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205391-01-1 | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5,6-diamino-3',6'-dihydroxy-
CAS No: 205391-01-1 Catalog No: AG002A2A MDL No:MFCD05865100
Product Description
Catalog Number:
AG002A2A
Chemical Name:
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5,6-diamino-3',6'-dihydroxy-
CAS Number:
205391-01-1
Molecular Formula:
C20H14N2O5
Molecular Weight:
362.3356
MDL Number:
MFCD05865100
IUPAC Name:
5,6-diamino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
InChI:
InChI=1S/C20H14N2O5/c21-15-7-11-14(8-16(15)22)20(27-19(11)25)12-3-1-9(23)5-17(12)26-18-6-10(24)2-4-13(18)20/h1-8,23-24H,21-22H2
InChI Key:
LTYUPYUWXRTNFQ-UHFFFAOYSA-N
SMILES:
Oc1ccc2c(c1)Oc1c(C32OC(=O)c2c3cc(N)c(c2)N)ccc(c1)O
Properties
Complexity:
589
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
362.09g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
362.341g/mol
Monoisotopic Mass:
362.09g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
128A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1
Literature
| Title | Journal |
|---|---|
| Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells. | American journal of physiology. Endocrinology and metabolism 20120601 |
| Pitfalls and limitations in using 4,5-diaminofluorescein for evaluating the influence of polyphenols on nitric oxide release from endothelial cells. | Free radical biology & medicine 20120601 |
| Spontaneous increases in the fluorescence of 4,5-diaminofluorescein and its analogs: their impact on the fluorometry of nitric oxide production in endothelial cells. | Biological & pharmaceutical bulletin 20120101 |
| Quantitative 3D analysis of nitric oxide diffusion in a 3D artery model using sensor particles. | Angewandte Chemie (International ed. in English) 20110808 |
| Response to 'The use of diaminofluorescein for nitric oxide detection: conceptual and methodological distinction between NO and nitrosation'. | Free radical biology & medicine 20110301 |
| The use of diaminofluorescein for nitric oxide detection: Conceptual and methodological distinction between NO and nitrosation. | Free radical biology & medicine 20100915 |
| A Maillard reaction product enhances eNOS activity in human endothelial cells. | Molecular nutrition & food research 20100701 |
| Reactivity of glass-embedded met hemoglobin derivatives toward external NO: implications for nitrite-mediated production of bioactive NO. | Journal of the American Chemical Society 20090902 |
| Micro gas analyzer measurement of nitric oxide in breath by direct wet scrubbing and fluorescence detection. | Analytical chemistry 20090815 |
| Exogenous vs. endogenous gamma-glutamyltransferase activity: Implications for the specific determination of S-nitrosoglutathione in biological samples. | Archives of biochemistry and biophysics 20090715 |
| Direct evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation. | The Journal of physiology 20090615 |
| Use of diaminofluoresceins to detect and measure nitric oxide in low level generating human immune cells. | Journal of immunological methods 20090315 |
| A novel method of measuring nitric-oxide-dependent fluorescence using 4,5-diaminofluorescein (DAF-2) in the isolated Langendorff-perfused rabbit heart. | Pflugers Archiv : European journal of physiology 20080601 |
| Nitric oxide modulates sodium taste via a cGMP-independent pathway. | Developmental neurobiology 20070201 |
| Nitrosation of N-terminally blocked tryptophan and tryptophan-containing peptides by peroxynitrite. | Chembiochem : a European journal of chemical biology 20070122 |
| Design and characterization of a nano-encapsulated self-referenced fluorescent nitric oxide sensor for wide-field optical imaging. | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20070101 |
| Synthesis of nitric oxide in human osteoblasts in response to physiologic stimulation of electrotherapy. | Annals of biomedical engineering 20061201 |
| Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium. | Canadian journal of physiology and pharmacology 20061001 |
| Thiocyanate cannot inhibit the formation of reactive nitrogen species in the human oral cavity in the presence of high concentrations of nitrite: detection of reactive nitrogen species with 4,5-diaminofluorescein. | Chemical research in toxicology 20060801 |
| Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body. | Cell and tissue research 20060701 |
| Measuring nitric oxide in single neurons by capillary electrophoresis with laser-induced fluorescence: use of ascorbate oxidase in diaminofluorescein measurements. | Analytical chemistry 20060315 |
| Extracellular ATP stimulates NO production in rat thick ascending limb. | Hypertension (Dallas, Tex. : 1979) 20060301 |
| Detection of N-nitrosomelatonin and other N-nitrosotryptophan derivatives by transnitrosation of APF and DAF-2. | Journal of pineal research 20060101 |
| Nitric oxide (NO) detection by DAF fluorescence and chemiluminescence: a comparison using abiotic and biotic NO sources. | Journal of experimental botany 20060101 |
