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235114-32-6 | Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-
CAS No: 235114-32-6 Catalog No: AG002NHU MDL No:MFCD09837852
Product Description
Catalog Number:
AG002NHU
Chemical Name:
Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-
CAS Number:
235114-32-6
Molecular Formula:
C56H71N9O23S
Molecular Weight:
1270.2744
MDL Number:
MFCD09837852
IUPAC Name:
[5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[[4-[5-(4-pentoxyphenyl)-1,2-oxazol-3-yl]benzoyl]amino]-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl] hydrogen sulfate
InChI:
InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1
InChI Key:
PIEUQSKUWLMALL-YABMTYFHSA-N
SMILES:
CCCCCOc1ccc(cc1)c1onc(c1)c1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@H](CN2C(=O)[C@@H](NC(=O)C(NC(=O)[C@H]2N(C(=O)C(NC1=O)[C@H](O)C)C[C@@H](C2)O)[C@@H]([C@H](c1ccc(c(c1)OS(=O)(=O)O)O)O)O)[C@@H](CC(=O)N)O)C
UNII:
R10H71BSWG
Properties
Complexity:
2580
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
15
Defined Bond Stereocenter Count:
0
Exact Mass:
1269.438g/mol
Formal Charge:
0
Heavy Atom Count:
89
Hydrogen Bond Acceptor Count:
24
Hydrogen Bond Donor Count:
16
Isotope Atom Count:
0
Molecular Weight:
1270.284g/mol
Monoisotopic Mass:
1269.438g/mol
Rotatable Bond Count:
18
Topological Polar Surface Area:
519A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.6
Literature
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| Cost-effectiveness analysis of micafungin versus fluconazole for prophylaxis of invasive fungal infections in patients undergoing hematopoietic stem cell transplantation in Korea. | Clinical therapeutics 20090501 |
| Different bile concentration of micafungin and itraconazole in a patient with candidal cholecystitis. | The Journal of infection 20090401 |
| Hepatitis associated with micafungin use in a preterm infant. | Journal of perinatology : official journal of the California Perinatal Association 20090401 |
| The impact of total bilirubin on plasma micafungin levels in living-donor liver transplantation recipients with severe liver dysfunction. | Biological & pharmaceutical bulletin 20090401 |
| Efficacy of micafungin in treating four premature infants with candidiasis. | Pediatrics international : official journal of the Japan Pediatric Society 20090401 |
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| [Clinical use of micafungin for the treatment of invasive candidiasis in critical ill patients]. | Revista iberoamericana de micologia 20090331 |
| [Micafungin in invasive candidiasis among oncohematological patients]. | Revista iberoamericana de micologia 20090331 |
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| Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan. | Medical mycology 20090301 |
| Micafungin-induced immune hemolysis attacks. | International journal of hematology 20090301 |
| Initial characterization of micafungin pulmonary delivery via two different nebulizers and multivariate data analysis of aerosol mass distribution profiles. | AAPS PharmSciTech 20090301 |
| Differential in vitro activity of anidulafungin, caspofungin and micafungin against Candida parapsilosis isolates recovered from a burn unit. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20090301 |
| Micafungin plus fluconazole in an infected knee with retained hardware due to Candida albicans. | The Annals of pharmacotherapy 20090301 |
| Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis. | Transplant infectious disease : an official journal of the Transplantation Society 20090201 |
| Localisation of Bgl2p upon antifungal drug treatment in Candida albicans. | International journal of antimicrobial agents 20090201 |
| Combined antifungal therapy in a murine model of disseminated infection by Cladophialophora bantiana. | Medical mycology 20090201 |
| In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201 |
| Breakthrough disseminated zygomycosis induced massive gastrointestinal bleeding in a patient with acute myeloid leukemia receiving micafungin. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201 |
| Micafungin: a sulfated echinocandin. | The Journal of antibiotics 20090101 |
| Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders. | Leukemia & lymphoma 20090101 |
| Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation. | Critical care (London, England) 20090101 |
| Micafungin: a review of its use in the prophylaxis and treatment of invasive Candida infections in pediatric patients. | Paediatric drugs 20090101 |
| Empiric anti-Candida therapy for patients with sepsis in the ICU: how little is too little? | Critical care (London, England) 20090101 |
| Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B. | Critical care (London, England) 20090101 |
| Review of the pharmacology and clinical studies of micafungin. | Drug design, development and therapy 20090101 |
