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Home > Nitro Compounds > 182004-65-5
182004-65-5 | Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1)
CAS No: 182004-65-5 Catalog No: AG00239H MDL No:MFCD00952138
Product Description
Catalog Number:
AG00239H
Chemical Name:
Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1)
CAS Number:
182004-65-5
Molecular Formula:
C17H21N3O6S2
Molecular Weight:
427.4951
MDL Number:
MFCD00952138
IUPAC Name:
methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate
InChI:
InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChI Key:
WGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)O.NC(=N)SCCc1ccc(cc1)OCc1ccc(cc1)[N+](=O)[O-]
Properties
Complexity:
479
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
427.087g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
427.49g/mol
Monoisotopic Mass:
427.087g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
193A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo. | Neuropharmacology 20120901 |
| TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. | Cell calcium 20120801 |
| Reverse-mode NCX current in mouse airway smooth muscle: Na(+) and voltage dependence, contributions to Ca(2+) influx and contraction, and altered expression in a model of allergen-induced hyperresponsiveness. | Acta physiologica (Oxford, England) 20120601 |
| Ouabain stimulates atrial natriuretic peptide secretion via the endothelin-1/ET(B) receptor-mediated pathway in beating rabbit atria. | Life sciences 20120522 |
| Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells. | American journal of physiology. Cell physiology 20120415 |
| High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. | British journal of pharmacology 20120401 |
| Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons. | American journal of physiology. Regulatory, integrative and comparative physiology 20120401 |
| Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation. | Experimental neurology 20120301 |
| Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers. | British journal of pharmacology 20120201 |
| PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle. | European journal of pharmacology 20120115 |
| Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons. | PloS one 20120101 |
| Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na+/Ca2+ exchanger activation. | Life sciences 20110704 |
| The protective effect of mitochondrial ATP-sensitive K+ channel opener, nicorandil, combined with Na+/Ca2+ exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in rat. | Cell biochemistry and biophysics 20110701 |
| Mitochondrial and cytosolic calcium in rat hearts under high-K(+) cardioplegia and pyruvate: mechano-energetic performance. | Canadian journal of physiology and pharmacology 20110701 |
| Effect of dexamethasone on Na+/Ca2+ exchanger in dendritic cells. | American journal of physiology. Cell physiology 20110601 |
| Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes. | Biochemical and biophysical research communications 20110311 |
| A role for orexin in central vestibular motor control. | Neuron 20110224 |
| KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I. | British journal of pharmacology 20110101 |
| Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase. | Cell calcium 20110101 |
| Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells. | Journal of pharmacological sciences 20110101 |
| Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. | PloS one 20110101 |
| Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. | Brain research 20101217 |
| Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes. | British journal of pharmacology 20101201 |
| Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells. | American journal of physiology. Cell physiology 20101201 |
| KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes. | The journal of physiological sciences : JPS 20101101 |
| Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728 |
| Cardiac basal metabolism: energetic cost of calcium withdrawal in the adult rat heart. | Acta physiologica (Oxford, England) 20100701 |
| Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. | Diabetes 20100701 |
| Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure. | International heart journal 20100701 |
| Electrophysiological characterization of store-operated and agonist-induced Ca2+ entry pathways in endothelial cells. | Pflugers Archiv : European journal of physiology 20100601 |
