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CAS No: 21364-46-5 Catalog No: AG00BCAO MDL No:
| Title | Journal |
|---|---|
| 6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells. | Chemico-biological interactions 20161225 |
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| The π-acceptor effect in the substitution reactions of tridentate N-donor ligand complexes of platinum(II): a detailed kinetic and mechanistic study. | Dalton transactions (Cambridge, England : 2003) 20120921 |
| Microwave-assisted extraction in combination with capillary electrophoresis for rapid determination of isoquinoline alkaloids in Chelidonium majus L. | Talanta 20120915 |
| Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine. | Molecules (Basel, Switzerland) 20120912 |
| Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901 |
| Steady state and time-resolved fluorescence study of isoquinoline: reinvestigation of excited state proton transfer. | The journal of physical chemistry. A 20120712 |
| Alkaloids produced by endophytic fungi: a review. | Natural product communications 20120701 |
| Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. | Journal of medicinal chemistry 20120628 |
| A ligand-free Pd-catalyzed cascade reaction: an access to the highly diverse isoquinolin-1(2H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursors. | Organic letters 20120615 |
| Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. | Bioorganic & medicinal chemistry letters 20120601 |
| One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation. | Chemical communications (Cambridge, England) 20120511 |
| Electronic spectra of gas-phase polycyclic aromatic nitrogen heterocycle cations: isoquinoline+ and quinoline+. | The journal of physical chemistry. A 20120503 |
| Silver triflate-copper(II) acetate cooperative catalysis in a cascade reaction for concise synthesis of 2-carbonyl H-pyrazolo[5,1-a]isoquinolines. | Chemical communications (Cambridge, England) 20120425 |
| 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists. | Journal of medicinal chemistry 20120308 |
| Amplifying vibrational circular dichroism by manipulation of the electronic manifold. | Chemical communications (Cambridge, England) 20120111 |
| Sensitivity 'hot spots' in the direct analysis in real time mass spectrometry of nerve agent simulants. | Journal of the American Society for Mass Spectrometry 20120101 |
| Electrochemical oxidation of nitrogen-heterocyclic compounds at boron-doped diamond electrode. | Chemosphere 20120101 |
| Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors. | Bioorganic & medicinal chemistry 20120101 |
| Fluorescent reporters of monoamine transporter distribution and function. | Bioorganic & medicinal chemistry letters 20111215 |
| Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand. | Bioorganic & medicinal chemistry 20111215 |
| The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase. | Bioorganic & medicinal chemistry letters 20111215 |
| Pyridine synthesis from oximes and alkynes via rhodium(III) catalysis: Cp* and Cp(t) provide complementary selectivity. | Chemical communications (Cambridge, England) 20111121 |
| An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. | Organic & biomolecular chemistry 20111021 |
| Expedient entry to the piperazinohydroisoquinoline ring system using a sequential Ugi/Pictet-Spengler/reductive methylation reaction protocol. | Chemical communications (Cambridge, England) 20111014 |
| Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility. | ChemMedChem 20111004 |
| RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor. | Bioorganic & medicinal chemistry letters 20111001 |
| Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. | Bioorganic & medicinal chemistry 20111001 |
| A tale of two compounds. | Nature chemistry 20110923 |
| Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy. | The Analyst 20110921 |
| Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice. | Journal of agricultural and food chemistry 20110727 |
| Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents. | Investigational new drugs 20110601 |
| 3-Indolylacyl radical cyclizations upon pyridines and tetrahydropyridines: access to ergoline-related indole [cd]-fused isoquinolines. | The Journal of organic chemistry 20110520 |
| Asymmetric synthesis of pyrrolo[2,1-a]isoquinoline derivatives by 1,3-dipolar cycloadditions of stabilized isoquinolinium N-ylides with sulfinyl dipolarophiles. | The Journal of organic chemistry 20110506 |
| Total synthesis of cortistatins A and J. | The Journal of organic chemistry 20110415 |
| 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). | Journal of medicinal chemistry 20110414 |
| Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as human scavenger receptor CD36 antagonists. | European journal of medicinal chemistry 20110401 |
| Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. | Bioorganic & medicinal chemistry letters 20110215 |
| Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. | Organic & biomolecular chemistry 20110207 |
| Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists. | Bioorganic & medicinal chemistry 20110115 |
| Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease. | Bioorganic & medicinal chemistry letters 20101215 |
| Isoquinoline alkaloids and their binding with DNA: calorimetry and thermal analysis applications. | Mini reviews in medicinal chemistry 20101101 |
| Isoquinoline-based chiral monodentate N-heterocyclic carbenes. | Chemical communications (Cambridge, England) 20101028 |
| Reactions of aromatic N-heterocycles with d0fn-metal alkyl complexes supported by chelating diamide ligands. | Accounts of chemical research 20101019 |
| Cytotoxicity of new pyrazino[1,2-b]isoquinoline and 6,15-iminoisoquino[3,2-b]3-benzazocine compounds. | Bioorganic & medicinal chemistry 20100915 |
