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206983-57-5 | Ethanone, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-iMino-3(2H)-benzothiazolyl)-
CAS No: 206983-57-5 Catalog No: AG00CFQ7 MDL No:
Product Description
Catalog Number:
AG00CFQ7
Chemical Name:
Ethanone, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-iMino-3(2H)-benzothiazolyl)-
CAS Number:
206983-57-5
IUPAC Name:
2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone
InChI:
InChI=1S/C16H18N2OS/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17/h6-9,17H,2-5,10H2,1H3
InChI Key:
OLTZHXYLLRJLST-UHFFFAOYSA-N
Properties
Complexity:
449
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
286.114g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
286.393g/mol
Monoisotopic Mass:
286.114g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
69.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3
Literature
| Title | Journal |
|---|---|
| Flavan enantiomers from Daphne giraldii selectively induce apoptotic cell death in p53-null hepatocarcinoma cells in vitro. | Chemico-biological interactions 20180601 |
| Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. | Toxicology and applied pharmacology 20141215 |
| Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells. | The Journal of toxicological sciences 20140601 |
| Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. | International journal of molecular medicine 20140401 |
| Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray. | Environmental toxicology 20131101 |
| p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. | Inflammation 20130401 |
| Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. | Molecular and cellular biochemistry 20121201 |
| Adenovirus-mediated expression of p33(ING1b) induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro. | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20121001 |
| The synthetic purine reversine selectively induces cell death of cancer cells. | Journal of cellular biochemistry 20121001 |
| Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. | Stem cells and development 20120901 |
| Novel multiple apoptotic mechanism of shikonin in human glioma cells. | Annals of surgical oncology 20120901 |
| Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. | Cell biology international 20120801 |
| Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells. | Journal of inorganic biochemistry 20120801 |
| Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. | Molecular cancer research : MCR 20120601 |
| The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. | Biochemical and biophysical research communications 20120413 |
| Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis. | Metabolism: clinical and experimental 20120401 |
| Functional characterization of the p53 binding site in the human PYNOD promoter. | Human immunology 20120401 |
| p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage. | CNS neuroscience & therapeutics 20120401 |
| XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway. | Biochemical and biophysical research communications 20120323 |
| P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. | Free radical research 20120301 |
| MicroRNA-34a upregulation during seizure-induced neuronal death. | Cell death & disease 20120301 |
| Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20120215 |
| Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. | Stroke 20120201 |
| Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. | Biochimica et biophysica acta 20120201 |
| The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. | American journal of physiology. Renal physiology 20120115 |
| p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. | PloS one 20120101 |
| Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-α, an inhibitor of p53. | Mutation research 20111127 |
| Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin. | Molecular and cellular biochemistry 20111101 |
| NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. | American journal of physiology. Cell physiology 20111101 |
| [Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20111101 |
| Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. | Molecular and cellular biochemistry 20110801 |
| Targeting the p53 pathway to protect the neonatal ischemic brain. | Annals of neurology 20110801 |
| PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway. | Shock (Augusta, Ga.) 20110601 |
| [Effects of hot shock protein 70 inhibitor PFTµ on inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells and mice underwent myocardial ischemia-reperfusion injury]. | Zhonghua xin xue guan bing za zhi 20110601 |
| Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. | Experimental cell research 20110501 |
| Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. | Life sciences 20110425 |
| Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart. | Cardiovascular research 20110401 |
| Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. | Free radical biology & medicine 20110315 |
| Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. | Blood 20110303 |
| Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture. | Journal of molecular and cellular cardiology 20110301 |
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. | Bioorganic & medicinal chemistry 20110301 |
| Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. | Acta biochimica et biophysica Sinica 20110201 |
| Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis. | World journal of gastroenterology 20110128 |
| p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. | American journal of nephrology 20110101 |
| Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α. | Cell transplantation 20110101 |
| Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel. | PloS one 20110101 |
| Autophagy impairment induces premature senescence in primary human fibroblasts. | PloS one 20110101 |
| High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. | Journal of nutritional science and vitaminology 20110101 |
| Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells. | Radiation research 20101101 |
| Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. | American journal of physiology. Cell physiology 20101101 |
| Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. | American journal of physiology. Cell physiology 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| A role for p53 in the beta-amyloid-mediated regulation of the lysosomal system. | Neurobiology of aging 20101001 |
| Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. | Cancer biology & therapy 20100915 |
| p53 Plays an important role in cell fate determination after exposure to microcystin-LR. | Environmental health perspectives 20100901 |
| Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53. | Mutation research 20100814 |
| Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells. | Experimental biology and medicine (Maywood, N.J.) 20100801 |
| Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells. | Biochemical pharmacology 20100701 |
| Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment. | International journal of oncology 20100701 |
| Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice. | Molecular and cellular biochemistry 20100401 |
| A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice. | Cell cycle (Georgetown, Tex.) 20100401 |
| Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100301 |
| Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. | Blood 20100204 |
| Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. | Journal of the American Society of Nephrology : JASN 20100101 |
| Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. | Journal of neurochemistry 20100101 |
| PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. | Biochemical and biophysical research communications 20100101 |
| Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity. | Frontiers in bioscience (Elite edition) 20100101 |
| Sodium orthovanadate inhibits p53-mediated apoptosis. | Cancer research 20100101 |
| The zebrafish embryo as a model for assessing off-target drug effects. | Disease models & mechanisms 20100101 |
| Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. | Pharmacology 20100101 |
| Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. | Biomedica : revista del Instituto Nacional de Salud 20100101 |
| Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. | American journal of physiology. Heart and circulatory physiology 20091201 |
| p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. | The European journal of neuroscience 20091201 |
| Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. | Mutagenesis 20091101 |
| NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway. | Archives of biochemistry and biophysics 20090901 |
| Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. | Cancer investigation 20090801 |
| Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis. | Toxicological sciences : an official journal of the Society of Toxicology 20090801 |
| Role of p53 in human chondrocyte apoptosis in response to shear strain. | Arthritis and rheumatism 20090801 |
| Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells. | Biotechnology and applied biochemistry 20090709 |
| Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. | International journal of oncology 20090701 |
| Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. | Cell death and differentiation 20090601 |
| The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. | Cell cycle (Georgetown, Tex.) 20090601 |
| Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability. | Stem cells (Dayton, Ohio) 20090501 |
| Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. | Annals of neurology 20090501 |
| p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. | Autophagy 20090401 |
| Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation. | Human reproduction (Oxford, England) 20090301 |
| The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. | The Journal of biological chemistry 20090213 |
| Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line. | Toxicology in vitro : an international journal published in association with BIBRA 20090201 |
| Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. | Stroke 20090201 |
| Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells. | Biochemistry. Biokhimiia 20090201 |
| Bmp2 is required for cephalic neural tube closure in the mouse. | Developmental dynamics : an official publication of the American Association of Anatomists 20090101 |
| Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake. | Neurochemistry international 20090101 |
| Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. | Molecular cancer 20090101 |
| p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. | Cancer research 20081215 |
| p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury. | American journal of physiology. Renal physiology 20081201 |
| Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways. | Cancer letters 20081128 |
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| Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. | Shock (Augusta, Ga.) 20081101 |
| Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts. | Experimental dermatology 20081101 |
| PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development. | Toxicological sciences : an official journal of the Society of Toxicology 20081101 |
| p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. | Blood 20081101 |
| ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20081101 |
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| Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. | Kidney international 20080901 |
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| Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. | Free radical biology & medicine 20080515 |
| Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. | Cell cycle (Georgetown, Tex.) 20080501 |
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| HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest. | American journal of physiology. Heart and circulatory physiology 20080401 |
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| Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. | International journal of oncology 20080101 |
| Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest. | Mechanisms of development 20080101 |
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| Bid is not required for Bax translocation during UV-induced apoptosis. | Cellular signalling 20071201 |
| Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. | Apoptosis : an international journal on programmed cell death 20071201 |
| Temozolomide induces senescence but not apoptosis in human melanoma cells. | British journal of cancer 20071105 |
| Activation and involvement of p53 in cisplatin-induced nephrotoxicity. | American journal of physiology. Renal physiology 20071001 |
| Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin. | Apoptosis : an international journal on programmed cell death 20071001 |
| Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest. | Journal of cellular physiology 20070901 |
| Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity. | Cell death and differentiation 20070801 |
| Transcription factor p53 in degenerating spinal cords. | Brain research 20070530 |
| NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. | Brain research 20070511 |
| Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin-alpha. | Cancer biology & therapy 20070501 |
| Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-kappaB and p53 activation in bovine embryos. | Theriogenology 20070415 |
| Dangerous habits of a security guard: the two faces of p53 as a drug target. | Human molecular genetics 20070415 |
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| Role of p53 in irinotecan-induced intestinal cell death and mucosal damage. | Anti-cancer drugs 20070201 |
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| A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. | Autophagy 20070101 |
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| Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils. | Indian journal of physiology and pharmacology 20070101 |
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| Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes. | The Journal of pharmacology and experimental therapeutics 20061201 |
| Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats. | Shock (Augusta, Ga.) 20061201 |
| Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. | Anesthesia and analgesia 20061201 |
| Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201 |
| Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. | Carcinogenesis 20061101 |
| Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. | Cancer research 20061001 |
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| Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation. | Development (Cambridge, England) 20060901 |
| TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways. | Biochemical and biophysical research communications 20060825 |
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| Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060701 |
| Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. | Stroke 20060701 |
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. | Journal of medicinal chemistry 20060615 |
| Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. | American journal of physiology. Heart and circulatory physiology 20060601 |
| Evidence for p53-like-mediated stress responses in green algae. | FEBS letters 20060529 |
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| Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. | Oncogene 20060406 |
| P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. | American journal of respiratory cell and molecular biology 20060401 |
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| Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. | Carcinogenesis 20060301 |
| Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway. | Growth factors (Chur, Switzerland) 20060301 |
| Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060201 |
| [Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy]. | Zhonghua yi xue za zhi 20060110 |
| Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice. | Journal of hepatology 20051101 |
| Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. | Journal of medicinal chemistry 20051006 |
| p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. | The Journal of biological chemistry 20050902 |
| An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. | Molecular cancer therapeutics 20050901 |
| Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050901 |
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| The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. | The Journal of pharmacology and experimental therapeutics 20050801 |
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| Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050501 |
| Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. | Bioorganic & medicinal chemistry letters 20050401 |
| Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53. | Gynecologic oncology 20050401 |
| Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. | Bioorganic & medicinal chemistry letters 20050315 |
| Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. | Neurobiology of disease 20050301 |
| 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. | Toxicological sciences : an official journal of the Society of Toxicology 20050201 |
| DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. | Hippocampus 20050101 |
| The p53 inhibitor pifithrin-alpha forms a sparingly soluble derivative via intramolecular cyclization under physiological conditions. | Molecular pharmaceutics 20050101 |
| Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. | The Journal of biological chemistry 20041231 |
| Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth. | International journal of cancer 20041220 |
| Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. | American journal of physiology. Renal physiology 20041201 |
| Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. | Circulation 20041123 |
| Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. | The Journal of biological chemistry 20040716 |
| Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. | Molecular cancer therapeutics 20040701 |
| The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. | Experimental neurology 20040601 |
| Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. | Hepatology (Baltimore, Md.) 20040601 |
| Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. | Oncogene 20040422 |
| Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. | American journal of physiology. Heart and circulatory physiology 20040301 |
| p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells. | Neuroscience letters 20040116 |
| Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die. | Journal of neuroscience research 20040101 |
| p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. | FEBS letters 20031204 |
| Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes. | Annals of the New York Academy of Sciences 20031201 |
| Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. | International journal of cancer 20031010 |
| Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917 |
| Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells. | DNA repair 20030812 |
| Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells. | Biochemical and biophysical research communications 20030725 |
| Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. | Free radical biology & medicine 20030701 |
| Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. | Molecular carcinogenesis 20030701 |
| p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. | The Journal of biological chemistry 20030502 |
| p53 inactivation leads to impaired motor synchronization in mice. | The European journal of neuroscience 20030501 |
| The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. | The Journal of biological chemistry 20030404 |
| Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401 |
| Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. | DNA repair 20030102 |
| P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. | Journal of the American Society of Nephrology : JASN 20030101 |
| p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults. | Neuromolecular medicine 20030101 |
| Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. | Neuroscience 20030101 |
| The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. | BMC molecular biology 20030101 |
| p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. | Annals of neurology 20021101 |
| CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53. | Experimental cell research 20021101 |
| p53 May positively regulate hepatocyte proliferation in rats. | Hepatology (Baltimore, Md.) 20020801 |
| Acceleration of cutaneous wound healing by transient p53 inhibition. | Laboratory investigation; a journal of technical methods and pathology 20020801 |
| Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice. | Journal of cancer research and clinical oncology 20020801 |
| Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. | The Journal of pharmacology and experimental therapeutics 20020701 |
| Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. | The Journal of biological chemistry 20020329 |
| Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. | Genes & development 20020315 |
| Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. | Mutation research 20020220 |
| Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation. | DNA repair 20020122 |
| Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. | British journal of pharmacology 20020101 |
| Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium. | Biomedical sciences instrumentation 20020101 |
| Regulation of functional nuclear pore size in fibroblasts. | Journal of cell science 20011201 |
| Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. | The Journal of biological chemistry 20010824 |
| p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. | Oncogene 20010607 |
| A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. | Journal of neurochemistry 20010401 |
| Suppression of p53: a new approach to overcome side effects of antitumor therapy. | Biochemistry. Biokhimiia 20000101 |
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