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1783-84-2 | 8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)-
CAS No: 1783-84-2 Catalog No: AG0025WS MDL No:MFCD00065721
Product Description
Catalog Number:
AG0025WS
Chemical Name:
8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)-
CAS Number:
1783-84-2
Molecular Formula:
C20H34O2
Molecular Weight:
306.4828
MDL Number:
MFCD00065721
IUPAC Name:
(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
InChI:
InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
InChI Key:
HOBAELRKJCKHQD-QNEBEIHSSA-N
SMILES:
CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O
EC Number:
217-233-0
UNII:
FC398RK06S
Properties
Complexity:
327
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
3
Exact Mass:
306.256g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
306.49g/mol
Monoisotopic Mass:
306.256g/mol
Rotatable Bond Count:
15
Topological Polar Surface Area:
37.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
7.2
Literature
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| 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120502 |
| Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). | European journal of clinical nutrition 20120501 |
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| Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation. | American journal of physiology. Heart and circulatory physiology 20120301 |
| Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury. | Journal of lipid research 20120301 |
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| 8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice. | PloS one 20120101 |
| 11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction. | PloS one 20120101 |
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| Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. | European journal of nutrition 20111201 |
| Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. | Clinical science (London, England : 1979) 20111201 |
| Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts. | Cardiovascular drugs and therapy 20111201 |
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| Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. | Prostaglandins & other lipid mediators 20111101 |
| Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. | American journal of physiology. Lung cellular and molecular physiology 20111101 |
| Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. | The Journal of pharmacology and experimental therapeutics 20111101 |
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| Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. | American journal of physiology. Renal physiology 20111001 |
| P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111001 |
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| Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901 |
| Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. | American journal of physiology. Heart and circulatory physiology 20110801 |
| Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats. | Liver international : official journal of the International Association for the Study of the Liver 20110701 |
| Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20110601 |
| Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. | Biochimica et biophysica acta 20110601 |
| CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). | The Journal of biological chemistry 20110520 |
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| Effects of DHLA-capped CdSe/ZnS quantum dots on the fibrillation of human serum albumin. | The journal of physical chemistry. B 20100826 |
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| Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice. | Journal of atherosclerosis and thrombosis 20090801 |
| Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function. | Cardiovascular research 20090715 |
| Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog. | American journal of physiology. Heart and circulatory physiology 20090701 |
| Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis. | The British journal of nutrition 20090601 |
| An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. | Journal of lipid research 20090601 |
| Subchronic (13-week) oral toxicity study of dihomo-gamma-linolenic acid (DGLA) oil in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090601 |
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| Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. | Journal of molecular and cellular cardiology 20090601 |
| 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. | Prostaglandins & other lipid mediators 20090601 |
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| A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. | Molecular pharmacology 20090401 |
| Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression. | The Tohoku journal of experimental medicine 20090401 |
| Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. | Prostaglandins, leukotrienes, and essential fatty acids 20090401 |
| Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct. | Journal of the American Society of Nephrology : JASN 20090301 |
| Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. | American journal of physiology. Heart and circulatory physiology 20090301 |
| Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. | American journal of physiology. Renal physiology 20090301 |
| Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy. | American journal of physiology. Renal physiology 20090301 |
| Associations between neonatal birth dimensions and maternal essential and trans fatty acid contents during pregnancy and at delivery. | The British journal of nutrition 20090201 |
| The depressive effects of 5,8,11-eicosatrienoic Acid (20:3n-9) on osteoblasts. | Lipids 20090201 |