| Rhodium-catalyzed asymmetric conjugate addition of organoboronic acids to nitroalkenes using chiral bicyclo[3.3.0] diene ligands. | Angewandte Chemie (International ed. in English) 20100802 |
| In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I. | Bioorganic & medicinal chemistry letters 20100801 |
| Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721 |
| Construction of indole- and isoquinoline-fused nitrogen-containing heterocycles through copper-catalyzed multi-component reaction. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100701 |
| Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists. | Bioorganic & medicinal chemistry letters 20100301 |
| Nitrate-dependent biodegradation of quinoline, isoquinoline, and 2-methylquinoline by acclimated activated sludge. | Journal of hazardous materials 20100115 |
| Synthesis and antitumor activity of cis-dichloridoplatinum(II) complexes of 1,1'-biisoquinolines. | European journal of medicinal chemistry 20100101 |
| Unusual mass spectrometric dissociation pathway of protonated isoquinoline-3-carboxamides due to multiple reversible water adduct formation in the gas phase. | Journal of the American Society for Mass Spectrometry 20091101 |
| A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part II: Physicochemical properties and structure elucidation. | The Journal of antibiotics 20091001 |
| A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities. | The Journal of antibiotics 20091001 |
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. | Bioorganic & medicinal chemistry letters 20091001 |
| Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes. | Journal of the American Chemical Society 20090902 |
| Interaction of isoquinoline alkaloids with polymorphic DNA structures. | Chemistry & biodiversity 20090901 |
| Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation. | The Journal of organic chemistry 20090821 |
| Total synthesis and biological evaluation of cortistatins A and J and analogues thereof. | Journal of the American Chemical Society 20090805 |
| Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression. | Journal of medicinal chemistry 20090723 |
| Synthesis of isoquinoline derivatives via Ag-catalyzed cyclization of 2-alkynyl benzyl azides. | The Journal of organic chemistry 20090403 |
| Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: a route to functionalized indolines, isoquinolinones, and indoles. | The Journal of organic chemistry 20090220 |
| Tandem electrophilic cyclization-[3+2] cycloaddition-rearrangement reactions of 2-alkynylbenzaldoxime, DMAD, and Br2. | The Journal of organic chemistry 20090116 |
| Detection of mismatched duplexes by synchronizing the pulse potential frequency with the dynamics of ferrocene/isoquinoline conjugate-connected DNA probes immobilized onto electrodes. | Chemistry (Weinheim an der Bergstrasse, Germany) 20090101 |
| Green method for the synthesis of highly substituted cyclohexa-1,3-diene, polyhydroindene, polyhydronaphthalene, isochromene, isothiochromene, and isoquinoline derivatives in ionic liquids. | Journal of combinatorial chemistry 20090101 |
| Mild conditions for Pd-catalyzed carboamination of N-protected hex-4-enylamines and 1-, 3-, and 4-substituted pent-4-enylamines. Scope, limitations, and mechanism of pyrrolidine formation. | The Journal of organic chemistry 20081121 |
| Iodine-mediated electrophilic cyclization of 2-alkynyl-1-methylene azide aromatics leading to highly substituted isoquinolines and its application to the synthesis of norchelerythrine. | Journal of the American Chemical Society 20081119 |
| Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. | Molecules (Basel, Switzerland) 20080925 |
| A versatile cyclodehydration reaction for the synthesis of isoquinoline and beta-carboline derivatives. | Organic letters 20080821 |
| Isoquinoline-based TQEN family as TPEN-derived fluorescent zinc sensors. | Inorganic chemistry 20080818 |
| [Development of novel methods for synthesis of heterocyclic compounds catalyzed by transition metals in fluorinated alcohols]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080801 |
| Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists. | Bioorganic & medicinal chemistry letters 20080715 |
| Novel multicomponent reactions involving isoquinoline or phenanthridine and activated acetylenic ester in the presence of heterocyclic NH or 1,3-dicarbonyl compounds. | Molecular diversity 20080501 |
| Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). | Bioorganic & medicinal chemistry 20080415 |
| Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2). | Bioorganic & medicinal chemistry 20080415 |
| Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists. | Bioorganic & medicinal chemistry 20080301 |
| Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids. | European journal of medicinal chemistry 20080101 |
| Synthesis of 1-aminoimidazo[5,1-a]isoquinolinium salts based on multicomponent reactions of isocyanides. | Journal of combinatorial chemistry 20080101 |
| Cytotoxicity of copper(II) complexes of N-salicylidene-L-glutamate: modulation by ascorbic acid. | Neoplasma 20080101 |
| Intramolecular cyclization of beta,beta-difluorostyrenes bearing an iminomethyl or a diazenyl group at the ortho position: synthesis of 3-fluorinated isoquinoline and cinnoline derivatives. | Organic & biomolecular chemistry 20071221 |
| Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. | Cancer letters 20071218 |
| Experimental and quantum-chemical studies of 1H, 13C and 15N NMR coordination shifts in Pd(II) and Pt(II) chloride complexes with quinoline, isoquinoline, and 2,2'-biquinoline. | Magnetic resonance in chemistry : MRC 20071201 |
