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17817-88-8 | Pentanoic acid, 3,5-dihydroxy-3-methyl-, (3R)-

CAS No: 17817-88-8 Catalog No: AG0025TG MDL No:

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Catalog Number:
Chemical Name:
Pentanoic acid, 3,5-dihydroxy-3-methyl-, (3R)-
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(3R)-3,5-dihydroxy-3-methylpentanoic acid
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Title Journal
Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate. Toxicological sciences : an official journal of the Society of Toxicology 20160201
Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity. Toxicology 20150302
Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. The FEBS journal 20140801
Evidence of a novel mevalonate pathway in archaea. Biochemistry 20140701
(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. The Journal of biological chemistry 20140606
Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. The Journal of clinical endocrinology and metabolism 20130301
Differentially expressed transcripts from leaf and root tissue of Chlorophytum borivilianum: a plant with high medicinal value. Gene 20121210
Biosynthesis of fomannoxin in the root rotting pathogen Heterobasidion occidentale. Phytochemistry 20121201
Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury. International journal of molecular medicine 20121201
Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. Thrombosis and haemostasis 20121101
Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. Plant physiology and biochemistry : PPB 20121101
Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. Blood 20121018
Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. The Biochemical journal 20121015
Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. Biochemistry 20121009
Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. European journal of pharmacology 20121005
Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiology of aging 20121001
Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase. Metabolism: clinical and experimental 20121001
Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal). Plant cell reports 20121001
Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice. Cardiovascular drugs and therapy 20121001
Ox-LDL-induced TGF-β1 production in human alveolar epithelial cells: involvement of the Ras/ERK/PLTP pathway. Journal of cellular physiology 20120901
No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. Journal of inherited metabolic disease 20120901
Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase. Biochimie 20120901
An ultrasensitive enzymatic method for measuring mevalonic acid in serum. Journal of lipid research 20120901
Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme A reductase (HMGR) gene in Gramineae. Molecular biology reports 20120901
Engineering triterpene metabolism in tobacco. Planta 20120901
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. The American journal of pathology 20120901
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. Biochemical pharmacology 20120815
ATP-citrate lyase: a key player in cancer metabolism. Cancer research 20120801
Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry 20120717
p53 and cancer stem cells: the mevalonate connexion. Cell cycle (Georgetown, Tex.) 20120715
Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. Applied biochemistry and biotechnology 20120701
HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology (Reading, England) 20120701
Isoprene hydrocarbons production upon heterologous transformation of Saccharomyces cerevisiae. Journal of applied microbiology 20120701
Novel aspects of mevalonate pathway inhibitors as antitumor agents. Clinical cancer research : an official journal of the American Association for Cancer Research 20120701
The isoprenoid-precursor dependence of Plasmodium spp. Natural product reports 20120701
Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem cells (Dayton, Ohio) 20120701
Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979) 20120701
Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120601
3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. Journal of cellular biochemistry 20120601
Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis 20120601
Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell death & disease 20120601
2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. Journal of hepatology 20120501
Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cells. Oncology reports 20120501
Statins and protein prenylation in cancer cell biology and therapy. Anti-cancer agents in medicinal chemistry 20120501
Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. Clinical and experimental immunology 20120501
De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum. Science China. Life sciences 20120501
3-Hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis. Gene 20120425
Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. Toxicology and applied pharmacology 20120415
Simvastatin inhibits glucose-stimulated vascular smooth muscle cell migration involving increased expression of RhoB and a block of Ras/Akt signal. Cardiovascular therapeutics 20120401
Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Molecular biology reports 20120401
A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis? Progress in lipid research 20120401
Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. International journal of molecular medicine 20120401
Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. Journal of experimental botany 20120401
Isoprenoid biosynthesis in eukaryotic phototrophs: a spotlight on algae. Plant science : an international journal of experimental plant biology 20120401
Current advances in detection and treatment of babesiosis. Current medicinal chemistry 20120401
Application of targeted proteomics to metabolically engineered Escherichia coli. Proteomics 20120401
Statins impair glucose uptake in tumor cells. Neoplasia (New York, N.Y.) 20120401
Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models. Iranian biomedical journal 20120401
Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. Journal of experimental botany 20120301
Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode. Metabolic engineering 20120301
Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. Journal of the American Chemical Society 20120215
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. International journal of cancer 20120201
Clinical, genetic, and therapeutic diversity in 2 patients with severe mevalonate kinase deficiency. Pediatrics 20120201
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. Neuroscience 20120127
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 20120120
The analytical determination of isoprenoid intermediates from the mevalonate pathway. Analytical and bioanalytical chemistry 20120101
Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. Journal of experimental botany 20120101
Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. The Journal of antimicrobial chemotherapy 20120101
Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. Metabolic engineering 20120101
Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. Plant methods 20120101
Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components. Frontiers in microbiology 20120101
Current approaches toward production of secondary plant metabolites. Journal of pharmacy & bioallied sciences 20120101
Effect of simvastatin on transforming growth factor beta-1-induced myofibroblast differentiation and collagen production in nasal polyp-derived fibroblasts. American journal of rhinology & allergy 20120101
NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements. Chinese medicine 20120101
Rosuvastatin: a review of the pharmacology and clinical effectiveness in cardiovascular disease. Clinical Medicine Insights. Cardiology 20120101
Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. Journal of pharmacological sciences 20120101
Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. PloS one 20120101
Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. PloS one 20120101
The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. PloS one 20120101
Pathways of carotenoid biosynthesis in bacteria and microalgae. Methods in molecular biology (Clifton, N.J.) 20120101
Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. PloS one 20120101
Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. Genetics, selection, evolution : GSE 20120101
Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. PloS one 20120101
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PloS one 20120101
Type 2 IDI performs better than type 1 for improving lycopene production in metabolically engineered E. coli strains. World journal of microbiology & biotechnology 20120101
FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection. PloS one 20120101
[Effect of bisphosphonates on anticancer activity in prostate cancer cells]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101
Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. European journal of pharmacology 20111230
Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. Journal of natural products 20111227
Biochemistry of the non-mevalonate isoprenoid pathway. Cellular and molecular life sciences : CMLS 20111201
Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. Biochemical pharmacology 20111201
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. Plant signaling & behavior 20111201
Five questions about non-mevalonate isoprenoid biosynthesis. PLoS pathogens 20111201
Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. Chembiochem : a European journal of chemical biology 20111125
12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. Blood 20111117
Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. Journal of immunology (Baltimore, Md. : 1950) 20111115
Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. Planta 20111101
Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. Clinical science (London, England : 1979) 20111101
Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. Journal of cellular biochemistry 20111101
Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Fertility and sterility 20111101
Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. Journal of experimental botany 20111101
Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). Metabolic engineering 20111101
Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. Cancer biology & therapy 20111015
Biosynthesis of cholesterol and other sterols. Chemical reviews 20111012
Characterization and expression of two cDNA encoding 3-Hydroxy-3-methylglutaryl coenzyme A reductase isoforms in coffee (Coffea arabica L.). Omics : a journal of integrative biology 20111001
Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-based mevalonic acid. Chemical biology & drug design 20111001
Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. Nutrition research and practice 20111001
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. The Journal of biological chemistry 20110916
Harnessing yeast subcellular compartments for the production of plant terpenoids. Metabolic engineering 20110901
Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. Expert opinion on drug delivery 20110901
Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes. Apoptosis : an international journal on programmed cell death 20110901
Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). Expert opinion on therapeutic patents 20110901
Hyper-IgD syndrome or mevalonate kinase deficiency. Current opinion in rheumatology 20110901
Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. Metabolic engineering 20110901
Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. Toxins 20110901
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. The Biochemical journal 20110815
Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 20110815
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. The Journal of infectious diseases 20110815
Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. Plant, cell & environment 20110801
Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. Journal of thrombosis and haemostasis : JTH 20110801
Effect of farnesol on mevalonate pathway of Staphylococcus aureus. The Journal of antibiotics 20110801
Modes of action of microbially-produced phytotoxins. Toxins 20110801
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. The Journal of biological chemistry 20110708
Antitumor effects of the combination of cholesterol reducing drugs. Oncology reports 20110701
Bisphosphonates inhibit expression of p63 by oral keratinocytes. Journal of dental research 20110701
Natural products in caries research: current (limited) knowledge, challenges and future perspective. Caries research 20110701
Screening for mevalonate biosynthetic pathway inhibitors using sensitized bacterial strains. Journal of biomolecular screening 20110701
[Plasmacytoid dendritic cells as therapeutic targets in novel therapeutics for autoimmune diseases]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701
Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. The Journal of surgical research 20110601
Bisphosphonates induce senescence in normal human oral keratinocytes. Journal of dental research 20110601
Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. The Korean journal of thoracic and cardiovascular surgery 20110601
A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂. Biochemical pharmacology 20110515
Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. The Journal of biological chemistry 20110513
A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. Biochemistry 20110503
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. Journal of hepatology 20110501
Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. The Journal of veterinary medical science 20110501
Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. Annals of clinical biochemistry 20110501
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer letters 20110501
The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. Clinical and experimental immunology 20110501
Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. The Journal of investigative dermatology 20110501
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. Experimental biology and medicine (Maywood, N.J.) 20110501
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. Biochemical and biophysical research communications 20110422
Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis. Applied microbiology and biotechnology 20110401
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b. Journal of leukocyte biology 20110401
Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. Biochimica et biophysica acta 20110401
Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. Applied microbiology and biotechnology 20110401
Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. Cytokine 20110401
Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. Journal of agricultural and food chemistry 20110309
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle. American journal of respiratory cell and molecular biology 20110301
Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cellular and molecular life sciences : CMLS 20110301
The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. Biomedical chromatography : BMC 20110301
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of lipid research 20110301
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. International journal of oncology 20110301
Targeted proteomics for metabolic pathway optimization: application to terpene production. Metabolic engineering 20110301
Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. American journal of physiology. Endocrinology and metabolism 20110301
Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. Naunyn-Schmiedeberg's archives of pharmacology 20110301
Osteonecrosis of the jaw and the role of macrophages. Journal of the National Cancer Institute 20110202
Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. Journal of cardiovascular pharmacology 20110201
Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. Thrombosis and haemostasis 20110201
Effect of temperature on postillumination isoprene emission in oak and poplar. Plant physiology 20110201
Design and application of a mevalonate-responsive regulatory protein. Angewandte Chemie (International ed. in English) 20110201
Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Archives of biochemistry and biophysics 20110115
Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. Evidence-based complementary and alternative medicine : eCAM 20110101
Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta oncologica (Stockholm, Sweden) 20110101
Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. Molecular biology and evolution 20110101
Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. Haematologica 20110101
Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. Anti-cancer drugs 20110101
Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. Drug metabolism and disposition: the biological fate of chemicals 20110101
Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug metabolism letters 20110101
[Anti-atherosclerotic and anti-inflammatory effects of statin on cardiovascular disease and their mechanisms]. Nihon rinsho. Japanese journal of clinical medicine 20110101
Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microbial cell factories 20110101
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one 20110101
Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. Clinical and experimental rheumatology 20110101
Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. Circulation journal : official journal of the Japanese Circulation Society 20110101
Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC musculoskeletal disorders 20110101
Mevalonate pathway is a novel target for hypertension. Circulation journal : official journal of the Japanese Circulation Society 20110101
Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PloS one 20110101
Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. BMC microbiology 20110101
Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae. Microbial cell factories 20110101
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PloS one 20110101
The role of fatty aldehyde dehydrogenase in epidermal structure and function. Dermato-endocrinology 20110101
The biosynthesis of isoprenoids and the mechanisms regulating it in plants. Bioscience, biotechnology, and biochemistry 20110101
Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). BMC genomics 20110101
Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. Microbial cell factories 20110101
Expression of Pigment Cell-Specific Genes in the Ontogenesis of the Sea Urchin Strongylocentrotus intermedius. Evidence-based complementary and alternative medicine : eCAM 20110101
Renal mitochondrial cytopathies. International journal of nephrology 20110101
Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. PloS one 20110101
Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. Journal of experimental & clinical cancer research : CR 20110101
Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PloS one 20110101
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. Respiratory research 20110101
Studies on the antibacterial effects of statins--in vitro and in vivo. PloS one 20110101
Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. PloS one 20110101
Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. Respiratory research 20110101
[Hyperimmunoglobulinemia D and periodic fever syndrome]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20110101
Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PloS one 20110101
Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. Journal of signal transduction 20110101
Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study. Acta biochimica Polonica 20110101
Evidence of isoprenoid precursor toxicity in Bacillus subtilis. Bioscience, biotechnology, and biochemistry 20110101
De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. BMC genomics 20110101
The mevalonate pathway in C. elegans. Lipids in health and disease 20110101
Novel effects of statins in enhancing efficacy of chemotherapy in vitro in nasopharyngeal carcinoma. International forum of allergy & rhinology 20110101
Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. BMC genomics 20110101
Triterpenoid biosynthesis and engineering in plants. Frontiers in plant science 20110101
Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. European journal of pharmacology 20101215
Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. European journal of pharmacology 20101215
Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. Journal of cellular and molecular medicine 20101201
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. Annals of the rheumatic diseases 20101201
Mast cell death induced by 24(S),25-epoxycholesterol. Experimental cell research 20101115
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. Biotechnology and bioengineering 20101015
Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. Endocrinology 20101001
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis 20101001
Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells. European journal of pharmacology 20100901
Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. Diabetes 20100901
Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. Hypertension (Dallas, Tex. : 1979) 20100901
[Effect of acetyl-CoA synthase gene overexpression on physiological function of Saccharomyces cerevisiae]. Wei sheng wu xue bao = Acta microbiologica Sinica 20100901
[Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20100818
Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway. Chemical communications (Cambridge, England) 20100807
Isoprenoids, small GTPases and Alzheimer's disease. Biochimica et biophysica acta 20100801
Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. Journal of applied physiology (Bethesda, Md. : 1985) 20100801
Atorvastatin affects TLR4 clustering via lipid raft modulation. International immunopharmacology 20100801
Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. Journal of neurochemistry 20100801
Biosynthesis of andrographolide in Andrographis paniculata. Phytochemistry 20100801
Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions. Brain research 20100730
Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. Cardiovascular research 20100715
Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. The Journal of biological chemistry 20100702
The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. European journal of human genetics : EJHG 20100701
Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. Molecular & cellular proteomics : MCP 20100701
Statins and inflammation: an update. Current opinion in cardiology 20100701
Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. Plant physiology 20100701
Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood 20100610
Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. Pharmacological research 20100601
Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway. International immunopharmacology 20100601
Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. Molecular neurobiology 20100601
The molecular basis of bisphosphonate activity: a preclinical perspective. Seminars in oncology 20100601
Coenzyme Q--biosynthesis and functions. Biochemical and biophysical research communications 20100521
A historical perspective on the discovery of statins. Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. Journal of cellular and molecular medicine 20100501
Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. Cardiovascular research 20100501
Atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving Nox4 and p38MAPK. Atherosclerosis 20100501
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. Biotechnology and bioengineering 20100501
The herbivore-induced plant volatile methyl salicylate negatively affects attraction of the parasitoid Diadegma semiclausum. Journal of chemical ecology 20100501
Lipid metabolism and HCV infection. Viruses 20100501
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. Neuroscience letters 20100426
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes 20100401
A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia. Pediatrics 20100401
Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. Anticancer research 20100401
Antiviral therapy for hepatitis C virus: beyond the standard of care. Viruses 20100401
In vitro antioxidant activity of pravastatin provides vascular protection. European journal of pharmacology 20100325
Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). Journal of molecular modeling 20100301
Targeting the mevalonate pathway in multiple myeloma. Leukemia research 20100301
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. Biochemical pharmacology 20100301
A genomics resource for investigating regulation of essential oil production in Lavandula angustifolia. Planta 20100301
The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. AAPS PharmSciTech 20100301
Steroid assays in paediatric endocrinology. Journal of clinical research in pediatric endocrinology 20100301
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. Journal of natural products 20100226
NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. Journal of the American Chemical Society 20100224
Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. International journal of cancer 20100215
Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. Toxicology and applied pharmacology 20100215
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. Applied microbiology and biotechnology 20100201
Light regulation of metabolic pathways in fungi. Applied microbiology and biotechnology 20100201
Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. Neurochemistry international 20100201
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemistry 20100201
Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation. Physiologia plantarum 20100201
Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. Bioorganic & medicinal chemistry 20100201
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. The Plant cell 20100201
[Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. Medecine sciences : M/S 20100201
Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochemical and biophysical research communications 20100122
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. The Journal of biological chemistry 20100115
Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. Plant physiology 20100101
Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. Cytokine 20100101
Mechanisms of action and medicinal applications of abscisic Acid. Current medicinal chemistry 20100101
Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. Medical science monitor : international medical journal of experimental and clinical research 20100101
The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. Bioscience, biotechnology, and biochemistry 20100101
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast cancer research : BCR 20100101
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. Cellular immunology 20100101
Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. Biological & pharmaceutical bulletin 20100101
Dynamics of lamin-A processing following precursor accumulation. PloS one 20100101
[Controversies regarding the use of statins in the acute coronary syndrome]. Medicina intensiva 20100101
Contribution of mevalonate and methylerythritol phosphate pathways to polyisoprenoid biosynthesis in the rubber-producing plant Eucommia ulmoides oliver. Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101
Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. Marine drugs 20100101
S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. Archaea (Vancouver, B.C.) 20100101
A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. BMC plant biology 20100101
Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. BMC plant biology 20100101
Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. Bioscience, biotechnology, and biochemistry 20100101
Hypercholesterolemia and microvascular dysfunction: interventional strategies. Journal of inflammation (London, England) 20100101
Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. BMC molecular biology 20100101
Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. Journal of clinical lipidology 20100101
Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. Drug design, development and therapy 20100101
Oleuropein in olive and its pharmacological effects. Scientia pharmaceutica 20100101
Elevated immunoglobulin D levels in children with PFAPA syndrome. Neuro endocrinology letters 20100101
Loss of caveolin-1 accelerates neurodegeneration and aging. PloS one 20100101
Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. Drug design, development and therapy 20100101
Structural and functional characterization of HMG-COA reductase from Artemisia annua. Bioinformation 20100101
Coenzyme q10 and statin-induced mitochondrial dysfunction. The Ochsner journal 20100101
Anethum graveolens: An Indian traditional medicinal herb and spice. Pharmacognosy reviews 20100101
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. Bioorganic & medicinal chemistry 20091201
Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. Toxins 20091201
Simvastatin as a potential therapeutic for acute respiratory distress syndrome. American journal of respiratory and critical care medicine 20091115
Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. Journal of immunology (Baltimore, Md. : 1950) 20091101
American Diabetes Association indications for statins in diabetes: is there evidence? Diabetes care 20091101
Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. American journal of respiratory and critical care medicine 20091015
Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. Virus research 20091001
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. Lipids 20091001
Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. Bioresource technology 20090901
Spatial expression of the mevalonate enzymes involved in juvenile hormone biosynthesis in the corpora allata in Bombyx mori. Journal of insect physiology 20090901
Adverse effects of statins - mechanisms and consequences. Current drug safety 20090901
[Pharmacological profile and clinical efficacy of minodronic acid hydrate as a new therapeutic agent for osteoporosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20090901
Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. European cytokine network 20090901
Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages. Bulletin of experimental biology and medicine 20090901
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. Biochemical pharmacology 20090815
Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach. Journal of molecular modeling 20090801
Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing bone morphogenetic protein-2 signal. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090801
Targeting the mevalonate pathway for improved anticancer therapy. Current cancer drug targets 20090801
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. Journal of molecular medicine (Berlin, Germany) 20090801
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. British journal of pharmacology 20090801
Synthetic protein scaffolds provide modular control over metabolic flux. Nature biotechnology 20090801
Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. International journal of molecular sciences 20090801
Cholesterol biosynthesis modulation regulates dengue viral replication. Virology 20090620
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. Journal of immunology (Baltimore, Md. : 1950) 20090615
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. Journal of biochemistry 20090601
Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. The Journal of pharmacology and experimental therapeutics 20090601
Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. European journal of immunology 20090601
Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. Journal of integrative plant biology 20090601
Established and newly proposed mechanisms of chronic cyclosporine nephropathy. The Korean journal of internal medicine 20090601
Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. Life sciences 20090522
Regulation of different inflammatory diseases by impacting the mevalonate pathway. Immunology 20090501
Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug metabolism and disposition: the biological fate of chemicals 20090501
d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. Pancreas 20090501
Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. International journal of molecular medicine 20090501
Complete blockage of the mevalonate pathway results in male gametophyte lethality. Journal of experimental botany 20090501
Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. Metabolic engineering 20090501
Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. Journal of immunology (Baltimore, Md. : 1950) 20090415
Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. Proteins 20090401
Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols. Applied microbiology and biotechnology 20090401
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature chemical biology 20090401
Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. Melanoma research 20090401
[The effects of simvastatin on cardiac hypertrophy and association on calcium channel modulation in rats with myocardial hypertrophy induced by abdominal aortic constriction]. Zhonghua xin xue guan bing za zhi 20090401
Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. Journal of biotechnology 20090325
Potential immunologic effects of statins in cancer following transplantation. Cancer immunology, immunotherapy : CII 20090301
High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. The international journal of biochemistry & cell biology 20090301
Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arteriosclerosis, thrombosis, and vascular biology 20090301
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature genetics 20090301
The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. Biochemical and biophysical research communications 20090220
Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells. Acta oto-laryngologica 20090201
Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. Arteriosclerosis, thrombosis, and vascular biology 20090201
Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. Journal of neurochemistry 20090201
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. European journal of pharmacology 20090114
Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma. Leukemia research 20090101