| Possible mediators of connecting tubule glomerular feedback. | Hypertension (Dallas, Tex. : 1979) 20090201 |
| Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. | Journal of hypertension 20090201 |
| Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. | The Journal of pharmacology and experimental therapeutics 20090101 |
| Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury. | Autonomic & autacoid pharmacology 20090101 |
| Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. | Ophthalmic research 20090101 |
| Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. | Surgery today 20090101 |
| Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. | Cardiovascular research 20081201 |
| Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201 |
| CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. | American journal of respiratory cell and molecular biology 20081201 |
| Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle. | Prostaglandins & other lipid mediators 20081201 |
| Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats. | American journal of physiology. Renal physiology 20081201 |
| Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension. | Arteriosclerosis, thrombosis, and vascular biology 20081201 |
| Determination of epoxyeicosatrienoic acids in human red blood cells and plasma by GC/MS in the NICI mode. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201 |
| Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. | Journal of immunology (Baltimore, Md. : 1950) 20081201 |
| Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules. | Hypertension research : official journal of the Japanese Society of Hypertension 20081201 |
| Cytochrome P-450 metabolites in renal circulation and excretion--interaction with the nitric oxide (NO) system. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201 |
| The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | The Journal of pharmacology and experimental therapeutics 20081101 |
| Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. | Pharmacogenetics and genomics 20081101 |
| Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis. | American journal of physiology. Cell physiology 20081101 |
| Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice. | American journal of physiology. Heart and circulatory physiology 20081101 |
| Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. | American journal of physiology. Heart and circulatory physiology 20081101 |
| [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells]. | Ai zheng = Aizheng = Chinese journal of cancer 20081101 |
| Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection. | Analytical and bioanalytical chemistry 20081001 |
| Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080801 |
| Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. | The Journal of pharmacology and experimental therapeutics 20080801 |
| Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. | American journal of physiology. Heart and circulatory physiology 20080801 |
| Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. | Infection and immunity 20080801 |
| Atopic dermatitis: the quest for the silver bullet. | Veterinary journal (London, England : 1997) 20080801 |
| LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium. | The Journal of biological chemistry 20080711 |
| Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. | Stroke 20080701 |
| An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. | Blood 20080615 |
| Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia. | Journal of cellular physiology 20080601 |
| Production of arachidonic acid and dihomo-gamma-linolenic acid from glycerol by oil-producing filamentous fungi, Mortierella in the ARS culture collection. | Journal of industrial microbiology & biotechnology 20080601 |
| Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4. | Arteriosclerosis, thrombosis, and vascular biology 20080601 |
| Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. | American journal of physiology. Renal physiology 20080601 |
| Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. | American journal of physiology. Heart and circulatory physiology 20080601 |
| Tone-dependent vascular responses to astrocyte-derived signals. | American journal of physiology. Heart and circulatory physiology 20080601 |
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| Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. | Cardiovascular research 20080501 |
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| Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. | Basic & clinical pharmacology & toxicology 20080501 |
| Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. | American journal of physiology. Gastrointestinal and liver physiology 20080501 |
| Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. | Hypertension (Dallas, Tex. : 1979) 20080501 |
| Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications. | Metabolism: clinical and experimental 20080501 |
| Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20080301 |
| 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20080301 |
| Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. | Investigative ophthalmology & visual science 20080301 |
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| Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. | The British journal of nutrition 20080201 |
| EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | American journal of respiratory cell and molecular biology 20080201 |
| Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. | Clinical and experimental immunology 20080201 |
| Age-related decrease in 15-lipoxygenase contributes to reduced vasorelaxation in rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20080201 |
