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188627-80-7

188627-80-7 | L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide

CAS No: 188627-80-7 Catalog No: AG001FDT MDL No:MFCD05662245

Product Description

Catalog Number:
AG001FDT
Chemical Name:
L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide
CAS Number:
188627-80-7
Molecular Formula:
C35H49N11O9S2
Molecular Weight:
831.9619
MDL Number:
MFCD05662245
SMILES:
OC(=O)C[C@@H]1NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)Cc1c[nH]c3c1cccc3)CCC2)C(=O)N

Literature

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Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy. Diabetes care 20090501
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Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert reviews in molecular medicine 20090501
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Perioperative management of antiplatelet-drugs in cardiac surgery. Current cardiology reviews 20090501
Empty microcatheter technique for the deployment of a self-expanding stent to treat refractory middle cerebral artery occlusion in the setting of severe proximal tortuosity. Journal of neuroimaging : official journal of the American Society of Neuroimaging 20090401
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Cost-effectiveness analysis of anticoagulation strategies in non-ST-elevation acute coronary syndromes. The Annals of pharmacotherapy 20090401
Spontaneous coronary artery dissection and severe hypothyroidism. The Journal of invasive cardiology 20090401
Adjunctive Pharmacotherapy Part II. The Journal of invasive cardiology 20090401
Characterization of static adhesion of human platelets in plasma to protein surfaces in microplates. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090401
Abbreviated infusion of eptifibatide after successful coronary intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) randomized trial. Journal of the American College of Cardiology 20090310
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Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. Coronary artery disease 20090301
Focus on adjunctive pharmacotherapy to improve outcomes of percutaneous coronary intervention. The Journal of invasive cardiology 20090301
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Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation. Thrombosis and haemostasis 20090301
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Determination of eptifibatide concentration in human plasma utilizing the liquid chromatography-tandem mass spectrometry method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215
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Eptifibatide overdose. International journal of cardiology 20090124
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Analysis of adenoviral attachment to human platelets. Virology journal 20090101
Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy? Thrombosis journal 20090101
Diabetes mellitus: a prothrombotic state implications for outcomes after coronary revascularization. Vascular health and risk management 20090101
Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction. Vascular health and risk management 20090101
Safety of enoxaparin versus unfractionated heparin during percutaneous coronary intervention. Texas Heart Institute journal 20090101
Clopidogrel resistance 'Live' - the risk of stent thrombosis should be evaluated before procedures. Thrombosis journal 20090101
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Selecting the optimal antithrombotic regimen for patients with acute coronary syndromes undergoing percutaneous coronary intervention. Vascular health and risk management 20090101
Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scandinavian journal of trauma, resuscitation and emergency medicine 20090101
Intracoronary versus intravenous abciximab in ST-segment elevation myocardial infarction: rationale and design of the CICERO trial in patients undergoing primary percutaneous coronary intervention with thrombus aspiration. Trials 20090101
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The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial. Stroke 20081201
Profound thrombocytopenia with glycoprotein IIb/IIIa inhibitors plus heparin for pump thrombus. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20081201
The rationale for and comparisons of different antiplatelet treatments in acute coronary syndrome. Journal of interventional cardiology 20081201
The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy. JACC. Cardiovascular interventions 20081201
The Optimal Route of Administration of the Glycoprotein IIb/IIIa Receptor Antagonist Abciximab During Percutaneous Coronary Intervention; Intravenous Versus Intracoronary. Current cardiology reviews 20081101
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Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis. Results of an in-vitro study. Thrombosis and haemostasis 20081001
Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial. American heart journal 20081001
