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Home > Other Building Blocks > 23210-58-4
CAS No: 23210-58-4 Catalog No: AG002MJC MDL No:MFCD28400106
Title | Journal |
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Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. | PloS one 20140101 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis. | Neurobiology of disease 20130101 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. | Neuropharmacology 20121101 |
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. | Neurobiology of disease 20121001 |
Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil. | The Journal of pharmacology and experimental therapeutics 20121001 |
Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis. | Medical hypotheses 20121001 |
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. | Brain research bulletin 20120901 |
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. | Molecular pharmacology 20120801 |
Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor. | The Journal of biological chemistry 20120720 |
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation. | Neurochemistry international 20120701 |
Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120606 |
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. | British journal of pharmacology 20120601 |
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models. | Pain 20120501 |
Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. | Journal of neurophysiology 20120301 |
Ifenprodil for the treatment of flashbacks in female posttraumatic stress disorder patients with a history of childhood sexual abuse. | Biological psychiatry 20120215 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons. | Naunyn-Schmiedeberg's archives of pharmacology 20120201 |
Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates. | Bioconjugate chemistry 20120118 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors. | PloS one 20120101 |
Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. | PloS one 20120101 |
A critical role for GluN2B-containing NMDA receptors in cortical development and function. | Neuron 20111208 |
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. | Neurobiology of aging 20111201 |
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice. | Journal of neuroscience research 20111101 |
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes. | Journal of neurochemistry 20111101 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain. | Brain, behavior, and immunity 20111001 |
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20111001 |
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. | Neuron 20110922 |
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831 |
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. | Nature 20110714 |
Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons. | The European journal of neuroscience 20110701 |
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro. | The Chinese journal of physiology 20110630 |
Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. | Alcoholism, clinical and experimental research 20110601 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. | Brain research 20110510 |
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. | Journal of neurochemistry 20110501 |
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. | Neuron 20110428 |
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401 |
Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats. | Neurochemical research 20110301 |
Amyloid β peptide oligomers directly activate NMDA receptors. | Cell calcium 20110301 |
The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats. | Acta physiologica Hungarica 20110301 |
NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters. | Behavioural brain research 20110202 |
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain. | European journal of pain (London, England) 20110201 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. | Molecular pain 20110101 |
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. | Journal of biomedical science 20110101 |
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. | PloS one 20110101 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. | European journal of pharmacology 20101125 |
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. | Bioorganic & medicinal chemistry 20101115 |
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors. | Journal of pharmaceutical and biomedical analysis 20101102 |
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. | Experimental neurology 20101001 |
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. | Neuron 20100923 |
NMDA receptor contributions to visual contrast coding. | Neuron 20100729 |
Rapid activation of dormant presynaptic terminals by phorbol esters. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728 |
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. | The Journal of pharmacology and experimental therapeutics 20100601 |
Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. | Journal of neurophysiology 20100601 |
Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists. | ChemMedChem 20100503 |
Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses. | Hippocampus 20100501 |
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. | European journal of pain (London, England) 20100501 |
Polyaminergic agents modulate contextual fear extinction in rats. | Neurobiology of learning and memory 20100501 |
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. | Journal of psychopharmacology (Oxford, England) 20100401 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. | Nature medicine 20100401 |
Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil. | Organic & biomolecular chemistry 20100307 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site. | The Journal of pharmacology and experimental therapeutics 20100301 |
Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents. | Neuroscience 20100203 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. | Neuroscience 20100120 |
The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze. | Behavioural brain research 20100105 |
Molecular structure of ionotropic glutamate receptors. | Current medicinal chemistry 20100101 |
Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors. | Neuroscience 20091229 |
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. | Neuroscience 20091110 |
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test. | Psychopharmacology 20091001 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium. | Canadian journal of physiology and pharmacology 20091001 |
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. | Neuropharmacology 20090801 |
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. | British journal of pharmacology 20090801 |
Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527 |
Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult. | Journal of neurophysiology 20090501 |
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat. | Brain research 20090331 |
Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis. | Neuroreport 20090325 |
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus. | Neuroscience 20090303 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity. | Neurochemical research 20090301 |
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats. | Anesthesia and analgesia 20090301 |
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution. | Cerebral cortex (New York, N.Y. : 1991) 20090201 |
Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats. | Epilepsy & behavior : E&B 20090101 |
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. | Molecular pharmacology 20090101 |
Molecular determinants of multiple effects of nickel on NMDA receptor channels. | Neurotoxicity research 20090101 |
Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats. | Pharmacology 20090101 |
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor. | Journal of neurochemistry 20081201 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. | Stroke 20081101 |
The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine. | The Journal of pharmacology and experimental therapeutics 20081001 |
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity. | Journal of neurophysiology 20081001 |
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. | Experimental cell research 20080815 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A. | Biochemical and biophysical research communications 20080725 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. | Alcoholism, clinical and experimental research 20080601 |
Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. | The Journal of physiology 20080515 |
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors. | Bioorganic & medicinal chemistry letters 20080501 |
[Determination of ifenprodil in human plasma using liquid chromatography with electrospray tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20080501 |
Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system. | The European journal of neuroscience 20080401 |
NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol. | Neuroendocrinology 20080101 |
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. | Molecular brain 20080101 |
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures. | Neuroscience 20071219 |
Improving solubility of NR2B amino-terminal domain of N-methyl-d-aspartate receptor expressed in Escherichia coli. | Biochemical and biophysical research communications 20071012 |
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071003 |
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding. | ChemMedChem 20071001 |
Rapid bidirectional switching of synaptic NMDA receptors. | Neuron 20070906 |
Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901 |
Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na+ channels in rat sensory neurons. | European journal of anaesthesiology 20070901 |
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart. | The Journal of pharmacology and experimental therapeutics 20070701 |
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. | Neuropharmacology 20070701 |
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. | Neuron 20070524 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. | Pain 20070501 |
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. | Neurochemistry international 20070501 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. | Journal of pharmacological sciences 20070501 |
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells. | The Journal of steroid biochemistry and molecular biology 20070501 |
[Developmental changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors in cultured rat hippocampal neurons]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501 |
NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice. | Brain research 20070302 |
Glutamate exocytosis from astrocytes controls synaptic strength. | Nature neuroscience 20070301 |
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. | Life sciences 20070206 |
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. | Experimental neurology 20070201 |
Effects of ifenprodil on the discriminative stimulus effects of cocaine in rhesus monkeys. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070201 |
[NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201 |
Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20070115 |
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. | Neuropharmacology 20070101 |
Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis. | Neuropharmacology 20070101 |
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. | Molecular pain 20070101 |
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus. | Hippocampus 20070101 |
Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma. | Neural plasticity 20070101 |
NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia. | Epilepsy research 20061201 |
[Treatment by medicine which improves cerebral circulation and metabolism]. | Nihon rinsho. Japanese journal of clinical medicine 20061128 |
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. | Journal of neuroscience research 20061115 |
Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learning. | The European journal of neuroscience 20061101 |
[Nicergoline, ibudilast, ifenprodil tartrate]. | Nihon rinsho. Japanese journal of clinical medicine 20061028 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. | Neuroscience 20060901 |
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor. | Molecular and cellular neurosciences 20060901 |
The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats. | Experimental neurology 20060801 |
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060705 |
NR2B subunit exerts a critical role in postischemic synaptic plasticity. | Stroke 20060701 |
Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20060601 |
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse. | The Journal of physiology 20060515 |
Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias. | Psychopharmacology 20060401 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315 |
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060301 |
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. | Brain research 20060216 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists. | Current opinion in pharmacology 20060201 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. | Investigative ophthalmology & visual science 20060201 |
NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore. | Current topics in medicinal chemistry 20060101 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex. | British journal of pharmacology 20051101 |
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. | Neuron 20051020 |
Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens. | Life sciences 20050916 |
Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. | Protein science : a publication of the Protein Society 20050901 |
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. | The European journal of neuroscience 20050901 |
Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons. | The Journal of biological chemistry 20050819 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. | Journal of neurophysiology 20050701 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice. | The journal of pain : official journal of the American Pain Society 20050701 |
The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. | Brain research 20050607 |
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil. | Neuroscience letters 20050513 |
Allosteric modulation of 5-HT3 serotonin receptors. | European journal of pharmacology 20050502 |
In vitro characterization of novel NR2B selective NMDA receptor antagonists. | Neurochemistry international 20050501 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420 |
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. | Current drug targets. CNS and neurological disorders 20050401 |
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302 |
Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function. | The European journal of neuroscience 20050301 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. | Pain 20050201 |
The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [(3)H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane. | The Journal of steroid biochemistry and molecular biology 20050201 |
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112 |
Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. | Neuroscience 20050101 |
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. | Neuroscience 20050101 |
The function of the amino terminal domain in NMDA receptor modulation. | Journal of molecular graphics & modelling 20050101 |
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. | Neuroscience 20050101 |
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. | Acta neurochirurgica. Supplement 20050101 |
Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex. | Journal of neurophysiology 20041001 |
Amino terminal domain regulation of NMDA receptor function. | European journal of pharmacology 20041001 |
Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit. | The Journal of physiology 20040915 |
NMDA receptor 2B-selective antagonist ifenprodil-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. | Brain research 20040910 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908 |
Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux. | Journal of neuroscience methods 20040830 |
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. | The Journal of physiology 20040715 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. | Brain research 20040611 |
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol. | Brain research 20040611 |
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. | Cerebral cortex (New York, N.Y. : 1991) 20040601 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. | Science (New York, N.Y.) 20040514 |