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metabolic engineering 20090101
Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. Experimental neurology 20090101
Hyper-IgD syndrome with novel mutation in a Japanese girl. Modern rheumatology 20090101
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. American journal of physiology. Cell physiology 20090101
QSAR and complex network study of the chiral HMGR inhibitor structural diversity. Bioorganic & medicinal chemistry 20090101
Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. PLoS genetics 20090101
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. BMC cancer 20090101
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PloS one 20090101
Developments in the scientific and clinical understanding of autoinflammatory disorders. Arthritis research & therapy 20090101
Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. Trials 20090101
Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. Interdisciplinary perspectives on infectious diseases 20090101
Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. BMC genomics 20090101
Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. BMC genomics 20090101
Pleiotropic vasoprotective effects of statins: the chicken or the egg? Drug design, development and therapy 20090101
Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. BMC genomics 20090101
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). PloS one 20090101
Conjugated hyperbilirubinaemia as the first manifestation of mevalonic aciduria in a term newborn. Neuro endocrinology letters 20090101
Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. PloS one 20090101
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. Journal of the American Chemical Society 20081224
Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Journal of lipid research 20081201
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. Endocrine-related cancer 20081201
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Archives of biochemistry and biophysics 20081201
Biosynthetic evidence supporting the generation of terpene chemodiversity in marine mollusks of the genus Doriopsilla. Journal of natural products 20081201
Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. Journal of medicinal food 20081201
Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. Journal of immunology (Baltimore, Md. : 1950) 20081115
Modulation of osteoclastogenesis by fatty acids. Endocrinology 20081101
Simvastatin activates Keap1/Nrf2 signaling in rat liver. Journal of molecular medicine (Berlin, Germany) 20081101
Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. Plant physiology 20081101
Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin. Molecular and cellular biochemistry 20081001
Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. The Journal of pharmacology and experimental therapeutics 20081001
Ecdysteroids in spinach (Spinacia oleracea L.): biosynthesis, transport and regulation of levels. Plant physiology and biochemistry : PPB 20081001
Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. Biochimica et biophysica acta 20081001
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. Kidney international 20080901
Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. Kidney international 20080901
Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings. Journal of cardiovascular pharmacology and therapeutics 20080901
Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent. Thrombosis and haemostasis 20080901
[The anticancer properties of statins]. Postepy higieny i medycyny doswiadczalnej (Online) 20080807
Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. Lipids 20080801
Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. European journal of immunology 20080801
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. Journal of bioenergetics and biomembranes 20080801
Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. Bioscience, biotechnology, and biochemistry 20080801
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. The Journal of biological chemistry 20080725
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresource technology 20080701
High-content assay to study protein prenylation. Journal of biomolecular screening 20080701
Statins and prostate cancer prevention: where we are now, and future directions. Nature clinical practice. Urology 20080701
Molecular cloning and characterization of two cDNAs encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Hevea brasiliensis. Journal of plant physiology 20080616
LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. Atherosclerosis 20080601
Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. Diabetes research and clinical practice 20080601
7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. Journal of atherosclerosis and thrombosis 20080601
Atorvastatin and cardiovascular risk in the elderly--patient considerations. Clinical interventions in aging 20080601
Cholesterol-induced stimulation of postinflammatory liver fibrosis. Bulletin of experimental biology and medicine 20080601
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 20080515
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Molecular pharmacology 20080501
Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. Applied microbiology and biotechnology 20080501
Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. Journal of biochemical and biophysical methods 20080424
Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. Plant & cell physiology 20080401
Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. The FEBS journal 20080401
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma research 20080401
Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. Liver international : official journal of the International Association for the Study of the Liver 20080401
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. The American journal of gastroenterology 20080401
Biphasic effects of atorvastatin on inflammation. Pakistan journal of pharmaceutical sciences 20080401
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. Current protein & peptide science 20080401
Combination therapy in cholesterol reduction: focus on ezetimibe and statins. Vascular health and risk management 20080401
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. FEBS letters 20080305
Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. Plant physiology 20080301
[Effect of pitavastatin on macrophage cholesterol metabolism]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. PLoS medicine 20080301
Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulation. Journal of neuroscience research 20080215
The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells. European journal of pharmacology 20080202
Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. Pain 20080201
Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. Nitric oxide : biology and chemistry 20080201
High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. The Journal of rheumatology 20080201
Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. Leukemia & lymphoma 20080201
Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. Archives of pharmacal research 20080201
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. Breast cancer research and treatment 20080101
Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. ChemMedChem 20080101
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. Cardiology 20080101
Bisphosphonates may increase peritoneal fibrinolytic activity by inhibiting the mevalonate pathway. Annals of surgery 20080101
Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. Molecular and cellular biochemistry 20080101
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. Nutrition & metabolism 20080101
Statins in the treatment of polycystic ovary syndrome. Seminars in reproductive medicine 20080101
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. BMC cancer 20080101
Small molecules for the activation of human gammadelta T cell responses against infection. Recent patents on anti-infective drug discovery 20080101
Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. American journal of nephrology 20080101
[Interrelation between the pathways of isoprenoid biosynthesis and carbon source catabolism in anaerobic and facultatively anaerobic bacteria]. Mikrobiologiia 20080101
Yeast cell factories for fine chemical and API production. Microbial cell factories 20080101
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC biology 20080101
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. Journal of muscle research and cell motility 20080101
Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. BMC systems biology 20080101
Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. Food & nutrition research 20080101
Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. Analytical chemistry insights 20080101
Neuroprotective effects of garlic a review. The Libyan journal of medicine 20080101
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood 20071215
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. Plant cell reports 20071201
Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. Journal of thrombosis and haemostasis : JTH 20071201
Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. Cytokine 20071201
Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. Journal of pharmacological sciences 20071201
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. Neoplasia (New York, N.Y.) 20071201
Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. Evidence-based complementary and alternative medicine : eCAM 20071201
Linköping University Medical Dissertation No. 1033. Following the mevalonate pathway to bone heal alley. Acta orthopaedica. Supplementum 20071201
[Influence on atherosclerosis of improvement of bone mineral density after medication for osteoporosis]. Nihon rinsho. Japanese journal of clinical medicine 20071128
Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. Plant biotechnology journal 20071101
[Simvastatin downregulates CD40L induced vascular cell adhesion molecule-1 expression and adhesive function in human umbilical vein endothelial cells]. Zhonghua xin xue guan bing za zhi 20071101
Biosynthesis of monoterpenes and norisoprenoids in raspberry fruits (Rubus idaeus L.): the role of cytosolic mevalonate and plastidial methylerythritol phosphate pathway. Journal of agricultural and food chemistry 20071031
Activation of the integrated stress response regulates lovastatin-induced apoptosis. The Journal of biological chemistry 20071012
Mevalonic aciduria: report of two cases. Journal of inherited metabolic disease 20071001
Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. Chemical & pharmaceutical bulletin 20071001
[Pharmacological and clinical profile of once weekly alendronate for the treatment of osteoporosis (Fosamac 35 mg/Bonalon 35 mg)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20071001
[Biosynthesis of a hybrid terpenoid polyketide-derived natural product and production of useful prenylated compounds by using prenyltransferase]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20071001
Are pleiotropic effects of statins real? Vascular health and risk management 20071001
Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. The Journal of biological chemistry 20070928
Mevalonic aciduria cured by bone marrow transplantation. The New England journal of medicine 20070927
Statins reduce amyloid-beta production through inhibition of protein isoprenylation. The Journal of biological chemistry 20070914
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. European journal of pharmacology 20070910
