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Home > Sulfanilamide > 211311-95-4
211311-95-4 | 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
CAS No: 211311-95-4 Catalog No: AG002LAB MDL No:MFCD07364003
Product Description
Catalog Number:
AG002LAB
Chemical Name:
2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
CAS Number:
211311-95-4
Molecular Formula:
C19H22N2O2S
Molecular Weight:
342.4552
MDL Number:
MFCD07364003
IUPAC Name:
N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide
InChI:
InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
InChI Key:
HOQAVGZLYRYHSO-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)c1ccc(cc1)C(CNS(=O)(=O)C(C)C)C
Properties
Complexity:
527
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
342.14g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
342.457g/mol
Monoisotopic Mass:
342.14g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
78.3A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8
Literature
| Title | Journal |
|---|---|
| The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null mice. | Neuropharmacology 20120101 |
| Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215 |
| Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. | Journal of medicinal chemistry 20101028 |
| Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. | Behavioural brain research 20100901 |
| AMPA receptor potentiation can prevent ethanol-induced intoxication. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080601 |
| Molecular mechanisms of neurite growth with AMPA receptor potentiation. | Neuropharmacology 20070201 |
| Pharmacological characterization of cGMP regulation by the biarylpropylsulfonamide class of positive, allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. | The Journal of pharmacology and experimental therapeutics 20061001 |
| A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives. | Bioorganic & medicinal chemistry letters 20061001 |
| Targeting neurological receptors. | IDrugs : the investigational drugs journal 20051201 |
| Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological magnetic resonance imaging. | Psychopharmacology 20050801 |
| The AMPA receptor potentiator LY404187 increases cerebral glucose utilization and c-fos expression in the rat. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20041001 |
| Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease. | European journal of pharmacology 20040220 |
| Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126 |
| Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus. | Neuropharmacology 20030601 |
| Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors. | Journal of medicinal chemistry 20020509 |
| Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator. | The Journal of pharmacology and experimental therapeutics 20010701 |
| Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro. | Neuropharmacology 20010601 |
| Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro. | Neuropharmacology 20010601 |
| Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo. | Neuropharmacology 20010601 |
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