| Use of micafungin versus fluconazole for antifungal prophylaxis in neutropenic patients receiving hematopoietic stem cell transplantation. | International journal of hematology 20081201 |
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| [Candidiasis]. | Nihon rinsho. Japanese journal of clinical medicine 20081201 |
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| In vitro interactions of itraconazole and micafungin against clinically important filamentous fungi. | International journal of antimicrobial agents 20081101 |
| Intravenous injection of micafungin counteracts Candida albicans-induced aggravation of duodenal ulcers caused by cysteamine in rats. | Digestive diseases and sciences 20080901 |
| Combined therapy in treatment of murine infection by Fusarium solani. | The Journal of antimicrobial chemotherapy 20080901 |
| Micafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: substudy of a randomized double-blind trial. | The Pediatric infectious disease journal 20080901 |
| Treatment of invasive candidal infections: systematic review and meta-analysis. | Mayo Clinic proceedings 20080901 |
| Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. | Life sciences 20080815 |
| Micafungin activity against Candida albicans with diverse azole resistance phenotypes. | The Journal of antimicrobial chemotherapy 20080801 |
| In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. | Antimicrobial agents and chemotherapy 20080801 |
| Use of a serum-based antifungal susceptibility assay to predict the in vivo efficacy of novel echinocandin compounds. | Microbiology and immunology 20080801 |
| Breakthrough cryptococcosis in a patient with systemic lupus erythematosus (SLE) receiving micafungin. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080801 |
| In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth. | The Journal of antimicrobial chemotherapy 20080701 |
| Economic analysis of micafungin versus liposomal amphotericin B for treatment of candidaemia and invasive candidiasis in Germany. | Current medical research and opinion 20080601 |
| Ocular distribution of intravenously administered micafungin in rabbits. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080601 |
| [Case of bronchocentric granulomatosis that became recognized in the course of allergic bronchopulmonary aspergillosis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080601 |
| Search for new antagonist ligands for adenosine receptors from QSAR point of view. How close are we? | Medicinal research reviews 20080501 |
| Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis. | Antimicrobial agents and chemotherapy 20080501 |
| Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis. | The Journal of antimicrobial chemotherapy 20080501 |
| Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin. | Bioorganic & medicinal chemistry letters 20080501 |
| Cost-effectiveness analysis of antifungal prophylaxis in patients undergoing hematopoietic stem cell transplantation. | Clinical therapeutics 20080501 |
| In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. | Antimicrobial agents and chemotherapy 20080401 |
| Micafungin combined with fluconazole, an effective therapy for murine blastoschizomycosis. | The Journal of antimicrobial chemotherapy 20080401 |
| Antifungal susceptibility testing of micafungin against Candida glabrata isolates. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080401 |
| Micafungin for the prophylaxis and treatment of Candida infections. | Expert review of anti-infective therapy 20080401 |
| Micafungin in pediatrics: when one size does not fit all. | Expert opinion on drug metabolism & toxicology 20080401 |
| Population pharmacokinetics of micafungin in adult patients. | Diagnostic microbiology and infectious disease 20080301 |
| Current approaches to management of cerebral fungal infection in pediatric patients with hematologic disorders. | Journal of pediatric hematology/oncology 20080301 |
| Points of concern related to the micafungin versus caspofungin trial. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080215 |
| Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20080201 |
| [Successful treatment of azole-refractory Candida guilliermondii fungemia with a combination therapy of micafungin and liposomal amphotericin B]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20080201 |
| The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. | The Journal of infectious diseases 20080101 |
| Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation. | International journal of hematology 20080101 |
| [Investigation of susceptibility testing methods for micafungin: comparison of two microdilution methods]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20080101 |
