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Home > Fluorides > 180200-68-4
180200-68-4 | Benzenesulfonamide, 4-(4-cyclohexyl-2-methyl-5-oxazolyl)-2-fluoro-
CAS No: 180200-68-4 Catalog No: AG0021SO MDL No:
Product Description
Catalog Number:
AG0021SO
Chemical Name:
Benzenesulfonamide, 4-(4-cyclohexyl-2-methyl-5-oxazolyl)-2-fluoro-
CAS Number:
180200-68-4
Molecular Formula:
C16H19FN2O3S
Molecular Weight:
338.3971
IUPAC Name:
4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide
InChI:
InChI=1S/C16H19FN2O3S/c1-10-19-15(11-5-3-2-4-6-11)16(22-10)12-7-8-14(13(17)9-12)23(18,20)21/h7-9,11H,2-6H2,1H3,(H2,18,20,21)
InChI Key:
MIMJSJSRRDZIPW-UHFFFAOYSA-N
SMILES:
Cc1nc(c(o1)c1ccc(c(c1)F)S(=O)(=O)N)C1CCCCC1
UNII:
G6VI5P84SX
Properties
Complexity:
504
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
338.11g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
338.397g/mol
Monoisotopic Mass:
338.11g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
94.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3
Literature
| Title | Journal |
|---|---|
| Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100501 |
| Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522. | Urologia internationalis 20100101 |
| Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. | Oncology reports 20071101 |
| Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. | International journal of cancer 20070201 |
| A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. | Cancer letters 20061208 |
| Bilateral induction of the S-100A9 gene in response to spreading depression is modulated by the cyclooxygenase-2 activity. | Journal of the neurological sciences 20050715 |
| Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells. | Cancer science 20050701 |
| Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest. | International journal of cancer 20050210 |
| Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. | Cancer science 20050201 |
| JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. | International journal of cancer 20050120 |
| JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. | BMC cancer 20050101 |
| JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. | International journal of cancer 20041220 |
| Enhanced sensitivity of bladder cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522. | The Journal of urology 20041001 |
| Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. | Life sciences 20040521 |
| Inhibition of azoxymethane-induced colon carcinogenesis in rats due to JTE-522, a selective cyclooxygenase-2 inhibitor. | Asian Pacific journal of cancer prevention : APJCP 20040101 |
| Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15. | Anticancer research 20040101 |
| Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. | Cancer letters 20031208 |
| COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. | Laboratory investigation; a journal of technical methods and pathology 20031001 |
| JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1. | Gastroenterology 20030801 |
| The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. | Anticancer research 20030101 |
| Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo. | In vivo (Athens, Greece) 20030101 |
| Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor. | Clinical & experimental metastasis 20030101 |
| Synergistic cytotoxicity and apoptosis of JTE-522, a selective cyclooxygenase-2 inhibitor, and 5-fluorouracil against bladder cancer. | The Journal of urology 20021201 |
| Pharmacokinetics and safety of JTE-522, a novel selective cyclooxygenase-2 inhibitor, in healthy male volunteers. | British journal of clinical pharmacology 20021101 |
| Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. | International journal of cancer 20020810 |
| JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells. | Acta pharmacologica Sinica 20020701 |
| Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020701 |
| Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species. | World journal of gastroenterology 20020615 |
| JTE-522-induced apoptosis in human gastric adenocarcinoma [correction of adenocarcinoma] cell line AGS cells by caspase activation accompanying cytochrome C release, membrane translocation of Bax and loss of mitochondrial membrane potential. | World journal of gastroenterology 20020415 |
| Inhibition of proliferation of gastric epithelial cells by a cyclooxygenase 2 inhibitor, JTE522, is also mediated by a PGE2-independent pathway. | Alimentary pharmacology & therapeutics 20020401 |
| 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). | Journal of medicinal chemistry 20020328 |
| Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries. | Arteriosclerosis, thrombosis, and vascular biology 20020201 |
| Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20010901 |
| Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. | Carcinogenesis 20010401 |
| Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells. | Biochemical and biophysical research communications 20010223 |
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