| The 1.3 isoform of Na+-Ca 2+ exchanger expressed in guinea pig tracheal smooth muscle is less sensitive to KB-R7943. | Journal of physiology and biochemistry 20100601 |
| Postconditioning in mouse hearts is inhibited by blocking the reverse mode of the sodium-calcium exchanger. | Interactive cardiovascular and thoracic surgery 20100501 |
| Inhibition of sodium-calcium exchange by KB-R7943: Dodecylamine and sphingosine in transfected Chinese hamster ovary cells. | Cell calcium 20100501 |
| Na+-Ca2+ exchanger contributes to Ca2+ extrusion in ATP-stimulated endothelium of intact rat aorta. | Biochemical and biophysical research communications 20100423 |
| Calcium transport and homeostasis in gill cells of a freshwater crab Dilocarcinus pagei. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301 |
| KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. | Biochemical and biophysical research communications 20100219 |
| Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization. | Neurochemical research 20100201 |
| Different mechanisms of Ca2+ regulation that influence synaptic transmission: comparison between crayfish and Drosophila neuromuscular junctions. | Synapse (New York, N.Y.) 20091201 |
| Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblasts. | The Journal of physiology 20091115 |
| Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner. | Journal of molecular and cellular cardiology 20091101 |
| Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells. | Toxicology and applied pharmacology 20091101 |
| Pharmacological modifications of the stretch-induced effects on ventricular fibrillation in perfused rabbit hearts. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1. | The Journal of biological chemistry 20091002 |
| Hypoxia-induced cytosolic calcium decrease is mediated primarily by the forward mode of Na(+)/Ca(2+) exchanger in smooth muscle cells of fetal ductus arteriosus. | Pediatric cardiology 20091001 |
| The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. | Molecular pharmacology 20090901 |
| Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange. | Cardiovascular drugs and therapy 20090601 |
| Contribution of Na+/Ca2+ exchange current to the formation of delayed afterdepolarizations in intact rat ventricular muscle. | Journal of cardiovascular pharmacology 20090601 |
| A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets. | Cell calcium 20090501 |
| The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. | Journal of neurophysiology 20090301 |
| Cardiac myocyte excitation by ultrashort high-field pulses. | Biophysical journal 20090218 |
| Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells. | Circulation research 20090102 |
| Potential therapeutic effects of Na+/Ca2+ exchanger inhibition in cardiac diseases. | Current medicinal chemistry 20090101 |
| New insights in the contribution of voltage-gated Na(v) channels to rat aorta contraction. | PloS one 20090101 |
| Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells. | Respiratory physiology & neurobiology 20081231 |
| Intracellular Na(+) modulates large conductance Ca(2+)-activated K (+) currents in human umbilical vein endothelial cells. | Pflugers Archiv : European journal of physiology 20081001 |
| High-frequency fatigue of skeletal muscle: role of extracellular Ca(2+). | European journal of applied physiology 20081001 |
| Na+/Ca2+ exchanger inhibitor ameliorates impaired endothelium-dependent Na+ relaxation induced by high glucose in rat aorta. | Clinical and experimental pharmacology & physiology 20081001 |
| [Effects of Astragalus membranaceus on atrial dynamics and ANP secretion]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001 |
| Endothelial nitric oxide attenuates Na+/Ca2+ exchanger-mediated vasoconstriction in rat aorta. | British journal of pharmacology 20080701 |
| Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation. | Toxicon : official journal of the International Society on Toxinology 20080615 |
| The ins and outs of calcium in heart failure. | Circulation research 20080606 |
| An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia. | Journal of cardiovascular pharmacology 20080501 |
| The Na(+)/Ca(2+) exchanger inhibitor KB-R7943 activates large-conductance Ca(2+)-activated K(+) channels in endothelial and vascular smooth muscle cells. | European journal of pharmacology 20080317 |
| [Role of sodium-calcium exchanger in the myocardial protection against ischemia-reperfusion injury]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080301 |
