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Home > Imidazoles > 22994-85-0
22994-85-0 | 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
CAS No: 22994-85-0 Catalog No: AG002LSW MDL No:MFCD00243089
Product Description
Catalog Number:
AG002LSW
Chemical Name:
1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
CAS Number:
22994-85-0
Molecular Formula:
C12H12N4O3
Molecular Weight:
260.2487
MDL Number:
MFCD00243089
IUPAC Name:
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
InChI:
InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
InChI Key:
CULUWZNBISUWAS-UHFFFAOYSA-N
SMILES:
O=C(Cn1ccnc1[N+](=O)[O-])NCc1ccccc1
UNII:
YC42NRJ1ZD
NSC Number:
299972
Properties
Complexity:
325
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
260.091g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
260.253g/mol
Monoisotopic Mass:
260.091g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
92.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.9
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| 2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi. | The Journal of parasitology 20090401 |
| Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents. | Bioorganic & medicinal chemistry 20090401 |
| A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease. | Journal of cardiac failure 20090401 |
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| Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. | PLoS neglected tropical diseases 20090201 |
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| Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection. | Antimicrobial agents and chemotherapy 20090101 |
| Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101 |
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| Copper (II) complexes of [1,2,4]triazolo [1,5-a]pyrimidine derivatives as potential anti-parasitic agents. | Drug metabolism letters 20090101 |
| GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi. | Molecular systems biology 20090101 |
| Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi. | BMC microbiology 20090101 |
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| Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi. | European journal of medicinal chemistry 20080801 |
| Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. | European journal of medicinal chemistry 20080801 |
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| Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). | American heart journal 20080701 |
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| Chagas disease, France. | Emerging infectious diseases 20080401 |
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| Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections. | Advances in experimental medicine and biology 20080101 |
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| Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes. | BMC cell biology 20080101 |
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| Combining residual insecticide spraying campaigns with targeted detection and specific chemotherapy for Trypanosoma cruzi infection in children. | PLoS neglected tropical diseases 20071201 |
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| In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. | Journal of medicinal chemistry 20071129 |
| Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives. | Journal of medicinal chemistry 20071115 |
| Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. | Bioorganic & medicinal chemistry 20071101 |
| An overview of Chagas disease treatment. | Memorias do Instituto Oswaldo Cruz 20071030 |
| Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice. | Parasitology research 20071001 |
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| Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. | ChemMedChem 20070901 |
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| Chagas disease: clinical overview and implications for nursing. | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20070801 |
| DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi. | Experimental parasitology 20070701 |
| Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. | International journal of antimicrobial agents 20070601 |
| Usefulness of PCR strategies for early diagnosis of Chagas' disease reactivation and treatment follow-up in heart transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070601 |
| Chagas' disease reactivation with skin symptoms in a patient with kidney transplant. | International journal of dermatology 20070601 |
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| The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole. | Antimicrobial agents and chemotherapy 20070401 |
| Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships. | Bioorganic & medicinal chemistry 20070401 |
| In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains. | Journal of enzyme inhibition and medicinal chemistry 20070401 |
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| Liver transplantation from deceased donors serologically positive for Chagas disease. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070301 |
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| Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series. | Bioorganic & medicinal chemistry 20070101 |
| Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS. | Annals of tropical medicine and parasitology 20070101 |
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| Novel potential drug against T. cruzi and its interaction with surfactant micelles. | Pharmaceutical development and technology 20070101 |
| Chagas disease: an impediment in achieving the Millennium Development Goals in Latin America. | BMC international health and human rights 20070101 |
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| Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol. | Bioorganic & medicinal chemistry 20061101 |
| Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile. | Scandinavian journal of immunology 20061101 |
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| Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis). | Human & experimental toxicology 20060801 |
| Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. | Bioorganic & medicinal chemistry letters 20060715 |
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