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178616-26-7

178616-26-7 | 4H-2,3-Benzodiazepin-4-one, 1-(4-aminophenyl)-3,5-dihydro-7,8-dimethoxy-

CAS No: 178616-26-7 Catalog No: AG00266W MDL No:MFCD01321072

Product Description

Catalog Number:
AG00266W
Chemical Name:
4H-2,3-Benzodiazepin-4-one, 1-(4-aminophenyl)-3,5-dihydro-7,8-dimethoxy-
CAS Number:
178616-26-7
Molecular Formula:
C17H17N3O3
Molecular Weight:
311.3352
MDL Number:
MFCD01321072
IUPAC Name:
1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one
InChI:
InChI=1S/C17H17N3O3/c1-22-14-7-11-8-16(21)19-20-17(13(11)9-15(14)23-2)10-3-5-12(18)6-4-10/h3-7,9H,8,18H2,1-2H3,(H,19,21)
InChI Key:
MJKADKZSYQWGLL-UHFFFAOYSA-N
SMILES:
COc1cc2c(cc1OC)CC(=O)NN=C2c1ccc(cc1)N

Properties

Complexity:
460  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
311.127g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
311.341g/mol
Monoisotopic Mass:
311.127g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
85.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1  

Literature

Title Journal
Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Molecular pain 20080101
AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer biology & therapy 20071201
An alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate glutamate-receptor antagonist can inhibit premicturition contractions in rats with bladder outlet obstruction. BJU international 20070701
Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy. Neuropharmacology 20061101
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton. Journal of medicinal chemistry 20060907
Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro. Journal of neuroscience research 20060501
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro. European journal of pharmacology 20060327
Glutamate receptors on human melanocytes regulate the expression of MiTF. Pigment cell research 20060201
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives. Farmaco (Societa chimica italiana : 1989) 20040101
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives. Journal of medicinal chemistry 20030814
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist. Journal of medicinal chemistry 20030102
Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block. European journal of pharmacology 20020906
Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. European journal of pharmacology 19990305

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