| Differential effects of the sodium calcium exchange inhibitor, KB-R7943, on ischemia and reperfusion injury in isolated guinea pig ventricular myocytes. | European journal of pharmacology 20080202 |
| Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange. | American journal of physiology. Renal physiology 20080101 |
| Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells. | American journal of physiology. Cell physiology 20080101 |
| A key role for reverse Na+/Ca2+ exchange influenced by the actin cytoskeleton in store-operated Ca2+ entry in human platelets: evidence against the de novo conformational coupling hypothesis. | Cell calcium 20071201 |
| SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes. | American journal of physiology. Cell physiology 20071201 |
| Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes. | European journal of pharmacology 20071114 |
| The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation. | Journal of cellular physiology 20071101 |
| Carbachol exhibited positive inotropic effect on rat ventricular myocytes via M₂ muscarinic receptors. | Sheng li xue bao : [Acta physiologica Sinica] 20071025 |
| Diastolic Ca2+ overload caused by Na+/Ca2+ exchanger during the first minutes of reperfusion results in continued myocardial stunning. | European journal of pharmacology 20071015 |
| The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. | Biochemical and biophysical research communications 20070914 |
| Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. | Cell death and differentiation 20070901 |
| Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha1A-adrenoceptor. | Journal of pharmacological sciences 20070901 |
| Store-refilling involves both L-type calcium channels and reverse-mode sodium-calcium exchange in airway smooth muscle. | The European respiratory journal 20070801 |
| Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+ exchanger inhibitors in ischaemic/reperfused rat hearts. | British journal of pharmacology 20070801 |
| Functional coupling between the Na+/Ca2+ exchanger and nonselective cation channels during histamine stimulation in guinea pig tracheal smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20070701 |
| The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter. | British journal of pharmacology 20070701 |
| Na+/Ca2+ exchange and regulation of cytoplasmic concentration of calcium in rat cerebellar neurons treated with glutamate. | Biochemistry. Biokhimiia 20070701 |
| Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle. | American journal of respiratory cell and molecular biology 20070501 |
| Role of reverse mode Na+/Ca2+ exchanger in the cardioprotection of metabolic inhibition preconditioning in rat ventricular myocytes. | European journal of pharmacology 20070430 |
| Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons. | Neuroscience 20070425 |
| [Na+/Ca2+ exchanger (NCX1) and cardiovascular disease]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401 |
| CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. | Cardiovascular research 20070301 |
| The role of Na+/Ca2+ exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells. | Annals of the New York Academy of Sciences 20070301 |
| The reverse mode of the Na(+)/Ca(2+) exchanger provides a source of Ca(2+) for store refilling following agonist-induced Ca(2+) mobilization. | American journal of physiology. Lung cellular and molecular physiology 20070201 |
| Propofol modulates Na+-Ca2+ exchange activity via activation of protein kinase C in diabetic cardiomyocytes. | Anesthesiology 20070201 |
| Calcium regulation in individual peripheral sensory nerve terminals of the rat. | The Journal of physiology 20070115 |
| Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig. | European journal of pharmacology 20061228 |
| 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201 |
| The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency. | Experimental eye research 20061101 |
| Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger. | Biochemistry 20061003 |
| Na+/Ca2+ exchanger modulates the flagellar wave pattern for the regulation of motility activation and chemotaxis in the ascidian spermatozoa. | Cell motility and the cytoskeleton 20061001 |
| Muscarine activates the sodium-calcium exchanger via M receptors in basal forebrain neurons. | The European journal of neuroscience 20061001 |
| Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. | Circulation 20060926 |
| Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. | American journal of physiology. Heart and circulatory physiology 20060901 |
| Loading rat heart myocytes with Mg2+ using low-[Na+] solutions. | The Journal of physiology 20060901 |
| Anesthetic preconditioning enhances Ca2+ handling and mechanical and metabolic function elicited by Na+-Ca2+ exchange inhibition in isolated hearts. | Anesthesiology 20060901 |
| Inhibition by SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, of Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells. | Journal of pharmacological sciences 20060901 |
| Quantitative fluorescence measurement of cardiac Na+/Ca2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells. | Journal of pharmacological sciences 20060801 |
| Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger. | Circulation 20060704 |
| Effects of a Na+/Ca2+ exchanger inhibitor on pulmonary vein electrical activity and ouabain-induced arrhythmogenicity. | Cardiovascular research 20060601 |
| High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage. | Hearing research 20060501 |
| Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. | The Journal of physiology 20060315 |
| Effects of caffeine, verapamil, lithium, and KB-R7943 on mechanics and energetics of rat myocardial bigeminies. | American journal of physiology. Heart and circulatory physiology 20060201 |
| Sodium-dependent recovery of ionised magnesium concentration following magnesium load in rat heart myocytes. | Pflugers Archiv : European journal of physiology 20060201 |
| Role of the Na+/Ca2+ exchanger in calcium homeostasis and human sperm motility regulation. | Cell motility and the cytoskeleton 20060201 |
| Involvement of Na+/Ca2+ exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20060101 |
| [Na+/Ca2+ exchanger(NCX1) and salt-sensitive hypertension]. | Nihon rinsho. Japanese journal of clinical medicine 20060101 |
| Sodium calcium exchange as a target for antiarrhythmic therapy. | Handbook of experimental pharmacology 20060101 |
| Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response. | Cardiovascular research 20051201 |
| The inhibitory effect of ouabain on the response of slowly adapting pulmonary stretch receptors to hyperinflation in the rabbit. | Life sciences 20051119 |
| Na+-K+ pump activation inhibits endothelium-dependent relaxation by activating the forward mode of Na+/Ca2+ exchanger in mouse aorta. | American journal of physiology. Heart and circulatory physiology 20051101 |
| Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production. | American journal of physiology. Heart and circulatory physiology 20051001 |
| Involvement of Na+-Ca2+ exchanger in intracellular Ca2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells. | The Journal of pharmacology and experimental therapeutics 20051001 |
| Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes. | The Journal of physiology 20051001 |
| Probing the endogenous Ca2+ buffers at the presynaptic terminals of the crayfish neuromuscular junction. | Journal of neurophysiology 20050701 |
| Inhibition of the reverse mode of the Na+/Ca2+ exchange by KB-R7943 augments arrhythmogenicity in the canine heart during rapid heart rates. | Journal of electrocardiology 20050701 |
| Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes. | Naunyn-Schmiedeberg's archives of pharmacology 20050701 |
| Mechanism-based modeling of reduced inotropic responsiveness to digoxin in endotoxemic rat hearts. | European journal of pharmacology 20050502 |
| Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury. | The Canadian journal of cardiology 20050501 |
| Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts. | The Journal of biological chemistry 20050415 |
| Na+/Ca2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes. | American journal of physiology. Heart and circulatory physiology 20050401 |
| Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis. | Cardiovascular research 20050401 |
| Na(+)/Ca(2+) exchange regulates Ca(2+)-dependent duodenal mucosal ion transport and HCO(3)(-) secretion in mice. | American journal of physiology. Gastrointestinal and liver physiology 20050301 |
| Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels. | Neuropharmacology 20050301 |
| Sodium channels are required during in vivo sodium chloride hyperosmolarity to stimulate increase in intestinal endothelial nitric oxide production. | American journal of physiology. Heart and circulatory physiology 20050101 |