Zoledronic acid-induced IPP/ApppI production in vivo. Life sciences 20070908
Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 20070901
Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. Free radical research 20070901
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. Biochemical pharmacology 20070815
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. Toxicology and applied pharmacology 20070815
Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. Journal of molecular biology 20070810
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. Cancer letters 20070808
A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. Journal of neurochemistry 20070801
Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. American journal of physiology. Lung cellular and molecular physiology 20070801
Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). Phytochemistry 20070801
Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis. Oncology reports 20070801
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. Insect biochemistry and molecular biology 20070801
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer research 20070801
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. PLoS pathogens 20070801
[Effects of enzyme inhibitors on the pigment synthesis in Monascus anka]. Wei sheng wu xue bao = Acta microbiologica Sinica 20070801
[Statin drugs decrease the plasma level of coenzyme Q10 (ubiquinone) in the organism]. Ideggyogyaszati szemle 20070730
[Abnormalities of the enzymes involved in lipid metabolism]. Nihon rinsho. Japanese journal of clinical medicine 20070728
The non-mevalonate pathway of isoprenoid precursor biosynthesis. The Journal of biological chemistry 20070727
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. The Journal of biological chemistry 20070706
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The Journal of pharmacology and experimental therapeutics 20070701
Isoprenoid biosynthesis authenticates the classification of the green alga Mesostigma viride as an ancient streptophyte. Gene 20070701
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. Stem cells (Dayton, Ohio) 20070701
Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. Phytochemistry 20070701
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. European journal of cell biology 20070701
Mevalonate kinase deficiency and autoinflammatory disorders. The New England journal of medicine 20070628
Allogeneic bone marrow transplantation in mevalonic aciduria. The New England journal of medicine 20070628
Modulation of COX-2 expression by statins in human monocytic cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. American journal of respiratory cell and molecular biology 20070601
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. ChemMedChem 20070601
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer science 20070601
Coenzyme Q10 in phenylketonuria and mevalonic aciduria. Mitochondrion 20070601
Mevalonate pathway: a review of clinical and therapeutical implications. Clinical biochemistry 20070601
Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. Clinical immunology (Orlando, Fla.) 20070601
The antioxidant role of coenzyme Q. Mitochondrion 20070601
Enhancement of cardenolide and phytosterol levels by expression of an N-terminally truncated 3-hydroxy-3-methylglutaryl CoA reductase in Transgenic digitalis minor. Planta medica 20070601
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. Molecular cancer therapeutics 20070601
Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. Journal of cardiovascular pharmacology 20070601
Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion. International journal of clinical pharmacology and therapeutics 20070601
Time-of-intake (morning versus evening) of extended-release fluvastatin in hyperlipemic patients is without influence on the pharmacodynamics (mevalonic acid excretion) and pharmacokinetics. International journal of clinical pharmacology and therapeutics 20070601
Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042. The Journal of organic chemistry 20070525
Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. Journal of lipid research 20070501
Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arteriosclerosis, thrombosis, and vascular biology 20070501
Pitavastatin inactivates NF-kappaB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncology reports 20070501
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. Protein science : a publication of the Protein Society 20070501
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nature chemical biology 20070501
Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity. Heart rhythm 20070501
Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. Journal of clinical biochemistry and nutrition 20070501
Pleiotropic effects of statins and related pharmacological experimental approaches. Timely topics in medicine. Cardiovascular diseases 20070418
Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. American journal of physiology. Heart and circulatory physiology 20070401
Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo. Experimental biology and medicine (Maywood, N.J.) 20070401
Towards complete sets of farnesylated and geranylgeranylated proteins. PLoS computational biology 20070401
Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface. Biochemical and biophysical research communications 20070309
Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. Leukemia research 20070301
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. Arteriosclerosis, thrombosis, and vascular biology 20070301
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metabolic engineering 20070301
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. The Journal of antimicrobial chemotherapy 20070301
A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. Current biology : CB 20070206
Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. Applied microbiology and biotechnology 20070201
Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells. International immunopharmacology 20070201
Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. International immunology 20070201
Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. British journal of pharmacology 20070201
Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. British journal of haematology 20070201
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways. Investigative ophthalmology & visual science 20070201
[Introduction to bisphosphonates. History and functional mechanisms]. Der Orthopade 20070201
The mevalonate pathway as a therapeutic target in the Ph-negative chronic myeloproliferative disorders. Current drug targets 20070201
Statins induce differentiation and cell death in neurons and astroglia. Glia 20070101
Microbial sensors for small molecules: development of a mevalonate biosensor. Metabolic engineering 20070101
Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. Biochemical pharmacology 20070101
Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. Arteriosclerosis, thrombosis, and vascular biology 20070101
Multilevel modulation of the mevalonate and protein-prenylation circuitries as a novel strategy for anticancer therapy. Trends in pharmacological sciences 20070101
Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats. American journal of therapeutics 20070101
Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. Molecular cancer 20070101
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. BMC structural biology 20070101
Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. Lipids in health and disease 20070101
Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. Anticancer research 20070101
Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. Endothelium : journal of endothelial cell research 20070101
Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. Biotechnology progress 20070101
Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. Journal of musculoskeletal & neuronal interactions 20070101
Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme. Oligonucleotides 20070101
Establishment of Croton stellatopilosus suspension culture for geranylgeraniol production and diterpenoid biosynthesis. Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. Endothelium : journal of endothelial cell research 20070101
Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. Clinical and experimental rheumatology 20070101
The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia. Heart international 20070101
Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. Biochemical and biophysical research communications 20061229
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. European journal of pharmacology 20061215
Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. Journal of lipid research 20061201
Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. Archives of microbiology 20061201
Simvastatin reduces CD40 expression in an experimental model of early arterialization of saphenous vein graft. The Journal of surgical research 20061201
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. Oncology reports 20061201
Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. Clinical and experimental immunology 20061201
9-epi-Viridiol, a novel cytotoxic furanosteroid from soil fungus Trichoderma virens. Natural product research 20061201
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced 'inside-out' signaling to extracellular matrix by preventing RhoA activation. American journal of physiology. Renal physiology 20061101
Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line. Metabolism: clinical and experimental 20061101
Potential benefit of statins for vascular disease in systemic sclerosis. Current opinion in rheumatology 20061101
A role for geranylgeranylation in interleukin-1beta secretion. Arthritis and rheumatism 20061101
Pleiotropic effects of statins and related pharmacological experimental approaches. Methods and findings in experimental and clinical pharmacology 20061101
Last generation of amino-bisphosphonates (N-BPs) and cancer angio-genesis: a new role for these drugs? Recent patents on anti-cancer drug discovery 20061101
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. European journal of pharmacology 20061024
Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. The Biochemical journal 20061015
Pig liver phosphomevalonate kinase: kinetic mechanism. Archives of biochemistry and biophysics 20061015
Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. FEBS letters 20061009
Statins in the treatment of polycythaemia vera and allied disorders: an antithrombotic and cytoreductive potential? Leukemia research 20061001
Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. Journal of neuroimmunology 20061001
Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. Journal of lipid research 20061001
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. Fertility and sterility 20061001
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. Neuropeptides 20061001
Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. Metabolic engineering 20060901
The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science (New York, N.Y.) 20060901
Growth inhibition of Candida species and Aspergillus fumigatus by statins. FEMS microbiology letters 20060901
HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. Life sciences 20060829
Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. Biotechnology and bioengineering 20060820
Herbicidal effects of statin pharmaceuticals in Lemna gibba. Environmental science & technology 20060815
Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. Clinica chimica acta; international journal of clinical chemistry 20060801
