200,000+ products from a single source!

sales@angenechem.com

Home > Other Building Blocks > 2430-27-5

2430-27-5

2430-27-5 | 2,2-DI-N-PROPYLACETAMIDE

CAS No: 2430-27-5 Catalog No: AG003FC1 MDL No:MFCD00051534

Product Description

Catalog Number:
AG003FC1
Chemical Name:
2,2-DI-N-PROPYLACETAMIDE
CAS Number:
2430-27-5
Molecular Formula:
C8H17NO
Molecular Weight:
143.2267
MDL Number:
MFCD00051534
IUPAC Name:
2-propylpentanamide
InChI:
InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)
InChI Key:
OMOMUFTZPTXCHP-UHFFFAOYSA-N
SMILES:
CCCC(C(=O)N)CCC
EC Number:
219-394-2
UNII:
RUA6CWU76G

Properties

Complexity:
95.4  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
143.131g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
143.23g/mol
Monoisotopic Mass:
143.131g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
43.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1  

Literature

Title Journal
Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs. Toxicological sciences : an official journal of the Society of Toxicology 20130101
Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease models & mechanisms 20120301
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia 20120101
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression. PloS one 20120101
Histone deacetylases are required for amphibian tail and limb regeneration but not development. Mechanisms of development 20120101
Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes. Neuroscience letters 20110622
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110601
Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Seminars in cell & developmental biology 20110201
Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells. PloS one 20110101
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells. PLoS currents 20101028
Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing. Reproductive toxicology (Elmsford, N.Y.) 20100801
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. The Journal of biological chemistry 20100402
[Pharmacokinetics of biological tags in a case of acute valpromide self poisoning]. Annales de biologie clinique 20100101
[Therapeutic drug monitoring of valproate]. Therapie 20100101
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Molecular pain 20100101
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. Journal of medicinal chemistry 20091126
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Journal of neurochemistry 20091101
[Neonatal Volkmann's syndrome]. Annales de dermatologie et de venereologie 20091101
Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage. Journal of the American Chemical Society 20090603
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid. Journal of medicinal chemistry 20090423
Agomelatine: The evidence for its place in the treatment of depression. Core evidence 20090101
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
Application of a metabolizing system as an adjunct to the rat whole embryo culture. Toxicology in vitro : an international journal published in association with BIBRA 20080801
[Effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. Neurochemical research 20080601
Valproic acid extends Caenorhabditis elegans lifespan. Aging cell 20080601
Acute and long-term treatment of mania. Dialogues in clinical neuroscience 20080601
Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide. Neuropharmacology 20080301
The effectiveness of anticonvulsants in psychiatric disorders. Dialogues in clinical neuroscience 20080301
Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments. Cell cycle (Georgetown, Tex.) 20080215
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. British journal of pharmacology 20080201
Modifications of antiepileptic drugs for improved tolerability and efficacy. Perspectives in medicinal chemistry 20080101
Lipid peroxidation in women with epilepsy. Annals of Indian Academy of Neurology 20080101
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. Journal of medicinal chemistry 20071213
Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar disorders 20070901
The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Molecular pharmacology 20070301
The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. British journal of pharmacology 20061001
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides. Drug metabolism and disposition: the biological fate of chemicals 20060401
Management of epilepsy in adults. Diagnosis guidelines. Postgraduate medicine 20051201
Catalytic mechanism of limonene epoxide hydrolase, a theoretical study. Journal of the American Chemical Society 20051019
Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. Journal of cellular biochemistry 20051015
Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. British journal of pharmacology 20050901
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives. Biochemical pharmacology 20050515
The role of histone acetylation in SMN gene expression. Human molecular genetics 20050501
Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth defects research. Part A, Clinical and molecular teratology 20050401
[Management of bipolar disorders]. La Revue du praticien 20050315
Mood stabilizer augmentation in apparently 'unipolar' MDD: predictors of response in the naturalistic French national EPIDEP study. Journal of affective disorders 20050201
[Valpromide poisoning associated with circulatory collapse]. Therapie 20050101
Valproate decreases inositol biosynthesis. Biological psychiatry 20041201
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorganic & medicinal chemistry letters 20041115
Polycomb homologs are involved in teratogenicity of valproic acid in mice. Birth defects research. Part A, Clinical and molecular teratology 20041101
[Deep lactic acidosis after valproate self-poisoning]. Annales francaises d'anesthesie et de reanimation 20041001
Characterization of the anticonvulsant profile of valpromide derivatives. Bioorganic & medicinal chemistry 20040715
Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis. The Journal of biological chemistry 20040430
Delayed toxicity following acute ingestion of valpromide. Human & experimental toxicology 20040301
Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology 20040201
Amidic modification of valproic acid reduces skeletal teratogenicity in mice. Birth defects research. Part B, Developmental and reproductive toxicology 20040201
[Valpromide, Valproic acid and removal of small intestine in the treatment of a chronic depression: a case report]. L'Encephale 20040101
Mood-stabilizers: the archeology of the concept. Bipolar disorders 20031201
Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharmaceutical research 20030801
Valproate induces replication-independent active DNA demethylation. The Journal of biological chemistry 20030725
Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. The EMBO journal 20030602
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? Current opinion in neurology 20030401
Lupus-like syndrome and vasculitis induced by valpromide. The Journal of rheumatology 20030101
[The Charles Bonnet syndrome: a case report and a brief review]. Actas espanolas de psiquiatria 20030101
[Severe oedema after valproate and valpromide]. Therapie 20020101
Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide. Therapeutic drug monitoring 20010801
Clonic seizure associated with high clozapine plasma level. The Journal of neuropsychiatry and clinical neurosciences 20010101
Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders. A placebo-controlled study. European psychiatry : the journal of the Association of European Psychiatrists 20001101
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy. Pharmaceutical research 20001101
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]. Presse medicale (Paris, France : 1983) 19881105

© 2019 Angene International Limited. All rights Reserved.