200,000+ products from a single source!

sales@angenechem.com

Home > Oxazole > 23327-57-3

23327-57-3

23327-57-3 | 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)

CAS No: 23327-57-3 Catalog No: AG002MVZ MDL No:MFCD00012750

Product Description

Catalog Number:
AG002MVZ
Chemical Name:
1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
CAS Number:
23327-57-3
Molecular Formula:
C17H20ClNO
Molecular Weight:
289.7998
MDL Number:
MFCD00012750
IUPAC Name:
5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;hydrochloride
InChI:
InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
InChI Key:
CNNVSINJDJNHQK-UHFFFAOYSA-N
SMILES:
CN1CCOC(c2c(C1)cccc2)c1ccccc1.Cl
EC Number:
245-585-5

Properties

Complexity:
274  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
289.123g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
289.803g/mol
Monoisotopic Mass:
289.123g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
12.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review. The Journal of rheumatology. Supplement 20120901
Compartmental pharmacokinetics of nefopam during mild hypothermia. British journal of anaesthesia 20120501
Neuromodulators for pain management in rheumatoid arthritis. The Cochrane database of systematic reviews 20120118
Study of pharmacokinetics and comparative bioavailability of nefopam 30 mg tablets in twelve fasting healthy Pakistani male young subjects: single-dose, randomized, two-period, two-treatment and two-way cross-over design. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20120101
A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. PloS one 20120101
[Comparison between two analgesic protocols on IVF success rates]. Journal de gynecologie, obstetrique et biologie de la reproduction 20110401
Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. British journal of anaesthesia 20110301
Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice. Pharmacological reports : PR 20110101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Nefopam pharmacokinetics in patients with end-stage renal disease. Anesthesia and analgesia 20101101
The effects of nefopam on the gain and maximum intensity of shivering in healthy volunteers. Anesthesia and analgesia 20100801
Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report. Progress in neuro-psychopharmacology & biological psychiatry 20100530
Fatal nefopam overdose. Emergency medicine journal : EMJ 20100501
[Watch out for headaches at the end of a pregnancy! Do not miss an autoimmune hypositys]. Gynecologie, obstetrique & fertilite 20100401
Nefopam but not physostigmine affects the thermoregulatory response in mice via alpha(2)-adrenoceptors. Neuropharmacology 20100201
Positive interference of the analgesic nefopam in the urine immunoassay for benzodiazepines in a secure setting. Journal of psychopharmacology (Oxford, England) 20091101
High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations. Organic & biomolecular chemistry 20090907
Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesthesia and analgesia 20090801
Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam. European journal of pain (London, England) 20090701
Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not. Anesthesiology 20090701
Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion. Journal of clinical pharmacy and therapeutics 20090201
Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents. Pharmacology 20090101
Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and ketamine in infusion solutions. European journal of anaesthesiology 20090101
Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice. Pharmacology 20090101
Single dose oral nefopam for acute postoperative pain in adults. The Cochrane database of systematic reviews 20090101
Development and evaluation of nefopam transdermal matrix patch system in human volunteers. PDA journal of pharmaceutical science and technology 20090101
Nefopam for the prevention of postoperative pain: quantitative systematic review. British journal of anaesthesia 20081101
[Physico-chemical stability and sterility of non-opioid analgesics in solution]. Annales francaises d'anesthesie et de reanimation 20081001
Nefopam and ketoprofen synergy in rodent models of antinociception. European journal of pharmacology 20080428
Cross-reactivity of nefopam and its metabolites with benzodiazepine EMIT immunoassay. Journal of analytical toxicology 20080101
Effective dose of nefopam in 80% of patients (ED80): a study using the continual reassessment method. British journal of clinical pharmacology 20071101
Hiccup during weaning from mechanical ventilation: the use of nefopam. British journal of anaesthesia 20071101
Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. British journal of anaesthesia 20071001
Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database. Fundamental & clinical pharmacology 20071001
A review of the literature on post-operative pain in older cancer patients. European journal of cancer (Oxford, England : 1990) 20071001
The immunopotentiator effects of nefopam. International immunopharmacology 20070201
Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation. Amino acids 20070101
[Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?]. Annales francaises d'anesthesie et de reanimation 20070101
