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CAS No: 206440-72-4 Catalog No: AG002II5 MDL No:
Title | Journal |
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Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. | Eukaryotic cell 20130201 |
2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity. | ACS chemical biology 20121019 |
PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots. | Physiologia plantarum 20121001 |
Map-based cloning of zb7 encoding an IPP and DMAPP synthase in the MEP pathway of maize. | Molecular plant 20120901 |
Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. | Applied biochemistry and biotechnology 20120701 |
Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway. | Molecular biology reports 20120501 |
Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. | Journal of experimental botany 20120301 |
Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098. | Acta crystallographica. Section D, Biological crystallography 20120201 |
Metabolic profiles and cDNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f. tomentosa Stib. | PloS one 20120101 |
Functional expression of an orchid fragrance gene in Lactococcus lactis. | International journal of molecular sciences 20120101 |
Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | PloS one 20120101 |
Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. | Journal of natural products 20111227 |
Intraerythrocytic stages of Plasmodium falciparum biosynthesize vitamin E. | FEBS letters 20111215 |
Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. | Journal of immunology (Baltimore, Md. : 1950) 20111115 |
Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. | Journal of experimental botany 20111101 |
Role of reactive oxygen species and proline cycle in anthraquinone accumulation in Rubia tinctorum cell suspension cultures subjected to methyl jasmonate elicitation. | Plant physiology and biochemistry : PPB 20110701 |
Induction of a longer term component of isoprene release in darkened aspen leaves: origin and regulation under different environmental conditions. | Plant physiology 20110601 |
Structural and functional studies of mycobacterial IspD enzymes. | Acta crystallographica. Section D, Biological crystallography 20110501 |
Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus. | FEBS letters 20110204 |
The methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis as a target for the development of new drugs against tuberculosis. | Current medicinal chemistry 20110101 |
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. | PloS one 20110101 |
Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). | BMC genomics 20110101 |
Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. | Microbial cell factories 20110101 |
[Investigation on traditional medicines of Guarany Indio and studies on diterpenes from Scoparia dulcis]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101 |
Genetic variation of γ-tocopherol methyltransferase gene contributes to elevated α-tocopherol content in soybean seeds. | BMC plant biology 20110101 |
Evidence of isoprenoid precursor toxicity in Bacillus subtilis. | Bioscience, biotechnology, and biochemistry 20110101 |
Supply of precursors for carotenoid biosynthesis in plants. | Archives of biochemistry and biophysics 20101201 |
A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101 |
Biosynthesis of the iridoid glucoside, lamalbid, in Lamium barbatum. | Phytochemistry 20101001 |
The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae. | The Journal of antibiotics 20101001 |
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. | Science (New York, N.Y.) 20101001 |
Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. | Plant physiology 20100701 |
Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis. | Journal of molecular modeling 20100601 |
Analysis of 1-deoxy-D-xylulose 5-phosphate synthase activity in Grey poplar leaves using isotope ratio mass spectrometry. | Phytochemistry 20100601 |
Virus-based microRNA expression for gene functional analysis in plants. | Plant physiology 20100601 |
Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. | Cell research 20100601 |
Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase. | The Journal of organic chemistry 20100521 |
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. | Journal of natural products 20100226 |
The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing. | The Plant journal : for cell and molecular biology 20100201 |
Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures. | FEBS letters 20100104 |
Essential oil biosynthesis and regulation in the genus Cymbopogon. | Natural product communications 20100101 |
A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.). | BMC plant biology 20100101 |
Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. | Chemistry & biology 20091224 |
Molecular characterization of the Oncidium orchid HDR gene encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, the last step of the methylerythritol phosphate pathway. | Plant cell reports 20091001 |
Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein. | Journal of the American Chemical Society 20090923 |
Identification and characterization of class 1 DXS gene encoding 1-deoxy-D-xylulose-5-phosphate synthase, the first committed enzyme of the MEP pathway from soybean. | Molecular biology reports 20090501 |
Regulation of resin acid synthesis in Pinus densiflora by differential transcription of genes encoding multiple 1-deoxy-D-xylulose 5-phosphate synthase and 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase genes. | Tree physiology 20090501 |
Complete blockage of the mevalonate pathway results in male gametophyte lethality. | Journal of experimental botany 20090501 |
The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico. | Marine drugs 20090301 |
Divergent regulation of terpenoid metabolism in the trichomes of wild and cultivated tomato species. | Plant physiology 20090101 |
Accumulation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in illuminated plant leaves at supraoptimal temperatures reveals a bottleneck of the prokaryotic methylerythritol 4-phosphate pathway of isoprenoid biosynthesis. | Plant, cell & environment 20090101 |
A plastidial pathway for protein isoprenylation in tobacco cells. | The Plant cell 20090101 |
The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells. | The Plant cell 20090101 |
Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants. | Journal of experimental botany 20090101 |
[2-(14)C-Methylerythritol 2,4-cyclodiphosphate incorporation into bacterial and plant isoprenoids]. | Prikladnaia biokhimiia i mikrobiologiia 20090101 |
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). | PloS one 20090101 |
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. | Journal of the American Chemical Society 20081224 |
The plastidial MEP pathway: unified nomenclature and resources. | Trends in plant science 20081201 |
Evolutionary diversification of plant shikimate kinase gene duplicates. | PLoS genetics 20081201 |
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis. | Bioscience, biotechnology, and biochemistry 20081101 |
Identification and functional analysis of light-responsive unique genes and gene family members in rice. | PLoS genetics 20080801 |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. | The Journal of biological chemistry 20080725 |
Contribution of hydroxymethylbutenyl diphosphate synthase to carotenoid biosynthesis in bacteria and plants. | Biochemical and biophysical research communications 20080704 |
A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus. | Molecular biology and evolution 20080601 |
Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. | Chemistry & biodiversity 20080401 |
Effects of feeding Spodoptera littoralis on lima bean leaves: IV. Diurnal and nocturnal damage differentially initiate plant volatile emission. | Plant physiology 20080301 |
The dioxanone approach to (2S,3R)-2-C-methylerythritol 4-phosphate and 2,4-cyclodiphosphate, and various MEP analogues. | The Journal of organic chemistry 20071221 |
Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv. | Journal of biochemistry and molecular biology 20071130 |
Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). | Phytochemistry 20070801 |
Isoprenoid biosynthesis authenticates the classification of the green alga Mesostigma viride as an ancient streptophyte. | Gene 20070701 |
Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum. | Memorias do Instituto Oswaldo Cruz 20070601 |
Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. | International immunology 20070501 |
A portfolio of plasmids for identification and analysis of carotenoid pathway enzymes: Adonis aestivalis as a case study. | Photosynthesis research 20070501 |
Apocarotenoid biosynthesis in arbuscular mycorrhizal roots: contributions from methylerythritol phosphate pathway isogenes and tools for its manipulation. | Phytochemistry 20070101 |
Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. | Current pharmaceutical design 20070101 |
The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves. | Plant physiology 20060801 |
Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba. | Phytochemistry 20060701 |
Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis. | Chemical & pharmaceutical bulletin 20060501 |
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. | Biochemistry 20060321 |
Molecular cloning and expression profile analysis of Ginkgo biloba DXS gene encoding 1-deoxy-D-xylulose 5-phosphate synthase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. | Planta medica 20060301 |
A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-D-xylulose 5-phosphate synthase. | FEBS letters 20060206 |
Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. | Biochimica et biophysica acta 20060101 |
The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway. | The Plant journal : for cell and molecular biology 20051001 |
fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | FEBS letters 20050704 |
Mechanistic studies with 2-C-methyl-D-erythritol 4-phosphate synthase from Escherichia coli. | Biochemistry 20050614 |
Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphoric acid analogues as alternate substrates for methylerythritol phosphate synthase. | The Journal of organic chemistry 20050318 |
Evolution of the isoprene biosynthetic pathway in kudzu. | Plant physiology 20050201 |
Pools of 14C-malic acid as a substrate for pyruvate production for the DOXP/MEP pathway of biosynthesis of carotenoids in chloroplasts. | Doklady. Biochemistry and biophysics 20050101 |
The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. | The Journal of biological chemistry 20041210 |
Are iridoids in leaf beetle larvae synthesized de novo or derived from plant precursors? A methodological approach. | Isotopes in environmental and health studies 20040901 |
Biosynthetic pathway for the C45 polyprenol, solanesol, in tobacco. | Bioscience, biotechnology, and biochemistry 20040901 |
Rapid regulation of the methylerythritol 4-phosphate pathway during isoprene synthesis. | Plant physiology 20040801 |
[Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040701 |
Synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a potential inhibitor of the nonmevalonate pathway. | Bioscience, biotechnology, and biochemistry 20040601 |
CHLOROPLAST BIOGENESIS genes act cell and noncell autonomously in early chloroplast development. | Plant physiology 20040501 |
Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase. | Biochemistry 20040413 |
Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. | The Plant journal : for cell and molecular biology 20040401 |
Heterologous mevalonate production in Streptomyces lividans TK23. | Bioscience, biotechnology, and biochemistry 20040401 |
The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. | FEBS letters 20040312 |
Synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate from D-arabitol. | Organic letters 20040108 |
Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. | The Plant cell 20040101 |
The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs. | Current pharmaceutical design 20040101 |
Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3,4)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate, the substrate of the 1-deoxy-D-xylulose 5-phosphate reducto-isomerase. | Organic & biomolecular chemistry 20031221 |
A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens. | Trends in immunology 20030801 |
Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. | The Journal of biological chemistry 20030718 |
Microbial isoprenoid biosynthesis and human gammadelta T cell activation. | FEBS letters 20030605 |
Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. | FEBS letters 20030424 |
High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection. | Journal of chromatography. A 20030207 |
Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. | FEBS letters 20021218 |
LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. | FEBS letters 20021218 |
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. | Planta 20021201 |
Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | Plant physiology 20021101 |
Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | European journal of biochemistry 20020901 |
Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. | Plant physiology 20020801 |
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol and 2-C-methyl-D-erythritol-4-phosphate. | The Journal of organic chemistry 20020726 |
Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. | Immunology 20020601 |
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. | Journal of biochemistry 20020301 |
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. | The Journal of biological chemistry 20020215 |
E. coli MEP synthase: steady-state kinetic analysis and substrate binding. | Biochemistry 20020108 |
Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. | Phytochemistry 20020101 |
Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. | FEBS letters 20011207 |
Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid Synthesis. | Biochemical and biophysical research communications 20011123 |
Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase. | The Journal of organic chemistry 20011116 |
Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. | Plant physiology 20011001 |
Evidence for the biosynthesis of squalene via the methylerythritol phosphate pathway in a Streptomyces sp. obtained from a marine sediment. | The Journal of organic chemistry 20010907 |
Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. | Nature structural biology 20010701 |
LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. | FEBS letters 20010615 |
Concise synthesis of (+)-2-C-methyl-D-erythritol-4-phosphate. | The Journal of organic chemistry 20010406 |
Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. | Journal of immunology (Baltimore, Md. : 1950) 20010315 |
Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. | Planta 20010201 |
Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. | FEBS letters 20010119 |
Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | The Biochemical journal 20010101 |
Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway. | Acta biochimica Polonica 20010101 |
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