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. | Resuscitation 20040501 |
Re-expression of NR2B-containing NMDA receptors in vitro by suppression of neuronal activity. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20040401 |
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains. | Biological & pharmaceutical bulletin 20040401 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice. | Methods and findings in experimental and clinical pharmacology 20040301 |
A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. | Epilepsy research 20040301 |
The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. | Current medicinal chemistry 20040201 |
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion. | Neuroscience 20040101 |
Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains. | Doklady. Biochemistry and biophysics 20040101 |
Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. | The Journal of pharmacology and experimental therapeutics 20031201 |
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[(11)C]one, as a potent NR(1A)/2B subtype selective NMDA PET radiotracer. | Bioorganic & medicinal chemistry 20031201 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil. | Alcoholism, clinical and experimental research 20031201 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201 |
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031112 |
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. | Alcoholism, clinical and experimental research 20031101 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging. | Journal of neuroscience methods 20031015 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. | Experimental neurology 20031001 |
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo. | The European journal of neuroscience 20031001 |
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze. | European journal of pharmacology 20030829 |
Polyamines in a genetic animal model of paroxysmal dyskinesia. | Brain research 20030815 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. | European journal of pharmacology 20030620 |
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. | Kidney international 20030501 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures. | Neuroscience letters 20030501 |
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. | Behavioural pharmacology 20030501 |
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice. | Behavioural pharmacology 20030501 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415 |
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. | The Journal of physiology 20030401 |
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor. | Journal of neurophysiology 20030201 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. | Neurochemistry international 20030101 |
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. | The Journal of pharmacology and experimental therapeutics 20030101 |
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. | Journal of neurophysiology 20030101 |
Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats. | Alcohol and alcoholism (Oxford, Oxfordshire) 20030101 |
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists. | Neurotoxicity research 20030101 |
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. | Brain research. Developmental brain research 20021215 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism. | Brain research 20021011 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. | Brain research 20021011 |
Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity. | Anesthesiology 20021001 |
Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. | Alcoholism, clinical and experimental research 20021001 |
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil. | Brain research. Molecular brain research 20020930 |
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis. | European journal of pharmacology 20020927 |
Differential regulation of synaptic and extra-synaptic NMDA receptors. | Nature neuroscience 20020901 |
Axonal projection, input and output synapses, and synaptic physiology of Cajal-Retzius cells in the developing rat neocortex. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity. | Naunyn-Schmiedeberg's archives of pharmacology 20020801 |
Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715 |
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors. | Nuclear medicine and biology 20020701 |
NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615 |
Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. | The Journal of pharmacology and experimental therapeutics 20020601 |
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. | European journal of pharmacology 20020524 |
Subtypes of NMDA receptors in new-born rat hippocampal granule cells. | The Journal of physiology 20020515 |
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. | Nature neuroscience 20020501 |
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem. | The Journal of physiology 20020501 |
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. | Journal of neuroscience research 20020501 |
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. | Movement disorders : official journal of the Movement Disorder Society 20020501 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses. | Neuron 20020314 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. | Brain research. Molecular brain research 20020131 |
Effect of multiple ifenprodil or spermidine treatment on social recognition in rats. | Journal of basic and clinical physiology and pharmacology 20020101 |
Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. | Neuron 20011120 |
Distinct NMDA and AMPA receptor-mediated responses in mouse and human Cajal-Retzius cells. | Journal of neurophysiology 20011101 |
[A case of eosinophilic pneumonia possibly due to ifenprodil]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20011101 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord. | The European journal of neuroscience 20011101 |
Lead inhibition of NMDA channels in native and recombinant receptors. | Neuroreport 20011008 |
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC. | FEBS letters 20011005 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. | Journal of neurophysiology 20011001 |
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus. | Journal of neuroendocrinology 20011001 |
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010901 |
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. | Nature neuroscience 20010901 |
Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. | Current drug targets 20010901 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. | European journal of pharmacology 20010629 |
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. | Journal of neurophysiology 20010601 |
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. | Pharmacology & toxicology 20010601 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain. | Brain research. Developmental brain research 20010430 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. | European journal of pharmacology 20010330 |
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex. | Synapse (New York, N.Y.) 20010315 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. | Neuropharmacology 20010101 |
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits. | The Journal of pharmacology and experimental therapeutics 20010101 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition. | Journal of neurochemistry 20010101 |
Effects of centrally-acting glutamatergic modulators on cardiovascular responses to stress in humans. | Journal of cardiology 20010101 |
Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. | Neuroscience 20010101 |
Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. | Pediatric research 20000401 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema. | Archives of toxicology 20000101 |
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. | The Journal of physiology 19981001 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. | European journal of pharmacology 19970411 |
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. | Nature medicine 19961201 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. | Brain research 19950206 |
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. | European journal of pharmacology 19901106 |
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