| Influence of pancreatic status and sex on polyunsaturated fatty acid profiles in cystic fibrosis. | Clinical chemistry 20080201 |
| Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels. | Microcirculation (New York, N.Y. : 1994) 20080201 |
| Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080101 |
| 11,12-Epoxyeicosatrienoic acid activates the L-arginine/nitric oxide pathway in human platelets. | Molecular and cellular biochemistry 20080101 |
| Oral administration of dihomo-gamma-linolenic acid prevents development of atopic dermatitis in NC/Nga mice. | Lipids 20080101 |
| Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101 |
| Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20071201 |
| Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning. | Journal of cardiovascular pharmacology 20071201 |
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| Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy. | World journal of surgery 20071101 |
| Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice. | Molecular pharmacology 20071001 |
| Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase. | American journal of physiology. Regulatory, integrative and comparative physiology 20070901 |
| Dynamic expression of epoxyeicosatrienoic acid synthesizing and metabolizing enzymes in the primate corpus luteum. | Molecular human reproduction 20070801 |
| Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
| Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. | American journal of physiology. Renal physiology 20070701 |
| Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity. | American journal of physiology. Renal physiology 20070701 |
| Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. | The FEBS journal 20070701 |
| A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat. | Experimental physiology 20070701 |
| Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. | Lipids 20070601 |
| Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | American journal of respiratory cell and molecular biology 20070501 |
| Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries. | The Journal of pharmacology and experimental therapeutics 20070501 |
| Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. | The Journal of pharmacology and experimental therapeutics 20070501 |
| Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. | The Journal of biological chemistry 20070427 |
| Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070425 |
| Action of epoxyeicosatrienoic acids on cellular function. | American journal of physiology. Cell physiology 20070301 |
| Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. | Journal of molecular and cellular cardiology 20070301 |
| Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation. | American journal of physiology. Heart and circulatory physiology 20070201 |
| Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation. | Prostaglandins & other lipid mediators 20070201 |
| Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. | Thrombosis and haemostasis 20070201 |
| Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. | Trends in pharmacological sciences 20070101 |
| Erythrocyte-derived epoxyeicosatrienoic acids. | Prostaglandins & other lipid mediators 20070101 |
| Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids. | Prostaglandins & other lipid mediators 20070101 |
| Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. | Prostaglandins & other lipid mediators 20070101 |
| Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. | Prostaglandins & other lipid mediators 20070101 |
| Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). | Prostaglandins & other lipid mediators 20070101 |
| Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury. | Prostaglandins & other lipid mediators 20070101 |
| Epoxyeicosatrienoic acids, cell signaling and angiogenesis. | Prostaglandins & other lipid mediators 20070101 |
| 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells. | Prostaglandins & other lipid mediators 20070101 |
| Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | Prostaglandins & other lipid mediators 20070101 |
| Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. | Cell biochemistry and biophysics 20070101 |
| Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro. | In vivo (Athens, Greece) 20070101 |
| Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats. | Vascular pharmacology 20070101 |
| Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress? | Prostaglandins, leukotrienes, and essential fatty acids 20070101 |
| Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. | American journal of physiology. Renal physiology 20061201 |
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| Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. | Arteriosclerosis, thrombosis, and vascular biology 20061101 |
| Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. | American journal of physiology. Heart and circulatory physiology 20061001 |
| High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061001 |
| From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling. | Pharmacology & therapeutics 20060901 |
| Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. | The Journal of physiology 20060901 |
| Compartmental analyses of plasma 13C- and 2H-labeled n-6 fatty acids arising from oral administrations of 13C-U-18:2n-6 and 2H5-20:3n-6 in newborn infants. | Pediatric research 20060901 |
| Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. | Biochimica et biophysica acta 20060901 |
| Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. | Bioscience, biotechnology, and biochemistry 20060901 |
| The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. | The Journal of endocrinology 20060901 |
| Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. | American journal of physiology. Heart and circulatory physiology 20060801 |
| Having a heart attack? Avoid the 'HETE'! | American journal of physiology. Heart and circulatory physiology 20060801 |
| Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. | American journal of physiology. Heart and circulatory physiology 20060801 |
| Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. | American journal of physiology. Renal physiology 20060701 |
| Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata. | The Journal of endocrinology 20060701 |
| Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis. | The Journal of pharmacy and pharmacology 20060601 |
| Allylic alcohol transposition by ortho ester-initiated carbonate extension. synthesis of the vasodilator 11(R),12(S),15(S)-trihydroxyeicosa- 5(Z),8(Z),13(E)-trienoic acid. | Organic letters 20060525 |
| Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. | Analytical biochemistry 20060501 |
| Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans. | Developmental biology 20060415 |
| Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. | American journal of physiology. Lung cellular and molecular physiology 20060401 |
| Endothelium-derived epoxyeicosatrienoic acids and vascular function. | Hypertension (Dallas, Tex. : 1979) 20060401 |
| Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. | American journal of physiology. Heart and circulatory physiology 20060401 |
| Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315 |
| Cytochrome P450 epoxygenases provide a novel mechanism for penile erection. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301 |
| Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201 |
| A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets. | The Journal of physiology 20060115 |
| Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | The Journal of biological chemistry 20060113 |
| 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. | American journal of physiology. Heart and circulatory physiology 20060101 |
| Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. | American journal of physiology. Heart and circulatory physiology 20060101 |
| A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes. | The Journal of pharmacology and experimental therapeutics 20060101 |
| Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. | The British journal of nutrition 20060101 |
| Hepoxilin analogs, potential new therapeutics in disease. | Current pharmaceutical design 20060101 |
| Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients. | Nutrition (Burbank, Los Angeles County, Calif.) 20060101 |
| Capping of CdSe-ZnS quantum dots with DHLA and subsequent conjugation with proteins. | Nature protocols 20060101 |
| Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. | Biochimica et biophysica acta 20051230 |
| PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo. | Biochemical and biophysical research communications 20051209 |
| Hepoxilin A3 synthase. | Biochemical and biophysical research communications 20051209 |
| TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. | Circulation research 20051209 |
| EDHF redux: EETs, TRPV4, and Ca2+ sparks. | Circulation research 20051209 |
| Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. | American journal of physiology. Renal physiology 20051201 |
| Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. | Journal of cell science 20051201 |
| [Arachidonic acid epoxygenases and their metabolites promote angiogenesis]. | Zhonghua xin xue guan bing za zhi 20051201 |
| Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. | American journal of respiratory and critical care medicine 20051101 |
| Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. | Hypertension (Dallas, Tex. : 1979) 20051101 |
| Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. | Circulation research 20051028 |
| 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase. | Journal of applied physiology (Bethesda, Md. : 1985) 20051001 |
| Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. | Cardiovascular research 20051001 |
| Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels. | The Journal of pharmacology and experimental therapeutics 20051001 |
| Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved. | Science in China. Series C, Life sciences 20051001 |
| A linchpin approach to unsaturated fatty acids: 11,12-epoxyeicosatrienoic acid and 11S,12S-dihydroxyeicosatrienoic acid ethyl esters. | The Journal of organic chemistry 20050930 |
| Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum. | European journal of pharmacology 20050920 |
| Cytochrome P450/NADPH-dependent biosynthesis of 5,6-trans-epoxyeicosatrienoic acid from 5,6-trans-arachidonic acid. | The Biochemical journal 20050915 |
| Role of Ca2+-independent phospholipase A2 and cytochrome P-450 in store-operated calcium entry in 3T6 fibroblasts. | Biochemical pharmacology 20050901 |
| Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. | Biological & pharmaceutical bulletin 20050901 |
| Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids. | American journal of physiology. Renal physiology 20050801 |
| Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). | The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20050801 |
| [Effect of 11, 12-epoxyeicosatrienoic acid on nitric oxide synthase of ischemia-reperfusion myocardium in rats]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20050801 |
| Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. | The Journal of biological chemistry 20050722 |
| Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. | British journal of pharmacology 20050701 |
| COX-2 inhibitors and metabolism of essential fatty acids. | Medical science monitor : international medical journal of experimental and clinical research 20050701 |
