hypertensive rat model.

Journal of cardiovascular pharmacology 20060801

Safety evaluation studies on argemone oil through dietary exposure for 90days in rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060701

Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid.

Biochimica et biophysica acta 20060701

Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20060701

Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine.

Cancer letters 20060608

Development of a kinetic metabolic model: application to Catharanthus roseus hairy root.

Bioprocess and biosystems engineering 20060501

The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.

The FEBS journal 20060501

The plant alkaloid Sanguinarine affects swine granulosa cell activity.

Reproductive toxicology (Elmsford, N.Y.) 20060401

Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.

Cancer research 20060401

Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301

Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060201

Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells.

Chemico-biological interactions 20060201

Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes.

Molecular cancer therapeutics 20060201

Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.

Plant, cell & environment 20060201

A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.

BMC cancer 20060101

Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.

BMC cell biology 20060101

Biosynthesis of antitumoral and bactericidal sanguinarine.

Journal of biomedicine & biotechnology 20060101

Analysis of secondary metabolites from eschscholtzia californica by high-performance liquid chromatography.

Phytochemical analysis : PCA 20060101

[Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101

Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine in fruits of Macleaya cordata by microwave-assisted solvent extraction and HPLC-ESI/MS.

Phytochemical analysis : PCA 20060101

Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins.

Nucleic acids symposium series (2004) 20060101

Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines.

Anticancer research 20060101

Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling.

Biochemistry 20051220

Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice.

International journal of cancer 20051210

A rapid and reliable solid-phase extraction method for high-performance liquid chromatographic analysis of opium alkaloids from papaver plants.

Chemical & pharmaceutical bulletin 20051101

Randomized controlled clinical trials on agents used for chemical plaque control.

International journal of dental hygiene 20051101

Effects of the limited analyte solubility on its mobility and zone shape: electrophoretic behavior of sanguinarine and chelerythrine around pH 7.

Electrophoresis 20050901

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.

Toxicology letters 20050814

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.

Toxicology letters 20050728

Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro.

International dental journal 20050601

Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine.

Journal of enzyme inhibition and medicinal chemistry 20050601

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

The Journal of biological chemistry 20050513

Capillary zone electrophoretic studies of interactions of some quaternary isoquinoline alkaloids with DNA constituents and DNA.

Electrophoresis 20050501

Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment.

Plant physiology 20050501

In situ extraction strategy affects benzophenanthridine alkaloid production fluxes in suspension cultures of Eschscholtzia californica.

Biotechnology and bioengineering 20050205

Immunohistochemical assessment of Viadent-associated leukoplakia.

Oral oncology 20050201

In vivo DNA damaging potential of sanguinarine alkaloid, isolated from argemone oil, using alkaline Comet assay in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101

Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.

BMC neuroscience 20050101

Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarine: a study on cardiotoxicity of sanguinarine.

Journal of biomedical science 20050101

[Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

[Effect of alkaloid sanguinarine and a pharmaceutical preparation ukrain on modulation of vesicular membrane fusion and actin cytoskeleton of macrophages].

Tsitologiia 20050101

Unequivocal evidence of genotoxic potential of argemone oil in mice.

International journal of cancer 20041210

Aggregation and other intermolecular interactions of biological buffers observed by capillary electrophoresis and UV photometry.

Journal of chromatography. A 20041008

Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.

The Plant journal : for cell and molecular biology 20041001

Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.

Biochemical pharmacology 20040915

Sanguinarine: an evaluation of in vivo cytogenetic activity.

Mutation research 20040912

Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.

Molecular cancer therapeutics 20040801

Involvement of cytochrome P450 1A in sanguinarine detoxication.

Toxicology letters 20040715

Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

British journal of pharmacology 20040701

Capillary electrophoretic studies of acid-base properties of sanguinarine and chelerythrine alkaloids.

Journal of chromatography. A 20040618

Suppression of angiogenesis by the plant alkaloid, sanguinarine.

Biochemical and biophysical research communications 20040430

Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans.

International journal of antimicrobial agents 20040401

Natural antimycobacterial metabolites: current status.

Phytochemistry 20040401

Hairy root induction of Papaver somniferum var. album, a difficult-to-transform plant, by A rhizogenes LBA 9402.

Planta 20040301

Quantitative liquid chromatographic determination of sanguinarine in cell culture medium and in rat urine and plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125

Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism.

Chemico-biological interactions 20040115

Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

[Biosynthesis of poppy isoquinoline alkaloids in nature and in vitro culture. 2. Bracteum poppy (Papaver bracteatum Lindl.)].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101

Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.

