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18551-00-3 | (2E)-3-(furan-2-yl)-1-(pyridin-2-yl)prop-2-en-1-one
CAS No: 18551-00-3 Catalog No: AG00IQQS MDL No:MFCD01315211
Product Description
Catalog Number:
AG00IQQS
Chemical Name:
(2E)-3-(furan-2-yl)-1-(pyridin-2-yl)prop-2-en-1-one
CAS Number:
18551-00-3
Molecular Formula:
C12H9NO2
Molecular Weight:
199.2054
MDL Number:
MFCD01315211
IUPAC Name:
3-(furan-2-yl)-1-pyridin-2-ylprop-2-en-1-one
InChI:
InChI=1S/C12H9NO2/c14-12(11-5-1-2-8-13-11)7-6-10-4-3-9-15-10/h1-9H
InChI Key:
XYESCZMPXGBLQS-UHFFFAOYSA-N
SMILES:
O=C(c1ccccn1)/C=C/c1ccco1
Properties
Complexity:
250
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
199.063g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
199.209g/mol
Monoisotopic Mass:
199.063g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
43.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1
XLogP3:
2.1
Literature
| Title | Journal |
|---|---|
| The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling. | Vascular pharmacology 20090101 |
| Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator. | The Journal of pharmacy and pharmacology 20080701 |
| In vitro characterization of the enzymes involved in the metabolism of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound. | Archives of pharmacal research 20080601 |
| Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity. | Toxicology and applied pharmacology 20080501 |
| 1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP. | European journal of pharmacology 20070719 |
| The effect of 1-furan-2-yl-3-pyridine-2-yl-propenone on pharmacokinetic parameters of warfarin. | Archives of pharmacal research 20070701 |
| Metabolism of FPP-3, an anti-inflammatory propenone compound, in rat by liquid chromatography-electrospray ionization tandem mass spectrometry. | Biological & pharmaceutical bulletin 20070501 |
| Identification of 1-furan-2-yl-3-pyridin-2-yl-propenone, an antiinflammatory agent, and its metabolites in rat liver subcellular fractions. | Archives of pharmacal research 20061101 |
| Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606 |
| The effect of 1-furan-2-yl-3-pyridine-2-yl-propenone on pharmacokinetic parameters of theophylline. | Biological & pharmaceutical bulletin 20060601 |
| Potent analgesic and anti-inflammatory activities of 1-furan-2-yl-3-pyridin-2-yl-propenone with gastric ulcer sparing effect. | Biological & pharmaceutical bulletin 20060201 |
| Inhibition of nitric oxide and tumor necrosis factor-alpha (TNF-alpha) production by propenone compound through blockade of nuclear factor (NF)-kappa B activation in cultured murine macrophages. | Biological & pharmaceutical bulletin 20040501 |
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