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Home > Pyridines > 201531-68-2
201531-68-2 | Pyridazinone
CAS No: 201531-68-2 Catalog No: AG002DHC MDL No:
Product Description
Catalog Number:
AG002DHC
Chemical Name:
Pyridazinone
CAS Number:
201531-68-2
Molecular Formula:
C4H4N2O
Molecular Weight:
96.0874
IUPAC Name:
1H-pyridazin-6-one
InChI:
InChI=1S/C4H4N2O/c7-4-2-1-3-5-6-4/h1-3H,(H,6,7)
InChI Key:
AAILEWXSEQLMNI-UHFFFAOYSA-N
SMILES:
O=c1cccn[nH]1
NSC Number:
21411
Properties
Complexity:
137
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
96.032g/mol
Formal Charge:
0
Heavy Atom Count:
7
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
96.089g/mol
Monoisotopic Mass:
96.032g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
41.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.7
Literature
| Title | Journal |
|---|---|
| N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study. | Molecules (Basel, Switzerland) 20120806 |
| Synthesis and in vitro biological activity of new 4,6-disubstituted 3(2H)-pyridazinone-acetohydrazide derivatives. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20120101 |
| Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA. | Chemical communications (Cambridge, England) 20111021 |
| Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity. | Bioorganic & medicinal chemistry letters 20110915 |
| Synthesis of functionalized pyridazin-3(2H)-ones via selective bromine-magnesium exchange and lactam directed ortho C-H magnesiation. | The Journal of organic chemistry 20110819 |
| Synthesis and complete assignment of the 1H and 13C NMR spectra of 6-substituted and 2,6-disubstituted pyridazin-3(2H)-ones. | Magnetic resonance in chemistry : MRC 20110701 |
| Analytical and semi-preparative HPLC enantioseparation of novel pyridazin-3(2H)-one derivatives with α-aminophosphonate moiety using immobilized polysaccharide chiral stationary phases. | Journal of separation science 20110201 |
| Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors. | Bioorganic & medicinal chemistry letters 20100715 |
| Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone. | Arzneimittel-Forschung 20100101 |
| Studies on the reactivity of (9-Methyl-5,6-dihydronaphtho[1â,2â:4,5]-thieno[2,3-d]pyrimidin-11-yl)hydrazine towards some reagents for biological evaluation. | Scientia pharmaceutica 20100101 |
| Synthesis of functionalized pyridazin-3(2H)-ones via bromine-magnesium exchange on bromopyridazin-3(2H)-ones. | The Journal of organic chemistry 20091218 |
| 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. | Journal of medicinal chemistry 20090827 |
| A facile synthesis of pyridazinone derivatives under ultrasonic irradiation. | Ultrasonics sonochemistry 20090401 |
| Screening and evaluation of antioxidant activity of some pyridazine derivatives. | Journal of enzyme inhibition and medicinal chemistry 20080401 |
| Functionalized heteroarylpyridazines and pyridazin-3(2H)-one derivatives via palladium-catalyzed cross-coupling methodology. | The Journal of organic chemistry 20080321 |
| Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents. | Bioorganic & medicinal chemistry letters 20080215 |
| Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents. | Arzneimittel-Forschung 20080101 |
| Effect of oxadiazolyl 3(2H)-pyridazinone on the larval growth and digestive physiology of the armyworm, Pseudaletia separata. | Journal of insect science (Online) 20080101 |
| Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity. | Journal of medicinal chemistry 20071227 |
| Moderate neonatal stress decreases within-group variation in behavioral, immune and HPA responses in adult mice. | PloS one 20070101 |
| 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists. | Neuropharmacology 20060701 |
| Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries. | Combinatorial chemistry & high throughput screening 20060101 |
| Syntheses, antifeedant activity, and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones. | Journal of agricultural and food chemistry 20050420 |
| 2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation. | Bioorganic & medicinal chemistry 20050315 |
| Synthesis and analgesic and antiinflammatory activity of methyl 6-substituted-3(2h)-pyridazinone-2-ylacetate derivatives. | Archiv der Pharmazie 20040801 |
| Synthesis and evaluation of the analgesic and anti-inflammatory activity of new 3(2H)-pyridazinone derivatives. | Arzneimittel-Forschung 20040101 |
| Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents. | The Journal of pharmacy and pharmacology 20030901 |
| The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites. | Pest management science 20030801 |
| Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones. | Journal of agricultural and food chemistry 20030101 |
| Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives. | Journal of medicinal chemistry 20020815 |
| Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors. | Journal of medicinal chemistry 20010621 |
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