| Assessment of S-nitrosothiols on diaminofluorescein gels. | Analytical biochemistry 20051101 |
| Production of nitric oxide-derived reactive nitrogen species in human oral cavity and their scavenging by salivary redox components. | Free radical research 20050701 |
| Increased intracellular pH at the macula densa activates nNOS during tubuloglomerular feedback. | Kidney international 20050501 |
| Nitric oxide release is induced by dopamine during illumination of the carp retina: serial neurochemical control of light adaptation. | The European journal of neuroscience 20050401 |
| Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs. | Journal of the American Chemical Society 20050323 |
| Nitric oxide mediates inhibitory effect of leptin on insulin-like growth factor I augmentation of 17beta-estradiol production in human granulosa cells. | Biology of reproduction 20050101 |
| Measurement of nitric oxide by 4,5-diaminofluorescein without interferences. | The Analyst 20041201 |
| High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism. | American journal of physiology. Renal physiology 20040901 |
| Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats. | The Journal of surgical research 20040515 |
| Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system. | The Journal of surgical research 20040401 |
| Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe. | Journal of the American Chemical Society 20040317 |
| Distinct glutamate receptors govern differential levels of nitric oxide production in a layer-specific manner in the rat cerebellar cortex. | Neuroscience 20040101 |
| Nitric oxide imaging in neurons using confocal microscopy. | Methods in molecular biology (Clifton, N.J.) 20040101 |
| A nonradioactive assay for nitric oxide synthase activity in tissue extracts. | Methods in molecular biology (Clifton, N.J.) 20040101 |
| Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells. | Nitric oxide : biology and chemistry 20030901 |
| Cooperation between insulin and leptin in the modulation of vascular tone. | Hypertension (Dallas, Tex. : 1979) 20030801 |
| Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. | American journal of physiology. Lung cellular and molecular physiology 20030401 |
| Nitric oxide mediated photo-induced cell death in human malignant cells. | International journal of oncology 20030401 |
| Nitric oxide inhibits adenosine 5'-triphosphate-induced Ca2+ response in inner hair cells of the guinea pig cochlea. | Neuroscience letters 20030213 |
| Interfering with nitric oxide measurements. 4,5-diaminofluorescein reacts with dehydroascorbic acid and ascorbic acid. | The Journal of biological chemistry 20021213 |
| Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. | Circulation research 20021213 |
| 4,5-diaminofluoroscein imaging of nitric oxide synthesis in crayfish terminal ganglia. | Journal of neurobiology 20021115 |
| Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells. | American journal of physiology. Heart and circulatory physiology 20021101 |
| Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration. | Journal of the American Society of Nephrology : JASN 20021101 |
| The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability. | Hearing research 20021001 |
| Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide. | Free radical biology & medicine 20020901 |
| Increased basal nitric oxide release despite enhanced free radical production in hypertension. | Journal of hypertension 20020601 |
| Sensory neurons respond to hypoxia with NO production associated with mitochondria. | Molecular and cellular neurosciences 20020601 |
| Nitric oxide-induced signalling in rat lacrimal acinar cells. | Acta physiologica Scandinavica 20020201 |
| Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein to detect NO. | The Journal of biological chemistry 20020104 |
| Quantitation of S-nitrosothiols in cells and biological fluids. | Methods in enzymology 20020101 |
| Nitric oxide production in living neurons is modulated by sphingosine: a fluorescence microscopy study. | FEBS letters 20011012 |
| Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein. | FEBS letters 20011005 |
| Determinants of shear stress-stimulated endothelial nitric oxide production assessed in real-time by 4,5-diaminofluorescein fluorescence. | Biochemical and biophysical research communications 20010817 |
| Distinction between nitrosating mechanisms within human cells and aqueous solution. | The Journal of biological chemistry 20010810 |
| Nitric oxide generation by isolated descending vasa recta. | American journal of physiology. Heart and circulatory physiology 20010701 |
| Effect of red wine and ethanol on production of nitric oxide in healthy subjects. | The American journal of cardiology 20010415 |
| Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging. | FEBS letters 20010302 |
| A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle. | Nitric oxide : biology and chemistry 20010101 |
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