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19728-88-2 | Piperazine, 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-, (2Z)-2-butenedioate (1:1)
CAS No: 19728-88-2 Catalog No: AG002APG MDL No:
Product Description
Catalog Number:
AG002APG
Chemical Name:
Piperazine, 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-, (2Z)-2-butenedioate (1:1)
CAS Number:
19728-88-2
Molecular Formula:
C24H28N2O4S2
Molecular Weight:
472.6201
IUPAC Name:
(Z)-but-2-enedioic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine
InChI:
InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key:
IWDBEHWZGDSFHR-BTJKTKAUSA-N
SMILES:
OC(=O)/C=C\C(=O)O.CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
Properties
Complexity:
529
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
472.149g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
472.618g/mol
Monoisotopic Mass:
472.149g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
132A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Mechanisms of amnesia induced by impairment of long-term memory reconsolidation in edible snail. | Bulletin of experimental biology and medicine 20120901 |
| μ1- and 5-HT1-dependent mechanisms in the anterior pretectal nucleus mediate the antinociceptive effects of retrosplenial cortex stimulation in rats. | Life sciences 20120614 |
| Characterization of 5-hydroxytryptamine-induced contraction and acetylcholine-induced relaxation in isolated chicken basilar artery. | Poultry science 20120501 |
| Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test. | Neuroscience letters 20111024 |
| 5-HT receptors mediate lineage-dependent effects of serotonin on adult neurogenesis in Procambarus clarkii. | Neural development 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. | Molecular pain 20100101 |
| Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system. | Journal of neurophysiology 20091201 |
| Neurochemical mechanisms of consolidation of associative aversive training to food in the common snail. | Neuroscience and behavioral physiology 20091101 |
| Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? | The Journal of experimental biology 20091101 |
| Neurochemical mechanisms of consolidation of associative aversive learning to food in the common snail. | Neuroscience and behavioral physiology 20090901 |
| Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition. | Neuroscience research 20090701 |
| 5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus. | Experimental neurology 20090501 |
| Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy. | Pharmacological reports : PR 20090101 |
| Combined blockade of serotonergic and muscarinic transmission disrupts the anterior thalamic head direction signal. | Behavioral neuroscience 20081201 |
| [Neurochemical mechanisms of food aversion conditioning consolidation in snail Helix lucorum]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20081101 |
| Serotonin and NMDA glutamate receptor antagonists selectively impair the reactivation of associative memory in the common snail. | Neuroscience and behavioral physiology 20080901 |
| The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists. | Journal of molecular graphics & modelling 20080801 |
| Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats. | American journal of physiology. Renal physiology 20080701 |
| Spatial-specific action of serotonin within the leech midbody ganglion. | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20080601 |
| Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. | PloS one 20080101 |
| An antidepressant that extends lifespan in adult Caenorhabditis elegans. | Nature 20071122 |
| Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart. | Clinical and experimental pharmacology & physiology 20071101 |
| [Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20071001 |
| Effects of medullary Raphé stimulation on fictive lung ventilation during development in Rana catesbeiana. | The Journal of experimental biology 20070601 |
| A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors. | Basic & clinical pharmacology & toxicology 20070401 |
| Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses. | Neuropharmacology 20070101 |
| Evaluation of the serotonin receptor blocker methiothepin in broilers injected intravenously with lipopolysaccharide and microparticles. | Poultry science 20061201 |
| Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera). | Journal of neurochemistry 20060901 |
| Methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of sensitization of the defensive response in the common snail. | Neuroscience and behavioral physiology 20060701 |
| Serotonin receptor antagonists discriminate between PKA- and PKC-mediated plasticity in aplysia sensory neurons. | Journal of neurophysiology 20060401 |
| Evaluation of the serotonin receptor blockers ketanserin and methiothepin on the pulmonary hypertensive responses of broilers to intravenously infused serotonin. | Poultry science 20060401 |
| Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. | European journal of pharmacology 20060327 |
| Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor. | European journal of pharmacology 20060217 |
| Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. | European journal of pharmacology 20051219 |
| Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. | Clinical and experimental pharmacology & physiology 20051001 |
| alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons. | European journal of pharmacology 20050704 |
| Involvement of pre- and post-synaptic serotonergic receptors of dorsal raphe nucleus neural network in the control of the sweet-substance-induced analgesia in adult Rattus norvegicus (Rodentia, Muridae). | Neuroscience letters 20050513 |
| In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking. | Brain research 20050510 |
| Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib. | European journal of pharmacology 20050418 |
| m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat. | Pharmacology 20050201 |
| Clozapine directly relaxes bovine retinal arteries. | Current eye research 20050201 |
| [Methiothepin-sensitive serotonin receptors are involved in postsynaptic mechanism of sensitization of Helix lucorum escape reaction]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20050101 |
| Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. | European journal of pharmacology 20040714 |
| Mechanism of action of A-85380 in an animal model of depression. | Progress in neuro-psychopharmacology & biological psychiatry 20040701 |
| Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor. | European journal of pharmacology 20040628 |
| Involvement of serotonin 5HT1 and 5HT2 receptors and nitric oxide synthase in the medial preoptic area on gonadotropin secretion. | Brain research bulletin 20040430 |
| Neocortical activation by electrical and chemical stimulation of the rat inferior colliculus: intra-collicular mapping and neuropharmacological characterization. | Experimental brain research 20040201 |
| SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron. | Journal of neurochemistry 20031001 |
| Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments. | Brain research bulletin 20030515 |
| 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. | Anesthesia and analgesia 20030401 |
| Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. | Journal of neurophysiology 20030301 |
| Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. | Naunyn-Schmiedeberg's archives of pharmacology 20030301 |
| h5-HT(1B) receptor-mediated constitutive Galphai3-protein activation in stably transfected Chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-HT. | British journal of pharmacology 20030301 |
| Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats. | Pharmacology & toxicology 20030301 |
| 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices. | The European journal of neuroscience 20021101 |
| 5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons. | Life sciences 20020927 |
| Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. | Life sciences 20020802 |
| Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure. | Brain research 20020301 |
| Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex. | European journal of pharmacology 20020201 |
| Mechanisms of analgesic action of B vitamins in formalin-induced inflammatory pain. | Proceedings of the Western Pharmacology Society 20020101 |
| Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors. | Journal of receptor and signal transduction research 20020101 |
| Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects. | The Journal of heart valve disease 20011101 |
| No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats. | European journal of pharmacology 20010914 |
| Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons. | Brain research bulletin 20010801 |
| Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. | British journal of pharmacology 20010601 |
| Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection. | Physiology & behavior 20010501 |
| S 14506: novel receptor coupling at 5-HT(1A) receptors. | Neuropharmacology 20010301 |
| Effects of the serotonin receptor ligand methiothepin on reproductive behavior of the freshwater snail Biomphalaria glabrata: reduction of egg laying and induction of penile erection. | The Journal of experimental zoology 20010215 |
| Intrarenal serotonin, dopamine, and phosphate handling in remnant kidneys. | Kidney international 20010201 |
| Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms. | Neuropharmacology 20010101 |
| Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor. | European journal of pharmacology 19990910 |
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