| 2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists. | Bioorganic & medicinal chemistry letters 20071015 |
| Quinoline and derivatives at a tar oil contaminated site: hydroxylated products as indicator for natural attenuation? | Environmental science & technology 20070801 |
| In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate. | Journal of cardiovascular pharmacology 20070401 |
| Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101 |
| A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor. | Journal of medicinal chemistry 20061228 |
| Secondary and tertiary isoquinoline alkaloids from Xylopia parviflora. | Phytochemistry 20061201 |
| Novel multicomponent reaction of [60]fullerene: the first example of 1,4-dipolar cycloaddition reaction in fullerene chemistry. | Organic & biomolecular chemistry 20061121 |
| CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells. | Oncogene 20060921 |
| Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. | Molecular pharmacology 20060901 |
| Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity. | Bioorganic & medicinal chemistry letters 20060615 |
| A QSAR study on influenza neuraminidase inhibitors. | Bioorganic & medicinal chemistry 20060215 |
| Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. | Bioorganic & medicinal chemistry 20060215 |
| Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. | Bioorganic & medicinal chemistry letters 20060201 |
| Biodegradation of biomass gasification wastewater by two species of pseudomonas using immobilized cell reactor. | Applied biochemistry and biotechnology 20060201 |
| Cholinergic activity of isoquinoline alkaloids from the showy autumn crocus (Colchicum speciosum Stev.). | Doklady. Biochemistry and biophysics 20060101 |
| Development of ligands for the peripheral benzodiazepine receptor. | Current medicinal chemistry 20060101 |
| Novel synthetic isoquinolino[5,4-ab]phenazines: inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities. | Bioorganic & medicinal chemistry 20051101 |
| [Interaction of cucurbit[ n ]urils and quinoline or its derivatives]. | Guang pu xue yu guang pu fen xi = Guang pu 20050801 |
| Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20050501 |
| Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. | Journal of medicinal chemistry 20050407 |
| DFT studies and vibrational spectra of isoquinoline and 8-hydroxyquinoline. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050201 |
| Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors. | Bioorganic & medicinal chemistry letters 20040716 |
| Asymmetric synthesis of isoquinoline alkaloids. | Chemical reviews 20040701 |
| Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands. | Bioorganic & medicinal chemistry 20040115 |
| Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids. | Toxicology letters 20031215 |
| Cis-[Pt(Cl)2(pyridine)(5-SO3H-isoquinoline)] complex, a selective inhibitor of telomerase enzyme. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20031201 |
| Synthesis and anti-measles virus activity of new isoquinolin-4-one derivatives. | Farmaco (Societa chimica italiana : 1989) 20031201 |
| Microbial production of isoquinoline from indene. | Canadian journal of microbiology 20031101 |
| The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. | Brain research 20030919 |
| New reactions of IBX: oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates. | Angewandte Chemie (International ed. in English) 20030905 |
| New strategy for the synthesis of tetrahydroisoquinoline alkaloids. | Organic letters 20030612 |
| Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. III. Synthesis and antifungal activity of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine salts. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030601 |
| A new isoquinolinone derivative with noble vasorelaxation activity. | Pharmacology 20030401 |
| In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. | Phytotherapy research : PTR 20030301 |
| [Genetic aspects of the relationship between isoquinoline alkaloids and mineral elements in greater celandine (Chelidonium majus L.)]. | Prikladnaia biokhimiia i mikrobiologiia 20030101 |
| Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption. | Nucleosides, nucleotides & nucleic acids 20030101 |
| A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. | Life sciences 20021227 |
| Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis. | Biological & pharmaceutical bulletin 20021201 |
| An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20021101 |
| Immunocytological localization of two enzymes involved in berberine biosynthesis. | Planta 20021101 |
| Determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione, in plasma, urine and tissue homogenates by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics. | Chemical reviews 20020501 |
| Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. | Biochemical pharmacology 20020301 |
| Nematocidal activity of isoquinoline alkaloids against a species of diplogastridae. | Planta medica 20020201 |
| Predicting the substrates of cloned plant O-methyltransferases. | Phytochemistry 20020101 |
| Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. | Bioorganic & medicinal chemistry 20011101 |
| Environmental and genotypic influences on isoquinoline alkaloid content in Sanguinaria canadensis. | Journal of chemical ecology 20010901 |
| N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands. | Bioorganic & medicinal chemistry 20010701 |
| Beta-phenylethylamines and the isoquinoline alkaloids. | Natural product reports 20010401 |
| Identification of a novel inhibitor of LPS-induced TNF-alpha production with antiproliferative activity in monocyte/macrophages. | Biochemical and biophysical research communications 20010309 |
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