| Stereospecific synthesis and mass spectrometry of 5,6-trans-epoxy-8Z,11Z,14Z-eicosatrienoic acid. | Bioorganic & medicinal chemistry letters 20050615 |
| Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. | Cancer research 20050601 |
| Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids. | The Journal of biological chemistry 20050513 |
| Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401 |
| Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation. | Hypertension (Dallas, Tex. : 1979) 20050401 |
| 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. | Hypertension (Dallas, Tex. : 1979) 20050401 |
| Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | American journal of physiology. Heart and circulatory physiology 20050301 |
| Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. | Circulation research 20050218 |
| Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20050201 |
| Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. | Archives of biochemistry and biophysics 20050115 |
| Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. | American journal of physiology. Heart and circulatory physiology 20050101 |
| Influence of testosterone on polyunsaturated fatty acid biosynthesis in Sertoli cells in culture. | Cell biochemistry and function 20050101 |
| Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | Nature medicine 20050101 |
| Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids. | Prostaglandins & other lipid mediators 20050101 |
| The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice. | In vivo (Athens, Greece) 20050101 |
| Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries. | European journal of pharmacology 20041215 |
| Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. | American journal of physiology. Heart and circulatory physiology 20041201 |
| Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. | Endocrinology 20041101 |
| Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. | Journal of immunology (Baltimore, Md. : 1950) 20041101 |
| Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. | Circulation research 20041015 |
| Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. | Circulation 20041012 |
| Beating ischemia: a new feat of EETs? | Circulation research 20040903 |
| Non-prostaglandin eicosanoids in fever and anapyrexia. | Frontiers in bioscience : a journal and virtual library 20040901 |
| Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells. | The Journal of biological chemistry 20040827 |
| Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. | Circulation research 20040611 |
| 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. | Pharmacological research 20040601 |
| Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants. | Nature biotechnology 20040601 |
| Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery. | The Journal of physiology 20040501 |
| Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid. | Biochemical pharmacology 20040415 |
| Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| Role of EETs in regulation of endothelial permeability in rat lung. | American journal of physiology. Lung cellular and molecular physiology 20040201 |
| Mediators of bradykinin-induced vasorelaxation in human coronary microarteries. | Hypertension (Dallas, Tex. : 1979) 20040201 |
| Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors. | British journal of pharmacology 20040201 |
| A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. | The American journal of pathology 20040201 |
| Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism? | Circulation research 20040109 |
| Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. | Progress in lipid research 20040101 |
| 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20031201 |
| The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes. | Journal of nutritional science and vitaminology 20031201 |
| 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. | Bioorganic & medicinal chemistry letters 20031117 |
| Role of epoxyeicosatrienoic acids in renal functional response to inhibition of NO production in the rat. | American journal of physiology. Renal physiology 20031101 |
| Nitric oxide-epoxygenase interactions and arachidonate-induced dilation of rat renal microvessels. | American journal of physiology. Heart and circulatory physiology 20031101 |
| Effect of 11,12-epoxyeicosatrienoic acid as an additive to St. Thomas' cardioplegia and University of Wisconsin solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries: influence of temperature and time. | The Annals of thoracic surgery 20031101 |
| Dihomo-gamma-linolenic acid inhibits tumour necrosis factor-alpha production by human leucocytes independently of cyclooxygenase activity. | Immunology 20031101 |
| Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. | Biochemistry 20031014 |
| To b'EET or not to b'EET? That is the question! | Clinical science (London, England : 1979) 20031001 |
| 5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR. | Hypertension (Dallas, Tex. : 1979) 20031001 |
| 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. | Hypertension (Dallas, Tex. : 1979) 20031001 |
| Effect of dietary fat level and sesamin on the polyunsaturated fatty acid metabolism in rats. | Journal of nutritional science and vitaminology 20031001 |
| Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20031001 |
| [Effects of 11,12-epoxyeicosatrienoic acid on cardioplegia and reperfusion arrhythmias in the isolated immature rabbit hearts]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001 |
| Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. | The Journal of biological chemistry 20030912 |
| Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement. | The Journal of experimental biology 20030901 |