A randomized trial comparing eptifibatide vs. placebo in patients with diffuse coronary artery disease undergoing drug-eluting stent implantation: design of the INtegrilin plus STenting to Avoid myocardial Necrosis Trial. Journal of cardiovascular medicine (Hagerstown, Md.) 20080901
GP IIb/IIIa inhibitors during primary percutaneous coronary intervention for STEMI: new trial and registry data. Current cardiology reports 20080901
Bolus-only versus bolus + infusion of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. American heart journal 20080901
Hemorrhagic pericarditis with cardiac tamponade after percutaneous coronary intervention associated with the use of abciximab. The Korean journal of internal medicine 20080901
Local intra-arterial eptifibatide for intraoperative vessel thrombosis during aneurysm coiling. AJNR. American journal of neuroradiology 20080801
A multicenter, randomized, open-label, therapeutic, and exploratory trial to evaluate the tolerability and efficacy of platelet glycoprotein IIb/IIIa receptor blocker (Clotinab) in high-risk patients with percutaneous coronary intervention. Yonsei medical journal 20080630
Treatment-competing events in dynamic regimes. Lifetime data analysis 20080601
Functional and computational studies of the ligand-associated metal binding site of beta3 integrins. Proteins 20080601
In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus. Coronary artery disease 20080601
Utilization of GP IIb/IIIa inhibitors in peripheral percutaneous interventions: current applications and in-hospital outcomes at a tertiary referral center. The Journal of invasive cardiology 20080601
Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
Percutaneous coronary intervention in patients with acute coronary syndrome: focus on bivalirudin. Vascular health and risk management 20080601
Antiplatelet drugs in cardiological practice: established strategies and new developments. Vascular health and risk management 20080601
Pharmacological and mechanical revascularization strategies in STEMI: integration of the two approaches. The Journal of invasive cardiology 20080501
Drug-eluting stent implantation for acute myocardial infarction during pregnancy with use of glycoprotein IIb/IIIa inhibitor, aspirin and clopidogrel. The Journal of invasive cardiology 20080501
The Role of Glycoprotein IIb/IIIa Inhibitors- A Promise Not Kept? Current cardiology reviews 20080501
Eptifibatide-induced thrombocytopenia. Journal of thrombosis and thrombolysis 20080401
Low-pressure balloon angioplasty with adjuvant pharmacological therapy in patients with acute ischemic stroke caused by intracranial arterial occlusions. Neuroradiology 20080401
Current update on glycoprotein IIb-IIIa and direct thrombin inhibition in percutaneous coronary intervention for non-ST elevation acute coronary syndromes: balancing bleeding risk and antiplatelet efficacy. Journal of interventional cardiology 20080401
Real-world safety and efficacy of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. The Journal of invasive cardiology 20080301
Abciximab: a reappraisal of its use in coronary care. Biologics : targets & therapy 20080301
Rescue use of tirofiban for acute carotid in-stent thrombosis. Yonsei medical journal 20080227
The relative safety and efficacy of abciximab and eptifibatide in patients undergoing primary percutaneous coronary intervention: insights from a large regional registry of contemporary percutaneous coronary intervention. Journal of the American College of Cardiology 20080205
The safety and efficacy of glycoprotein IIb/IIIa inhibitors for primary angioplasty: more options to choose and more time to decide. Journal of the American College of Cardiology 20080205
Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen. Blood 20080201
High-dose tirofiban administered as bolus-only during percutaneous coronary intervention. The Journal of invasive cardiology 20080201
ST-elevation myocardial infarction: the role of adjunctive antiplatelet therapy. The American journal of emergency medicine 20080201
[Acute profound thrombocytopenia associated with tirofiban: clinical approach to diagnosis and therapeutic management]. Giornale italiano di cardiologia (2006) 20080201
A review of cardiogenic shock in acute myocardial infarction. Current cardiology reviews 20080201
Emergency coronary artery bypass grafting in patients with acute myocardial infarction treated with glycoprotein IIb/IIIa receptor inhibitors. International journal of cardiology 20080124
Complications of Neuroform stent in endovascular treatment of intracranial aneurysms. Neurocritical care 20080101
Postprocedure intravenous eptifibatide following intra-arterial reteplase in patients with acute ischemic stroke. Journal of neuroimaging : official journal of the American Society of Neuroimaging 20080101
Platelet GPIIb/IIIa receptor antagonists in human ischemic brain disease. Current vascular pharmacology 20080101
The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR research 20080101
Platelet anaesthesia during extracorporeal circulation: differential effects of GP IIb/IIIa blockers on platelet activation marker P-selectin expression at hypothermia. Thrombosis research 20080101