Recent advances in the pharmacological management of pain. Drugs 20070101
Specific and sensitive analysis of nefopam and its main metabolite desmethyl-nefopam in human plasma by liquid chromatography-ion trap tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20061116
Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research 20060901
[What are the cardiovascular complications of the analgesics and glucocorticoids?]. Presse medicale (Paris, France : 1983) 20060901
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Application of polymeric surfactants in micellar electrokinetic chromatography-electrospray ionization mass spectrometry of benzodiazepines and benzoxazocine chiral drugs. Electrophoresis 20060301
The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesthesia and analgesia 20060101
Cyclodextrin inclusion complexes of the central analgesic drug nefopam. Drug development and industrial pharmacy 20060101
Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: a study of interaction using sequential analysis and isobolographic analysis. Anesthesiology 20050601
Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam. Anaesthesia 20050501
Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels. Amino acids 20050301
Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology. Anaesthesia 20050201
Nefopam and ketamine comparably enhance postoperative analgesia. Anesthesia and analgesia 20050101
[Analgesic effect of continuous intravenous nefopam after urological surgery]. Annales francaises d'anesthesie et de reanimation 20050101
Role of the histamine system in nefopam-induced antinociception in mice. European journal of pharmacology 20041025
Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials. Anesthesia and analgesia 20040901
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain research 20040709
Spectrophotometric microdetermination of nefopam, mebevrine and phenylpropanolamine hydrochloride in pharmaceutical formulations using alizarins. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701
A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study. Anaesthesia 20040601
Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat. Pharmacology, biochemistry, and behavior 20040401
[The management of acute pain in ambulatory patients. The place of nefopam]. Presse medicale (Paris, France : 1983) 20040227
The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-blinded isobolographic study of their analgesic action. Anesthesia and analgesia 20040201
Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects. Anesthesiology 20040101
Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. British journal of anaesthesia 20031201
Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy. European journal of anaesthesiology 20031201
Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers. Pharmacology & toxicology 20030601
Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam. Therapeutic drug monitoring 20030401
Sensitive determination of nefopam and its metabolite desmethyl-nefopam in human biological fluids by HPLC. Journal of pharmaceutical and biomedical analysis 20021107
Nefopam abuse. The Annals of pharmacotherapy 20021001
Pharmacological prevention of postanesthetic shivering. Anesthesia and analgesia 20021001
[A new cause of postoperative confusion syndrome: nefopam]. Annales francaises d'anesthesie et de reanimation 20020601
Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat. European journal of pharmacology 20020419
Fatal overdosage with nefopam (Acupan). Journal of analytical toxicology 20020101
Nefopam and tramadol for the prevention of shivering during neuraxial anesthesia. Regional anesthesia and pain medicine 20020101
Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity. Amino acids 20020101
Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacological research 20011201
Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine. Neuropharmacology 20011201
Nefopam for refractory postoperative hiccups. Anesthesia and analgesia 20011101
Managing postoperative pain. Hospital medicine (London, England : 1998) 20010901
Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients. Anaesthesia 20010601
Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection. Anaesthesia 20010601
Nefopam analgesia as a substitute of neurolept analgesia for extracorporeal shock wave lithotripsy. Anesthesia and analgesia 20010201
[Pharmacologic dependence on nefopam (Acupan): a case report]. Therapie 20010101
Postanaesthetic shivering: epidemiology, pathophysiology, and approaches to prevention and management. Drugs 20010101
Effect of a non-opiate analgesic, nefopam hydrochloride, on stress gastric ulcer in rats. Proceedings of the Western Pharmacology Society 20010101
Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrobial agents and chemotherapy 19960201
Molecular properties and inhibition kinetics of acetylcholinesterase obtained from rat brain and cockroach ganglion. Toxicology and industrial health 19901201
[Analgesic and respiratory effects of nalbuphine during the immediate postoperative period in thoracotomy]. Annales francaises d'anesthesie et de reanimation 19900101
Nefopam and propoxyphene in episiotomy pain. Clinical pharmacology and therapeutics 19800401

Related Products

© 2019 Angene International Limited. All rights Reserved.