| Fowl (Gallus domesticus) sperm motility depends upon mitochondrial calcium cycling driven by extracellular sodium. | Biology of reproduction 20050101 |
| Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons. | Neuroscience 20050101 |
| Cardioprotective effects of KB-R7943, a novel inhibitor of Na+/Ca2+ exchanger, on stunned myocardium in anesthetized dogs. | Journal of anesthesia 20050101 |
| The role of Ca2+ transport across the plasma membrane for cell migration. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101 |
| Functional differences of Na+/Ca2+ exchanger expression in Ca2+ transport system of smooth muscle of guinea pig stomach. | Canadian journal of physiology and pharmacology 20050101 |
| Cross-talk between native plasmalemmal Na+/Ca2+ exchanger and inositol 1,4,5-trisphosphate-sensitive ca2+ internal store in Xenopus oocytes. | The Journal of biological chemistry 20041210 |
| Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger. | Journal of cardiovascular pharmacology 20041101 |
| Systems analysis of digoxin kinetics and inotropic response in the rat heart: effects of calcium and KB-R7943. | American journal of physiology. Heart and circulatory physiology 20041001 |
| Presynaptic alpha2-receptors regulate reverse Na+/Ca2+-exchange and transmitter release in Na+-loaded peripheral sympathetic nerves. | Neurochemistry international 20041001 |
| Participation of Na/Ca-exchanger and sarcoplasmic reticulum in the high [K]-protection against ischaemia-reperfusion dysfunction in rat hearts. | Acta physiologica Scandinavica 20041001 |
| High activity of K+-dependent plasmalemmal Na+/Ca2+ exchangers in hippocampal CA1 neurons. | Neuroreport 20040915 |
| Sodium-calcium exchanger contributes to membrane hyperpolarization of intact endothelial cells from rat aorta during acetylcholine stimulation. | British journal of pharmacology 20040901 |
| A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca(2+) before its increase. | Developmental biology 20040815 |
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| Differential contribution of plasmalemmal Na/Ca exchange isoforms to sodium-dependent calcium influx and NMDA excitotoxicity in depolarized neurons. | Journal of neurochemistry 20040701 |
| Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury. | Molecular pharmacology 20040701 |
| Counteracting effects of NADPH oxidase and the Na+/Ca2+ exchanger on membrane repolarisation and store-operated uptake of Ca2+ by chemoattractant-activated human neutrophils. | Biochemical pharmacology 20040615 |
| The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. | Expert opinion on investigational drugs 20040601 |
| Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. | The Journal of biological chemistry 20040402 |
| Calcium dynamics and vasomotion in rat mesenteric arteries. | Journal of cardiovascular pharmacology 20040401 |
| Development and application of Na+/Ca2+ exchange inhibitors. | Molecular and cellular biochemistry 20040401 |
| Molecular determinants of Na+/Ca2+ exchange (NCX1) inhibition by SEA0400. | The Journal of biological chemistry 20040227 |
| KB-R7943 reveals possible involvement of Na(+)-Ca2+ exchanger in elevation of intracellular Ca2+ in rat carotid arterial myocytes. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20040201 |
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| Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures. | Neuroscience 20040101 |
| Aspartate release from rat hippocampal synaptosomes. | Neuroscience 20040101 |
| Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig. | Journal of muscle research and cell motility 20040101 |
| A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release. | Cardiovascular research 20031201 |
| Ca2+-dependent modulation of intracellular Mg2+ concentration with amiloride and KB-R7943 in pig carotid artery. | The Journal of biological chemistry 20031128 |
| Influence of Na+-independent Cl--HCO3- exchange on the slow force response to myocardial stretch. | Circulation research 20031128 |
| Influence of lidocaine on ouabain-induced inotropic response in rat atria. | Biochemical pharmacology 20031101 |
| A novel and selective Na+/Ca2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury. | European journal of pharmacology 20031008 |
| Resting membrane potential regulates Na(+)-Ca2+ exchange-mediated Ca2+ overload during hypoxia-reoxygenation in rat ventricular myocytes. | The Journal of physiology 20030801 |