Glycoprotein IIb/IIIa antagonists in acute ischaemic stroke: current status and future directions. Drugs 20080101
A longitudinal analysis of outcomes associated with abciximab and eptifibatide in a consecutive series of 3074 percutaneous coronary interventions. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101
Glycoprotein IIb/IIIa inhibitors in patients with renal insufficiency undergoing percutaneous coronary intervention. Cardiology in review 20080101
Diagnostic uncertainty of Takotusbo cardiomyopathy in a woman with cardiovascular risk factors hijacked at gunpoint: a case report. Cases journal 20080101
Plateletworks: a novel point of care platelet function screen. Molecular diagnosis & therapy 20080101
Cardiovascular magnetic resonance of scar and ischemia burden early after acute ST elevation and non-ST elevation myocardial infarction. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20080101
Successful catheter ablation of persistent electrical storm late post myocardial infarction by targeting purkinje arborization triggers. Indian pacing and electrophysiology journal 20080101
Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: rationale and design of the Sonolysis study. Trials 20080101
Eptifibatide and abciximab inhibit insulin-induced focal adhesion formation and proliferative responses in human aortic smooth muscle cells. Cardiovascular diabetology 20080101
Phase I study of eptifibatide in patients with sickle cell anaemia. British journal of haematology 20071101
Effectiveness and safety of reduced-dose enoxaparin in non-ST-segment elevation acute coronary syndrome followed by antiplatelet therapy alone for percutaneous coronary intervention. The American journal of cardiology 20071101
Effects of platelet glycoprotein IIb-IIIa number and glycoprotein IIIa Leu33Pro polymorphism on platelet aggregation and sensitivity to glycoprotein IIb-IIIa antagonists. Platelets 20071101
Glycoprotein IIb/IIIa antagonists during carotid artery stenting: results from the carotid artery stenting (CAS) registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK). Clinical research in cardiology : official journal of the German Cardiac Society 20071001
Efficacy and safety of triple antiplatelet therapy with and without concomitant anticoagulation during elective percutaneous coronary intervention (the REMOVE trial). The American journal of cardiology 20071001
Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention. The Canadian journal of cardiology 20071001
[Massive pulmonary embolism mimicking ST-elevation acute coronary syndrome successfully treated with hybrid therapy in a trauma patient receiving nadroparin: diagnostic and therapeutic dilemmas]. Kardiologia polska 20071001
Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils. The Journal of biological chemistry 20070921
Assessment of eptifibatide dosing in renal impairment before and after in-service education provided by pharmacists. Journal of managed care pharmacy : JMCP 20070901
Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils. Arteriosclerosis, thrombosis, and vascular biology 20070801
Optimal platelet inhibition in patients undergoing PCI: data from the Multicenter Registry of High-Risk Percutaneous Coronary Intervention and Adequate Platelet Inhibition (MR PCI) study. American heart journal 20070801
Immediate and intermediate results of intracoronary stand-alone bolus administration of eptifibatide during coronary intervention (ICE) study. American heart journal 20070801
A randomised controlled trial of upstream administration of eptifibatide in patients presenting non-ST segment elevation acute coronary syndrome treated with an invasive strategy. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20070801
Complementary effects of thienopyridine pretreatment and platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention; results from the ESPRIT trial. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20070701
Impact of iodinated contrast injections on percent diameter coronary arterial stenosis and implications for trials of intracoronary pharmacotherapies in patients with ST-elevation myocardial infarction. The American journal of cardiology 20070701
Association of prerandomization anticoagulant switching with bleeding in the setting of percutaneous coronary intervention (A REPLACE-2 analysis). The American journal of cardiology 20070615
Elevated plasma fibrinogen level predicts suboptimal response to therapy with both single- and double-bolus eptifibatide during percutaneous coronary intervention. Journal of the American College of Cardiology 20070605
The role of eptifibatide in patients undergoing percutaneous coronary intervention. Expert opinion on pharmacotherapy 20070601
The direct thrombin inhibitor argatroban: a review of its use in patients with and without HIT. Biologics : targets & therapy 20070601
Timing of glycoprotein IIb/IIIa inhibitor use and outcomes among patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (results from CRUSADE). The American journal of cardiology 20070515
Present and evolving role of eptifibatide in the treatment of acute coronary syndromes. Expert review of cardiovascular therapy 20070501
