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18000-24-3

18000-24-3 | 2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-

CAS No: 18000-24-3 Catalog No: AG0021LB MDL No:MFCD00069227

Product Description

Catalog Number:
AG0021LB
Chemical Name:
2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-
CAS Number:
18000-24-3
Molecular Formula:
C10H6ClNO3
Molecular Weight:
223.6125
MDL Number:
MFCD00069227
IUPAC Name:
7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
InChI:
InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
InChI Key:
UAWVRVFHMOSAPU-UHFFFAOYSA-N
SMILES:
Clc1ccc2c(c1)nc(cc2O)C(=O)O
EC Number:
241-913-6
UNII:
S7936QON2K
NSC Number:
149792

Properties

Complexity:
340  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
223.004g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
223.612g/mol
Monoisotopic Mass:
223.004g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
66.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9  

Literature

Title Journal
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context. Behavioural brain research 20101225
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production. The Journal of biological chemistry 20100716
Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis. Neuropharmacology 20071201
N-methyl-D-aspartate receptors and amnesia in mice with depression-like state. Bulletin of experimental biology and medicine 20071101
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. The Journal of pharmacology and experimental therapeutics 20070801
D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro. Neuroscience letters 20070501
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. Journal of pharmacological sciences 20070501
Characterisation of the human NMDA receptor subunit NR3A glycine binding site. Neuropharmacology 20070301
Glycine binding sites of presynaptic NMDA receptors may tonically regulate glutamate release in the rat visual cortex. Journal of neurophysiology 20070101
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats. Neuropharmacology 20060801
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. The European journal of neuroscience 20060701
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? Journal of neurochemistry 20060301
NMDA receptors mediate feeding elicited by neuropeptide Y in the lateral and perifornical hypothalamus. Brain research 20051123
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. Epilepsia 20051101
Cell-specific expression of N-methyl-D-aspartate receptor subunits in Müller glia and neurons from the chick retina. Investigative ophthalmology & visual science 20051001
Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050907
Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. Epilepsia 20050701
Role of the glycine site of the N-methyl-D-aspartate receptor in synaptic plasticity induced by pairing. The European journal of neuroscience 20050501
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. Experimental brain research 20050301
Subthreshold contribution of N-methyl-d-aspartate receptors to long-term potentiation induced by low-frequency pairing in rat hippocampal CA1 pyramidal cells. Neuroscience 20040101
Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse. The European journal of neuroscience 20031201
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons. The Journal of pharmacology and experimental therapeutics 20031001
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. European journal of pharmacology 20030620
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons. The Journal of physiology 20030415
Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats. Psychopharmacology 20030401
Kynurenate production by cultured human astrocytes. Journal of neural transmission (Vienna, Austria : 1996) 20030101
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism. Brain research 20021011
In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site. Brain research 20020719
Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport. Journal of medicinal chemistry 20020523
A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches. Invertebrate neuroscience : IN 20020401
Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro. Brain research 20011123
Stimulation of 5-HT(1A) receptors in the dorsal raphe ameliorates the impairment of spatial learning caused by intrahippocampal 7-chloro-kynurenic acid in naive and pretrained rats. Psychopharmacology 20011001
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo. Neuroscience letters 20010525
Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex. Neuroscience letters 20010504
Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex. Neuropharmacology 20000128
Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine. The Journal of pharmacology and experimental therapeutics 19990501
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. European journal of pharmacology 19970411
Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats. Journal of neural transmission. General section 19940101
Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists. Polish journal of pharmacology 19940101

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