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2086-83-1 | Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-
CAS No: 2086-83-1 Catalog No: AG002JSP MDL No:MFCD01175817
Product Description
Catalog Number:
AG002JSP
Chemical Name:
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-
CAS Number:
2086-83-1
Molecular Formula:
C20H18NO4+
Molecular Weight:
336.3612
MDL Number:
MFCD01175817
IUPAC Name:
16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
InChI:
InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
InChI Key:
YBHILYKTIRIUTE-UHFFFAOYSA-N
SMILES:
COc1c(OC)ccc2c1c[n+]1CCc3c(c1c2)cc1c(c3)OCO1
EC Number:
218-229-1
UNII:
0I8Y3P32UF
Properties
Complexity:
488
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
336.124g/mol
Formal Charge:
1
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
336.367g/mol
Monoisotopic Mass:
336.124g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
40.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6
Literature
| Title | Journal |
|---|---|
| The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins. | Chemico-biological interactions 20180925 |
| Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes. | Toxicology letters 20180901 |
| Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR-γ and subsequent expression of HGF in colons. | Toxicology and applied pharmacology 20180315 |
| Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101 |
| Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801 |
| Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice. | Chemico-biological interactions 20170425 |
| Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. | Toxicology and applied pharmacology 20170201 |
| Berberine acts as a putative epigenetic modulator by affecting the histone code. | Toxicology in vitro : an international journal published in association with BIBRA 20161001 |
| Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. | Toxicology and applied pharmacology 20160115 |
| Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/β-catenin signaling pathway. | Toxicology letters 20160105 |
| Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). | Chemico-biological interactions 20151005 |
| The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats. | Metabolic brain disease 20150801 |
| (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling. | Psychopharmacology 20150301 |
| Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141201 |
| Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line. | Chemico-biological interactions 20141105 |
| The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140701 |
| Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20140601 |
| Structural optimization of berberine as a synergist to restore antifungal activity of fluconazole against drug-resistant Candida albicans. | ChemMedChem 20140101 |
| Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. | Toxicology and applied pharmacology 20131101 |
| Mechanism study of goldenseal-associated DNA damage. | Toxicology letters 20130731 |
| Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: a biphasic experimental study. | Toxicology letters 20130523 |
| Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes. | Reproductive toxicology (Elmsford, N.Y.) 20130401 |
| Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. | Aging 20121201 |
| Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats. | Journal of ethnopharmacology 20121121 |
| Berberine: new perspectives for old remedies. | Biochemical pharmacology 20121115 |
| Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. | Bioorganic & medicinal chemistry letters 20121115 |
| Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. | Molecular and cellular endocrinology 20121105 |
| Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell. | European journal of pharmacology 20121105 |
| Interaction mechanism between berberine and the enzyme lysozyme. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101 |
| Radiosensitization effects of berberine on human breast cancer cells. | International journal of molecular medicine 20121101 |
| On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis. | Analytical and bioanalytical chemistry 20121101 |
| Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy. | Analytica chimica acta 20121017 |
| Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa. | Journal of molecular biology 20121012 |
| Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling. | Biochemical and biophysical research communications 20121005 |
| Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region. | The pharmacogenomics journal 20121001 |
| Electrochemical oxidation of berberine and mass spectrometric identification of its oxidation products. | Bioelectrochemistry (Amsterdam, Netherlands) 20121001 |
| Simultaneous quantification of berberine and lysergol by HPLC-UV: evidence that lysergol enhances the oral bioavailability of berberine in rats. | Biomedical chromatography : BMC 20121001 |
| An isoquinoline alkaloid, berberine, can inhibit fungal alpha amylase: enzyme kinetic and molecular modeling studies. | Chemical biology & drug design 20121001 |
| Possible therapeutic potential of berberine in diabetic osteopathy. | Medical hypotheses 20121001 |
| Increased serotonergic neurotransmission is not responsible for the anticompulsive effect of berberine in a murine model of obsessive-compulsive disorder. | Behavioural pharmacology 20121001 |
| Use of a lipid-lowering food supplement in patients on hormone therapy following breast cancer. | Minerva ginecologica 20121001 |
| The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase. | Journal of ethnopharmacology 20120928 |
| Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via Akt pathway modulation. | Journal of agricultural and food chemistry 20120926 |
| Synthesis and cytotoxicity evaluation of 13-n-alkyl berberine and palmatine analogues as anticancer agents. | Molecules (Basel, Switzerland) 20120925 |
| Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages. | European journal of pharmacology 20120905 |
| Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase. | Phytotherapy research : PTR 20120901 |
| Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120901 |
| Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). | Planta medica 20120901 |
| Combining human periodontal ligament cell membrane chromatography with online HPLC/MS for screening osteoplastic active compounds from Coptidis Rhizoma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901 |
| Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA). | Molecules (Basel, Switzerland) 20120829 |
| Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules. | Analytical chemistry 20120821 |
| Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815 |
| Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection. | Analytica chimica acta 20120806 |
| The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. | European journal of pharmacology 20120805 |
| Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic action. | Endocrinology 20120801 |
| Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana. | Plant molecular biology 20120801 |
| Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine. | Pharmaceutical biology 20120801 |
| Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. | Bioorganic & medicinal chemistry letters 20120715 |
| Lipid-lowering effect of berberine in human subjects and rats. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120715 |
| Berberine acutely inhibits the digestion of maltose in the intestine. | Journal of ethnopharmacology 20120713 |
| Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-α in breast cancer cells. | The Journal of surgical research 20120701 |
| Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. | International journal of oncology 20120701 |
| Design, synthesis and multidrug resistance reversal activity evaluation of 8-oxocoptisine derivatives. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701 |
| Structural studies on ligand-DNA systems: A robust approach in drug design. | Journal of biosciences 20120701 |
| Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells. | Journal of proteomics 20120618 |
| Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120615 |
| Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA. | ACS chemical biology 20120615 |
| Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines. | Journal of chromatography. A 20120615 |
| Berberine ameliorates pro-inflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitro. | Inflammation 20120601 |
| Synthesis, structure-activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives. | European journal of medicinal chemistry 20120601 |
| Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. | Mutation research 20120601 |
| Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis. | Immunopharmacology and immunotoxicology 20120601 |
| A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study. | Bioanalysis 20120601 |
| Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids. | Archives of pharmacal research 20120601 |
| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
| Straightforward preparation of organic colloidal particles by harnessing spontaneous non-covalent interactions of active molecules from natural origin. | Journal of colloid and interface science 20120515 |
| Berberine-induced haemolysis revisited: safety of Rhizoma coptidis and Cortex phellodendri in chronic haematological diseases. | Phytotherapy research : PTR 20120501 |
| Drug-drug interactions between ketoconazole and berberine in rats: pharmacokinetic effects benefit pharmacodynamic synergism. | Phytotherapy research : PTR 20120501 |
| Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. | Clinical and experimental pharmacology & physiology 20120501 |
| Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. | Atherosclerosis 20120501 |
| Effects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with the metabolic syndrome. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20120501 |
| A combination of metabolomics and metallomics studies of urine and serum from hypercholesterolaemic rats after berberine injection. | Analytical and bioanalytical chemistry 20120501 |
| Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids. | Bioorganic & medicinal chemistry 20120501 |
| Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx. | Acta pharmacologica Sinica 20120501 |
| Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor-α. | Investigative ophthalmology & visual science 20120430 |
| Simultaneous fluorescence light-up and selective multicolor nucleobase recognition based on sequence-dependent strong binding of berberine to DNA abasic site. | Organic & biomolecular chemistry 20120428 |
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. | Bioorganic & medicinal chemistry letters 20120415 |
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. | Bioorganic & medicinal chemistry 20120415 |
| Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system. | Journal of medicinal food 20120401 |
| Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway. | Cancer science 20120401 |
| Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate. | Biopharmaceutics & drug disposition 20120401 |
| Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. | Diabetes 20120401 |
| CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines. | Acta pharmacologica Sinica 20120401 |
| Antidiabetic properties of berberine: from cellular pharmacology to clinical effects. | Hospital practice (1995) 20120401 |
| [Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401 |
| High-performance liquid chromatography-electrospray ionization-mass spectrometry ligand fishing assay: a method for screening triplex DNA binders from natural plant extracts. | Analytical chemistry 20120306 |
| Modulations of cytochrome P450 expression in diabetic mice by berberine. | Chemico-biological interactions 20120305 |
| Molecular characterization, recombinant expression in Escherichia coli and biological activity of (S)-Tetrahydroberberine oxidase from Corydalis saxicola Bunt. | Molecular biology reports 20120301 |
| Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120301 |