Middle cerebral artery stenting for acute ischemic stroke after unsuccessful Merci retrieval. Neurosurgery 20070401
Current strategies with high-dose tirofiban. Expert opinion on drug metabolism & toxicology 20070401
Enoxaparin injection for the treatment of high-risk patients with non-ST elevation acute coronary syndrome. Vascular health and risk management 20070401
AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. Journal of thrombosis and haemostasis : JTH 20070301
Current incidence and clinical outcomes of bivalirudin administration among patients undergoing primary coronary intervention for stent thrombosis elevation acute myocardial infarction. Coronary artery disease 20070301
Preoperative platelet inhibition with eptifibatide during coronary artery bypass grafting with cardiopulmonary bypass. Journal of cardiovascular pharmacology and therapeutics 20070301
Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate? Journal of the American College of Cardiology 20070213
[Update on antithrombotic treatments in arterial diseases]. Revue medicale suisse 20070207
Bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in drug-eluting stent implantations in the absence of acute myocardial infarction: clinical and economic results. The Journal of invasive cardiology 20070201
Eptifibatide vs abciximab as adjunctive therapy during primary percutaneous coronary intervention for acute myocardial infarction. Mayo Clinic proceedings 20070201
Prolonged intravenous eptifibatide infusion for prevention of coronary stent thrombosis. International journal of cardiology 20070118
Clinical outcomes comparing eptifibatide and abciximab in ST elevation acute myocardial infarction patients undergoing percutaneous coronary interventions. Cardiology 20070101
Rapid disappearance of an endothelial ulceration in the left main coronary artery. Cardiology 20070101
Role of antiplatelets in carotid artery stenting. Stroke 20070101
The integrins. Genome biology 20070101
Utility of PFA-100 closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro. Clinical chemistry and laboratory medicine 20070101
Systemic reperfusion therapy in acute ischemic stroke. Cerebrovascular diseases (Basel, Switzerland) 20070101
A review of clinical trials with eptifibatide in cardiology. Cardiovascular drug reviews 20070101
[Von Willebrand factor and soluble P-selectin in patients with non ST-Elevation acute coronary syndrome during treatment with glycoprotein IIb/IIIa antagonist eptifibatide]. Kardiologiia 20070101
Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. Journal of the American College of Cardiology 20061205
Delayed profound thrombocytopenia associated with eptifibatide. American journal of hematology 20061201
Safety and efficacy of low-dose unfractionated heparin during percutaneous coronary revascularisation and the relationship between activated clotting time and haemorrhagic or ischaemic complications: our results. Journal of cardiovascular medicine (Hagerstown, Md.) 20061201
Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIba. Thrombosis and haemostasis 20061201
PCI with and without abciximab after upstream eptifibatide use: outcomes in high-risk patients. The Journal of invasive cardiology 20061201
Bivalirudin in percutaneous coronary intervention. Vascular health and risk management 20061201
Clinical update on the therapeutic use of clopidogrel: treatment of acute ST-segment elevation myocardial infarction (STEMI). Vascular health and risk management 20061201
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Bolus-only platelet glycoprotein IIb-IIIa inhibition during percutaneous coronary intervention. The Journal of invasive cardiology 20061101
Bolus-only glycoprotein IIb/IIIa inhibitor revisited. The Journal of invasive cardiology 20061101
Early initiation of eptifibatide in the emergency department before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results of the Time to Integrilin Therapy in Acute Myocardial Infarction (TITAN)-TIMI 34 trial. American heart journal 20061001
Unfractionated heparin reduces the anti-platelet effects of abciximab but not eptifibatide during PCI. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20061001
Eptifibatide-induced thrombocytopenia and thrombosis. Journal of thrombosis and thrombolysis 20061001
Initial experience with the use of intravenous eptifibatide bolus during endovascular treatment of intracranial aneurysms. AJNR. American journal of neuroradiology 20061001
High-dose, single-bolus eptifibatide: a safe and cost-effective alternative to conventional glycoprotein IIb/IIIa inhibitor use for elective coronary interventions. The Journal of invasive cardiology 20061001
Commentary: Alternative safe, effective and cost-efficient dosing for eptifibatide in low-risk patients. The Journal of invasive cardiology 20061001
[Platelet and tissue factor: review]. Zhongguo shi yan xue ye xue za zhi 20061001
Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Circulation 20060926
Role of abciximab in the treatment of coronary artery disease. Expert opinion on biological therapy 20060901
