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Home > Other Heterocycles > 185099-63-2
185099-63-2 | 8-Azabicyclo[3.2.1]octane, 8-methyl-3-phenyl-
CAS No: 185099-63-2 Catalog No: AG0074M8 MDL No:
Product Description
Catalog Number:
AG0074M8
Chemical Name:
8-Azabicyclo[3.2.1]octane, 8-methyl-3-phenyl-
CAS Number:
185099-63-2
Molecular Formula:
C14H19N
Molecular Weight:
201.3074
IUPAC Name:
8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane
InChI:
InChI=1S/C14H19N/c1-15-13-7-8-14(15)10-12(9-13)11-5-3-2-4-6-11/h2-6,12-14H,7-10H2,1H3
InChI Key:
VGZDEVKDDGMADS-UHFFFAOYSA-N
SMILES:
CN1C2CCC1CC(C2)c1ccccc1
Properties
Complexity:
205
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
201.152g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
201.313g/mol
Monoisotopic Mass:
201.152g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
2
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1
Literature
| Title | Journal |
|---|---|
| The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. | PloS one 20110101 |
| Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. | Pharmacology, biochemistry, and behavior 20100901 |
| An extended study of dimeric phenyl tropanes. | Bioorganic & medicinal chemistry 20090715 |
| Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. | British journal of pharmacology 20090401 |
| Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter. | Journal of medicinal chemistry 20081225 |
| Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. | Pharmacology, biochemistry, and behavior 20080901 |
| Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition. | The Journal of pharmacology and experimental therapeutics 20080601 |
| Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT. | Nuclear medicine and biology 20080501 |
| Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. | Pharmacology, biochemistry, and behavior 20070101 |
| Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration. | European journal of pharmacology 20061228 |
| Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter. | The Journal of pharmacology and experimental therapeutics 20060401 |
| Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse. | The AAPS journal 20060301 |
| Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative. | Bioorganic & medicinal chemistry letters 20060115 |
| Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. | Brain research 20050907 |
| Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters. | Journal of medicinal chemistry 20050421 |
| Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. | Bioorganic & medicinal chemistry letters 20041115 |
| Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. | The Journal of pharmacology and experimental therapeutics 20040201 |
| Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. | Journal of medicinal chemistry 20030410 |
| RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys. | European journal of pharmacology 20020503 |
| Locomotor stimulant effects of novel phenyltropanes in the mouse. | Drug and alcohol dependence 20011201 |
| Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. | Psychopharmacology 20011201 |
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