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193012-35-0 | 1H-Benzimidazole-6-carboxamide,1-[(2,4-dichlorophenyl)methyl]-2-methyl-N-(pentylsulfonyl)-
CAS No: 193012-35-0 Catalog No: AG00I2W1 MDL No:
Product Description
Catalog Number:
AG00I2W1
Chemical Name:
1H-Benzimidazole-6-carboxamide,1-[(2,4-dichlorophenyl)methyl]-2-methyl-N-(pentylsulfonyl)-
CAS Number:
193012-35-0
IUPAC Name:
3-[(2,4-dichlorophenyl)methyl]-2-methyl-N-pentylsulfonylbenzimidazole-5-carboxamide
InChI:
InChI=1S/C21H23Cl2N3O3S/c1-3-4-5-10-30(28,29)25-21(27)15-7-9-19-20(11-15)26(14(2)24-19)13-16-6-8-17(22)12-18(16)23/h6-9,11-12H,3-5,10,13H2,1-2H3,(H,25,27)
InChI Key:
UYGZODVVDUIDDQ-UHFFFAOYSA-N
UNII:
V5Q32BZX79
Properties
Complexity:
688
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
467.084g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
468.393g/mol
Monoisotopic Mass:
467.084g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
89.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.3
Literature
| Title | Journal |
|---|---|
| HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. | Chemistry & biology 20120727 |
| Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats. | Diabetes, obesity & metabolism 20070501 |
| A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation. | European journal of pharmacology 20060308 |
| Unique properties of coactivator recruitment caused by differential binding of FK614, an anti-diabetic agent, to peroxisome proliferator-activated receptor gamma. | Biological & pharmaceutical bulletin 20060301 |
| FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators. | Journal of pharmacological sciences 20051201 |
| Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat. | European journal of pharmacology 20050905 |
| FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs. | Metabolism: clinical and experimental 20050901 |
| Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614. | European journal of pharmacology 20040628 |
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