Hypothesis: the antitumor activities of statins may be mediated by IL-18. Journal of leukocyte biology 20060801
Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. Stroke 20060801
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. Clinical cancer research : an official journal of the American Association for Cancer Research 20060715
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. International journal of cancer 20060701
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biology of reproduction 20060701
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochimica et biophysica acta 20060701
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701
The nonlipid effects of statins on endothelial function. Trends in cardiovascular medicine 20060701
Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells. Cancer letters 20060618
Location and biosynthesis of monoterpenyl fatty acyl esters in rose petals. Phytochemistry 20060601
Simvastatin decreases IL-6 and IL-8 production in epithelial cells. Journal of dental research 20060601
Cloning and characterization of a root-specific expressing gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Ginkgo biloba. Molecular biology reports 20060601
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. Journal of bacteriology 20060501
Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. Journal of immunology (Baltimore, Md. : 1950) 20060501
Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 20060413
Statins prevent NF-kappaB transactivation independently of the IKK-pathway in human endothelial cells. Atherosclerosis 20060401
Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20060401
Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. Biological & pharmaceutical bulletin 20060401
Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060401
[Auto-inflammatory disease with hyperimmunoglobulinemia D of late onset]. Annales de dermatologie et de venereologie 20060401
Bisphosphonates: from bench to bedside. Annals of the New York Academy of Sciences 20060401
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Organic letters 20060316
Reduction of background interference in the spectrophotometric assay of mevalonate kinase. Analytical and bioanalytical chemistry 20060301
Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors. Pharmacotherapy 20060301
N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301
Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. The Journal of rheumatology 20060301
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. Journal of agricultural and food chemistry 20060222
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. Bone 20060201
Rho/ROCK pathway as a target of tumor therapy. Journal of neuroscience research 20060201
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. Immunology and cell biology 20060201
Simvastatin protection against acute immune-mediated glomerulonephritis in mice. Kidney international 20060201
Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. Arthritis and rheumatism 20060201
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201
Anti-cancer therapy: targeting the mevalonate pathway. Current cancer drug targets 20060201
[Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201
The emerging role of statins in the treatment of heart failure. Journal of the American College of Cardiology 20060117
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood 20060115
Erythropoietin receptor signal transduction requires protein geranylgeranylation. The Journal of pharmacology and experimental therapeutics 20060101
Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. The FEBS journal 20060101
Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. Fungal genetics and biology : FG & B 20060101
Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. Journal of cardiovascular pharmacology 20060101
New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway. Current pharmaceutical design 20060101
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. BMC biochemistry 20060101
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. American journal of nephrology 20060101
Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20060101
A new water-based topical carrier with polar skin-lipids. Lipids in health and disease 20060101
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. Microbial cell factories 20060101
Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. Orphanet journal of rare diseases 20060101
Regulation of inducible nitric oxide synthase gene in glial cells. Antioxidants & redox signaling 20060101
Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. Skin pharmacology and physiology 20060101
Statins may decrease skeletal-related events in breast cancer patients with bone metastases. Medical hypotheses 20060101
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. Arthritis research & therapy 20060101
Cholesterol, statins and tau. Acta neurologica Scandinavica. Supplementum 20060101
The role of pleiotropic effects of statins in dementia. Acta neurologica Scandinavica. Supplementum 20060101
In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. Breast cancer research : BCR 20060101
Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. Journal of oleo science 20060101
Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. The Journal of biological chemistry 20051230
Regulation of fatty acid synthesis by farnesyl pyrophosphate. The Journal of biological chemistry 20051223
Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. Journal of cellular biochemistry 20051215
Effect of incadronate on proliferation of mesenchymal tumor cells with or without activated Ras mutation. Journal of experimental & clinical cancer research : CR 20051201
Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. The Journal of organic chemistry 20051111
Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. Toxicology 20051105
HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101
Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. Journal of lipid research 20051001
Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. The Journal of pharmacology and experimental therapeutics 20050901
Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clinical immunology (Orlando, Fla.) 20050901
Effect of statins on the proteasomal activity in mammalian endothelial and vascular smooth muscle cells. Biochemical pharmacology 20050815
MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. Cancer research 20050815
Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. British journal of cancer 20050808
Statins and cancer development. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050801
Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. Pharmacology 20050701
Polyisoprenoids: structure, biosynthesis and function. Progress in lipid research 20050701
Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Digestive diseases and sciences 20050701
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050701
A novel type of geosmin biosynthesis in myxobacteria. The Journal of organic chemistry 20050624
Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. The Journal of biological chemistry 20050610
Statins downregulate myeloperoxidase gene expression in macrophages. Biochemical and biophysical research communications 20050603
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. Journal of chemical ecology 20050601
Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. The Journal of biological chemistry 20050527
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Molecular cell 20050513
Molecular clues into the pathogenesis of statin-mediated muscle toxicity. Muscle & nerve 20050501
Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses. Radiation research 20050501
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. Current drug targets 20050501
Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. The Journal of biological chemistry 20050408
Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. Journal of agricultural and food chemistry 20050406
Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. Applied microbiology and biotechnology 20050401
Effects of statin therapy on the progression of chronic kidney disease. Advances in chronic kidney disease 20050401
Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes. The Journal of antibiotics 20050401
Statin-associated neuromyotoxicity. Drugs of today (Barcelona, Spain : 1998) 20050401
Pitavastatin at low dose activates endothelial nitric oxide synthase through PI3K-AKT pathway in endothelial cells. Life sciences 20050325
HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation 20050322
A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense. American journal of respiratory and critical care medicine 20050315
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. Clinical cancer research : an official journal of the American Association for Cancer Research 20050315
Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Journal of leukocyte biology 20050301
Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. Arteriosclerosis, thrombosis, and vascular biology 20050301
Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. FEBS letters 20050214
Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. Arteriosclerosis, thrombosis, and vascular biology 20050201
Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. Molecular nutrition & food research 20050201
A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. Chembiochem : a European journal of chemical biology 20050201
Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways. Phytochemistry 20050201
Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. Metabolism: clinical and experimental 20050201
[Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes]. The Japanese journal of antibiotics 20050201
Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. Journal of periodontology 20050201
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. International journal of cancer 20050120
Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. Archives of biochemistry and biophysics 20050115
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112
The mevalonate pathway and the synthesis of juvenile hormone in insects. Annual review of entomology 20050101
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and experimental immunology 20050101
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. PLoS medicine 20050101
HMG-CoA reductase inhibitors and coenzyme Q10. Cardiology in review 20050101
Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? Arthritis research & therapy 20050101
Antitumor effect of geranylamine derivatives on human hepatoma. In vivo (Athens, Greece) 20050101
New lipid-lowering agents acting on LDL receptors. Current topics in medicinal chemistry 20050101
[Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups]. Mikrobiologiia 20050101
Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. BMC cell biology 20050101
Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. Journal of atherosclerosis and thrombosis 20050101
The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. Drug safety 20050101
Biochemical changes of mevalonate pathway in human colorectal cancer. Anticancer research 20050101
Bisphosphonates and atherosclerosis: why? Lupus 20050101
First-trimester enzymatic and molecular prenatal diagnosis of mevalonic aciduria. Journal of inherited metabolic disease 20050101
Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant biotechnology journal 20050101
Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. Biochemistry 20041228
