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207220-71-1 | Phosphine oxide, [5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-
CAS No: 207220-71-1 Catalog No: AG002IWE MDL No:
Product Description
Catalog Number:
AG002IWE
Chemical Name:
Phosphine oxide, [5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-
CAS Number:
207220-71-1
Molecular Formula:
C22H29OP
Molecular Weight:
340.4388
IUPAC Name:
[(5-methyl-2-propan-2-ylcyclohexyl)-phenylphosphoryl]benzene
InChI:
InChI=1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3
InChI Key:
BPCNGVCAHAIZEE-UHFFFAOYSA-N
SMILES:
CC1CCC(C(C1)P(=O)(c1ccccc1)c1ccccc1)C(C)C
Properties
Complexity:
409
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
340.196g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
340.447g/mol
Monoisotopic Mass:
340.196g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
17.1A^2
Undefined Atom Stereocenter Count:
3
Undefined Bond Stereocenter Count:
0
XLogP3:
6
Literature
| Title | Journal |
|---|---|
| Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. | American journal of physiology. Cell physiology 20110701 |
| Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. | Cardiovascular research 20110301 |
| Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1. | Journal of molecular and cellular cardiology 20100601 |
| Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. | Journal of molecular and cellular cardiology 20100201 |
| Effects of potassium channel blockers on changes in refractoriness of atrial cardiomyocytes induced by stretch. | Experimental biology and medicine (Maywood, N.J.) 20090701 |
| High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5. | Biochemical pharmacology 20090115 |
| In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. | The Journal of pharmacology and experimental therapeutics 20060201 |
| In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. | The Journal of pharmacology and experimental therapeutics 20051201 |
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