| Micafungin: a review of its use in adults for the treatment of invasive and oesophageal candidiasis, and as prophylaxis against Candida infections. | Drugs 20080101 |
| Effect of liver and kidney function on migafungin disposition in patients with hematologic malignancies. | European journal of drug metabolism and pharmacokinetics 20080101 |
| A review of the new antifungals: posaconazole, micafungin, and anidulafungin. | Journal of drugs in dermatology : JDD 20071201 |
| In vitro activity of micafungin combined with itraconazole against Candida spp. | International journal of antimicrobial agents 20071101 |
| Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071001 |
| [New development in the treatment of deep-seated mycoses]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070910 |
| Relationship between the initial dose of micafungin and its efficacy in patients with candidemia. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070801 |
| Successful treatment of refractory chronic necrotizing pulmonary aspergillosis with micafungin. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070801 |
| In vitro interaction of micafungin and fluconazole against Candida. | The Journal of antimicrobial chemotherapy 20070701 |
| A comparative evaluation of properties and clinical efficacy of the echinocandins. | Expert opinion on pharmacotherapy 20070701 |
| Acute pancreatitis in a patient treated with micafungin. | Clinical therapeutics 20070701 |
| Acquired resistance to echinocandins in Candida albicans: case report and review. | The Journal of antimicrobial chemotherapy 20070601 |
| The echinocandin micafungin: a review of the pharmacology, spectrum of activity, clinical efficacy and safety. | Expert opinion on pharmacotherapy 20070601 |
| Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial. | Lancet (London, England) 20070505 |
| Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method. | Diagnostic microbiology and infectious disease 20070501 |
| Bacteria-associated haemophagocytic syndrome and septic pulmonary embolism caused by Burkholderia cepacia complex in a woman with chronic granulomatous disease. | Journal of medical microbiology 20070501 |
| Clinical efficacy of micafungin for chronic pulmonary aspergillosis. | Medical mycology 20070501 |
| Pharmacokinetics of antifungal agent micafungin in critically ill patients receiving continuous hemodialysis filtration. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070501 |
| [Breakthrough pulmonary mucormycosis during voriconazole treatment after reduced-intensity cord blood transplantation for a patient with acute myeloid leukemia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20070501 |
| Comparison of micafungin and fluconazole for experimental Candida keratitis in rabbits. | Cornea 20070401 |
| Successful medical treatment of cutaneous aspergillosis in a premature infant using liposomal amphotericin B, voriconazole and micafungin. | The Pediatric infectious disease journal 20070401 |
| [Two cases of successfully treated invasive pulmonary aspergillosis following influenza virus infection]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070401 |
| X-linked severe combined immunodeficiency (X-SCID) with high blood levels of immunoglobulins and Aspergillus pneumonia successfully treated with micafangin followed by unrelated cord blood stem cell transplantation. | European journal of pediatrics 20070301 |
| The echinocandins. | Pharmacotherapy 20070301 |
| [Fermentation research on natural products derived from micro-organisms for the discovery of new drugs]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070301 |
| Impact of pharmacometric reviews on new drug approval and labeling decisions--a survey of 31 new drug applications submitted between 2005 and 2006. | Clinical pharmacology and therapeutics 20070201 |
| Plasma concentration of micafungin in patients with hematologic malignancies. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070201 |
| Micafungin: a new echinocandin antifungal. | Pharmacotherapy 20070101 |
| Efficacy and safety of micafungin in febrile neutropenic patients treated for hematological malignancies. | Internal medicine (Tokyo, Japan) 20070101 |
| Analysis of micafungin in serum by capillary zone electrophoresis. | Journal of chromatographic science 20070101 |
| [The future of antifungal agents]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20070101 |
| A case of invasive central nervous system aspergillosis treated with micafungin with monitoring of micafungin concentrations in the cerebrospinal fluid. | Scandinavian journal of infectious diseases 20070101 |
| Role of micafungin in the antifungal armamentarium. | Current medicinal chemistry 20070101 |
| Invasive pulmonary aspergillosis with hematological malignancy caused by Aspergillus terreus and in vitro susceptibility of A. terreus isolate to micafungin. | Internal medicine (Tokyo, Japan) 20070101 |