| Protective effect of berberine on serum glucose levels in non-obese diabetic mice. | International immunopharmacology 20120301 |
| Chiral HPLC determination and stereoselective pharmacokinetics of tetrahydroberberine enantiomers in rats. | Chirality 20120301 |
| Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. | The Journal of pharmacy and pharmacology 20120301 |
| Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1. | Yonsei medical journal 20120301 |
| Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines. | The journal of obstetrics and gynaecology research 20120301 |
| Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method. | Journal of pharmaceutical and biomedical analysis 20120223 |
| Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding. | The journal of physical chemistry. B 20120223 |
| Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215 |
| Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin. | Bioorganic & medicinal chemistry letters 20120215 |
| The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine. | Phytotherapy research : PTR 20120201 |
| Repeated administration of berberine inhibits cytochromes P450 in humans. | European journal of clinical pharmacology 20120201 |
| Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. | Biochimica et biophysica acta 20120201 |
| Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase-9 activity following transient global cerebral ischemia. | Journal of neuroscience research 20120201 |
| COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120201 |
| Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption. | Drug metabolism and disposition: the biological fate of chemicals 20120201 |
| Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. | Biochemical pharmacology 20120201 |
| [Intestinal absorption of berberine alone and in combinations by rats single pass intestinal perfusion in situ]. | Yao xue xue bao = Acta pharmaceutica Sinica 20120201 |
| PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. | European journal of pharmacology 20120115 |
| Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells. | Journal of natural medicines 20120101 |
| Effect of berberine on p53 expression by TPA in breast cancer cells. | Oncology reports 20120101 |
| Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice. | Planta medica 20120101 |
| Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism? | Medical hypotheses 20120101 |
| A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. | European journal of endocrinology 20120101 |
| Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes. | International immunopharmacology 20120101 |
| Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators. | Drug and chemical toxicology 20120101 |
| Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia. | International immunopharmacology 20120101 |
| Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101 |
| Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine. | Journal of biomedical science 20120101 |
| Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease. | TheScientificWorldJournal 20120101 |
| The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene. | PloS one 20120101 |
| G-quadruplex binding ligands: from naturally occurring to rationally designed molecules. | Current pharmaceutical design 20120101 |
| Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings. | The American journal of Chinese medicine 20120101 |
| Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. | PloS one 20120101 |
| Biophysical characterization of the strong stabilization of the RNA triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) alkyl ether berberine analogs. | PloS one 20120101 |
| Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. | Biological & pharmaceutical bulletin 20120101 |
| Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice. | Biological & pharmaceutical bulletin 20120101 |
| Formation and conformation of baicalin-berberine and wogonoside-berberine complexes. | Chemical & pharmaceutical bulletin 20120101 |
| [Preparation and stuctural behavior of the inclusion complex of beta-cyclodextrin and coptisine hydrochloride]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120101 |
| [Chemical constituents from Corydalis yanhusuo]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101 |
| The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet. | Lipids in health and disease 20120101 |
| Berberine inhibits growth and induces G1 arrest and apoptosis in human cholangiocarcinoma QBC939 cells. | Journal of pharmacological sciences 20120101 |
| Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. | PloS one 20120101 |
| Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment. | Lipids in health and disease 20120101 |
| Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. | Pharmacological reports : PR 20120101 |
| [Berberine activates volume-sensitive chloride channel in human colorectal carcinoma cells]. | Sheng li xue bao : [Acta physiologica Sinica] 20111225 |
| Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography-electrospray ionization-mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20111215 |
| Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line. | Medical oncology (Northwood, London, England) 20111201 |
| Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. | Inflammation 20111201 |
| Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. | Biotechnology and bioengineering 20111201 |
| Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription. | Fitoterapia 20111201 |
| Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner. | International immunopharmacology 20111201 |
| CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds. | Drug metabolism and disposition: the biological fate of chemicals 20111201 |
| Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation. | European journal of medicinal chemistry 20111201 |
| Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells. | Bioorganic & medicinal chemistry letters 20111201 |
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. | Bioorganic & medicinal chemistry 20111201 |
| Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. | Advances in therapy 20111201 |
| [Effect of berberine on expression of transforming growth factor-beta1 and type IV collagen proteins in mesangial cells of diabetic rats with nephropathy]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201 |
| [Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201 |
| [Effect of different compatibility of Wuji Wan on bile excretion of representative ingredient]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201 |
| Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients. | Molecules (Basel, Switzerland) 20111103 |
| Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. | Medicinal research reviews 20111101 |
| Novel mitochondria-targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatine. | Pharmaceutical research 20111101 |
| Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis). | International immunopharmacology 20111101 |
| CYP2D plays a major role in berberine metabolism in liver of mice and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20111101 |
| Berberine inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-κB pathway in mast cells. | International immunopharmacology 20111101 |
| Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms. | Acta pharmacologica Sinica 20111101 |
| Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography. | Journal of separation science 20111101 |
| Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy. | PLoS neglected tropical diseases 20111101 |
| [Research on therapeutic effect and hemorrheology change of berberine in new diagnosed patients with type 2 diabetes combining nonalcoholic fatty liver disease]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101 |
| Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine. | Mini reviews in medicinal chemistry 20111101 |
| [Effect of enhanced UV-B radiation on metabolism and berberine content of Coptis chinensis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101 |
| Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. | Journal of ethnopharmacology 20111031 |
| Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma coptidis alkaloids. | Journal of ethnopharmacology 20111031 |
| Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver. | European journal of pharmacology 20111015 |
| Protective effect of berberine on expression pattern of apoptotic, cell proliferative, inflammatory and angiogenic markers during 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. | Pakistan journal of biological sciences : PJBS 20111015 |
| Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. | Fitoterapia 20111001 |
| Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle. | Bioorganic & medicinal chemistry 20111001 |
| [Effects of berberine on the pancreatic beta cell apoptosis in rats with insulin resistance]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20111001 |
| [Correlation analysis soil nutrition as sell as yield and active compounds of Coptis teeta]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001 |
| [Study on effect of berberine on modulating lipid and CPT I A gene expression]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001 |
| [Extract berberine hydrochloride by aqueous two-phase system]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111001 |
| Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110918 |
| Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway. | Molecular and cellular biochemistry 20110901 |
| Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. | Fitoterapia 20110901 |
| Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Micelle to solvent stacking of two alkaloids in nonaqueous capillary electrophoresis. | Journal of chromatography. A 20110826 |
| Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway. | Journal of agricultural and food chemistry 20110810 |
| Berberine: a potential multipotent natural product to combat Alzheimer's disease. | Molecules (Basel, Switzerland) 20110809 |
| Determination of ethambutol by a sensitive fluorescent probe. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110801 |
| The effects of jatrorrhizine on contractile responses of rat ileum. | European journal of pharmacology 20110801 |
| Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice. | Journal of agricultural and food chemistry 20110727 |
| Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). | Journal of natural products 20110722 |
| Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids. | Talanta 20110715 |
| Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells. | Neuroscience letters 20110712 |
| Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. | Cancer science 20110701 |
| Antitumor effects of the combination of cholesterol reducing drugs. | Oncology reports 20110701 |
| Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. | Anti-cancer drugs 20110701 |
| Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells. | European journal of pharmacology 20110701 |
| Berberine acutely activates the glucose transport activity of GLUT1. | Biochimie 20110701 |
| Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica. | Plant & cell physiology 20110701 |
| Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats. | European journal of pharmacology 20110625 |
| Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. | FEBS letters 20110623 |
| Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. | Behavioural brain research 20110620 |
| Identification of novel pregnane X receptor activators from traditional Chinese medicines. | Journal of ethnopharmacology 20110614 |
| Effect of berberine and Berberis aetnensis C. Presl. alkaloid extract on glutamate-evoked tissue transglutaminase up-regulation in astroglial cell cultures. | Phytotherapy research : PTR 20110601 |
| Protective effects of berberine in an experimental rat osteoarthritis model. | Phytotherapy research : PTR 20110601 |
| In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures. | Archives of oral biology 20110601 |
| Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells. | Fitoterapia 20110601 |
| Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia. | The Journal of infectious diseases 20110601 |
| Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats. | AAPS PharmSciTech 20110601 |
| Effects of cinnamon granules on pharmacokinetics of berberine in Rhizoma Coptidis granules in healthy male volunteers. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601 |
| [Quantitative analysis of four alkaloids in Xianglian preparations by QAMS method]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601 |
| Recognition of molecularly imprinted polymers for a quaternary alkaloid of berberine. | Talanta 20110530 |
| Fluorescence detection by intensity changes for high-performance thin-layer chromatography separation of lipids using automated multiple development. | Journal of chromatography. A 20110513 |
| X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG). | Chemical communications (Cambridge, England) 20110507 |
| l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. | Synapse (New York, N.Y.) 20110501 |
| Oxidative damage and antioxidant responses in Microcystis aeruginosa exposed to the allelochemical berberine isolated from golden thread. | Journal of plant physiology 20110501 |
| Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit. | International journal of food sciences and nutrition 20110501 |
| Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition. | Planta medica 20110501 |
| Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene. | European journal of medicinal chemistry 20110501 |
| Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93Å and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine. | Biochimica et biophysica acta 20110501 |
| Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. | Bioorganic & medicinal chemistry letters 20110501 |
| Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. | Nutrition research (New York, N.Y.) 20110501 |
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. | Journal of natural products 20110425 |
| Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists. | Toxicology and applied pharmacology 20110415 |
| Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes. | Biochimica et biophysica acta 20110401 |
| Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat. | Fitoterapia 20110401 |
| Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes. | Pharmacological research 20110401 |
| Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma. | Journal of natural medicines 20110401 |
| Casparian bands occur in the periderm of Pelargonium hortorum stem and root. | Annals of botany 20110401 |
| Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. | Biochimica et biophysica acta 20110401 |
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. | European journal of medicinal chemistry 20110401 |
| Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. | Xenobiotica; the fate of foreign compounds in biological systems 20110401 |
| Vacuole-localized berberine bridge enzyme-like proteins are required for a late step of nicotine biosynthesis in tobacco. | Plant physiology 20110401 |
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. | Bioorganic & medicinal chemistry 20110401 |
| Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS. | Advances in dental research 20110401 |
| Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions. | Chinese medical journal 20110401 |
| [The synergistic antitumor effects of berberine alpha-hydroxy-beta-decanoylethyl sulfonate with hydroxycamptothecine and its effect on topoisomerase]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110401 |
| Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. | European journal of pharmacology 20110311 |
| Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. | Fitoterapia 20110301 |
| Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-[kappa]B[alpha] phosphorylation and apoptosis in mice. | Shock (Augusta, Ga.) 20110301 |
| Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. | American journal of physiology. Regulatory, integrative and comparative physiology 20110301 |
| A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity. | Journal of biomolecular screening 20110301 |
| Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. | Chinese journal of integrative medicine 20110301 |
| [Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose diet]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110301 |
| Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. | Toxicology 20110204 |
| Thousand fold concentration of an alkaloid in capillary zone electrophoresis by micelle to solvent stacking. | Journal of chromatography. A 20110204 |
| Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats. | Metabolism: clinical and experimental 20110201 |
| The protective effect of berberine on β-cell lipoapoptosis. | Journal of endocrinological investigation 20110201 |
| Berberine protects C57BL/6J mice against ethanol withdrawal-induced hyperexcitability. | Phytotherapy research : PTR 20110201 |
| Enhanced DNA binding of 9-ω-amino alkyl ether analogs from the plant alkaloid berberine. | DNA and cell biology 20110201 |
| Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. | International journal of oncology 20110201 |
| Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle. | Toxicologic pathology 20110201 |
| [Antidiabetic activity of berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats]. | Georgian medical news 20110201 |
| [Changes of metabolic indices caused by berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats]. | Georgian medical news 20110201 |
| Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid. | European journal of pharmacology 20110125 |
| Antiurolithic effect of berberine is mediated through multiple pathways. | European journal of pharmacology 20110125 |
| Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. | International journal of cardiology 20110121 |
| Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells. | European journal of pharmacology 20110115 |
| Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathway. | Molecular and cellular endocrinology 20110101 |
| Antidiarrheal activity, chemical and toxicity profile of Berberis aristata. | Pharmaceutical biology 20110101 |
| Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro. | Fertility and sterility 20110101 |
| Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101 |
| Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors. | Carcinogenesis 20110101 |
| Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. | Molecular carcinogenesis 20110101 |
| The effect of coptis chinensis on the signaling network in the squamous carcinoma cells. | Frontiers in bioscience (Elite edition) 20110101 |
| Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. | Journal of Alzheimer's disease : JAD 20110101 |
| Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. | PloS one 20110101 |
| Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. | PloS one 20110101 |
| Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. | PloS one 20110101 |
| Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. | Molecular cancer 20110101 |
| Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver x receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters. | Biological & pharmaceutical bulletin 20110101 |
| Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. | Journal of translational medicine 20110101 |
| Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes. | International journal of biological sciences 20110101 |
| Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway. | Endocrine journal 20110101 |
| Modulating gut microbiota as an anti-diabetic mechanism of berberine. | Medical science monitor : international medical journal of experimental and clinical research 20110101 |
| Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes. | PloS one 20110101 |
| Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. | PloS one 20110101 |
| Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box. | PloS one 20110101 |
| Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice. | PloS one 20110101 |
| Berberine hydrochloride: anticancer activity and nanoparticulate delivery system. | International journal of nanomedicine 20110101 |
| Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. | PloS one 20110101 |
| Berberine attenuates doxorubicin-induced cardiotoxicity in mice. | The Journal of international medical research 20110101 |
| Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells. | BMC neuroscience 20110101 |
| Protein kinase D activation stimulates the transcription of the insulin receptor gene. | Molecular and cellular endocrinology 20101215 |
| Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. | Journal of cellular biochemistry 20101215 |
| Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease. | Neuroscience letters 20101203 |
| Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells. | Phytotherapy research : PTR 20101201 |
| Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San. | Archives of virology 20101201 |
| Inhibitory effect of berberine on the motivational effects of ethanol in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20101201 |
| Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta. | Neuropharmacology 20101201 |
| Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation. | European journal of pharmacology 20101201 |
| Targeting metabolic syndrome: candidate natural agents. | Journal of diabetes 20101201 |
| TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling. | Journal of cell science 20101201 |
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. | Bioorganic & medicinal chemistry letters 20101115 |
| Synthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives. | Bioorganic & medicinal chemistry letters 20101115 |
| Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. | Journal of pharmaceutical and biomedical analysis 20101102 |
| Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20101101 |
| Berberine-induced activation of 5'-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles. | Metabolism: clinical and experimental 20101101 |
| Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats. | Planta medica 20101101 |
| Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | Archives of biochemistry and biophysics 20101015 |
| Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis. | Planta medica 20101001 |
| Anti-clastogenic effect of berberine against DMBA-induced clastogenesis. | Basic & clinical pharmacology & toxicology 20101001 |
| Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis. | Fitoterapia 20101001 |
| The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells. | Cellular signalling 20101001 |
| Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
| [Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001 |
| [Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001 |
| A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. | Chemical communications (Cambridge, England) 20100921 |
| Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages. | Journal of cellular biochemistry 20100901 |
| Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction. | Toxicology in vitro : an international journal published in association with BIBRA 20100901 |
| Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. | Bioorganic & medicinal chemistry 20100901 |
| Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery. | AAPS PharmSciTech 20100901 |
| [Synthesis and structure-activity relationship of 13-hexylberberine analogues as CD36 antagonists]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100901 |
| 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models. | Bioorganic & medicinal chemistry 20100815 |
| Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells. | Planta medica 20100801 |
| Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. | Diabetes 20100801 |
| Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine. | Journal of immunology (Baltimore, Md. : 1950) 20100801 |
| Effects of berberine against radiation-induced intestinal injury in mice. | International journal of radiation oncology, biology, physics 20100801 |
| Identification of berberine as a novel agonist of fatty acid receptor GPR40. | Phytotherapy research : PTR 20100801 |
| [Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801 |
| Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury. | European journal of pharmacology 20100725 |
| Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721 |
| Berberine inhibits PTP1B activity and mimics insulin action. | Biochemical and biophysical research communications 20100702 |
| Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. | Fitoterapia 20100701 |
| The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells. | Cell stress & chaperones 20100701 |
| Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. | Epilepsy & behavior : E&B 20100701 |
| [Simultaneous determination of berberine, palmatine, matrine, catechin and baicalin in Funing Shuan by micellar electrokinetic capillary chromatography-electrospray ionization mass spectrometry]. | Se pu = Chinese journal of chromatography 20100701 |
| Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. | Bioorganic & medicinal chemistry 20100615 |
| L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. | Neurobiology of aging 20100601 |
| Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation. | Fitoterapia 20100601 |
| The mechanisms of ROS-photogeneration by berberine, a natural isoquinoline alkaloid. | Journal of photochemistry and photobiology. B, Biology 20100601 |
| Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia. | Journal of cellular biochemistry 20100601 |
| [Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100601 |
| [Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100601 |
| Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. | Talanta 20100515 |
| Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells. | Journal of ethnopharmacology 20100504 |
| The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501 |
| Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. | Journal of bone and mineral metabolism 20100501 |
| Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. | Acta pharmacologica Sinica 20100501 |
| Berberine modulates insulin signaling transduction in insulin-resistant cells. | Molecular and cellular endocrinology 20100412 |
| Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. | Biochemical pharmacology 20100401 |
| Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. | Naunyn-Schmiedeberg's archives of pharmacology 20100401 |
| Advance of studies on anti-atherosclerosis mechanism of berberine. | Chinese journal of integrative medicine 20100401 |
| Effect of Huang-Lian-Jie-Du-Decoction on pharmacokinetics of verapamil in rats. | The Journal of pharmacy and pharmacology 20100401 |
| [Simultaneous determination of the five alkaloids in Rhizoma Coptidis by nonaqueous capillary electrophoresis]. | Se pu = Chinese journal of chromatography 20100401 |
| Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. | Atherosclerosis 20100301 |
| Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. | Phytotherapy research : PTR 20100301 |
| Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours. | Current drug discovery technologies 20100301 |
| Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine. | AAPS PharmSciTech 20100301 |
| Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages. | Canadian journal of physiology and pharmacology 20100301 |
| [In situ intestinal absorption kinetics of berberine and jatrorrhizine from extractive Rhizoma Coptidis in rats]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301 |
| [Studies on NACE-DAD fingerprint of Cortex Phellodendri]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100301 |
| Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. | Journal of ethnopharmacology 20100217 |
| Microcalorimetric and spectrographic studies on the interaction of DNA with betaxolol. | International journal of pharmaceutics 20100215 |
| Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. | Metabolism: clinical and experimental 20100201 |
| In vitro antifungal activity of the berberine and its synergism with fluconazole. | Antonie van Leeuwenhoek 20100201 |
| Transcriptional profile of the Shigella flexneri response to an alkaloid: berberine. | FEMS microbiology letters 20100201 |
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. | Bioorganic & medicinal chemistry 20100201 |
| CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity. | Acta pharmacologica Sinica 20100201 |
| [Controlling effect of berberine on in vitro synthesis and metabolism of steroid hormones in insulin resistant ovary]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100201 |
| [Comparison of pharmacokinetics about ermiao capsules and ermiao pellet]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201 |
| The application of digital image recognition to the analysis of two-dimensional fingerprints. | Analytica chimica acta 20100111 |
| Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. | Mutation research 20100105 |
| A new benzylisoquinoline alkaloid from Argemone mexicana. | Natural product research 20100101 |
| Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. | PloS one 20100101 |
| [Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101 |
| [Effects of four components of Rhizoma Corydalis on anoxia and peroxidation injuries in neonatal cardiomyocytes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101 |
| Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine. | Biological & pharmaceutical bulletin 20100101 |
| Rhizoma Coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway. | Mediators of inflammation 20100101 |
| Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs. | Endocrine journal 20100101 |
| [Hypoglycemic activity of berberin and extract obtained from the bark of Phellodendron lavalei, introduced in sub tropic areas of Georgia]. | Georgian medical news 20100101 |
| Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. | Biological & pharmaceutical bulletin 20100101 |
| Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | International journal of biological sciences 20100101 |
| Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. | PloS one 20100101 |
| Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. | PloS one 20100101 |
| Redox regulation of the AMP-activated protein kinase. | PloS one 20100101 |
| High-performance thin layer chromatography for quality control of multicomponent herbal drugs: example of cangzhu xianglian san. | Journal of AOAC International 20100101 |
| Enantioselective total synthesis of (-)-(S)-stepholidine. | The Journal of organic chemistry 20091204 |
| Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease. | Medical hypotheses 20091201 |
| Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201 |
| RNA-binding potential of protoberberine alkaloids: spectroscopic and calorimetric studies on the binding of berberine, palmatine, and coralyne to protonated RNA structures. | DNA and cell biology 20091201 |
| Berberine improves free-fatty-acid-induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator-activated receptor gamma and fatty acid transferase expressions. | Metabolism: clinical and experimental 20091201 |
| Matrix-free thin-layer chromatography/laser desorption ionization mass spectrometry for facile separation and identification of medicinal alkaloids. | Rapid communications in mass spectrometry : RCM 20091201 |
| Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats. | Journal of pharmaceutical sciences 20091101 |
| Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp. | Phytotherapy research : PTR 20091101 |
| D(1)/D(2) receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice. | Pharmacology, biochemistry, and behavior 20091101 |
| Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. | Schizophrenia research 20091101 |
| Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation. | Journal of proteome research 20091101 |
| Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D(1) and antagonist at D(2) receptors, in rats. | British journal of pharmacology 20091101 |
| Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. | Bioorganic & medicinal chemistry letters 20091101 |
| [8-hydroxy-dihydroberberine ameliorated insulin resistance induced by high FFA and high glucose in 3T3-L1 adipocytes]. | Yao xue xue bao = Acta pharmaceutica Sinica 20091101 |
| Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. | The Journal of biological chemistry 20091016 |
| Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin. | European journal of pharmacology 20091012 |
| Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. | The Journal of biological chemistry 20091009 |
| Interaction of isoquinoline alkaloids with an RNA triplex: structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)(*)poly(U). | The journal of physical chemistry. B 20091008 |
| Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567. | The Journal of biological chemistry 20091002 |
| Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis. | Journal of applied microbiology 20091001 |
| Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine. | Journal of enzyme inhibition and medicinal chemistry 20091001 |
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. | Bioorganic & medicinal chemistry letters 20091001 |
| Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901 |
| Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter. | Journal of plant physiology 20090901 |
| Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901 |
| [Effects of extracts and active components of Rhizoma Coptidis on contraction of circular smooth muscle isolated from guinea pig gastric antrum]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901 |
| Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatography. | Biomedical chromatography : BMC 20090801 |
| Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. | Endocrinology 20090801 |
| The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells. | Journal of cellular biochemistry 20090801 |
| Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage. | Cell research 20090801 |
| [Study on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase in vitro]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090801 |
| The examination of berberine excited state by laser flash photolysis. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090715 |
| Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. | Cancer letters 20090708 |
| Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. | Journal of ethnopharmacology 20090706 |
| Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. | The Journal of pharmacy and pharmacology 20090701 |
| [Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090701 |
| Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats. | Regulatory peptides 20090605 |
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. | Bioorganic & medicinal chemistry 20090601 |
| Berberine reduces the hypoxic-ischemic insult in rat pup brain. | Acta physiologica Hungarica 20090601 |
| Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. | Saudi medical journal 20090601 |
| Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition. | Molecular and cellular biochemistry 20090501 |
| Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum. | Journal of pharmaceutical and biomedical analysis 20090501 |
| Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC. | Journal of separation science 20090501 |
| [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501 |
| Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats. | World journal of gastroenterology 20090428 |
| Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. | The Prostate 20090401 |
| Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. | American journal of physiology. Endocrinology and metabolism 20090401 |
| Berberine suppresses proinflammatory responses through AMPK activation in macrophages. | American journal of physiology. Endocrinology and metabolism 20090401 |
| Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090401 |
| [Study on vitro release and transdermal behaviors of Yulian cataplasm]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090401 |
| Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. | European journal of pharmacology 20090315 |
| Two-stage culture for producing berberine by cell suspension and shoot cultures of Berberis buxifolia Lam. | Biotechnology letters 20090301 |
