200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 2002-35-9
2002-35-9 | Adenosine, 2'-deoxy-N-methyl-
CAS No: 2002-35-9 Catalog No: AG002CM4 MDL No:MFCD00055999
Product Description
Catalog Number:
AG002CM4
Chemical Name:
Adenosine, 2'-deoxy-N-methyl-
CAS Number:
2002-35-9
Molecular Formula:
C11H15N5O3
Molecular Weight:
265.2685
MDL Number:
MFCD00055999
IUPAC Name:
(2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
InChI:
InChI=1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1
InChI Key:
DYSDOYRQWBDGQQ-XLPZGREQSA-N
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1ncnc2NC
UNII:
48QZW2IR9H
Properties
Complexity:
321
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
265.117g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
265.273g/mol
Monoisotopic Mass:
265.117g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.2
Literature
| Title | Journal |
|---|---|
| Effects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel. | British journal of pharmacology 20120501 |
| Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats. | The Journal of physiology 20120401 |
| P2Y1 purinoceptor inhibition reduces extracellular signal-regulated protein kinase 1/2 phosphorylation in spinal cord and dorsal root ganglia: implications for cancer-induced bone pain. | Acta biochimica et biophysica Sinica 20120401 |
| Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. | Assay and drug development technologies 20120201 |
| P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices. | Journal of neurophysiology 20120201 |
| Functional contribution of P2Y1 receptors to the control of coronary blood flow. | Journal of applied physiology (Bethesda, Md. : 1985) 20111201 |
| Prevention of extracellular ADP-induced ATP accumulation of the cultured rat spinal astrocytes via P2Y(1)-mediated inhibition of AMPK. | Neuroscience letters 20111010 |
| Local Ca2+ detection and modulation of synaptic release by astrocytes. | Nature neuroscience 20110911 |
| Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade. | Pain 20110801 |
| Regional functional specialization and inhibitory nitrergic and nonnitrergic coneurotransmission in the human esophagus. | American journal of physiology. Gastrointestinal and liver physiology 20110501 |
| ADP ribose is an endogenous ligand for the purinergic P2Y1 receptor. | Molecular and cellular endocrinology 20110210 |
| P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells. | American journal of physiology. Cell physiology 20110201 |
| Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. | Immunobiology 20110101 |
| Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. | PloS one 20110101 |
| Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells. | PloS one 20110101 |
| Metabolic regulation of coronary vascular tone: role of hydrogen peroxide, purinergic components, and angiotensin. | European journal of pharmacology 20101025 |
| TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. | Journal of neurochemistry 20101001 |
| Facilitation of Ih channels by P2Y1 receptors activation in Mesencephalic trigeminal neurons. | Neuroscience letters 20100927 |
| Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress. | Investigative ophthalmology & visual science 20100801 |
| Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder. | Basic & clinical pharmacology & toxicology 20100701 |
| Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells. | Journal of periodontal research 20100601 |
| P2Y1 receptors mediate apamin-sensitive and -insensitive inhibitory junction potentials in murine colonic circular smooth muscle. | The Journal of pharmacology and experimental therapeutics 20100501 |
| Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors. | Molecular and cellular neurosciences 20100401 |
| AMP N(1)-oxide, a unique compound of royal jelly, induces neurite outgrowth from PC12 cells via signaling by protein kinase A independent of that by mitogen-activated protein kinase. | Evidence-based complementary and alternative medicine : eCAM 20100301 |
| Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. | Journal of neurochemistry 20100301 |
| Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes. | American journal of physiology. Cell physiology 20100301 |
| Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia. | Glia 20100101 |
| CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells. | Journal of vascular research 20100101 |
| Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. | PloS one 20100101 |
| The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. | Neurochemistry international 20091201 |
| Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat. | The Journal of comparative neurology 20091010 |
| Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina. | Journal of neurochemistry 20091001 |
| Role of P2Y1 receptor in astroglia-to-neuron signaling at dorsal spinal cord. | Journal of neuroscience research 20090901 |
| P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus. | Journal of neurophysiology 20090901 |
| Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. | American journal of physiology. Regulatory, integrative and comparative physiology 20090801 |
| Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons. | American journal of physiology. Gastrointestinal and liver physiology 20090701 |
| The NANC relaxation of the human ileal longitudinal and circular muscles is inhibited by MRS 2179, a P2 purinoceptor antagonist. | Life sciences 20090619 |
| Mechanism of activation and functional role of protein kinase Ceta in human platelets. | The Journal of biological chemistry 20090515 |
| Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090301 |
| Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. | Blood cells, molecules & diseases 20090101 |
| P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling. | Molecular pharmacology 20081201 |
| Ca2+ signaling in injured in situ endothelium of rat aorta. | Cell calcium 20080901 |
| Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways. | Neuroscience bulletin 20080801 |
| Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures. | Neuroscience letters 20080425 |
| Functional evidence for purinergic inhibitory neuromuscular transmission in the mouse internal anal sphincter. | American journal of physiology. Gastrointestinal and liver physiology 20080401 |
| Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. | The Journal of pharmacology and experimental therapeutics 20080301 |
| Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents. | Platelets 20080301 |
| P2Y1 receptors mediate inhibitory neuromuscular transmission and enteric neuronal activation in small intestine. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080201 |
| Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons. | Journal of neurochemistry 20080101 |
| Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments. | Journal of pharmacological sciences 20080101 |
| GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. | BMC bioinformatics 20080101 |
| Inhibition of ATP-induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes. | Pharmacology 20080101 |
| Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. | Journal of cell science 20071215 |
| Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon. | Regulatory peptides 20071204 |
| P2Y receptor-activating nucleotides modulate cellular reactive oxygen species production in dissociated hippocampal astrocytes and neurons in culture independent of parallel cytosolic Ca(2+) rise and change in mitochondrial potential. | Journal of neuroscience research 20071115 |
