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Home > Pyridines > 180384-57-0
180384-57-0 | 2-Pyridinesulfonamide, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-
CAS No: 180384-57-0 Catalog No: AG0021YT MDL No:
Product Description
Catalog Number:
AG0021YT
Chemical Name:
2-Pyridinesulfonamide, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-
CAS Number:
180384-57-0
Molecular Formula:
C27H27N9O6S
Molecular Weight:
605.6250
IUPAC Name:
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide
InChI:
InChI=1S/C27H27N9O6S/c1-16(2)18-8-9-22(29-15-18)43(38,39)34-26-23(42-21-7-5-4-6-20(21)40-3)27(41-13-12-37)31-24(30-26)17-10-11-28-19(14-17)25-32-35-36-33-25/h4-11,14-16,37H,12-13H2,1-3H3,(H,30,31,34)(H,32,33,35,36)
InChI Key:
TUYWTLTWNJOZNY-UHFFFAOYSA-N
SMILES:
OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C(C)C)c1ccnc(c1)c1nn[nH]n1
UNII:
64J9J55263
Properties
Complexity:
962
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
605.181g/mol
Formal Charge:
0
Heavy Atom Count:
43
Hydrogen Bond Acceptor Count:
14
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
605.63g/mol
Monoisotopic Mass:
605.181g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
209A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4
Literature
| Title | Journal |
|---|---|
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| Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B. Jararacussu. | International journal of molecular sciences 20080501 |
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| Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome. | Hepatology (Baltimore, Md.) 20080101 |
| Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction. | Medical & biological engineering & computing 20080101 |
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| The effects of TBC3214, a selective endothelin ETA receptor antagonist, on orthodontic tooth movement in rats. | European journal of orthodontics 20071201 |
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| Preconditioning protects endothelium by preventing ET-1-induced activation of NADPH oxidase and xanthine oxidase in post-ischemic heart. | Journal of molecular and cellular cardiology 20070201 |
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| Tezosentan inhibits both equinatoxin II and endotelin-1 induced contractions of isolated porcine coronary artery in a similar way. | Journal of natural toxins 20020801 |
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| Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro. | Journal of gastroenterology and hepatology 20020301 |
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| A pilot safety trial of prolonged (48 h) infusion of the dual endothelin-receptor antagonist tezosentan in patients with advanced heart failure. | Chest 20010801 |
| Endothelin-1 blockade corrects mesenteric hypoperfusion in a porcine low cardiac output model. | Critical care medicine 20010801 |
| Tezosentan (an intravenous endothelin receptor A/B antagonist) reduces peripheral resistance and increases cardiac power therefore preventing a steep decrease in blood pressure in patients with congestive heart failure. | European journal of heart failure 20010801 |
| Endothelin receptor blockade improves oxygenation in contralateral TRAM flap tissue in pigs. | British journal of plastic surgery 20010701 |
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| 50th Annual scientific sessions of the American college of cardiology. | Circulation 20010410 |
| Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. | Circulation 20010220 |
| The use of the endothelin receptor antagonist, tezosentan, before or after renal ischemia protects renal function. | Transplantation 20010127 |
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