| [Effect of berberine on the differentiation and apoptosis of K562 cell line]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301 |
| Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. | Chemico-biological interactions 20090212 |
| Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. | The Journal of endocrinology 20090201 |
| Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells. | Journal of molecular and cellular cardiology 20090201 |
| Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods. | Biochimie 20090201 |
| [Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201 |
| [Studies on the chemical constituents of Phellodendron chinense]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090201 |
| Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides. | The journal of physical chemistry. B 20090129 |
| Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors. | Brain research 20090123 |
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. | Journal of medicinal chemistry 20090122 |
| Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. | Metabolism: clinical and experimental 20090101 |
| Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. | Biological & pharmaceutical bulletin 20090101 |
| New alkaloids from Corydalis species. | Natural product research 20090101 |
| Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine. | Journal of gastroenterology 20090101 |
| [Drug discovery based on classic natural products]. | Yao xue xue bao = Acta pharmaceutica Sinica 20090101 |
| [Study on traditional Chinese medicine extracts of rhizoma coptidis by FTIR spectroscopy]. | Guang pu xue yu guang pu fen xi = Guang pu 20090101 |
| Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. | Journal of Asian natural products research 20090101 |
| Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives. | Journal of Asian natural products research 20090101 |
| Development of a rapid resolution liquid chromatographic method for simultaneous analysis of four alkaloids in Rhizoma coptidis under different cultivation conditions. | Journal of AOAC International 20090101 |
| Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. | Phytochemical analysis : PCA 20090101 |
| Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes. | Free radical research 20090101 |
| Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells. | Immunopharmacology and immunotoxicology 20090101 |
| Neuroprotective effects of berberine on stroke models in vitro and in vivo. | Neuroscience letters 20081205 |
| Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. | Molecules (Basel, Switzerland) 20081203 |
| Berberine decreases PCSK9 expression in HepG2 cells. | Atherosclerosis 20081201 |
| Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20081201 |
| LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine. | Biomedical chromatography : BMC 20081201 |
| Covalent bonding of azoles to quaternary protoberberine alkaloids. | Magnetic resonance in chemistry : MRC 20081201 |
| DNA-binding cytotoxic alkaloids: comparative study of the energetics of binding of berberine, palmatine, and coralyne. | DNA and cell biology 20081201 |
| A concerted mechanism for berberine bridge enzyme. | Nature chemical biology 20081201 |
| [Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201 |
| Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. | Chinese medical journal 20081105 |
| Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101 |
| Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats. | Atherosclerosis 20081101 |
| Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion. | Phytotherapy research : PTR 20081101 |
| Isolation and identification of urinary metabolites of berberine in rats and humans. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
| Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells. | Bioscience, biotechnology, and biochemistry 20081101 |
| [Five alkaloids from vine stems of Diploclisia affinis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101 |
| [Effects of berberine on cell proliferation, peroxisome proliferation activated receptor gamma, CAAT/enhancer binding protein mRNA and protein expression in 3T3-L1 pre-adipocytes]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081101 |
| [Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101 |
| Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity. | World journal of gastroenterology 20081021 |
| Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. | The Journal of biological chemistry 20080926 |
| Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. | Journal of ethnopharmacology 20080902 |
| Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway. | Endocrinology 20080901 |
| Induced ion currents and the endothelin pathway as targets for anti-arrhythmic agents. | Current opinion in investigational drugs (London, England : 2000) 20080901 |
| [Advance on study in anti-atherosclerosis mechanism of berberine]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901 |
| [Effects of berberine on expression of hepatocyte nuclear factor 4alpha and glucokinase activity in mouse primary hepatocytes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901 |
| Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells. | European journal of pharmacology 20080820 |
| Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. | Bioorganic & medicinal chemistry letters 20080815 |
| QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. | Biochemistry 20080805 |
| The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist. | Psychopharmacology 20080801 |
| Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. | Phytotherapy research : PTR 20080801 |
| Combination of simvastatin with berberine improves the lipid-lowering efficacy. | Metabolism: clinical and experimental 20080801 |
| Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. | The Journal of pharmacy and pharmacology 20080801 |
| [Advances in the study of berberine and its derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080801 |
| On the mechanism of antidepressant-like action of berberine chloride. | European journal of pharmacology 20080728 |
| Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula. | Journal of ethnopharmacology 20080723 |
| Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose. | Archives of biochemistry and biophysics 20080715 |
| Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. | The Journal of clinical endocrinology and metabolism 20080701 |
| Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. | Cancer research 20080701 |
| [Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient]. | Ying yong sheng tai xue bao = The journal of applied ecology 20080701 |
| [Study on self-microemulsifying drug delivery system of Jiaotai Pill active components]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701 |
| Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction. | Cellular and molecular neurobiology 20080601 |
| Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity. | Journal of human hypertension 20080601 |
| Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. | Biological & pharmaceutical bulletin 20080601 |
| Traditional chinese medicine in treatment of metabolic syndrome. | Endocrine, metabolic & immune disorders drug targets 20080601 |
| Effect of berberine on expression of hepatocyte nuclear factor-4alpha in rats with fructose-induced insulin resistance. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601 |
| Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. | Endocrine 20080601 |
| Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. | Toxicology and applied pharmacology 20080515 |
| Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. | Cancer chemotherapy and pharmacology 20080501 |
| Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20080501 |
| Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism. | Clinical and experimental pharmacology & physiology 20080501 |
| Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. | Diabetes 20080501 |
| Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice. | Shock (Augusta, Ga.) 20080501 |
| Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. | Acta pharmacologica Sinica 20080501 |
| Efficacy of berberine in patients with type 2 diabetes mellitus. | Metabolism: clinical and experimental 20080501 |
| Berberine, a natural product, combined with cisplatin enhanced apoptosis through a mitochondria/caspase-mediated pathway in HeLa cells. | Biological & pharmaceutical bulletin 20080501 |
| Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats. | Die Pharmazie 20080501 |
| [Absorption of extractive Rhizoma Coptidis in rat everted gut scas]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501 |
| Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. | Chinese medical journal 20080420 |
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. | Bioorganic & medicinal chemistry 20080401 |
| Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. | Biological & pharmaceutical bulletin 20080401 |
| Berberine targets assembly of Escherichia coli cell division protein FtsZ. | Biochemistry 20080311 |
| Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. | Journal of mass spectrometry : JMS 20080301 |
| Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. | Clinical and experimental pharmacology & physiology 20080301 |
| Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301 |
| Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response. | International journal of molecular medicine 20080301 |
| [Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080301 |
| [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080301 |
| Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. | World journal of gastroenterology 20080214 |
| Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. | European journal of pharmacology 20080202 |
| Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). | Naunyn-Schmiedeberg's archives of pharmacology 20080201 |
| Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death. | International journal of radiation oncology, biology, physics 20080201 |
| Relaxant action mechanism of berberine identified as the active principle of Argemone ochroleuca Sweet in guinea-pig tracheal smooth muscle. | The Journal of pharmacy and pharmacology 20080201 |
| Galactinol synthase gene of Coptis japonica is involved in berberine tolerance. | Bioscience, biotechnology, and biochemistry 20080201 |
| Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives. | Planta medica 20080201 |
| Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. | British journal of cancer 20080129 |
| Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons. | Biomedical chromatography : BMC 20080101 |
| Berberine improves glucose metabolism through induction of glycolysis. | American journal of physiology. Endocrinology and metabolism 20080101 |
| The microenvironment of DNA switches the activity of singlet oxygen generation photosensitized by berberine and palmatine. | Photochemistry and photobiology 20080101 |
| Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine. | Archives of pharmacal research 20080101 |
| Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. | BMC cancer 20080101 |
| Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro. | In vivo (Athens, Greece) 20080101 |
| Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study. | Journal of AOAC International 20080101 |
| Estimation of berberine in ayurvedic formulations containing Berberis aristata. | Journal of AOAC International 20080101 |
| The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. | Experimental diabetes research 20080101 |
| Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. | Journal of experimental therapeutics & oncology 20080101 |
| Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. | Cancer letters 20071218 |
| Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. | Journal of agricultural and food chemistry 20071212 |
| Simultaneous quantification of three alkaloids of Coptidis Rhizoma in rat urine by high-performance liquid chromatography: application to pharmacokinetic study. | Biopharmaceutics & drug disposition 20071201 |
| Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide. | Acta pharmacologica Sinica 20071201 |
| Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat. | The Journal of pharmacy and pharmacology 20071201 |
| [Molecular mechanism of berberine in improving insulin resistance induced by free fatty acid through inhibiting nuclear trascription factor-kappaB p65 in 3T3-L1 adipocytes]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071201 |
| [Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201 |
| [Fast and simultaneous determination of four index components in Qingwei Huanglian tablets by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201 |
| Effect of berberine on PPARalpha/delta/gamma expression in type 2 diabetic rat retinae. | Yao xue xue bao = Acta pharmaceutica Sinica 20071201 |
| Supramolecular interaction of ethylenediamine linked beta-cyclodextrin dimer and berberine hydrochloride by spectrofluorimetry and its analytical application. | Talanta 20071115 |
| Berberine-induced LDLR up-regulation involves JNK pathway. | Biochemical and biophysical research communications 20071103 |
| Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. | The Journal of pharmacology and experimental therapeutics 20071101 |
| Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes. | Biological & pharmaceutical bulletin 20071101 |
| [Recent advances in the study of antifungal lead compounds with new chemical scaffolds]. | Yao xue xue bao = Acta pharmaceutica Sinica 20071101 |
| [Effect of berberine on insulin secretion and glucokinase activity of NIT-1 cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20071001 |
| [Refinement study of macroporous resin for Huang-Lian-Jie-Du decoction]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001 |
| Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20070921 |
| Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives. | Medicinal research reviews 20070901 |
| Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. | Biophysical journal 20070901 |
| Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells. | Pharmacological research 20070901 |
| Determination of colchicine in mouse plasma by high performance liquid-chromatographic method with UV detection and its application to pharmacokinetic studies. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901 |
| Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. | Life sciences 20070823 |
| Determination of berberine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20070815 |
| Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. | European journal of pharmacology 20070813 |
| Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry. | Journal of chromatography. A 20070803 |
| Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. | Letters in applied microbiology 20070801 |
| [Studies on chemical constituents in fresh fleshy scaleleaf of Lilium lancifolium]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801 |
| [Preparation and examination of the vitro releasing of pH-dependent kuijiekang tablet for colon-specific delivery]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801 |
| Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. | Acta pharmacologica Sinica 20070701 |
| Theoretical analysis of tablet hardness prediction using chemoinformetric near-infrared spectroscopy. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070701 |
| [Simultaneous determination of geniposide, baicalin and berberine hydrochloride in Angong Niuhuang pill by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070701 |
| Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells. | Cancer letters 20070628 |
| Analysis of berberine and total alkaloid content in cortex phellodendri by near infrared spectroscopy (NIRS) compared with high-performance liquid chromatography coupled with ultra-visible spectrometric detection. | Analytica chimica acta 20070605 |
| Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017. | Acta pharmacologica Sinica 20070601 |
| Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501 |
| l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. | Acta pharmacologica Sinica 20070501 |
| Inclusion effect and structural basis of cyclodextrins for increased extraction of medicinal alkaloids from natural medicines. | Chemical & pharmaceutical bulletin 20070501 |
| [Influence of compatibility on content of berberine in Maxingganshi decoction]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070501 |
| Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala. | Bioorganic & medicinal chemistry letters 20070401 |
| Effect of baicalin and berberine on transport of nimodipine on primary-cultured, rat brain microvascular endothelial cells. | Acta pharmacologica Sinica 20070401 |
| High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs. | Journal of separation science 20070401 |
| Antiviral activity of berberine and related compounds against human cytomegalovirus. | Bioorganic & medicinal chemistry letters 20070315 |
| Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017. | Naunyn-Schmiedeberg's archives of pharmacology 20070301 |
| Berberine stimulates glucose transport through a mechanism distinct from insulin. | Metabolism: clinical and experimental 20070301 |
| The natural product berberine is a human prolyl oligopeptidase inhibitor. | ChemMedChem 20070301 |
| Diagnosis and therapy of oral squamous cell carcinoma. | Expert review of anticancer therapy 20070301 |
| Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20070201 |
| The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats. | Neuropharmacology 20070201 |
| Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique. | Electrophoresis 20070201 |
| RNA binding small molecules: studies on t-RNA binding by cytotoxic plant alkaloids berberine, palmatine and the comparison to ethidium. | Biophysical chemistry 20070201 |
| Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica. | The FEBS journal 20070201 |
| [Protective action of effective components of Huanglian Jiedu decoction on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070201 |
| Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. | Biochemical and biophysical research communications 20070112 |
| Human MDR1 and MRP1 recognize berberine as their transport substrate. | Bioscience, biotechnology, and biochemistry 20070101 |
| Effect of berberine on barrier function in a human retinal pigment epithelial cell line. | Japanese journal of ophthalmology 20070101 |
| Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. | Arzneimittel-Forschung 20070101 |
| Effects of oral administration of berberine on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats. | In vivo (Athens, Greece) 20070101 |
| Berberine inhibits WEHI-3 leukemia cells in vivo. | In vivo (Athens, Greece) 20070101 |
| Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA. | Rapid communications in mass spectrometry : RCM 20070101 |
| Polygonum cuspidatum, compared with baicalin and berberine, inhibits inducible nitric oxide synthase and cyclooxygenase-2 gene expressions in RAW 264.7 macrophages. | Vascular pharmacology 20070101 |
| Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. | Anticancer research 20070101 |
| GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cells. | Anticancer research 20070101 |
| Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. | Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia 20070101 |
| Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications. | Current medicinal chemistry 20070101 |
| Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. | Experimental & molecular medicine 20061231 |
| Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| Nanostructured electrochemical DNA biosensors for detection of the effect of berberine on DNA from cancer cells. | Analytical and bioanalytical chemistry 20061201 |
| Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | Oncology reports 20061201 |
| Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. | Journal of ethnopharmacology 20061103 |
| Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. | Neuroscience 20061103 |
| Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. | Biochimica et biophysica acta 20061101 |
| 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. | Biological & pharmaceutical bulletin 20061101 |
| Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. | Carcinogenesis 20061001 |
| The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. | Journal of lipid research 20061001 |
| [Quality analysis and evaluation of Rhizoma Coptidis under different cultivation conditions]. | Yao xue xue bao = Acta pharmaceutica Sinica 20061001 |
| [Determination of 3 kinds of components in huanglian jiedu decoction by HPLC under different UV wavelengths]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001 |
| Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. | Biochemical and biophysical research communications 20060922 |
| Effects of (-)stepholidine in animal models for schizophrenia. | Acta pharmacologica Sinica 20060901 |
| In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine. | Biological & pharmaceutical bulletin 20060901 |
| Pharmacological properties of traditional medicine (XXXII): protective effects of hangeshashinto and the combinations of its major constituents on gastric lesions in rats. | Biological & pharmaceutical bulletin 20060901 |
| Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | Journal of separation science 20060901 |
| [Liquid chromatography-tandem electrospray ionization ion trap mass spectrometric assay for the metabolites of jatrorrhizine in rat urine]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060901 |
| Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. | Cancer letters 20060808 |
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. | Bioorganic & medicinal chemistry letters 20060801 |
| Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line. | Life sciences 20060801 |
| Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. | Diabetes 20060801 |
| Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA. | Bioorganic & medicinal chemistry 20060701 |
| [Fingerprints of Rhizoma Coptidis from Shizhu by HPLC]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060701 |
| Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060621 |
| Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction. | Journal of pharmaceutical and biomedical analysis 20060607 |
| Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. | Journal of lipid research 20060601 |
| The Galpha protein controls a pH-dependent signal path to the induction of phytoalexin biosynthesis in Eschscholzia californica. | The Plant cell 20060601 |
| Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. | Chemical research in toxicology 20060601 |
| Nonaqueous capillary electrophoresis coupled with laser-induced native fluorescence detection for the analysis of berberine, palmatine, and jatrorrhizine in Chinese herbal medicines. | Journal of separation science 20060601 |
| Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20060501 |
| Acetylcholinesterase inhibitors from Stephania venosa tuber. | The Journal of pharmacy and pharmacology 20060501 |
| [Assessment of taste development in 62 newborn infants]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20060501 |
| Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia. | Biological & pharmaceutical bulletin 20060401 |
| Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation. | Journal of enzyme inhibition and medicinal chemistry 20060401 |
| [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060401 |
| Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method. | Journal of pharmaceutical and biomedical analysis 20060318 |
| [The content condition of effective composition in Sanhuang Xiexin decoction]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301 |
| [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060301 |
| Simultaneous determination of four active alkaloids from a traditional Chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC-MS-MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202 |
| The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC).poly(rG): spectroscopic and viscometric study. | Bioorganic & medicinal chemistry 20060201 |
| Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors. | Bioorganic & medicinal chemistry 20060201 |
