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2113-05-5 | Imidodicarbonimidic diamide, N-(3-chlorophenyl)-, hydrochloride (1:1)
CAS No: 2113-05-5 Catalog No: AG002LA3 MDL No:MFCD00053019
Product Description
Catalog Number:
AG002LA3
Chemical Name:
Imidodicarbonimidic diamide, N-(3-chlorophenyl)-, hydrochloride (1:1)
CAS Number:
2113-05-5
Molecular Formula:
C8H11Cl2N5
Molecular Weight:
248.1124
MDL Number:
MFCD00053019
IUPAC Name:
2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine;hydrochloride
InChI:
InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
InChI Key:
FOWAIJYHRWFTHR-UHFFFAOYSA-N
SMILES:
NC(=N)NC(=N)Nc1cccc(c1)Cl.Cl
NSC Number:
210906
Properties
Complexity:
246
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
247.039g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
248.111g/mol
Monoisotopic Mass:
247.039g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
103A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way. | ACS chemical neuroscience 20121017 |
| Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20121003 |
| Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats. | Journal of gastroenterology and hepatology 20120901 |
| 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide. | Epilepsy research 20120901 |
| Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system. | Neuroscience letters 20120726 |
| Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons. | BMC neuroscience 20120101 |
| Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). | Neurochemical research 20111101 |
| Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss. | Neuroscience letters 20111031 |
| Blockade of the NMDA and AMPA/kainate receptors in the dorsal raphe nucleus prevents the 5-HT₃ receptor agonist m-chlorophenylbiguanide-induced suppression of REM sleep in the rat. | Progress in neuro-psychopharmacology & biological psychiatry 20110701 |
| Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation. | Neuropeptides 20110601 |
| The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. | Epilepsy & behavior : E&B 20110601 |
| Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. | Brain research 20110525 |
| 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems. | Respiratory physiology & neurobiology 20100630 |
| Granisetron ameliorates acetic acid-induced colitis in rats. | Human & experimental toxicology 20100401 |
| Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment. | Journal of neural transmission (Vienna, Austria : 1996) 20100301 |
| Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor. | Neuroscience letters 20091106 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. | Journal of neurophysiology 20090901 |
| Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals. | Acta pharmacologica Sinica 20090601 |
| Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus. | Hearing research 20090501 |
| Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission. | Behavioural pharmacology 20090501 |
| Activation of the serotonin 5-HT3 receptor in the dorsal raphe nucleus suppresses REM sleep in the rat. | Progress in neuro-psychopharmacology & biological psychiatry 20080515 |
| The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. | Journal of neurophysiology 20061201 |
| Activation of serotonin-3 receptors increases dopamine release within the ventral tegmental area of Wistar and alcohol-preferring (P) rats. | Alcohol (Fayetteville, N.Y.) 20061101 |
| Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats. | Brain research 20060712 |
| Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats. | Pharmacology, biochemistry, and behavior 20060601 |
| Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog. | European journal of pharmacology 20060524 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord. | Pharmacology 20060101 |
| Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour. | Psychopharmacology 20050901 |
| The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide. | Biochemistry 20050628 |
| The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes. | Endocrine 20050601 |
| Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release. | European journal of pharmacology 20050221 |
| Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors. | Behavioural pharmacology 20050201 |
| Serotonin type 3 receptors stimulate offensive aggression in Syrian hamsters. | Behavioural brain research 20050106 |
| Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. | Brain research 20041126 |
| Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect. | Molecular pharmacology 20040901 |
| The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. | Pain 20040701 |
| Excitatory action of prostanoids on the ferret isolated vagus nerve preparation. | European journal of pharmacology 20040426 |
| Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. | Neuroscience 20040101 |
| Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats. | Brain research 20030815 |
| Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG). | Bioorganic & medicinal chemistry letters 20030324 |
| Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells. | Neuropharmacology 20030201 |
| Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis. | Mediators of inflammation 20030201 |
| Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. | Synapse (New York, N.Y.) 20021201 |
| Central 5-HT(3) receptors and water intake in rats. | Physiology & behavior 20021101 |
| Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020801 |
| Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii. | Neuroreport 20020507 |
| Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020201 |
| 5-HT3 receptors in selective animal models of cognition. | Indian journal of experimental biology 20020201 |
| Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla. | Neuroscience 20020101 |
| Hypoglossal nerve response to 5-HT3 drugs injected into the XII nucleus and vena cava in the rat. | Sleep 20011215 |
| Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons. | Journal of neurophysiology 20010501 |
| The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. | Pharmacology, biochemistry, and behavior 20010401 |
| Postsynaptic target regulates functional responses induced by 5-HT3 serotonin receptors on axonal varicosities of NG108-15 hybrid neuroblastoma cells. | Neuroscience 20010101 |
| Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. | European journal of pharmacology 20001208 |
| Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit. | European journal of pharmacology 20000707 |
| The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. | The Journal of biological chemistry 19991022 |
| Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors. | European journal of pharmacology 19990312 |
| Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. | British journal of pharmacology 19980201 |
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