Toxicology letters 20031215

Local anti-infective therapy: pharmacological agents. A systematic review.

Annals of periodontology 20031201

Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031125

A tale of three cell types: alkaloid biosynthesis is localized to sieve elements in opium poppy.

The Plant cell 20031101

Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy.

Phytochemistry 20030901

Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes.

Clinical cancer research : an official journal of the American Association for Cancer Research 20030801

Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion.

Cancer chemotherapy and pharmacology 20030601

Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures.

Journal of biomolecular structure & dynamics 20030401

In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.

Phytotherapy research : PTR 20030301

Achiral and chiral determination of benzophenanthridine alkaloids from methanol extracts of Hylomecon species by high performance liquid chromatography.

Archives of pharmacal research 20030201

In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor.

European journal of pharmacology 20030105

Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids.

Plant molecular biology 20030101

Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines.

Physiological research 20030101

Argemone oil induced cellular damage in the reproductive tissues of transgenic Drosophila melanogaster: protective role of 70 kDa heat shock protein.

Journal of biochemical and molecular toxicology 20030101

Sensitivity of lysosomal enzymes to the plant alkaloid sanguinarine: comparison with other SH-specific agents.

Cell biology international 20030101

[Biosynthesis of poppy isoquinoline alkaloids in nature and in vitro culture. 1. Opium poppy (Papaver somniferum L.)].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

[Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their derivative drugs].

Tsitologiia 20030101

Influence of DNA structures on the conversion of sanguinarine alkanolamine form to iminium form.

Journal of biomolecular structure & dynamics 20021201

Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis.

Biological & pharmaceutical bulletin 20021201

Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.

Planta medica 20020901

DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique.

Chemico-biological interactions 20020815

[Effect of a fungal elicitor on levels of sanguinarine and polyphenoloxidase activity in a suspension culture of Papaver somniferum L].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20020701

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death.

Biochemical pharmacology 20020415

Epidemic dropsy: observations on pathophysiology and clinical features during the Delhi epidemic of 1998.

Tropical doctor 20020401

Interaction of sanguinarine with double stranded RNA structures.

Indian journal of biochemistry & biophysics 20020401

Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV.

Phytotherapy research : PTR 20020201

Capillary electrophoresis of phytochemical substances.

Journal of pharmaceutical and biomedical analysis 20020201

Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy.

Plant physiology 20020201

The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.

Journal of ethnopharmacology 20020101

Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice.

BMC complementary and alternative medicine 20020101

[Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood].

Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101

The association between Viadent use and oral leukoplakia--results of a matched case-control study.

Journal of public health dentistry 20020101

White patch of maxillary vestibule. Sanguinarine-associated leukoplakia.

General dentistry 20020101

Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids.

Toxicology letters 20011215

The association between Viadent use and oral leukoplakia.

Epidemiology (Cambridge, Mass.) 20011101

In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.

Planta medica 20011001

Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant.

Planta 20011001

Argemone mexicana and epidemic dropsy: phytopharmacology and putative sequelae and therapy.

The Journal of the Association of Physicians of India 20011001

Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death.

Experimental and molecular pathology 20010801

Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain.

Phytotherapy research : PTR 20010301

Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1.

Planta medica 20010301

Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps.

Naunyn-Schmiedeberg's archives of pharmacology 20010201

Benzo[c]phenanthridine bases and their antituberculosis activity.

Medicinal research reviews 20010101

Mechanisms underlying the induction of vasorelaxation in rat thoracic aorta by sanguinarine.

Japanese journal of pharmacology 20010101

Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.

Cell biology and toxicology 20010101

Molecular aspects on the interaction of sanguinarine with B-form, Z-form and HL-form DNA structures.

Indian journal of biochemistry & biophysics 20010101

Sanguinarine induces bimodal cell death in K562 but not in high Bcl-2-expressing JM1 cells.

Pathology, research and practice 20010101

Role of Bcl-2 family proteins and caspase-3 in sanguinarine-induced bimodal cell death.

Cell biology and toxicology 20010101

[The inhibition enzymatic hydrolysis of acetylthiocholine by acetylcholinesterase using principal alkaloids isolated from celandine and macleya and their derivatives].

Tsitologiia 20010101

Isoquinoline alkaloid production by transformed cultures of Papaver somniferum.

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20010101

Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity.

General dentistry 20010101

Alkaloid biosynthesis in Papaver sp. cells in culture and during organogenesis.

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20010101

Relationship between oral pain and ethanol concentration in mouthrinses.

Journal of periodontal research 19950501

Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal of natural products 19910101