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CAS No: 2430-27-5 Catalog No: AG003FC1 MDL No:MFCD00051534
Title | Journal |
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Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs. | Toxicological sciences : an official journal of the Society of Toxicology 20130101 |
Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. | Disease models & mechanisms 20120301 |
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. | Epilepsia 20120101 |
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression. | PloS one 20120101 |
Histone deacetylases are required for amphibian tail and limb regeneration but not development. | Mechanisms of development 20120101 |
Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes. | Neuroscience letters 20110622 |
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110601 |
Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. | Seminars in cell & developmental biology 20110201 |
Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells. | PloS one 20110101 |
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells. | PLoS currents 20101028 |
Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing. | Reproductive toxicology (Elmsford, N.Y.) 20100801 |
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. | The Journal of biological chemistry 20100402 |
[Pharmacokinetics of biological tags in a case of acute valpromide self poisoning]. | Annales de biologie clinique 20100101 |
[Therapeutic drug monitoring of valproate]. | Therapie 20100101 |
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. | Molecular pain 20100101 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. | Journal of medicinal chemistry 20091126 |
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. | Journal of neurochemistry 20091101 |
[Neonatal Volkmann's syndrome]. | Annales de dermatologie et de venereologie 20091101 |
Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage. | Journal of the American Chemical Society 20090603 |
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid. | Journal of medicinal chemistry 20090423 |
Agomelatine: The evidence for its place in the treatment of depression. | Core evidence 20090101 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
Application of a metabolizing system as an adjunct to the rat whole embryo culture. | Toxicology in vitro : an international journal published in association with BIBRA 20080801 |
[Effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy]. | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701 |
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. | Neurochemical research 20080601 |
Valproic acid extends Caenorhabditis elegans lifespan. | Aging cell 20080601 |
Acute and long-term treatment of mania. | Dialogues in clinical neuroscience 20080601 |
Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide. | Neuropharmacology 20080301 |
The effectiveness of anticonvulsants in psychiatric disorders. | Dialogues in clinical neuroscience 20080301 |
Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments. | Cell cycle (Georgetown, Tex.) 20080215 |
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. | British journal of pharmacology 20080201 |
Modifications of antiepileptic drugs for improved tolerability and efficacy. | Perspectives in medicinal chemistry 20080101 |
Lipid peroxidation in women with epilepsy. | Annals of Indian Academy of Neurology 20080101 |
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. | Journal of medicinal chemistry 20071213 |
Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. | Bipolar disorders 20070901 |
The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. | Molecular pharmacology 20070301 |
The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. | British journal of pharmacology 20061001 |
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides. | Drug metabolism and disposition: the biological fate of chemicals 20060401 |
Management of epilepsy in adults. Diagnosis guidelines. | Postgraduate medicine 20051201 |
Catalytic mechanism of limonene epoxide hydrolase, a theoretical study. | Journal of the American Chemical Society 20051019 |
Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. | Journal of cellular biochemistry 20051015 |
Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. | British journal of pharmacology 20050901 |
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives. | Biochemical pharmacology 20050515 |
The role of histone acetylation in SMN gene expression. | Human molecular genetics 20050501 |
Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. | Birth defects research. Part A, Clinical and molecular teratology 20050401 |
[Management of bipolar disorders]. | La Revue du praticien 20050315 |
Mood stabilizer augmentation in apparently 'unipolar' MDD: predictors of response in the naturalistic French national EPIDEP study. | Journal of affective disorders 20050201 |
[Valpromide poisoning associated with circulatory collapse]. | Therapie 20050101 |
Valproate decreases inositol biosynthesis. | Biological psychiatry 20041201 |
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. | Bioorganic & medicinal chemistry letters 20041115 |
Polycomb homologs are involved in teratogenicity of valproic acid in mice. | Birth defects research. Part A, Clinical and molecular teratology 20041101 |
[Deep lactic acidosis after valproate self-poisoning]. | Annales francaises d'anesthesie et de reanimation 20041001 |
Characterization of the anticonvulsant profile of valpromide derivatives. | Bioorganic & medicinal chemistry 20040715 |
Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis. | The Journal of biological chemistry 20040430 |
Delayed toxicity following acute ingestion of valpromide. | Human & experimental toxicology 20040301 |
Valproate potentiates androgen biosynthesis in human ovarian theca cells. | Endocrinology 20040201 |
Amidic modification of valproic acid reduces skeletal teratogenicity in mice. | Birth defects research. Part B, Developmental and reproductive toxicology 20040201 |
[Valpromide, Valproic acid and removal of small intestine in the treatment of a chronic depression: a case report]. | L'Encephale 20040101 |
Mood-stabilizers: the archeology of the concept. | Bipolar disorders 20031201 |
Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. | Pharmaceutical research 20030801 |
Valproate induces replication-independent active DNA demethylation. | The Journal of biological chemistry 20030725 |
Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. | The EMBO journal 20030602 |
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? | Current opinion in neurology 20030401 |
Lupus-like syndrome and vasculitis induced by valpromide. | The Journal of rheumatology 20030101 |
[The Charles Bonnet syndrome: a case report and a brief review]. | Actas espanolas de psiquiatria 20030101 |
[Severe oedema after valproate and valpromide]. | Therapie 20020101 |
Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide. | Therapeutic drug monitoring 20010801 |
Clonic seizure associated with high clozapine plasma level. | The Journal of neuropsychiatry and clinical neurosciences 20010101 |
Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders. A placebo-controlled study. | European psychiatry : the journal of the Association of European Psychiatrists 20001101 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy. | Pharmaceutical research 20001101 |
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]. | Presse medicale (Paris, France : 1983) 19881105 |
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