| Update on new antifungal therapy. | AACN advanced critical care 20070101 |
| Safety and efficacy of micafungin in transplantation recipients. | Transplantation 20061215 |
| Combined antifungal therapy in a murine infection by Candida glabrata. | The Journal of antimicrobial chemotherapy 20061201 |
| Antifungal susceptibilities of the species of the Pseudallescheria boydii complex. | Antimicrobial agents and chemotherapy 20061201 |
| Determination of MICs of aminocandin for Candida spp. and filamentous fungi. | Journal of clinical microbiology 20061201 |
| In vitro effects of micafungin against Candida biofilms on polystyrene and central venous catheter sections. | International journal of antimicrobial agents 20061201 |
| The pharmacokinetics and safety of micafungin, a novel echinocandin, in premature infants. | The Pediatric infectious disease journal 20061201 |
| [Preoperative antifungal agent for pulmonary aspergilloma]. | Kyobu geka. The Japanese journal of thoracic surgery 20061201 |
| Effects of hepatic CYP3A4 activity on disposition of micafungin in liver transplant recipients with markedly small-for-size grafts. | Transplantation proceedings 20061201 |
| Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis. | The Journal of infection 20061101 |
| New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061015 |
| Comparative study of disc diffusion and microdilution methods in susceptibility testing of micafungin against Candida species. | The Journal of antimicrobial chemotherapy 20061001 |
| Echinocandins in the management of invasive fungal infections, Part 2. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061001 |
| Candin family antifungal agent micafungin (FK463) modulates the inflammatory cytokine production stimulated by lipopolysaccharide in THP-1 cells. | Translational research : the journal of laboratory and clinical medicine 20061001 |
| Echinocandins in the management of invasive fungal infections, part 1. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060915 |
| Echinocandins for candidemia in adults without neutropenia. | The New England journal of medicine 20060914 |
| Effective blood concentration of micafungin for pulmonary aspergillosis. | Biological & pharmaceutical bulletin 20060901 |
| Candida glabrata fungemia in a diabetic patient with neurogenic bladder: successful treatment with micafungin. | Clinical nephrology 20060901 |
| Antifungal susceptibility of epigallocatechin 3-O-gallate (EGCg) on clinical isolates of pathogenic yeasts. | Biochemical and biophysical research communications 20060825 |
| Successful treatment of breakthrough Trichosporon asahii fungemia with voriconazole in a patient with acute myeloid leukemia. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060815 |
| Linear pharmacokinetics of micafungin and its active metabolites in Japanese pediatric patients with fungal infections. | Biological & pharmaceutical bulletin 20060801 |
| Population pharmacokinetic analysis of micafungin in Japanese patients with fungal infections. | Drug metabolism and pharmacokinetics 20060801 |
| Micafungin sodium, the second of the echinocandin class of antifungals: theory and practice. | Future microbiology 20060801 |
| A study to determine the safety profile and maximum tolerated dose of micafungin (FK463) in patients undergoing haematopoietic stem cell transplantation. | Bone marrow transplantation 20060701 |
| Breakthrough trichosporonosis in patients with acute myeloid leukemia receiving micafungin. | Leukemia & lymphoma 20060601 |
| [Micafungin therapy for a case of chronic necrotizing pulmonary aspergillosis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060601 |
| Early diagnosis and successful management of atypical invasive Aspergillus sinusitis in a hematopoietic cell transplant patient: a case report. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20060501 |
| Emerging echinocandins for treatment of invasive fungal infections. | Expert opinion on emerging drugs 20060501 |
| Micafungin: a new echinocandin. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060415 |
| Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis. | The Journal of antimicrobial chemotherapy 20060401 |
| Echinocandin antifungals: review and update. | Expert review of anti-infective therapy 20060401 |
| Breakthrough trichosporonosis in patients with hematologic malignancies receiving micafungin. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060315 |
| Cost-effectiveness analysis of antifungal treatment for patients on chemotherapy. | European journal of cancer care 20060301 |
| [Successful treatment of invasive sinus aspergillosis with micafungin and itraconazole]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20060301 |
