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Home > Aldehydes > 199396-76-4
199396-76-4 | Benzaldehyde, 4-[(11β,17β)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]-, 1-oxime, [C(E)]-
CAS No: 199396-76-4 Catalog No: AG002C39 MDL No:
Product Description
Catalog Number:
AG002C39
Chemical Name:
Benzaldehyde, 4-[(11β,17β)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]-, 1-oxime, [C(E)]-
CAS Number:
199396-76-4
Molecular Formula:
C28H35NO4
Molecular Weight:
449.5818
IUPAC Name:
(8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
InChI:
InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1
InChI Key:
GJMNAFGEUJBOCE-MEQIQULJSA-N
SMILES:
COC[C@]1(OC)CC[C@@H]2[C@]1(C)C[C@@H](c1ccc(cc1)/C=N/O)C1=C3CCC(=O)C=C3CC[C@@H]21
UNII:
72W09924WP
Properties
Complexity:
867
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
5
Defined Bond Stereocenter Count:
1
Exact Mass:
449.257g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
449.591g/mol
Monoisotopic Mass:
449.257g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
68.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2
Literature
| Title | Journal |
|---|---|
| Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides. | Bioorganic & medicinal chemistry letters 20121201 |
| X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids. | The Journal of biological chemistry 20120608 |
| The state-of-the-art of emergency contraception with the cutting edge drug. | German medical science : GMS e-journal 20110101 |
| [Uterine leiomyoma]. | Orvosi hetilap 20101017 |
| Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth. | Seminars in reproductive medicine 20100501 |
| Clinical utility of progesterone receptor modulators and their effect on the endometrium. | Current opinion in obstetrics & gynecology 20090801 |
| Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN. | Human reproduction (Oxford, England) 20090501 |
| Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system. | The Journal of steroid biochemistry and molecular biology 20090101 |
| Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor alpha in rat uterine cells and tissues. | Steroids 20090101 |
| Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy. | The Journal of clinical endocrinology and metabolism 20081201 |
| Development and validation of an improved inducer-regulator protein complex in the pBRES-regulated expression system. | Human gene therapy 20081101 |
| A new generation of progesterone receptor modulators. | Steroids 20080801 |
| Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer. | Human reproduction (Oxford, England) 20080401 |
| Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). | Journal of medicinal chemistry 20080327 |
| 11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists. | Bioorganic & medicinal chemistry 20080315 |
| Non-surgical management of uterine fibroids. | Human reproduction update 20080101 |
| Action of progesterone receptor modulators on uterine leiomyomas. | Clinical and experimental obstetrics & gynecology 20080101 |
| Comparative effects of SPRM asoprisnil (J867) on proliferation, apoptosis, and the expression of growth factors in cultured uterine leiomyoma cells and normal myometrial cells. | Reproductive sciences (Thousand Oaks, Calif.) 20071201 |
| Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells. | American journal of physiology. Endocrinology and metabolism 20071001 |
| A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata. | Fertility and sterility 20070601 |
| The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. | Human reproduction (Oxford, England) 20070601 |
| A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. | Molecular endocrinology (Baltimore, Md.) 20070501 |
| A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. | The Journal of clinical endocrinology and metabolism 20070201 |
| Determination of conformational changes in the progesterone receptor using ELISA-like assays. | Steroids 20060901 |
| A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells. | Human reproduction (Oxford, England) 20060701 |
| A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. | The Journal of clinical endocrinology and metabolism 20060401 |
| Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs). | Reproductive biology and endocrinology : RB&E 20060101 |
| Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. | Endocrine reviews 20050501 |
| The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women. | Human reproduction (Oxford, England) 20050401 |
| Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs). | Seminars in reproductive medicine 20050201 |
| Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. | Human reproduction update 20050101 |
| Molecule of the month: asoprisnil. | Drug news & perspectives 20050101 |
| Therapeutic potential for the selective progesterone receptor modulator asoprisnil in the treatment of leiomyomata. | Seminars in reproductive medicine 20040501 |
| Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy. | Steroids 20031101 |
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