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21102-94-3

21102-94-3 | 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-

CAS No: 21102-94-3 Catalog No: AG002L57 MDL No:

Product Description

Catalog Number:
AG002L57
Chemical Name:
8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
CAS Number:
21102-94-3
Molecular Formula:
C22H31N3O3
Molecular Weight:
385.4998
IUPAC Name:
8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
InChI:
InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
InChI Key:
AYYCFGDXLUPJAQ-UHFFFAOYSA-N
SMILES:
COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2
UNII:
08EI0K81OL

Properties

Complexity:
547  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
385.237g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
385.508g/mol
Monoisotopic Mass:
385.237g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
53.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  

Literature

Title Journal
Blockade of voltage-gated calcium channel Cav1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol. European journal of pharmacology 20120815
Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. European journal of pharmacology 20120315
Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors. Journal of medicinal chemistry 20120112
Molecular and pharmacological characteristics of the gerbil α(1a)-adrenergic receptor. Hearing research 20120101
Effect of inter-renal aortic coarctation-induced hypertension on function and expression of vascular α(1A)- and α(1D)-adrenoceptors. Canadian journal of physiology and pharmacology 20120101
[Medical expulsive therapy facilitated by alpha 1 adrenoceptor antagonist]. Clinical calcium 20111001
Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties. European journal of medicinal chemistry 20110701
Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion. Investigative ophthalmology & visual science 20110701
Vasopressor nerve responses in the pithed rat, previously identified as α2-adrenoceptor mediated, may be α1D-adrenoceptor mediated. European journal of pharmacology 20110511
Characterization of α1-adrenoceptor subtypes mediating contraction in human isolated ureters. Urology 20110301
α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice. Autonomic & autacoid pharmacology 20110101
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors. European journal of medicinal chemistry 20100901
alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries. American journal of physiology. Heart and circulatory physiology 20100601
Discovery of a new series of 5-HT1A receptor agonists. Bioorganic & medicinal chemistry letters 20100315
Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter. World journal of urology 20091201
Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats. Acta pharmacologica Sinica 20090901
Mechanical function and gene expression of alpha(1)-adrenoceptor subtypes in dog intravesical ureter. Urology 20090801
Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Autonomic & autacoid pharmacology 20090701
Inhibitory effect of fentanyl on phenylephrine-induced contraction of the rat aorta. Yonsei medical journal 20090630
Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors. European journal of pharmacology 20090624
Serotonin1A-mediated amplification of light-induced phase advances of circadian rhythms in the Syrian hamster: post-light effects. Brain research 20090123
Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats. Autonomic & autacoid pharmacology 20090101
Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats. World journal of urology 20081201
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. Journal of medicinal chemistry 20081023
Smooth muscle alpha1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles. British journal of pharmacology 20081001
The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism. Molecular pharmacology 20081001
Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica 20080501
Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations. European journal of pharmacology 20080428
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse. British journal of pharmacology 20080201
Noradrenergic vasoconstriction of pig prostatic small arteries. Naunyn-Schmiedeberg's archives of pharmacology 20080201
Characteristics of contractile activity in the renal artery of ovariectomized rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080201
Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats. Autonomic & autacoid pharmacology 20080101
Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease. Autonomic & autacoid pharmacology 20080101
Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II. Autonomic & autacoid pharmacology 20080101
Alpha(1D)-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens: evidence obtained from knockout technology. Autonomic & autacoid pharmacology 20080101
Ma huang and alpha subtype adrenoceptors in the cat pulmonary vascular bed. Journal of dietary supplements 20080101
Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter. European journal of pharmacology 20071114
Trophic effects induced by alpha1D-adrenoceptors on endothelial cells are potentiated by hypoxia. American journal of physiology. Heart and circulatory physiology 20071001
alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats. Naunyn-Schmiedeberg's archives of pharmacology 20071001
Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat. European journal of pharmacology 20070813
Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Autonomic & autacoid pharmacology 20070701
Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus. The Journal of pharmacology and experimental therapeutics 20070601
Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes. Cardiovascular research 20070601
Identification of alpha-1L and alpha-1A adrenoceptors in human prostate by tissue segment binding. The Journal of urology 20070101
Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing. Autonomic & autacoid pharmacology 20070101
Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat. Clinical and experimental pharmacology & physiology 20070101
Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. American journal of physiology. Cell physiology 20061101
Alpha(1A/L)-adrenoceptors mediate contraction of the circular smooth muscle of the pig urethra. Autonomic & autacoid pharmacology 20061001
Selective agonists reveal alpha(1A)- and alpha(1B)-adrenoceptor subtypes in caudal artery of the young rat. Autonomic & autacoid pharmacology 20061001
Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists. Neuroscience 20060901
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes. European journal of pharmacology 20060814
Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia. European journal of pharmacology 20060814
Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors. Fundamental & clinical pharmacology 20060801
Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity. Molecular pharmacology 20060101
Captopril therapy decreases both expression and function of alpha-adrenoceptors in pre- hypertensive rat aorta. Autonomic & autacoid pharmacology 20060101
A two model receptor system of the alpha1D adrenergic receptor to describe interactions with epinephrine and BMY7378. Journal of chemical information and modeling 20060101
Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. European journal of pharmacology 20051219
Correlation between mRNA levels and functional role of alpha1-adrenoceptor subtypes in arteries: evidence of alpha1L as a functional isoform of the alpha1A-adrenoceptor. American journal of physiology. Heart and circulatory physiology 20051101
Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice. British journal of pharmacology 20051001
The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist. Autonomic & autacoid pharmacology 20051001
Chloroethylclonidine reveals that alpha (1 A)-adrenoceptors mediate contraction in aorta of alpha (1 D)-adrenoceptor knockout mice. Autonomic & autacoid pharmacology 20051001
Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery. The Journal of pharmacology and experimental therapeutics 20050801
Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland. Investigative ophthalmology & visual science 20050801
Fentanyl attenuates alpha1B-adrenoceptor-mediated pulmonary artery contraction. Anesthesiology 20050801
Postjunctional alpha1-adrenoceptors in the vasculature of the pithed mouse are of the alpha1A-subtype. Autonomic & autacoid pharmacology 20050701
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists. Journal of medicinal chemistry 20050421
1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands. Bioorganic & medicinal chemistry letters 20050215
Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta. European journal of pharmacology 20050131
Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. British journal of pharmacology 20041101
Effects of norepinephrine on alpha-subtype receptors in the feline pulmonary vascular bed. Critical care medicine 20041101
Pharmacological characterization of alpha1-adrenoceptors in mouse isolated femoral small arteries. European journal of pharmacology 20041025
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. The Journal of pharmacy and pharmacology 20041001
Different roles of alpha1-adrenoceptor subtypes in mediating cardiomyocyte protein synthesis in neonatal rats. Clinical and experimental pharmacology & physiology 20040901
Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle. Life sciences 20040806
Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane. Science in China. Series C, Life sciences 20040801
Alpha1-adrenoceptor subtype substitution in knockout mice. British journal of pharmacology 20040701
Hepatocytes from alpha1B-adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution. British journal of pharmacology 20040701
Alpha-1D adrenoceptors are involved in reserpine-induced supersensitivity of rat tail artery. British journal of pharmacology 20040601
The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British journal of pharmacology 20040601
Human alpha1D-adrenoceptor phosphorylation and desensitization. Biochemical pharmacology 20040515
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. Journal of medicinal chemistry 20040408
Evidence that alpha(1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery. European journal of pharmacology 20040319
Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries. British journal of pharmacology 20040301
alpha1A-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat. Science in China. Series C, Life sciences 20040201
The hypotensive effect of BMY 7378 involves central 5-HT1A receptor stimulation in the adult but not in the young rat. Archives of medical research 20040101
Alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contraction of pulmonary artery from pulmonary hypertensive rats. European journal of pharmacology 20031215
Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor. The Journal of urology 20031201
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes. Journal of medicinal chemistry 20030703
Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction. BJU international 20030701
Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats. European journal of pharmacology 20030620
Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens. European journal of pharmacology 20030620
Cytosolic Ca2+ and phosphoinositide hydrolysis linked to constitutively active alpha 1D-adrenoceptors in vascular smooth muscle. The Journal of pharmacology and experimental therapeutics 20030601
Interaction between neuropeptide Y Y1 receptors and alpha1B-adrenoceptors in the neurovascular junction of canine splenic arteries. European journal of pharmacology 20030418
Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. American journal of physiology. Heart and circulatory physiology 20030401
Functional alpha1-adrenergic receptor subtypes in human right gastroepiploic artery. Acta pharmacologica Sinica 20030401
Investigation of postjunctional alpha1- and alpha2-adrenoceptor subtypes in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice. British journal of pharmacology 20030301
Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery. Vascular pharmacology 20030201
Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms. Neuroscience 20030101
Pharmacological characterization of alpha1-adrenoceptor in mouse iliac artery. European journal of pharmacology 20021205
5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. European journal of pharmacology 20021004
Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. American journal of physiology. Heart and circulatory physiology 20021001
Pharmacological characterization of alpha1-adrenoceptor subtypes in the bovine tail artery. Journal of veterinary pharmacology and therapeutics 20021001
Noradrenaline-induced contraction of human saphenous vein and human internal mammary artery: involvement of different alpha-adrenoceptor subtypes. Naunyn-Schmiedeberg's archives of pharmacology 20020801
(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors. European journal of pharmacology 20020607
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes. Journal of medicinal chemistry 20020411
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes. Cardiovascular research 20020401
The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. The Journal of clinical investigation 20020315
Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries. American journal of physiology. Heart and circulatory physiology 20020201
alpha(1A)-adrenoceptors mediate sympathetically evoked pupillary dilation in rats. The Journal of pharmacology and experimental therapeutics 20020201
Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats. Naunyn-Schmiedeberg's archives of pharmacology 20020201
Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries. Japanese journal of pharmacology 20020201
Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats. British journal of pharmacology 20020101
The functional alpha-adrenoceptor in dog caudal vesical arteries is mainly an alpha1A subtype. Autonomic & autacoid pharmacology 20020101
The role of alpha1D-adrenoceptors in prostatic contraction examined using protection studies. Autonomic & autacoid pharmacology 20020101
A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity. European journal of pharmacology 20011214
Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes. The Journal of biological chemistry 20011102
Functional characterization of alpha1-adrenoceptor subtypes in human subcutaneous resistance arteries. The Journal of pharmacology and experimental therapeutics 20011101
alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta. British journal of pharmacology 20011101
Existence of alpha(1A)- and alpha(1B)-adrenoceptor subtypes in canine mandibular alveolar arteries. Clinical and experimental pharmacology & physiology 20010901
Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor. European journal of pharmacology 20010831
alpha(1D)-Adrenoceptors do not contribute to phosphoinositide hydrolysis in adult rat cardiac myocytes. Archives of biochemistry and biophysics 20010801
Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta. European journal of pharmacology 20010720
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists. The Journal of biological chemistry 20010706
Alpha1-adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR. American journal of physiology. Renal physiology 20010701
Functional characterization of alpha(1)-adrenoceptor subtypes in human skeletal muscle resistance arteries. British journal of pharmacology 20010701
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries. European journal of pharmacology 20010622
Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Japanese journal of pharmacology 20010601
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. Bioorganic & medicinal chemistry letters 20010507
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats. American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Use of antisense oligonucleotides to verify the role of the alpha(1A)-adrenergic receptor in the contractility of the rat uterus post partum. Molecular pharmacology 20010501
The role of several alpha(1)- and alpha(2)-adrenoceptor subtypes mediating vasoconstriction in the canine external carotid circulation. British journal of pharmacology 20010301
Failure of AH11110A to functionally discriminate between alpha(1)-adrenoceptor subtypes A, B and D or between alpha(1)- and alpha(2)-adrenoceptors. European journal of pharmacology 20010301
Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation. Naunyn-Schmiedeberg's archives of pharmacology 20010301
Alpha1-adrenoceptor subtypes mediating vasoconstriction in the carotid circulation of anaesthetized pigs: possible avenues for antimigraine drug development. Cephalalgia : an international journal of headache 20010301
The hypotensive effect of BMY 7378 is antagonized by a silent 5-HT(1A) receptor antagonist: comparison with 8-hydroxy-dipropylamino tetralin. Archives of medical research 20010101
Characterization of alpha1-adrenoceptor subtypes mediating noradrenaline-induced contraction of rat epididymal vas deferens in calcium-free medium. Life sciences 19990101
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. Journal of medicinal chemistry 19980409
Pharmacological characterization of recombinant human 5-hydroxytryptamine1A receptors using a novel antagonist radioligand, [3H]WAY-100635. Life sciences 19970101

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