| 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. | The Journal of biological chemistry 20030808 |
| Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. | Journal of the American Society of Nephrology : JASN 20030701 |
| 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. | Experimental biology and medicine (Maywood, N.J.) 20030701 |
| Effects of eicosatrienoic acid (20:3 n-9, Mead's acid) on some promalignant-related properties of three human cancer cell lines. | Prostaglandins & other lipid mediators 20030701 |
| Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta. | Biochimica et biophysica acta 20030620 |
| Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. | Kidney international 20030601 |
| The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. | Prostaglandins, leukotrienes, and essential fatty acids 20030501 |
| Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR). | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401 |
| HETEs/EETs in renal glomerular and epithelial cell functions. | Current opinion in pharmacology 20030401 |
| Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. | Prostaglandins & other lipid mediators 20030401 |
| The regulation of arachidonic acid metabolism in human first trimester trophoblast by cyclic AMP. | Prostaglandins & other lipid mediators 20030401 |
| Effect of DHLA on response of isolated rat urinary bladder to repetitive field stimulation. | Molecular and cellular biochemistry 20030401 |
| Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. | Archives of biochemistry and biophysics 20030315 |
| Biosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells. | FEBS letters 20030313 |
| The nitric oxide- and prostaglandin-independent component of the renal vasodilator effect of thimerosal is mediated by epoxyeicosatrienoic acids. | The Journal of pharmacology and experimental therapeutics 20030301 |
| Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. | Circulation 20030211 |
| Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. | American journal of physiology. Heart and circulatory physiology 20030101 |
| Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. | American journal of physiology. Heart and circulatory physiology 20030101 |
| Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | European journal of pharmacology 20030101 |
| A lipoxygenase product, hepoxilin A(3), enhances nerve growth factor-dependent neurite regeneration post-axotomy in rat superior cervical ganglion neurons in vitro. | Neuroscience 20030101 |
| Eicosanoid precursor polyenoic fatty acids modulate synaptic levels of dopamine in ex-vivo slices of rat brain striatum. | In vivo (Athens, Greece) 20030101 |
| Cytochrome P450-derived eicosanoids mediators of ocular surface inflammation. are. | Advances in experimental medicine and biology 20030101 |
| Beneficial effects of n-9 eicosatrienoic acid on experimental bowel lesions. | Surgery today 20030101 |
| The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells. | Anticancer research 20030101 |
| The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100. | Thrombosis research 20030101 |
| Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. | American journal of physiology. Heart and circulatory physiology 20021201 |
| Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. | Stroke 20021201 |
| Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation. | The Journal of investigative dermatology 20021201 |
| Capillary electrophoresis of cytochrome P-450 epoxygenase metabolites of arachidonic acid. 2. Resolution of stereoisomers. | Analytical chemistry 20021115 |
| Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. | American journal of physiology. Heart and circulatory physiology 20021101 |
| Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. | American journal of physiology. Heart and circulatory physiology 20021101 |
| Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: a structural determinant study. | Molecular pharmacology 20021101 |
| Production of 5,8,11-eicosatrienoic acid by a delta5 and delta6 desaturation activity-enhanced mutant derived from a delta12 desaturation activity-defective mutant of Mortierella alpina 1S-4. | Applied microbiology and biotechnology 20021101 |
| Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3. | Prostaglandins, leukotrienes, and essential fatty acids 20021101 |
| Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. | Lipids 20021001 |
| Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone. | American journal of physiology. Lung cellular and molecular physiology 20020801 |
| The production of progesterone and 5,6-epoxyeicosatrienoic acid by human granulosa cells. | The Journal of steroid biochemistry and molecular biology 20020801 |
| Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. | The Biochemical journal 20020715 |
| To move or not to move? Cytochrome P450 products and cell migration. | Circulation research 20020517 |
| Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. | Circulation research 20020517 |
| 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. | Circulation research 20020517 |
| Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells. | The Journal of biological chemistry 20020510 |
| Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1. | The Journal of biological chemistry 20020503 |
| Polyunsaturated fatty acid biosynthesis from [1-14C]20:3 n-6 acid in rat cultured Sertoli cells. Linoleic acid effect. | The international journal of biochemistry & cell biology 20020501 |
| 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. | American journal of physiology. Heart and circulatory physiology 20020501 |
| Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse. | The Journal of pharmacology and experimental therapeutics 20020501 |