| Na(+)-Ca2+ exchange function underlying contraction frequency inotropy in the cat myocardium. | The Journal of physiology 20030801 |
| Does enhanced expression of the Na+-Ca2+ exchanger increase myocardial vulnerability to ischemia/reperfusion injury in rabbit hearts? | Molecular and cellular biochemistry 20030601 |
| Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats. | European journal of pharmacology 20030319 |
| Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943. | American journal of physiology. Heart and circulatory physiology 20030301 |
| Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart. | European journal of pharmacology 20030214 |
| Attenuation of ischemia/reperfusion-induced renal injury in mice deficient in Na+/Ca2+ exchanger. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries. | European journal of pharmacology 20030101 |
| Importance of Ca2+ influx by Na+/Ca2+ exchange under normal and sodium-loaded conditions in mammalian ventricles. | Molecular and cellular biochemistry 20030101 |
| Pharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitor. | Cardiovascular drug reviews 20030101 |
| Quantitative analysis of hyperosmotic and hypothermic blood-brain barrier opening. | Acta neurochirurgica. Supplement 20030101 |
| In depolarized and glucose-deprived neurons, Na+ influx reverses plasmalemmal K+-dependent and K+-independent Na+/Ca2+ exchangers and contributes to NMDA excitotoxicity. | Journal of neurochemistry 20021201 |
| Negative and positive inotropic effects of propofol via L-type calcium channels and the sodium-calcium exchanger in rat cardiac trabeculae. | Anesthesiology 20021101 |
| [Functional analysis of Na+/Ca2+ exchanger using novel drugs and genetically engineered mice]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| KB-R7943, a Na+/Ca2+ exchange inhibitor, does not suppress ischemia/reperfusion arrhythmias nor digitalis arrhythmias in dogs. | Japanese journal of pharmacology 20021101 |
| Electrophysiological studies of the cloned rat cardiac NCX1.1 in transfected HEK cells: a focus on the stoichiometry. | Annals of the New York Academy of Sciences 20021101 |
| Pharmacology of Na+/Ca2+ exchanger. | Annals of the New York Academy of Sciences 20021101 |
| Effect of KB-R7943 on oscillatory Na+/Ca2+ exchange current in guinea pig ventricular myocytes. | Annals of the New York Academy of Sciences 20021101 |
| Inhibition of the Drosophila Na+/Ca2) exchanger, CALX1.1, by KB-R7943. | Annals of the New York Academy of Sciences 20021101 |
| Modulation of exocytosis by the Na(+)/Ca(2+) exchanger of chromaffin cells. | Annals of the New York Academy of Sciences 20021001 |
| Kb-R7943 prevents acute, atrial fibrillation-induced shortening of atrial refractoriness in anesthetized dogs. | Circulation 20020910 |
| Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. | Circulation research 20020906 |
| Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death. | Cardiovascular research 20020901 |
| Lithium and KB-R7943 effects on mechanics and energetics of rat heart muscle. | Acta physiologica Scandinavica 20020901 |
| Developmental changes of Ca(2+) handling in mouse ventricular cells from early embryo to adulthood. | Life sciences 20020802 |
| Involvement of Na(+)/Ca(2+) exchanger in endothelial NO production and endothelium-dependent relaxation. | American journal of physiology. Heart and circulatory physiology 20020801 |
| Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. | Circulation research 20020726 |
| Amiloride and KB-R7943 in outward Na+ /Ca2+ exchange current in guinea pig ventricular myocytes. | Journal of cardiovascular pharmacology 20020701 |
| Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury. | Cardiovascular drugs and therapy 20020701 |
| Inhibition by KB-r7943 of the reverse mode of the Na+/Ca2+ exchanger reduces Ca2+ overload in ischemic-reperfused rat hearts. | Circulation journal : official journal of the Japanese Circulation Society 20020401 |
| Instrumental role of Na+ in NMDA excitotoxicity in glucose-deprived and depolarized cerebellar granule cells. | Journal of neurochemistry 20020401 |
| Autocrine stimulation of cardiac Na(+)-Ca(2+) exchanger currents by endogenous endothelin released by angiotensin II. | Circulation research 20020308 |
| Synergistic effect of cold mannitol and Na(+)/Ca(2+) exchange blocker on blood-brain barrier opening. | Biochemical and biophysical research communications 20020301 |
| Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. | British journal of pharmacology 20020301 |
| Time course and mechanisms of phosphorylation of phospholamban residues in ischemia-reperfused rat hearts. Dissociation of phospholamban phosphorylation pathways. | Journal of molecular and cellular cardiology 20020101 |
| Role of Na(+)-Ca(2+) exchanger after traumatic or hypoxic/ischemic injury to spinal cord white matter. | The spine journal : official journal of the North American Spine Society 20020101 |
| Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215 |
| Reperfusion arrhythmias: new insights into the role of the Na(+)/Ca(2+) exchanger. | Journal of molecular and cellular cardiology 20011201 |
| Very low dose of the Na(+)/Ca(2+) exchange inhibitor, KB-R7943, protects ischemic reperfused aged Fischer 344 rat hearts: considerable strain difference in the sensitivity to KB-R7943. | Cardiovascular research 20011201 |
| KB-R7943. Kanebo. | Current opinion in investigational drugs (London, England : 2000) 20011201 |
| Gender influences [Ca(2+)](i) during metabolic inhibition in myocytes overexpressing the Na(+)-Ca(2+) exchanger. | Circulation 20011023 |
| Inhibition of Na(+)/Ca(2+) exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. | Brain research 20011019 |
| On the source of Ca(2+) activating the tonic component of contraction of myocytes of guinea pig heart. | Cardiovascular research 20011001 |
| Reperfusion-induced Ins(1,4,5)P(3) generation and arrhythmogenesis require activation of the Na(+)/Ca(2+) exchanger. | Journal of molecular and cellular cardiology 20011001 |
| Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences. | American journal of physiology. Heart and circulatory physiology 20010901 |
| Cardiac sodium-calcium exchanger: a double-edged sword. | Cardiovascular research 20010801 |
| Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury. | Cardiovascular research 20010801 |
| Inhibition of Na+/Ca2+ exchange with KB-R7943 or bepridil diminished mineral deposition by osteoblasts. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010801 |
| Differential roles of the sodium-calcium exchanger in renin secretion and renal vascular resistance. | Pflugers Archiv : European journal of physiology 20010801 |
| SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. | The Journal of pharmacology and experimental therapeutics 20010701 |
| Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development. | Developmental dynamics : an official publication of the American Association of Anatomists 20010701 |
| The effects of the Na(+)/Ca(++) exchange blocker on osmotic blood-brain barrier disruption. | Brain research 20010511 |
| Inhibition of aggregation of rabbit and human platelets induced by adrenaline and 5-hydroxytryptamine by KB-R7943, a Na(+)/Ca(2+) exchange inhibitor. | British journal of pharmacology 20010401 |
| Structural domains influencing sensitivity to isothiourea derivative inhibitor KB-R7943 in cardiac Nna(+)/Ca(2+) exchanger. | Molecular pharmacology 20010301 |
| The sodium pump modulates the influence of I(Na) on [Ca2+]i transients in mouse ventricular myocytes. | Biophysical journal 20010301 |
| KB-R7943, a selective Na+/Ca2+ exchange inhibitor, protects against ischemic acute renal failure in mice by inhibiting renal endothelin-1 overproduction. | Journal of cardiovascular pharmacology 20010301 |
| Pre- or post-ischemic treatment with a novel Na+/Ca2+ exchange inhibitor, KB-R7943, shows renal protective effects in rats with ischemic acute renal failure. | The Journal of pharmacology and experimental therapeutics 20010201 |
| Functional role of sodium-calcium exchange in the regulation of renal vascular resistance. | American journal of physiology. Renal physiology 20010101 |
| Protein kinase C suppresses spontaneous, transient, outwards K+ currents through modulation of the Na/Ca exchanger in guinea-pig gastric myocytes. | Pflugers Archiv : European journal of physiology 20010101 |
| [The Na+/Ca2+ exchanger as responsible for myocardial stunning]. | Medicina 20010101 |
| Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter. | Neuroscience 20010101 |
| [Effect of KB-R7943 on Na(+)-Ca2+ exchange current in guinea pig ventricular myocytes]. | Yao xue xue bao = Acta pharmaceutica Sinica 20010101 |
| ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. | American journal of physiology. Cell physiology 20000301 |
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