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215803-78-4 | N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
CAS No: 215803-78-4 Catalog No: AG00BF4J MDL No:
Product Description
Catalog Number:
AG00BF4J
Chemical Name:
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
CAS Number:
215803-78-4
Molecular Formula:
C28H30N4O
Molecular Weight:
438.5640
IUPAC Name:
N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide
InChI:
InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)
InChI Key:
OLWRVVHPJFLNPW-UHFFFAOYSA-N
SMILES:
N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2
Properties
Complexity:
708
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
438.242g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
438.575g/mol
Monoisotopic Mass:
438.242g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
69A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.6
Literature
| Title | Journal |
|---|---|
| Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. | Journal of neuroscience research 20121001 |
| High-affinity and selective dopamine D₃ receptor full agonists. | Bioorganic & medicinal chemistry letters 20120901 |
| YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. | Addiction biology 20120301 |
| The acute administration of the selective dopamine D(3) receptor antagonist SB-277011A reverses conditioned place aversion produced by naloxone precipitated withdrawal from acute morphine administration in rats. | Synapse (New York, N.Y.) 20120101 |
| Roles of BDNF, dopamine D(3) receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20111101 |
| Dopamine D(3) receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. | European journal of pharmacology 20110601 |
| Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists. | Psychopharmacology 20100901 |
| The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking. | The international journal of neuropsychopharmacology 20100301 |
| 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists. | Journal of medicinal chemistry 20100114 |
| In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice. | Synapse (New York, N.Y.) 20090901 |
| Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. | Bioorganic & medicinal chemistry letters 20090901 |
| Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors. | Behavioural pharmacology 20090901 |
| Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. | Bioorganic & medicinal chemistry letters 20090815 |
| Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat. | The journal of sexual medicine 20090401 |
| Blockade of dopamine D(3) receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D(1) receptor agonists, but not of D(2) antagonists. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090101 |
| Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15. | Naunyn-Schmiedeberg's archives of pharmacology 20081101 |
| The dopamine D3/D2 agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] protects against acute and cocaine-kindled seizures in mice: further evidence for the involvement of D3 receptors. | The Journal of pharmacology and experimental therapeutics 20080901 |
| The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. | Pharmacology, biochemistry, and behavior 20080601 |
| The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. | Psychopharmacology 20080301 |
| New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems. | Bioorganic & medicinal chemistry letters 20080201 |
| New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems. | Bioorganic & medicinal chemistry letters 20080201 |
| Drug seeking under a second-order schedule of reinforcement depends on dopamine D3 receptors in the basolateral amygdala. | Behavioral neuroscience 20080201 |
| Role of dopamine D3 receptors in the expression of conditioned fear in rats. | European journal of pharmacology 20080128 |
| Experimental pharmacotherapeutics for schizophrenia and addiction. | IDrugs : the investigational drugs journal 20080101 |
| The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats. | European journal of pharmacology 20071031 |
| 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists. | Journal of medicinal chemistry 20071018 |
| Effects of antipsychotics and selective D3 antagonists on PPI deficits induced by PD 128907 and apomorphine. | Behavioural brain research 20070822 |
| Pharmacological modulation of functional connectivity: the correlation structure underlying the phMRI response to d-amphetamine modified by selective dopamine D3 receptor antagonist SB277011A. | Magnetic resonance imaging 20070701 |
| Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain. | Brain research 20070529 |
| Selective antagonism at dopamine D3 receptors attenuates cocaine-seeking behaviour in the rat. | The international journal of neuropsychopharmacology 20070401 |
| Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats. | European journal of pharmacology 20070322 |
| Evidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in mice. | Addiction biology 20070301 |
| Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs. | The Journal of pharmacology and experimental therapeutics 20070201 |
| The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061101 |
| The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. | The international journal of neuropsychopharmacology 20061001 |
| Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. | European journal of pharmacology 20060318 |
| Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats. | Drug and alcohol dependence 20060104 |
| The European Association of Addiction Therapy - Inaugural Conference. | IDrugs : the investigational drugs journal 20051001 |
| Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. | Synapse (New York, N.Y.) 20050701 |
| Dopamine D3 receptor antagonists as therapeutic agents. | Drug discovery today 20050701 |
| Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. | Journal of medicinal chemistry 20050602 |
| Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats. | The European journal of neuroscience 20050601 |
| Chronicles in drug discovery. | Drug news & perspectives 20050601 |
| Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. | Psychopharmacology 20050501 |
| The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats. | Pharmacology, biochemistry, and behavior 20050501 |
| Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats. | Psychopharmacology 20041001 |
| Selective dopamine D(3) receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain. | Synapse (New York, N.Y.) 20041001 |
| The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia. | Pharmacology, biochemistry, and behavior 20040801 |
| Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011. | Behavioural pharmacology 20040701 |
| Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation. | The European journal of neuroscience 20040501 |
| Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701 |
| Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats. | Synapse (New York, N.Y.) 20030601 |
| Selective antagonism at dopamine D3 receptors enhances monoaminergic and cholinergic neurotransmission in the rat anterior cingulate cortex. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030501 |
| Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030201 |
| Disruption of nicotine conditioning by dopamine D(3) receptor ligands. | Molecular psychiatry 20030201 |
| Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference. | Neuroreport 20030120 |
| Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101 |
| SB-277011 GlaxoSmithKline. | Current opinion in investigational drugs (London, England : 2000) 20010701 |
| Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor. | Bioorganic & medicinal chemistry letters 20010312 |
| Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase. | Xenobiotica; the fate of foreign compounds in biological systems 20010101 |
| Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. | The Journal of pharmacology and experimental therapeutics 20000901 |
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