Eptifibatide-eluting stent as an antiproliferative and antithrombotic agent: in vitro evaluation. The Journal of invasive cardiology 20060901
Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060801
Intracoronary bolus administration of eptifibatide during percutaneous coronary stenting for non ST elevation myocardial infarction and unstable angina. Journal of thrombosis and thrombolysis 20060801
C-reactive protein promotes platelet adhesion to endothelial cells: a potential pathway in atherothrombosis. British journal of haematology 20060801
Complementary effects of sirolimus-eluting stents and glycoprotein IIb/IIIa inhibitors for percutaneous coronary intervention in diabetic patients: one-year follow up of a single-centre registry. Heart (British Cardiac Society) 20060801
Greater inhibitory effects of bivalirudin compared with unfractionated heparin plus eptifibitide on thrombin-induced platelet activation. Coronary artery disease 20060801
Alveolar hemorrhage: an underdiagnosed complication of treatment with glycoprotein IIb/IIIa inhibitors. Journal of interventional cardiology 20060801
Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets. Circulation research 20060707
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters. Life sciences 20060620
A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. Journal of the American College of Cardiology 20060620
Correlates of bleeding events among moderate- to high-risk patients undergoing percutaneous coronary intervention and treated with eptifibatide: observations from the PROTECT-TIMI-30 trial. Journal of the American College of Cardiology 20060620
The future of an illusion. Journal of the American College of Cardiology 20060620
Self-expanding stent-assisted middle cerebral artery recanalization: technical note. Neuroradiology 20060601
Anticoagulant and antiplatelet medications. Critical care nurse 20060601
Cold leg in patient with high coated platelets: possible association with the use of rofecoxib. The Journal of invasive cardiology 20060601
Comparison of effects of bare metal versus drug-eluting stent implantation on biomarker levels following percutaneous coronary intervention for non-ST-elevation acute coronary syndrome. The American journal of cardiology 20060515
Cost-effectiveness analysis of antithrombotic therapy in nonurgent percutaneous coronary intervention. Pharmacotherapy 20060501
[Acute coronary syndrome: peri-interventional antithrombotic therapy]. Hamostaseologie 20060501
Suspected clopidogrel resistance in a patient with acute stent thrombosis. Nature clinical practice. Cardiovascular medicine 20060401
Treating the acute stroke patient as an emergency: current practices and future opportunities. International journal of clinical practice 20060401
(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. Journal of thrombosis and haemostasis : JTH 20060401
Tirofiban (Aggrastat) protects platelets and decreases platelet-granulocyte binding in an extracorporeal circulation model. The Thoracic and cardiovascular surgeon 20060401
Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors. Journal of thrombosis and haemostasis : JTH 20060301
Abciximab-associated thrombocytopenia after previous tirofiban-related thrombocytopenia. Pharmacotherapy 20060301
Anti-thrombotic effect of bivalirudin compared with eptifibatide and unfractionated heparin in diabetic patients: an ex vivo human study. Thrombosis and haemostasis 20060301
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis. Thrombosis and haemostasis 20060301
Platelet inhibitors in non-ST-segment elevation acute coronary syndromes and percutaneous coronary intervention: glycoprotein IIb/IIIa inhibitors, clopidogrel, or both? Vascular health and risk management 20060301
Clinical characteristics predict benefits from eptifibatide therapy during coronary stenting: insights from the Enhanced Suppression of the Platelet IIb/IIIa Receptor With Integrilin Therapy (ESPRIT) trial. Journal of the American College of Cardiology 20060221
The value of selectivity. Journal of the American College of Cardiology 20060221
Variability in extent of platelet function inhibition after administration of optimal dose of glycoprotein IIb/IIIa receptor blockers in patients undergoing a high-risk percutaneous coronary intervention. The American journal of cardiology 20060215
The role of risk stratification in the decision to provide upstream versus selective glycoprotein IIb/IIIa inhibitors for acute coronary syndromes: a cost-effectiveness analysis. Journal of the American College of Cardiology 20060207
Upstream/downstream glycoprotein IIb/IIIa in non-ST-segment elevation myocardial infarction. Journal of the American College of Cardiology 20060207
Increased ability of tirofiban to maintain its inhibitory effects on the binding of fibrinogen to platelets in blood from patients with and without diabetes mellitus. Coronary artery disease 20060201
Frequency and management of thrombocytopenia with the glycoprotein IIb/IIIa receptor antagonists. The American journal of cardiology 20060201
Randomized evaluation of the efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Long-term results of the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) trial. American heart journal 20060201