A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. Analytical biochemistry 20041215
From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates. Calcified tissue international 20041201
Regulation and degradation of HMGCo-A reductase. Applied microbiology and biotechnology 20041201
[Anabolic effects of statin and beta-blocker on bone metabolism]. Clinical calcium 20041201
Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. Bioscience, biotechnology, and biochemistry 20041201
Molecular functions of conserved aspects of the GHMP kinase family. Biochemistry 20041123
Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. Journal of cellular biochemistry 20041115
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. The Journal of biological chemistry 20041112
Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. British journal of pharmacology 20041101
Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. Circulation journal : official journal of the Japanese Circulation Society 20041101
Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. The Journal of antibiotics 20041101
Statins effect on smooth muscle cell proliferation. Seminars in vascular medicine 20041101
Effects of pravastatin on the expression of ATP-binding cassette transporter A1. The Journal of pharmacology and experimental therapeutics 20041001
Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway. Trends in cardiovascular medicine 20041001
Production of mevalonate by a metabolically-engineered Escherichia coli. Biotechnology letters 20041001
The metabolic imbalance underlying lesion formation in Arabidopsis thaliana overexpressing farnesyl diphosphate synthase (isoform 1S) leads to oxidative stress and is triggered by the developmental decline of endogenous HMGR activity. Planta 20041001
Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. The Journal of biological chemistry 20040910
Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. Journal of lipid research 20040901
Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. Journal of thrombosis and haemostasis : JTH 20040901
Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Molecular carcinogenesis 20040901
Are iridoids in leaf beetle larvae synthesized de novo or derived from plant precursors? A methodological approach. Isotopes in environmental and health studies 20040901
Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). Phytochemistry 20040901
Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. Biochemical and biophysical research communications 20040827
Multienzyme mevalonate pathway bioreactor. Biotechnology and bioengineering 20040820
Update on statins: 2003. Circulation 20040817
Statins inhibit HIV-1 infection by down-regulating Rho activity. The Journal of experimental medicine 20040816
Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. The Journal of biological chemistry 20040806
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology 20040801
Lipid rafts mediate the synaptic localization of alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728
Solid phase extraction procedure for urinary organic acid analysis by gas chromatography mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. Biochimica et biophysica acta 20040705
Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Experimental biology and medicine (Maywood, N.J.) 20040701
[Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040701
Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem : a European journal of chemical biology 20040607
Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells. American journal of physiology. Heart and circulatory physiology 20040601
Compactin-a review. Applied microbiology and biotechnology 20040601
Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. Analytical biochemistry 20040601
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. Protein science : a publication of the Protein Society 20040601
Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. Biochimica et biophysica acta 20040601
Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. Arthritis and rheumatism 20040601
Biosynthesis of isoprenoids via the non-mevalonate pathway. Cellular and molecular life sciences : CMLS 20040601
Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Clinical pharmacology and therapeutics 20040501
Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. DNA and cell biology 20040501
Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1. Oncogene 20040415
Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20. Cancer research 20040415
Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. The Journal of biological chemistry 20040409
Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. Journal of the American College of Cardiology 20040407
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. The Journal of biological chemistry 20040402
HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. Journal of neurochemistry 20040401
Origins and evolution of isoprenoid lipid biosynthesis in archaea. Molecular microbiology 20040401
Biosynthesis of unusual monocyclic alkenes by the diatom Rhizosolenia setigera (Brightwell). Phytochemistry 20040401
Heterologous mevalonate production in Streptomyces lividans TK23. Bioscience, biotechnology, and biochemistry 20040401
Mevalonate kinase deficiency: Evidence for a phenotypic continuum. Neurology 20040323
Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. Biochemical and biophysical research communications 20040319
The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS letters 20040312
Enterococcus faecalis mevalonate kinase. Protein science : a publication of the Protein Society 20040301
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. The Plant journal : for cell and molecular biology 20040301
Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular research 20040301
The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301
Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries. Journal of cardiovascular pharmacology 20040301
Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency. The Journal of biological chemistry 20040206
Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Developmental cell 20040201
Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040201
[The role of mevalonate pathway in osteogenic cells]. Nihon rinsho. Japanese journal of clinical medicine 20040201
Metabolism and function of coenzyme Q. Biochimica et biophysica acta 20040128
Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. Biochemical and biophysical research communications 20040123
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. Biochemical pharmacology 20040115
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. Neuroscience letters 20040109
Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. The Plant cell 20040101
Novel genotype of mevalonic aciduria with fatalities in premature siblings. Archives of disease in childhood. Fetal and neonatal edition 20040101
Down-regulating effect of nicotine on connexin43 gap junctions in human umbilical vein endothelial cells is attenuated by statins. European journal of cell biology 20040101
Investigation of regulatory mechanisms in coenzyme Q metabolism. Methods in enzymology 20040101
Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. BMC cell biology 20040101
Bone metabolism, mineral homeostasis and its pharmacological modulation. Clinical laboratory 20040101
The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs. Current pharmaceutical design 20040101
Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. Nephron. Experimental nephrology 20040101
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. Digestion 20040101
Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps. Journal of pharmacological and toxicological methods 20040101
The toxicology of HMG-CoA reductase inhibitors: prediction of human risk. Toxicologic pathology 20040101
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Genome biology 20040101
Lipid metabolism in zebrafish. Methods in cell biology 20040101
Linking lipids, Alzheimer's and LXRs? Nuclear receptor signaling 20040101
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. The Journal of biological chemistry 20031226
Statins induce suppressor of cytokine signaling-3 in macrophages. FEBS letters 20031204
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20031203
Statin therapy and angiogenesis. Current opinion in lipidology 20031201
Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire 20031201
Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Clinical and experimental pharmacology & physiology 20031201
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. Journal of lipid research 20031101
3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk. General and comparative endocrinology 20031101
Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Free radical biology & medicine 20031101
A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. The Journal of antibiotics 20031101
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. The Journal of biological chemistry 20031031
Methodology for synthesis and isolation of 5-phosphomevalonic acid. Analytical biochemistry 20031015
Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. Journal of cellular biochemistry 20031015
Potential antitumor effects of statins (Review). International journal of oncology 20031001
The mevalonate synthesis pathway as a therapeutic target in cancer. Clinical orthopaedics and related research 20031001
All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. Atherosclerosis 20031001
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. Circulation 20030923
cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. Archives of biochemistry and biophysics 20030915
Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. Virology 20030915
Isoprenoid metabolism and the pleiotropic effects of statins. Current atherosclerosis reports 20030901
Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. Journal of immunology (Baltimore, Md. : 1950) 20030901
Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. Basic research in cardiology 20030901
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030901
Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery. Pharmacology & toxicology 20030901
Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. Cardiovascular research 20030901
An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. Journal of biosciences 20030901
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. Pharmacopsychiatry 20030901
Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. Hypertension research : official journal of the Japanese Society of Hypertension 20030901
Computational analysis of the evolution of the structure and function of 1-deoxy-D-xylulose-5-phosphate synthase, a key regulator of the mevalonate-independent pathway in plants. Gene 20030814
HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030801
Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. Journal of biochemistry 20030801
Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. The Journal of biological chemistry 20030718
Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. Bioorganic & medicinal chemistry letters 20030707
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. Cellular signalling 20030701
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nature biotechnology 20030701
Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells. International journal of oncology 20030701
Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells. The Journal of urology 20030701
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701
