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185991-07-5 | N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-Pyridinemethanamine hexahydrobromide
CAS No: 185991-07-5 Catalog No: AG003NTV MDL No:MFCD20926342
Product Description
Catalog Number:
AG003NTV
Chemical Name:
N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-Pyridinemethanamine hexahydrobromide
CAS Number:
185991-07-5
Molecular Formula:
C24H44Br6N6
Molecular Weight:
896.0704
MDL Number:
MFCD20926342
IUPAC Name:
N-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine;hexahydrobromide
InChI:
InChI=1S/C24H38N6.6BrH/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30;;;;;;/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2;6*1H
InChI Key:
ARHBIBDGWDRBJH-UHFFFAOYSA-N
SMILES:
C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CNCc1ccccn1.Br.Br.Br.Br.Br.Br
Properties
Complexity:
413
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
7
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
895.867g/mol
Formal Charge:
0
Heavy Atom Count:
36
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
10
Isotope Atom Count:
0
Molecular Weight:
896.082g/mol
Monoisotopic Mass:
889.873g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
64.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer. | Neoplasia (New York, N.Y.) 20120801 |
| Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists. | Leukemia & lymphoma 20120101 |
| CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess. | Circulation. Heart failure 20110901 |
| Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110601 |
| Importance of receptor flexibility in binding of cyclam compounds to the chemokine receptor CXCR4. | Journal of chemical information and modeling 20110124 |
| Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication. | Journal of medicinal chemistry 20100211 |
| Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4. | Biochemical pharmacology 20091015 |
| Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. | Blood 20090611 |
| Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors. | Molecular pharmacology 20081201 |
| Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. | The Journal of biological chemistry 20070914 |
| Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes. | Virology 20070801 |
| AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. | Biochemical pharmacology 20050901 |
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