| Chiral high-performance liquid chromatographic separation of the enantiomers of tetrahydropalmatine and tetrahydroberberine, isolated from Corydalis yanhusuo. | Analytical and bioanalytical chemistry 20060201 |
| Metabolites of the 'smoke tree', Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. | Journal of natural products 20060201 |
| Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. | Molecular cancer therapeutics 20060201 |
| A rapid and simple determination of protoberberine alkaloids in cortex phellodendri by 1H NMR and its application for quality control of commercial traditional Chinese medicine prescriptions. | Journal of pharmaceutical and biomedical analysis 20060123 |
| Synthesis, DNA-binding affinities, and binding mode of berberine dimers. | Bioorganic & medicinal chemistry 20060101 |
| Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line. | Ophthalmic research 20060101 |
| The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. | Methods and findings in experimental and clinical pharmacology 20060101 |
| Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry. | Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20060101 |
| CPU86017: a novel Class III antiarrhythmic agent with multiple actions at ion channels. | Cardiovascular drug reviews 20060101 |
| Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. | Molecules and cells 20051231 |
| Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. | Journal of cardiovascular pharmacology 20051201 |
| Antiproliferative activity of berberine in vitro and in vivo. | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201 |
| Rational method development strategies on a fluorinated liquid chromatography stationary phase: mobile phase ion concentration and temperature effects on the separation of ephedrine alkaloids. | Journal of chromatography. A 20051118 |
| Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an 'in vitro' replicative system. | Antiviral research 20051101 |
| CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway. | Acta pharmacologica Sinica 20051101 |
| Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. | Acta pharmacologica Sinica 20051101 |
| Cytotoxic constituents from the whole plant of Corydalis pallida. | Archives of pharmacal research 20051101 |
| [Studies on the alkaloids from herb of Corydalis adunca]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101 |
| Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract. | Life sciences 20051028 |
| Synthesis and DNA-binding affinities of monomodified berberines. | Bioorganic & medicinal chemistry 20051015 |
| Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. | Biochemical pharmacology 20051015 |
| Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi. | Current microbiology 20051001 |
| Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. | Arteriosclerosis, thrombosis, and vascular biology 20051001 |
| Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. | Journal of biomedical science 20051001 |
| The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction. | Chemical research in toxicology 20051001 |
| Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1. | Biochemical pharmacology 20050915 |
| Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. | European journal of clinical pharmacology 20050901 |
| Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum. | Electrophoresis 20050901 |
| [Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers]. | Chinese journal of integrative medicine 20050901 |
| [HPLC fingerprint for the Corydalis saxicola Bunting injection]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050901 |
| LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivation. | Analytical biochemistry 20050815 |
| Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt. | Neuroscience letters 20050805 |
| Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica. | Plant physiology 20050801 |
| Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. | Biological & pharmaceutical bulletin 20050801 |
| Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes. | Cellular & molecular immunology 20050801 |
| [Effects of berberine on DNFB-induced delayed type hypersensitivity in mice]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20050701 |
| [Chemical constituents from Corydalis humosa]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701 |
| Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. | British journal of pharmacology 20050601 |
| Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts. | Electrophoresis 20050601 |
| [Effects of berberine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro]. | Zhonghua nan ke xue = National journal of andrology 20050601 |
| Berberine--a novel approach to cholesterol lowering. | Expert opinion on investigational drugs 20050501 |
| Inhibitory effects of Stephania tetrandra S. Moore on free radical-induced lysis of rat red blood cells. | Biological & pharmaceutical bulletin 20050401 |
| Search of chemical scaffolds for novel antituberculosis agents. | Journal of biomolecular screening 20050401 |
| [Quality assessment of Coptis chinensis in China]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401 |
| Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis. | The Plant cell 20050301 |
| Berberine synergy with amphotericin B against disseminated candidiasis in mice. | Biological & pharmaceutical bulletin 20050301 |
| Cheap Chinese herb lowers cholesterol. | Health news (Waltham, Mass.) 20050301 |
| Binding of the bioactive component jatrorrhizine to human serum albumin. | Biochimica et biophysica acta 20050211 |
| Regeneration of Psychotria umbellata and production of the analgesic indole alkaloid umbellatine. | Tree physiology 20050201 |
| Effects of l-stepholidine on forebrain Fos expression: comparison with clozapine and haloperidol. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050201 |
| [Study on the interaction of anticancer drugs and DNA using fluorescence spectroscopy]. | Guang pu xue yu guang pu fen xi = Guang pu 20050201 |
| Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts. | Bioscience, biotechnology, and biochemistry 20050101 |
| Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis. | Journal of separation science 20050101 |
| Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. | In vivo (Athens, Greece) 20050101 |
| A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. | American journal of therapeutics 20050101 |
| Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells. | Anticancer research 20050101 |
| Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption. | Biotechnology progress 20050101 |
| Pharmacokinetics of berberine in rat thalamus after intravenous administration of Coptidis rhizoma extract. | The American journal of Chinese medicine 20050101 |
| Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. | Journal of medicinal food 20050101 |
| Hypoglycemic activity of jatrorrhizine. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101 |
| [Berberine and amitozine binding with calf thymus DNA]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101 |
| Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila. | Journal of neurobiology 20041201 |
| Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. | Nature medicine 20041201 |
| [Effect of berberine on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosum]. | Zhonghua nan ke xue = National journal of andrology 20041201 |
| [Establishment of the control substance of plant drug and fingerprints of Coptis chinensis]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201 |
| Structural elucidation and identification of alkaloids in Rhizoma Coptidis by electrospray ionization tandem mass spectrometry. | Journal of mass spectrometry : JMS 20041101 |
| Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. | Archives of pharmacal research 20041101 |
| Study on the precipitation reaction between baicalin and berberine by HPLC. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015 |
| Inhibitory effects of berberine on ion channels of rat hepatocytes. | World journal of gastroenterology 20041001 |
| Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. | Life sciences 20041001 |
| Recent pharmacological studies on natural products in China. | European journal of pharmacology 20041001 |
| [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001 |
| Improved detection of Coptidis alkaloids by field-amplified sample stacking in capillary electrophoresis. | Journal of pharmaceutical and biomedical analysis 20040921 |
| Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908 |
| Berberine inhibits HIF-1alpha expression via enhanced proteolysis. | Molecular pharmacology 20040901 |
| [The clinical study on the adjunctive effects of aqueous extract from coptis root for the treatment of chronic periodontitis]. | Shanghai kou qiang yi xue = Shanghai journal of stomatology 20040801 |
| Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium. | Phytotherapy research : PTR 20040801 |
| Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. | Phytotherapy research : PTR 20040801 |
| Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents. | Biochemical and biophysical research communications 20040702 |
| Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor. | British journal of pharmacology 20040701 |
| In vitro cytotoxicity of berberine against HeLa and L1210 cancer cell lines. | Die Pharmazie 20040701 |
| Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats. | Acta pharmacologica Sinica 20040601 |
| Determination of rhein, baicalin and berberine in traditional Chinese medicinal preparations by capillary electrophoresis with two-marker technique. | Biomedical chromatography : BMC 20040601 |
| Effect of auxins on berberine synthesis in cell suspension culture of Coscinium fenestratum (Gaertn.) Colebr--a critically endangered medicinal liana of Western Ghats. | Indian journal of experimental biology 20040601 |
| Neurotrophin-3 regulates mast cell functions in neonatal mouse skin. | Experimental dermatology 20040501 |
| A selective and sensitive assay of berberine using total internal reflected resonance light scattering technique with fluorescein at the water/1,2-dichloroethane interface. | Journal of pharmaceutical and biomedical analysis 20040401 |
| Hepatobiliary excretion of berberine. | Drug metabolism and disposition: the biological fate of chemicals 20040401 |
| Blockade of L-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by CPU 86017. | Acta pharmacologica Sinica 20040401 |
| Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. | Acta pharmacologica Sinica 20040401 |
| [Screening for inhibitors of tumor invasion into basement membranes]. | Gan to kagaku ryoho. Cancer & chemotherapy 20040401 |
| Determination of mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill by high-performance liquid chromatography. | Journal of chromatographic science 20040401 |
| Cytotoxic activity of five compounds isolated from Colombian plants. | Fitoterapia 20040301 |
| [Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040301 |
| Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis. | International immunopharmacology 20040301 |
| [Extraction and HPLC analysis of alkaloids in goldenseal]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040301 |
| Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. | Brain research 20040227 |
| Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. | Bioscience, biotechnology, and biochemistry 20040201 |
| [Distribution of four alkaloids in plants of Berberis]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201 |
| The anti-inflammatory potential of berberine in vitro and in vivo. | Cancer letters 20040120 |
| Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | Biological & pharmaceutical bulletin 20040101 |
| Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. | Clinical and experimental pharmacology & physiology 20040101 |
| Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. | Archives of pharmacal research 20040101 |
| A new approach to investigate the pharmacokinetics of traditional chinese medicine YL2000. | The American journal of Chinese medicine 20040101 |
