CAS 20578-92-1 | Benzene, 1-[2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy- | CAS Number 20578-92-1

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20578-92-1 | Benzene, 1-[2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-

CAS No: 20578-92-1 Catalog No: AG002ACH MDL No:

Product Description

Catalog Number:

AG002ACH

Chemical Name:

Benzene, 1-[2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-

CAS Number:

20578-92-1

Molecular Formula:

C18H20O4

Molecular Weight:

300.3490

IUPAC Name:

1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene

InChI:

InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+

InChI Key:

JDBCWSHYEQUBLW-AATRIKPKSA-N

SMILES:

COc1ccc(c(c1)OC)C=Cc1cc(OC)cc(c1)OC

Properties

Complexity:

332

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

300.136g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

300.354g/mol

Monoisotopic Mass:

300.136g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

36.9A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

4.1

Literature

Title	Journal
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170501
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension.	Circulation 20120828
Involvement of cytochrome P-450 1B1 in renal dysfunction, injury, and inflammation associated with angiotensin II-induced hypertension in rats.	American journal of physiology. Renal physiology 20120215
CYP1B1 detection.	Current protocols in toxicology 20120201
The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene.	Mutagenesis 20110901
Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland.	Breast cancer research and treatment 20110401
2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1.	American journal of physiology. Heart and circulatory physiology 20101201
Quantification of oxyresveratrol analog trans-2,4,3',5'-tetramethoxystilbene in rat plasma by a rapid HPLC method: application in a pre-clinical pharmacokinetic study.	Biomedical chromatography : BMC 20101201
TMS, a chemically modified herbal derivative of resveratrol, induces cell death by targeting Bax.	Breast cancer research and treatment 20101101
Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.	Hypertension (Dallas, Tex. : 1979) 20101001
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.	Chemical research in toxicology 20090701
Induction of p27(kip1) by 2,4,3',5'- tetramethoxystilbene is regulated by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells.	Archives of pharmacal research 20080901
Trans- and cis-stilbene polyphenols induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer cells but not normal cells.	European journal of pharmacology 20080610
DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons.	Mutation research 20080201
Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway.	Molecular pharmacology 20071101
Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.	Toxicology and applied pharmacology 20061101
Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.	Bioorganic & medicinal chemistry letters 20061101
Modulation of human cytochrome P450 1B1 expression by 2,4,3',5'-tetramethoxystilbene.	Drug metabolism and disposition: the biological fate of chemicals 20051201
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.	The Journal of biological chemistry 20051111
Metabolism of melatonin by human cytochromes p450.	Drug metabolism and disposition: the biological fate of chemicals 20050401
Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.	Biochemical pharmacology 20040415
Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.	Journal of medicinal chemistry 20020103
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.	Cancer research 20011115
Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells.	Archives of pharmacal research 20011001