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241799-10-0 | [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
CAS No: 241799-10-0 Catalog No: AG01ENPH MDL No:
Product Description
Catalog Number:
AG01ENPH
Chemical Name:
[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
CAS Number:
241799-10-0
IUPAC Name:
5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride
InChI:
InChI=1S/C17H16N6O.2ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);2*1H
InChI Key:
ARZNPJAGKWHEHT-UHFFFAOYSA-N
Properties
Complexity:
515
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
392.092g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
393.272g/mol
Monoisotopic Mass:
392.092g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Chemical stability of amorphous materials: specific and general media effects in the role of water in the degradation of freeze-dried zoniporide. | Journal of pharmaceutical sciences 20120901 |
| Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide. | Drug metabolism and disposition: the biological fate of chemicals 20120801 |
| Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs. | Drug metabolism and disposition: the biological fate of chemicals 20120301 |
| Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors. | The Journal of physiology 20111101 |
| Role of the spinal Na+/H+ exchanger in formalin-induced nociception. | Neuroscience letters 20110821 |
| Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart. | British journal of pharmacology 20110201 |
| Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences. | Drug metabolism and disposition: the biological fate of chemicals 20100401 |
| Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress? | Journal of molecular and cellular cardiology 20090201 |
| Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct. | Brain research 20090112 |
| Na+/H+ exchanger-1 inhibitors reduce neuronal excitability and alter na+ channel inactivation properties in rat primary sensory neurons. | Toxicological sciences : an official journal of the Society of Toxicology 20080601 |
| Neurotoxic effects of zoniporide: a selective inhibitor of the NA+/H+ exchanger isoform 1. | Toxicologic pathology 20080601 |
| Does the use of a volatile anesthetic regimen attenuate the incidence of cardiac events after vascular surgery? | Acta anaesthesiologica Belgica 20080101 |
| Solute diffusion through stripped mouse duodenum. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201 |
| Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolism. | Critical care medicine 20071001 |
| The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. | Pflugers Archiv : European journal of physiology 20070901 |
| Initial rate analysis of zoniporide hydrolysis degradants using high-performance liquid chromatography coupled with mass spectrometric detection. | Pharmaceutical development and technology 20070101 |
| Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients. | Journal of cardiothoracic and vascular anesthesia 20051001 |
| Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform 1, in an experimental model of cardiopulmonary bypass. | British journal of pharmacology 20040501 |
| Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli. | The Journal of physiology 20040401 |
| Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). | Cardiovascular drug reviews 20030101 |
| Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. | European journal of pharmacology 20020906 |
| A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. | The Journal of pharmacology and experimental therapeutics 20010401 |
| Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. | Bioorganic & medicinal chemistry letters 20010326 |
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