Glycoprotein IIb/IIIa inhibitors during rescue percutaneous coronary intervention in acute myocardial infarction. The Journal of invasive cardiology 20060201
Recurrent acute profound thrombocytopenia related to readministration of eptifibatide. Journal of interventional cardiology 20060201
Differential inhibitory effects of platelet glycoprotein IIb/IIIa antagonists on aggregation induced by procoagulant agonists. Thrombosis research 20060101
Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin. Thrombosis research 20060101
Tirofiban for the treatment of ischaemic stroke. Expert opinion on pharmacotherapy 20060101
Eptifibatide in peripheral vascular interventions: results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions (INFLAME) trial. The Journal of invasive cardiology 20060101
Thrombosis, inflammation, and our evolving understanding of vascular biology during interventional therapy. The Journal of invasive cardiology 20060101
Platelet receptors. AJNR. American journal of neuroradiology 20060101
Spotlight on eptifibatide in patients with acute coronary syndromes and/or undergoing percutaneous coronary intervention. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20060101
[Glycoprotein IIb/IIIa antagonist eptifibatide in acute coronary syndrome without elevation of ST segment]. Kardiologiia 20060101
Acute ischemic heart disease and interventional cardiology: a time for pause. BMC medicine 20060101
An audit of the use and complications of glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention against national UK standards. Cardiovascular revascularization medicine : including molecular interventions 20060101
A comparative study on the cost of new antibiotics and drugs of other therapeutic categories. PloS one 20060101
Effects of GP IIb/IIIa inhibitors on vascular inflammation, coronary microcirculation, and platelet function. Reviews in cardiovascular medicine 20060101
Glycoprotein IIb-IIIa receptor inhibition with eptifibatide in percutaneous intervention for symptomatic peripheral vascular disease: the circulate pilot trial. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20051201
Administration of intracoronary eptifibatide during ST-elevation myocardial infarction. The American journal of cardiology 20051201
Successful management of the no-reflow syndome after venous graft stenting. The Journal of invasive cardiology 20051201
Current strategies with eptifibatide and other antiplatelet agents in percutaneous coronary intervention and acute coronary syndromes. Expert opinion on drug metabolism & toxicology 20051201
Early eptifibatide improves TIMI 3 patency before primary percutaneous coronary intervention for acute ST elevation myocardial infarction: results of the randomized integrilin in acute myocardial infarction (INTAMI) pilot trial. European heart journal 20051001
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Differential effects of citrate versus PPACK anticoagulation on measured platelet inhibition by abciximab, eptifibatide and tirofiban. Journal of thrombosis and thrombolysis 20011001
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Anti-GPIIb/IIIa drugs: current strategies and future directions. Thrombosis and haemostasis 20010701
Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation 20010615
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Greater inhibition of platelet procoagulant activity by antibody-derived glycoprotein IIb--IIIa inhibitors than by peptide and peptidomimetic inhibitors. British journal of haematology 20010401
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Prognostic importance of concomitant heparin with eptifibatide in acute coronary syndromes. PURSUIT Investigators. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy. The American journal of cardiology 20010301
Meta-analysis of effectiveness and safety of abciximab versus eptifibatide or tirofiban in percutaneous coronary intervention. The American journal of cardiology 20010301
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Comparative 30-day economic and clinical outcomes of platelet glycoprotein IIb/IIIa inhibitor use during elective percutaneous coronary intervention: Prairie ReoPro versus Integrilin Cost Evaluation (PRICE) Trial. American heart journal 20010301
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Effect of Ca2+ chelation on the platelet inhibitory ability of the GPIIb/IIIa antagonists abciximab, eptifibatide and tirofiban. Thrombosis and haemostasis 20010301
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Utility of mechanical rheolysis as an adjunct to rescue angioplasty and platelet inhibition in acute myocardial infarction and cardiogenic shock: a case report. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20010201
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Therapeutic value of eptifibatide at community hospitals transferring patients to tertiary referral centers early after admission for acute coronary syndromes. PURSUIT Investigators. Journal of the American College of Cardiology 20010201
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