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204326-43-2 | 1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-
CAS No: 204326-43-2 Catalog No: AG0029G2 MDL No:
Product Description
Catalog Number:
AG0029G2
Chemical Name:
1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-
CAS Number:
204326-43-2
Molecular Formula:
C9H5BrN2O3
Molecular Weight:
269.0516
IUPAC Name:
8-bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
InChI:
InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
InChI Key:
MUDRLQRJCGJJTB-UHFFFAOYSA-N
SMILES:
Brc1ccc2c(c1)n1c(CO2)noc1=O
Properties
Complexity:
333
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
267.948g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
269.054g/mol
Monoisotopic Mass:
267.948g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
51.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2
Literature
| Title | Journal |
|---|---|
| The inotropic effects of ammonia on isolated perfused rat hearts and the mechanisms involved. | The Journal of experimental biology 20111201 |
| The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells. | Nitric oxide : biology and chemistry 20110801 |
| Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells. | PloS one 20110101 |
| Endothelium-derived nitric oxide inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing big conductance calcium-activated potassium channels of vascular smooth muscle. | The Journal of pharmacology and experimental therapeutics 20100701 |
| The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. | American journal of physiology. Regulatory, integrative and comparative physiology 20100301 |
| Effects of carbon monoxide on trout and lamprey vessels. | American journal of physiology. Regulatory, integrative and comparative physiology 20090101 |
| cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines. | British journal of pharmacology 20081101 |
| Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. | Journal of medicinal chemistry 20080724 |
| Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080201 |
| Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate. | Nature chemical biology 20071101 |
| NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes. | Cardiovascular research 20070715 |
| Up-regulation of microglial CD11b expression by nitric oxide. | The Journal of biological chemistry 20060526 |
| Nitric oxide inhibits gastric acid secretion by increasing intraparietal cell levels of cGMP in isolated human gastric glands. | American journal of physiology. Gastrointestinal and liver physiology 20051201 |
| Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. | Molecular human reproduction 20031201 |
| Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta. | The Journal of biological chemistry 20030124 |
| Facilitatory role of NO in neural norepinephrine release in the rat kidney. | American journal of physiology. Regulatory, integrative and comparative physiology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Comparative vasodilation of peroxynitrite and 3-morpholinosydnonimine. | Life sciences 20011005 |
| Both serotonin and a nitric-oxide donor cause chloride secretion in rat colonocytes by stimulating cGMP. | Surgery 20010801 |
| Accumulation of HIF-1alpha under the influence of nitric oxide. | Blood 20010215 |
| Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. | British journal of pharmacology 19980101 |
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