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221529-58-4 | N-[4-[(4-propan-2-yloxyphenyl)methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine
CAS No: 221529-58-4 Catalog No: AG0038VS MDL No:MFCD08062147
Product Description
Catalog Number:
AG0038VS
Chemical Name:
N-[4-[(4-propan-2-yloxyphenyl)methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine
CAS Number:
221529-58-4
Molecular Formula:
C19H23N3O
Molecular Weight:
309.4054
MDL Number:
MFCD08062147
IUPAC Name:
N-[4-[(4-propan-2-yloxyphenyl)methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine
InChI:
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChI Key:
GYYRMJMXXLJZAB-UHFFFAOYSA-N
SMILES:
CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C
UNII:
DH5W8F3S4H
Properties
Complexity:
380
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
309.184g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
309.413g/mol
Monoisotopic Mass:
309.184g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
45.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6
Literature
| Title | Journal |
|---|---|
| Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. | Toxicology and applied pharmacology 20171101 |
| Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. | Pharmacological research 20120901 |
| Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner. | Cancer science 20120601 |
| Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001 |
| Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815 |
| Glial cells isolated from dorsal root ganglia express prostaglandin E(2) (EP(4)) and prostacyclin (IP) receptors. | European journal of pharmacology 20110701 |
| PGE1 and PGE2 modify platelet function through different prostanoid receptors. | Prostaglandins & other lipid mediators 20110201 |
| Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. | Vascular pharmacology 20110101 |
| The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice. | Prostaglandins, leukotrienes, and essential fatty acids 20090701 |
| Effect of vitamin B(6) vitamers on platelet aggregation. | Platelets 20090301 |
| 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. | The Journal of pharmacology and experimental therapeutics 20080201 |
| Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. | British journal of pharmacology 20060901 |
| RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. | British journal of pharmacology 20060201 |
| Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists [corrected]. | Bioorganic & medicinal chemistry letters 20040223 |
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