| New drugs 06, part I. | Nursing 20060201 |
| Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis. | Medical mycology 20060201 |
| [Combined effect of micafangin and itraconazole on severe aspergillosis of the bilateral pleural cavities in a patient with Wegener's granulomatosis]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20060101 |
| Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia. | Internal medicine (Tokyo, Japan) 20060101 |
| Pharmacokinetics-pharmacodynamics of micafungin in Japanese patients with deep-seated mycosis. | European journal of drug metabolism and pharmacokinetics 20060101 |
| [Efficacies and clinical roles of new antifungal agents]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20060101 |
| The echinocandins: comparison of their pharmacokinetics, pharmacodynamics and clinical applications. | Pharmacology 20060101 |
| [Efficacy of micafungin sodium on fungal infection in critical care]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20060101 |
| [Two cases of pulmonary aspergillosis successfully treated with combinated micafungin and itraconazole therapy]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20051201 |
| Update on antifungal drug resistance mechanisms of Aspergillus fumigatus. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20051201 |
| Micafungin in combination with voriconazole in Aspergillus species: a pharmacodynamic approach for detection of combined antifungal activity in vitro. | The Journal of antimicrobial chemotherapy 20051101 |
| Pharmacokinetics of micafungin in healthy volunteers, volunteers with moderate liver disease, and volunteers with renal dysfunction. | Journal of clinical pharmacology 20051001 |
| [Drug-drug interaction of antifungal drugs]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051001 |
| Advances in antifungal therapy. | The Pediatric infectious disease journal 20051001 |
| Efficacy of micafungin for the treatment of candidemia. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051001 |
| International, open-label, noncomparative, clinical trial of micafungin alone and in combination for treatment of newly diagnosed and refractory candidemia. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051001 |
| Concomitant tacrolimus and micafungin pharmacokinetics in healthy volunteers. | Journal of clinical pharmacology 20050901 |
| Successful topical application of a new antifungal agent, micafungin, in the treatment of refractory fungal corneal ulcers: report of three cases and literature review. | Cornea 20050801 |
| Concomitant cyclosporine and micafungin pharmacokinetics in healthy volunteers. | Journal of clinical pharmacology 20050801 |
| Antifungal treatment in pediatric patients. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20050801 |
| Glucan-associated protein modulations and ultrastructural changes of the cell wall in Candida albicans treated with micafungin, a water-soluble, lipopeptide antimycotic. | Journal of chemotherapy (Florence, Italy) 20050801 |
| Electron microscopic findings for micafungin-treated experimental pulmonary aspergillosis in mice. | Medical mycology 20050801 |
| Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway. | The Journal of biological chemistry 20050729 |
| In vitro interactions of micafungin with other antifungal drugs against clinical isolates of four species of Cryptococcus. | Antimicrobial agents and chemotherapy 20050701 |
| Micafungin (Mycamine) for fungal infections. | The Medical letter on drugs and therapeutics 20050620 |
| In vitro interaction of micafungin with conventional and new antifungals against clinical isolates of Trichosporon, Sporobolomyces and Rhodotorula. | The Journal of antimicrobial chemotherapy 20050601 |
| Choosing a study population for the evaluation of antifungal prophylaxis. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050601 |
| Antifungal agents in children. | Pediatric clinics of North America 20050601 |
| Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. | The Journal of pharmacy and pharmacology 20050601 |
| Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice. | The Journal of antimicrobial chemotherapy 20050401 |
| A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis. | Alimentary pharmacology & therapeutics 20050401 |
| Toxicological evaluation of micafungin ophthalmic solution in rabbit eyes. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050401 |
| Micafungin: pharmacology, experimental therapeutics and clinical applications. | Expert opinion on investigational drugs 20050401 |
| Micafungin: the US perspective. | Expert review of anti-infective therapy 20050401 |
| [Sucessful treatment by micafungin of pulmonary aspergillosis occurring in an old lung abscess]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20050401 |