| The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia. | Journal of thrombosis and thrombolysis 20071001 |
| Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. | Platelets 20070801 |
| ATP release and hydrolysis contribute to rat pial arteriolar dilatation elicited by neuronal activation. | Experimental physiology 20070701 |
| Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine. | American journal of physiology. Gastrointestinal and liver physiology 20070601 |
| Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. | British journal of pharmacology 20070501 |
| Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. | Thrombosis and haemostasis 20070301 |
| Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. | American journal of physiology. Gastrointestinal and liver physiology 20070201 |
| A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201 |
| P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070131 |
| ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors. | American journal of physiology. Regulatory, integrative and comparative physiology 20070101 |
| Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors. | Journal of cellular biochemistry 20061101 |
| Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. | Biochemical pharmacology 20061016 |
| P2Y1 receptors mediate inhibitory purinergic neuromuscular transmission in the human colon. | American journal of physiology. Gastrointestinal and liver physiology 20061001 |
| Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides. | The European journal of neuroscience 20061001 |
| PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. | The Journal of biological chemistry 20060908 |
| P2Y receptor-mediated excitation in the posterior hypothalamus. | The European journal of neuroscience 20060901 |
| Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition. | Endocrinology 20060701 |
| Can the PFA-100 be modified to detect P2Y12 inhibition? | Journal of thrombosis and haemostasis : JTH 20060601 |
| Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase. | FEBS letters 20060529 |
| Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland. | Archives of oral biology 20060501 |
| Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine. | European journal of pharmacology 20060424 |
| Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts. | European journal of pharmacology 20060318 |
| Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice. | British journal of pharmacology 20060301 |
| Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. | Development (Cambridge, England) 20060201 |
| Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. | Journal of neurochemistry 20051201 |
| Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons. | European journal of pharmacology 20051003 |
| Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706 |
| Inhibition of purinoceptors amplifies glucose-stimulated insulin release with removal of its pulsatility. | Diabetes 20050701 |
| The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. | Naunyn-Schmiedeberg's archives of pharmacology 20050701 |
| Metabotropic P2Y purinoceptor-mediated presynaptic and postsynaptic enhancement of cerebellar GABAergic transmission. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223 |
| ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. | Circulation research 20050204 |
| Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201 |
| Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. | The Journal of pharmacology and experimental therapeutics 20041001 |
| Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells. | Pflugers Archiv : European journal of physiology 20041001 |
| Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation. | British journal of pharmacology 20040801 |
| The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented. | Journal of thrombosis and haemostasis : JTH 20040601 |
| Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y(1) receptor antagonists. | Bioorganic & medicinal chemistry 20040401 |
| ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells. | American journal of respiratory cell and molecular biology 20040301 |
| N(6)-Methyldeoxyadenosine, a nucleoside commonly found in prokaryotes, induces C2C12 myogenic differentiation. | Biochemical and biophysical research communications 20040206 |
| ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells. | The Journal of physiology 20031101 |
| Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity. | Arteriosclerosis, thrombosis, and vascular biology 20031001 |
| Nucleotide coronary vasodilation in guinea pig hearts. | American journal of physiology. Heart and circulatory physiology 20030901 |
| Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors. | Glia 20030901 |
| Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system. | The Journal of physiology 20030715 |
| The platelet P2Y receptors as targets for new antithrombotic drugs. | Journal of thrombosis and haemostasis : JTH 20030601 |
| Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. | Journal of thrombosis and haemostasis : JTH 20030601 |
| Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways. | Biochemical and biophysical research communications 20030516 |
| P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip5I, and not by MRS-2197. | European journal of pharmacology 20030502 |
| Effects of inhibition of P2Y(1) and P2Y(12) on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry. | Thrombosis research 20030315 |
| P2Y receptor-mediated inhibition of voltage-dependent Ca2+ channels in rat dorsal root ganglion neurons. | Synapse (New York, N.Y.) 20030201 |
| P2Y(1) receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex. | Neurochemistry international 20030101 |
| The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179. | Cardiovascular drug reviews 20030101 |
| The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation. | Thrombosis research 20030101 |
| Activation of adenosine and P2Y receptors by ATP in human peripheral nerve. | Naunyn-Schmiedeberg's archives of pharmacology 20021101 |
| Effects of dinucleoside polyphosphates on regulation of coronary vascular tone. | European journal of pharmacology 20020719 |
| P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed. | British journal of pharmacology 20020701 |
| 2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al. | British journal of pharmacology 20020401 |
| 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. | British journal of pharmacology 20020401 |
| Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques. | Journal of medicinal chemistry 20020214 |
| Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179. | British journal of pharmacology 20020101 |
| Effects of P2Y(1) and P2Y(12) receptor antagonists on ADP-induced shape change of equine platelets: comparison with human platelets. | Platelets 20020101 |
| The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cells. | Biochemical and biophysical research communications 20010720 |
| Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y(1) receptor on bone cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501 |
| Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. | Circulation 20010206 |
| Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. | European journal of pharmacology 20010202 |
| Endothelium-dependent, MRS2179-independent actions of uridine 5'-triphosphate in guinea pig aorta. | Proceedings of the Western Pharmacology Society 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.