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189279-58-1 | 3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-
CAS No: 189279-58-1 Catalog No: AG002I64 MDL No:
Product Description
Catalog Number:
AG002I64
Chemical Name:
3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-
CAS Number:
189279-58-1
Molecular Formula:
C18H12ClF3N4O4
Molecular Weight:
440.7605
IUPAC Name:
1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylic acid
InChI:
InChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
InChI Key:
DYDCPNMLZGFQTM-UHFFFAOYSA-N
SMILES:
OC1CN(C1)c1c(F)cc2c(c1Cl)n(cc(c2=O)C(=O)O)c1nc(N)c(cc1F)F
UNII:
6315412YVF
Properties
Complexity:
755
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
440.05g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
11
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
440.763g/mol
Monoisotopic Mass:
440.05g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
120A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
Literature
| Title | Journal |
|---|---|
| Managing community acquired pneumonia in the elderly - the next generation of pharmacotherapy on the horizon. | Expert opinion on pharmacotherapy 20170801 |
| The 2009 Nobel Prize in Chemistry: Thomas A. Steitz and the structure of the ribosome. | The Yale journal of biology and medicine 20110601 |
| Methicillin-resistant Staphylococcus aureus: a pervasive pathogen highlights the need for new antimicrobial development. | The Yale journal of biology and medicine 20101201 |
| New antibiotics for antibiotic-resistant bacteria. | F1000 biology reports 20090101 |
| Comparative pharmacodynamics of the new fluoroquinolone ABT492 and levofloxacin with Streptococcus pneumoniae in an in vitro dynamic model. | International journal of antimicrobial agents 20050501 |
| Comparative pharmacodynamics of the new fluoroquinolone ABT492 and ciprofloxacin with Escherichia coli and Pseudomonas aeruginosa in an in vitro dynamic model. | International journal of antimicrobial agents 20040801 |
| The in vitro activity of a new fluoroquinolone, ABT-492, against recent clinical isolates of Chlamydia pneumoniae. | The Journal of antimicrobial chemotherapy 20040701 |
| ABT492 and levofloxacin: comparison of their pharmacodynamics and their abilities to prevent the selection of resistant Staphylococcus aureus in an in vitro dynamic model. | The Journal of antimicrobial chemotherapy 20040701 |
| In vitro activity of ABT-492 against anaerobic bacteria. | Journal of chemotherapy (Florence, Italy) 20040601 |
| Comparative study of the in vitro activity of a new fluoroquinolone, ABT-492. | The Journal of antimicrobial chemotherapy 20040501 |
| Comparative antimicrobial activities of the newly synthesized quinolone WQ-3034, levofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex. | Antimicrobial agents and chemotherapy 20000201 |
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