| A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function. | Life sciences 20020421 |
| Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid. | Circulation research 20020419 |
| Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells. | American journal of physiology. Heart and circulatory physiology 20020401 |
| The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP. | FEBS letters 20020327 |
| Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle. | American journal of physiology. Cell physiology 20020301 |
| Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols. | Archives of biochemistry and biophysics 20020101 |
| P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Physiological reviews 20020101 |
| Hepoxilin B3 and its enzymatically formed derivative trioxilin B3 are incorporated into phospholipids in psoriatic lesions. | The Journal of investigative dermatology 20020101 |
| Substrate down regulation of 12-lipoxygenase in human platelets. | Advances in experimental medicine and biology 20020101 |
| Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs. | Advances in experimental medicine and biology 20020101 |
| Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. | The Journal of physiology 20011215 |
| Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. | Hypertension (Dallas, Tex. : 1979) 20011201 |
| Epoxyeicosatrienoic acids (EET(11,12)) may partially restore endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries. | The Annals of thoracic surgery 20011201 |
| Vicinal nitrohydroxyeicosatrienoic acids: vasodilator lipids formed by reaction of nitrogen dioxide with arachidonic acid. | The Journal of pharmacology and experimental therapeutics 20011101 |
| A critical review of the role of endothelial factors in the pathogenesis of hypertension. | Journal of cardiovascular pharmacology 20011101 |
| Cytochrome p450 and vascular homeostasis. | Circulation research 20011026 |
| Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. | American journal of physiology. Heart and circulatory physiology 20011001 |
| Stereospecific synthesis of trans-arachidonic acids. | Bioorganic & medicinal chemistry letters 20010917 |
| Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1beta in the rat. | Neuroscience letters 20010914 |
| Dihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytes. | The Journal of physiology 20010801 |
| Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis. | Journal of periodontology 20010801 |
| Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctions. | Microcirculation (New York, N.Y. : 1994) 20010801 |
| Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids. | Japanese journal of pharmacology 20010801 |
| The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells. | Pflugers Archiv : European journal of physiology 20010701 |
| EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. | American journal of physiology. Heart and circulatory physiology 20010601 |
| EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. | American journal of physiology. Heart and circulatory physiology 20010601 |
| Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | American journal of physiology. Heart and circulatory physiology 20010601 |
| Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. | The Journal of biological chemistry 20010511 |
| Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries. | Biochemical and biophysical research communications 20010511 |
| Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. | The Journal of biological chemistry 20010504 |
| EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. | American journal of physiology. Lung cellular and molecular physiology 20010501 |
| Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | Analytical biochemistry 20010501 |
| Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. | Journal of hypertension 20010501 |
| Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases. | The Journal of biological chemistry 20010330 |
| Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. | American journal of physiology. Regulatory, integrative and comparative physiology 20010301 |
| Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. | American journal of physiology. Heart and circulatory physiology 20010301 |
| Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. | Hypertension (Dallas, Tex. : 1979) 20010301 |
| Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. | American journal of hypertension 20010301 |
| Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. | Archives of biochemistry and biophysics 20010301 |
| Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | Cancer letters 20010226 |
| Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. | Molecular and cellular biochemistry 20010201 |
| Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | Biochemistry 20010130 |
| Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. | Circulation research 20010119 |
| Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. | The Biochemical journal 20010101 |
| The lung HETEs (and EETs) up. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid. | Molecular pharmacology 20010101 |
| Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin. | Journal of vascular research 20010101 |
| Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. | Trends in cardiovascular medicine 20010101 |
| Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. | Journal of perinatal medicine 20010101 |
| Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques. | Advances in experimental medicine and biology 20010101 |
| Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | Nutrition and cancer 20010101 |
| Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. | Circulation research 20001124 |
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