| [Successful treatment with micafungin in a case of candidemia associated with pneumonia]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20050401 |
| Analysis of the blood level of micafungin involving patients with hematological diseases: new findings regarding combination therapy with tacrolimus. | Biological & pharmaceutical bulletin 20050301 |
| Pharmacokinetic behavior of micafungin in rats with carbon tetrachloride-induced acute hepatic failure. | Biological & pharmaceutical bulletin 20050301 |
| [Successful treatment with micafungin (MCFG) of severe peritonitis due to Candida parapsilosis with chronic renal failure patient on hemodialysis]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20050301 |
| [Combination therapy of micafungin and itraconazole for a case of pulmonary aspergillosis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20050201 |
| [A case of chronic mucocutaneous candidasis cured with micafungin]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20050201 |
| Effects of micafungin on the morphology of Aspergillus fumigatus. | Journal of electron microscopy 20050101 |
| New drugs: exenatide, pramlintide acetate, and micafungin sodium. | Journal of the American Pharmacists Association : JAPhA 20050101 |
| Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits. | Documenta ophthalmologica. Advances in ophthalmology 20050101 |
| [Antifungal activity and clinical efficacy of micafungin (funguard)]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20050101 |
| [Antifungal susceptibility among the isolates of yeast from the University Hospital of the Ryukyus]. | Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology 20050101 |
| Optimal prophylactic dosage and disposition of micafungin in living donor liver recipients. | Clinical transplantation 20041201 |
| Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041115 |
| Potential use of (1,3)-beta-D-glucan as target of diagnosis and treatment of keratomycosis. | Cornea 20041101 |
| Pharmacokinetics/pharmacodynamics of echinocandins. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20041101 |
| Combination antifungal therapy: where are we now, and where are we going? | Oncology (Williston Park, N.Y.) 20041101 |
| Micafungin. | The Annals of pharmacotherapy 20041001 |
| Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20041001 |
| A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040915 |
| Echinocandins: ask not what they can do for esophageal candidiasis--ask what studies of esophageal candidiasis can do for them. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040915 |
| Successful treatment of oesophageal candidiasis by micafungin: a novel systemic antifungal agent. | Alimentary pharmacology & therapeutics 20040815 |
| Tissue distribution after intravenous dosing of micafungin, an antifungal drug, to rats. | Biological & pharmaceutical bulletin 20040701 |
| The efficiency of the benzothiazole APB, the echinocandin micafungin, and amphotericin B in fluconazole-resistant Candida albicans and Candida dubliniensis. | Die Pharmazie 20040701 |
| Micafungin: a therapeutic review. | Expert review of anti-infective therapy 20040601 |
| Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. | The Journal of antimicrobial chemotherapy 20040501 |
| Successful micafungin (FK463) treatment of invasive pulmonary aspergillosis in a patient with acute lymphoblastic leukemia in a phase II study. | International journal of hematology 20040501 |
| Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against Aspergillus fumigatus. | Microbes and infection 20040401 |
| National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. | The Journal of antimicrobial chemotherapy 20040201 |
| Successful treatment with micafungin of invasive pulmonary aspergillosis in acute myeloid leukemia, with renal failure due to amphotericin B therapy. | Annals of hematology 20040101 |
| Micafungin. | Drugs 20040101 |
| Susceptibility of Pseudallescheria boydii and Scedosporium apiospermum to new antifungal agents. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20040101 |
| A multicenter, open-label clinical study of micafungin (FK463) in the treatment of deep-seated mycosis in Japan. | Scandinavian journal of infectious diseases 20040101 |
| Fluconazole-resistant pathogens Candida inconspicua and C. norvegensis: DNA sequence diversity of the rRNA intergenic spacer region, antifungal drug susceptibility, and extracellular enzyme production. | Microbiology and immunology 20040101 |
| [Guidelines for the management of deep mycosis in neutropenic patients]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20040101 |
| [In vitro activity of a new semisynthetic echinocandin, micafungin, against clinical isolates of Candida species isolated in Tenri Hospital]. | The Japanese journal of antibiotics 20031201 |
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