| [Simultaneous determination of berberin hydrochloride, baicalin and glibenclamide in kangtang tablets by RP-HPLC]. | Se pu = Chinese journal of chromatography 20040101 |
| [The interaction of berberine and human serum albumin]. | Guang pu xue yu guang pu fen xi = Guang pu 20040101 |
| Transport and uptake characteristics of a new derivative of berberine (CPU-86017) by human intestinal epithelial cell line: Caco-2. | Acta pharmacologica Sinica 20031201 |
| Cytotoxicity and DNA binding properties of the plant alkaloid burasaine. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031201 |
| [Inhibitory action of berberine on glucose absorption]. | Yao xue xue bao = Acta pharmaceutica Sinica 20031201 |
| [Determination of four alkaloids in Berberis plants by HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201 |
| Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray. | International journal of cancer 20031120 |
| Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. | The Journal of biological chemistry 20031003 |
| Berberine formate-succinic acid (1/1). | Acta crystallographica. Section C, Crystal structure communications 20031001 |
| [Precipitation reaction between berberine and rheinic acid by capillary electrophoresis]. | Yao xue xue bao = Acta pharmaceutica Sinica 20031001 |
| Isoflavones as potentiators of antibacterial activity. | Journal of agricultural and food chemistry 20030910 |
| [The inhibit effect of berberine on human colon cell line cyclooxygenase-2]. | Zhonghua nei ke za zhi 20030801 |
| Determination of berberine by measuring the enhanced total internal reflected fluorescence at water/tetrachloromethane interface in the presence of sodium dodecyl benzene sulfonate. | Analytical and bioanalytical chemistry 20030701 |
| Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. | International journal of antimicrobial agents 20030701 |
| High-performance capillary electrophoresis for determining the contents of berberine, jatrorrhizine and palmatine in Gegenqinlian decoction. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030701 |
| The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. | Planta medica 20030701 |
| [Protective effect of berberine on cardiac myocyte injured by ischemia-reperfusion]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20030701 |
| [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701 |
| Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. | Planta medica 20030601 |
| Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance. | European journal of pharmacology 20030523 |
| Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy. | Life sciences 20030418 |
| Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures. | Journal of biomolecular structure & dynamics 20030401 |
| Palmatine and berberine isolation artifacts. | Journal of natural products 20030401 |
| Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2). | Bioorganic & medicinal chemistry 20030220 |
| Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. | Plant & cell physiology 20030201 |
| Thalictrum minus cell cultures and ABC-like transporter. | Phytochemistry 20030201 |
| A simple method for fabrication of silver-coated sheathless electrospray emitters. | Rapid communications in mass spectrometry : RCM 20030101 |
| Variations in alkaloid content of herbal products containing goldenseal. | Journal of the American Pharmacists Association : JAPhA 20030101 |
| P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. | Journal of pharmaceutical sciences 20021201 |
| Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. | Planta medica 20021201 |
| (-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro. | Neuroreport 20021115 |
| Effects of berberine on glucose metabolism in vitro. | Metabolism: clinical and experimental 20021101 |
| Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver. | Archives of toxicology 20021101 |
| Immunocytological localization of two enzymes involved in berberine biosynthesis. | Planta 20021101 |
| Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. | Bioscience, biotechnology, and biochemistry 20021101 |
| [Determination of alkaloids from Coptis chinensis Franch. and Phellodendron amurense Rupr. Decocted together in baitouweng decocta by high performance capillary electrophoresis]. | Se pu = Chinese journal of chromatography 20021101 |
| A sensitive optode membrane for berberine using conjugated polymer as sensing material. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021001 |
| The involvement of P-glycoprotein in berberine absorption. | Pharmacology & toxicology 20021001 |
| [In situ thin layer chromatography-fourier transform-surface-enhanced Raman spectrum study on ingredients of berberine]. | Guang pu xue yu guang pu fen xi = Guang pu 20021001 |
| Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. | Journal of experimental botany 20020901 |
| Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells. | Neurochemical research 20020901 |
| [Determination of furazolidone, carbenoxolone sodium and berberine hydrochloride in wei kang tablets by reversed-phase high performance liquid chromatography(RP-HPLC)]. | Se pu = Chinese journal of chromatography 20020701 |
| Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to high-performance liquid chromatography. | Journal of chromatography. A 20020628 |
| Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei. | Die Pharmazie 20020601 |
| Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. | Biochemical pharmacology 20020515 |
| Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | Thrombosis research 20020515 |
| Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma. | International journal of cancer 20020510 |
| [The changes of some chemical components in banxiaxiexintang decoction of different combinations]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020501 |
| Selective inhibition of MAPKK Wis1 in the stress-activated MAPK cascade of Schizosaccharomyces pombe by novel berberine derivatives. | The Journal of biological chemistry 20020405 |
| A validated high performance liquid chromatographic method for the analysis of Goldenseal. | The Journal of pharmacy and pharmacology 20020301 |
| Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. | Planta medica 20020301 |
| Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. | Planta medica 20020301 |
| Functional cloning and characterization of a plant efflux carrier for multidrug and heavy metal detoxification. | The Journal of biological chemistry 20020215 |
| Study on the resonance light scattering spectrum of berberine-cetyltrimethylammonium bromide system and the determination of nucleic acids at nanogram levels. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020201 |
| Thermodynamic study on the effects of beta-cyclodextrin inclusion with berberine. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020115 |
| [Inhibitory action of CPU86035 on L-type calcium current in single ventricular myocyte of guinea pig]. | Zhonghua yi xue za zhi 20020110 |
| (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions. | Trends in pharmacological sciences 20020101 |
| Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration. | Acta pharmacologica Sinica 20020101 |
| Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. | BMC complementary and alternative medicine 20020101 |
| [Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101 |
| Effect of berberine and (+/-)-bicuculline isolated from Corydalis chaerophylla on spore germination of some fungi. | Folia microbiologica 20020101 |
| [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis]. | Likars'ka sprava 20020101 |
| Antimicrobial activity of berberine--a constituent of Mahonia aquifolium. | Folia microbiologica 20020101 |
| Inhibition of type A monoamine oxidase by coptisine in mouse brain. | Life sciences 20011228 |
| Structural mechanisms of QacR induction and multidrug recognition. | Science (New York, N.Y.) 20011207 |
| Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane. | IUBMB life 20011201 |
| Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung. | European journal of pharmacology 20011116 |
| Enhanced tumor necrosis factor-alpha-specific and decreased interleukin-10-specific immune responses to LPS during the third trimester of pregnancy in mice. | The Journal of endocrinology 20011101 |
| Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. | Chemical research in toxicology 20011101 |
| Gastric-mucous membrane protection activity of coptisine derivatives. | Biological & pharmaceutical bulletin 20011101 |
| [Anticomplement activity of Mahonia aquifolium bisbenzylisoquinoline alkaloids and berberine extract]. | Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101 |
| [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901 |
| [Study on the quality standards for xianghe suppository]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901 |
| [Protective effect of berberine on isolated perfused heart in heart failure]. | Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010901 |
| Determination of berberine and strychnine in medicinal plants and herbal preparations by pressurized liquid extraction with capillary zone electrophoresis. | Electrophoresis 20010801 |
| Chemiluminescence flow sensor for berberine with immobilized reagents. | Bioorganic & medicinal chemistry 20010701 |
| High-performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal. | Journal of pharmaceutical sciences 20010701 |
| In vitro cytotoxicity of the protoberberine-type alkaloids. | Journal of natural products 20010701 |
| HWY-289, a novel semi-synthetic protoberberine derivative with multiple target sites in Candida albicans. | The Journal of antimicrobial chemotherapy 20010501 |
| Inhibition of chemical carcinogenesis by berberine in rats and mice. | The Journal of pharmacy and pharmacology 20010501 |
| Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats. | Pharmacology & toxicology 20010501 |
| Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. | Cancer letters 20010410 |
| Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. | Neurochemistry international 20010401 |
| Synthesis of glycosylated porphyrins as neutral ionophores for a berberine-sensitive electrode. | Fresenius' journal of analytical chemistry 20010301 |
| Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c. | Bioscience, biotechnology, and biochemistry 20010201 |
| Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine. | Farmaco (Societa chimica italiana : 1989) 20010101 |
| Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells. | Cell biology and toxicology 20010101 |
| Cardiovascular actions of berberine. | Cardiovascular drug reviews 20010101 |
| Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017. | Acta pharmacologica Sinica 20010101 |
| Effects of berberine on intracellular free calcium in smooth muscle cells of Guinea pig colon. | Digestion 20010101 |
| [Berberine Hydrochloride Reference Standard (Control 001) of National Institute of Health Sciences]. | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20010101 |
| Antimicrobial activity of 9-O-acyl- and 9-O-benzoyl-substituted berberrubines. | Planta medica 20000501 |
| Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis-electrospray ion trap mass spectrometry. | Journal of chromatography. A 20000114 |
| Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. | The Journal of antimicrobial chemotherapy 19990501 |
| The effect of Kampo formulae on bone resorption in vitro and in vivo. I. Active constituents of Tsu-kan-gan. | Biological & pharmaceutical bulletin 19981201 |
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. | Journal of natural products 19981001 |
| Screening of compounds for antimicrosporidial activity in vitro. | Folia parasitologica 19980101 |
| Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase. | Anticancer research 19980101 |
| Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. | Japanese journal of pharmacology 19970701 |
| HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. | Biochemical and biophysical research communications 19920529 |
| Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | Journal of natural products 19910101 |
| Screening for new compounds with antiherpes activity. | Antiviral research 19841001 |
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