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203191-10-0 | Acetic acid, 2-[[2-(3,4-dimethoxyphenyl)-5-methoxy-4-oxo-4H-1-benzopyran-7-yl]oxy]-
CAS No: 203191-10-0 Catalog No: AG0028PR MDL No:
Product Description
Catalog Number:
AG0028PR
Chemical Name:
Acetic acid, 2-[[2-(3,4-dimethoxyphenyl)-5-methoxy-4-oxo-4H-1-benzopyran-7-yl]oxy]-
CAS Number:
203191-10-0
Molecular Formula:
C20H18O8
Molecular Weight:
386.3521
IUPAC Name:
2-[2-(3,4-dimethoxyphenyl)-5-methoxy-4-oxochromen-7-yl]oxyacetic acid
InChI:
InChI=1S/C20H18O8/c1-24-14-5-4-11(6-16(14)25-2)15-9-13(21)20-17(26-3)7-12(8-18(20)28-15)27-10-19(22)23/h4-9H,10H2,1-3H3,(H,22,23)
InChI Key:
BCPQOBQIVJZOFL-UHFFFAOYSA-N
SMILES:
COc1cc(OCC(=O)O)cc2c1c(=O)cc(o2)c1ccc(c(c1)OC)OC
UNII:
U96J5LG435
Properties
Complexity:
603
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
386.1g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
386.356g/mol
Monoisotopic Mass:
386.1g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
101A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
Literature
| Title | Journal |
|---|---|
| DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. | Journal of gastroenterology and hepatology 20120201 |
| A mechanism for the action of the compound DA-6034 on NF-κB pathway activation in Helicobacter pylori-infected gastric epithelial cells. | Scandinavian journal of immunology 20110901 |
| The therapeutic effect of DA-6034 on ocular inflammation via suppression of MMP-9 and inflammatory cytokines and activation of the MAPK signaling pathway in an experimental dry eye model. | Current eye research 20100201 |
| Liquid chromatography-mass spectrometry for the simultaneous determination of the catalpol-related iridoid glucosides, verproside, isovanilloylcatalpol, catalposide and 6-O-veratroyl catalpol in rat plasma. | Biomedical chromatography : BMC 20090901 |
| Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601 |
| Effects of DA-6034, a flavonoid derivative, on mucin-like glycoprotein and ocular surface integrity in a rabbit model. | Arzneimittel-Forschung 20090101 |
| Gastroretentive drug delivery system of DA-6034, a new flavonoid derivative, for the treatment of gastritis. | International journal of pharmaceutics 20080522 |
| DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. | Experimental biology and medicine (Maywood, N.J.) 20080201 |
| The effects of DA-6034 on NF-kappaB activity induced by lipopolysaccharide or tumor necrosis factor alpha in a human colonic epithelial cell line. | Hepato-gastroenterology 20080101 |
| Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models. | Digestive diseases and sciences 20071101 |
| Inhibitory effects of 7-carboxymethyloxy-3',4',5-trimethoxyflavone (DA-6034) on Helicobacter pylori-induced NF-kappa B activation and iNOS expression in AGS cells. | Annals of the New York Academy of Sciences 20070101 |
| Pharmacokinetics of DA-6034, an agent for inflammatory bowel disease, in rats and dogs: Contribution of intestinal first-pass effect to low bioavailability in rats. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060301 |
| Gender differences in the pharmacokinetics of DA-6034, a derivative of flavonoids, in rats. | Biopharmaceutics & drug disposition 20060101 |
| Pharmacokinetics of 7-carboxymethyloxy-3',4',5-trimethoxy flavone (DA-6034), a derivative of flavonoid, in mouse and rat models of chemically-induced inflammatory bowel disease. | The Journal of pharmacy and pharmacology 20060101 |
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