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Home > Aldehydes > 191338-86-0
191338-86-0 | Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
CAS No: 191338-86-0 Catalog No: AG01E732 MDL No:
Product Description
Catalog Number:
AG01E732
Chemical Name:
Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
CAS Number:
191338-86-0
IUPAC Name:
(4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[[(2S,3R)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
InChI:
InChI=1S/C21H34N4O10/c1-5-10(2)17(22-12(4)28)20(34)24-14(6-7-15(29)30)19(33)25-18(11(3)27)21(35)23-13(9-26)8-16(31)32/h9-11,13-14,17-18,27H,5-8H2,1-4H3,(H,22,28)(H,23,35)(H,24,34)(H,25,33)(H,29,30)(H,31,32)/t10-,11+,13-,14-,17-,18-/m0/s1
InChI Key:
AXTKTZHLZLOIIO-PBEPODTISA-N
Properties
Complexity:
803
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
6
Defined Bond Stereocenter Count:
0
Exact Mass:
502.227g/mol
Formal Charge:
0
Heavy Atom Count:
35
Hydrogen Bond Acceptor Count:
10
Hydrogen Bond Donor Count:
7
Isotope Atom Count:
0
Molecular Weight:
502.521g/mol
Monoisotopic Mass:
502.227g/mol
Rotatable Bond Count:
16
Topological Polar Surface Area:
228A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2
Literature
| Title | Journal |
|---|---|
| α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. | Toxicology and applied pharmacology 20150801 |
| Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. | Bioorganic & medicinal chemistry letters 20110415 |
| Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. | Journal of medicinal chemistry 20090423 |
| Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity. | Toxicology and applied pharmacology 20081015 |
| Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. | Free radical biology & medicine 20041015 |
| Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis. | Toxicology and applied pharmacology 20010915 |
| Butyric acid-induced T-cell apoptosis is mediated by caspase-8 and -9 activation in a Fas-independent manner. | Clinical and diagnostic laboratory immunology 20010301 |
| Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells. | Toxicology and applied pharmacology 20001015 |
| Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. | Cancer research 19991001 |
| The atomic-resolution structure of human caspase-8, a key activator of apoptosis. | Structure (London, England : 1993) 19990915 |
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