Monoterpene regulation of Ras and Ras-related protein expression. Journal of lipid research 20030601
Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney international 20030601
Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis. Biochemical Society transactions 20030601
Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. Cellular and molecular life sciences : CMLS 20030601
HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells. Thrombosis research 20030601
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arteriosclerosis, thrombosis, and vascular biology 20030501
Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. Cellular immunology 20030501
Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production. Cellular immunology 20030501
Isoprenoid pyrophosphate analogues regulate expression of Ras-related proteins. Biochemistry 20030422
Statin rebound effect? The Journal of laboratory and clinical medicine 20030401
Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. The Journal of laboratory and clinical medicine 20030401
Diversity of the biosynthesis of the isoprene units. Natural product reports 20030401
Terpene biosynthesis in the nudibranch Doriopsilla areolata. The Journal of organic chemistry 20030321
Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. Arteriosclerosis, thrombosis, and vascular biology 20030301
Beyond lipid-lowering: effects of statins on endothelial nitric oxide. European journal of clinical pharmacology 20030301
Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. Trends in molecular medicine 20030301
Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. Journal of natural products 20030301
Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids. Cardiovascular surgery (London, England) 20030201
Mevalonate kinase deficiency: enlarging the clinical and biochemical spectrum. Pediatrics 20030201
Bisphosphonate mechanism of action. Current rheumatology reports 20030201
Statins can inhibit proliferation of human breast cancer cells in vitro. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201
Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. Phytochemistry 20030201
Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. The Journal of nutritional biochemistry 20030201
Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. Journal of agricultural and food chemistry 20030115
HMGCoA reductase inhibition partially mediates tumor necrosis factor alpha-induced apoptosis in human U-937 and HL-60 cells. Biochemical and biophysical research communications 20030110
Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. Cellular signalling 20030101
Squalene epoxidase as hypocholesterolemic drug target revisited. Progress in lipid research 20030101
Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. Kidney international 20030101
Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]. European journal of clinical investigation 20030101
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta crystallographica. Section D, Biological crystallography 20030101
Cloning, expression, and purification of His-tagged rat mevalonate kinase. Protein expression and purification 20030101
Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3. Journal of leukocyte biology 20030101
Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. Plant physiology 20030101
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Molecular cell 20030101
Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. Biotechnology progress 20030101
Put your heart into the joint benefits of statins! Arthritis research & therapy 20030101
HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. BMC cardiovascular disorders 20030101
Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard. Rapid communications in mass spectrometry : RCM 20030101
Immunomodulatory effects of HMG-CoA reductase inhibitors. Archivum immunologiae et therapiae experimentalis 20030101
Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101
Cerivastatin ameliorates high insulin-enhanced neutrophil-endothelial cell adhesion and endothelial intercellular adhesion molecule-1 expression by inhibiting mitogen-activated protein kinase activation. Journal of diabetes and its complications 20030101
Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. Clinical & experimental metastasis 20030101
Hypergravity-induced changes in gene expression in Arabidopsis hypocotyls. Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20030101
Age-related changes of isoprenoid biosynthesis in rat liver and brain. Biogerontology 20030101
Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. The Journal of biological chemistry 20021220
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research 20021220
Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. Human molecular genetics 20021201
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. Planta 20021201
Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. Clinical and experimental immunology 20021201
Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201
Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. Plant & cell physiology 20021201
Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. Plant & cell physiology 20021201
[Pharmacological and clinical properties of alendronate sodium hydrate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021201
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. The Journal of biological chemistry 20021122
Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. FEBS letters 20021120
Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry 20021119
The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia. Atherosclerosis 20021101
Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. The Journal of pharmacology and experimental therapeutics 20021101
Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101
3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. Arteriosclerosis, thrombosis, and vascular biology 20021101
Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant physiology 20021101
Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. British journal of clinical pharmacology 20021101
Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. European journal of pharmacology 20021025
Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. Circulation research 20021018
Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation. The Journal of pharmacology and experimental therapeutics 20021001
Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are able to reduce superoxide anion production by NADPH oxidase in THP-1-derived monocytes. Journal of cardiovascular pharmacology 20021001
Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. Journal of lipid research 20021001
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. Arthritis and rheumatism 20021001
Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. The Journal of antibiotics 20021001
Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. Journal of nutritional science and vitaminology 20021001
Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. The Biochemical journal 20020915
Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. Gene 20020904
Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. Molecular pharmacology 20020901
The succinate mechanism of insulin release. Diabetes 20020901
Effects of pravastatin sodium on mevalonate metabolism in common marmosets. Journal of biochemistry 20020901
[Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. Comptes rendus biologies 20020901
Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. Diabetes 20020801
The mevalonate pathway during acute tubular injury: selected determinants and consequences. The American journal of pathology 20020801
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. Clinical science (London, England : 1979) 20020801
Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. Bioscience, biotechnology, and biochemistry 20020801
Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. FEMS yeast research 20020801
Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia (New York, N.Y.) 20020701
Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. Journal of vascular surgery 20020701
Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. The Journal of endocrinology 20020701
Validation and application of an assay for the determination of mevalonic acid in human plasma by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020625
Disparity between angiographic regression and clinical event rates with hydrophobic statins. Lancet (London, England) 20020622
Biosynthesis of nodulisporic acid A: precursor studies. Journal of the American Chemical Society 20020619
Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. Planta 20020601
Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Plant physiology 20020601
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. Journal of neuroscience research 20020601
The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. The Journal of biological chemistry 20020517
Hereditary periodic fever. The New England journal of medicine 20020502
Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer research 20020501
Age-related changes of cholesterol and dolichol biosynthesis in rat liver. Mechanisms of ageing and development 20020430
The genetics and molecular genetics of terpene and sterol origami. Current opinion in plant biology 20020401
Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. Atherosclerosis 20020401
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. Blood 20020401
Statins and osteoporosis: can these lipid-lowering drugs also bolster bones? Cleveland Clinic journal of medicine 20020401
Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. The Plant journal : for cell and molecular biology 20020401
The biosynthesis of C5-C25 terpenoid compounds. Natural product reports 20020401
Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. Bioscience, biotechnology, and biochemistry 20020401
Regulatory aspects of coenzyme Q metabolism. Free radical research 20020401
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. The Journal of biological chemistry 20020322
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. The Journal of biological chemistry 20020308
Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. Circulation research 20020308
3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 20020301
[Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action]. Nihon rinsho. Japanese journal of clinical medicine 20020301
Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. Circulation 20020226
HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. Circulation 20020226
Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. Journal of molecular biology 20020208
Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. The Journal of organic chemistry 20020208
Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. American journal of physiology. Heart and circulatory physiology 20020201
Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. Phytochemistry 20020201
Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. Lipids 20020201
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. Breast cancer research and treatment 20020201
Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. FEBS letters 20020116
Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. Phytochemistry 20020101
Genes for mevalonate biosynthesis in Phycomyces. Molecular genetics and genomics : MGG 20020101
Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase. Journal of neuro-oncology 20020101
An intestinal obstruction in an eight-month-old child suffering from mevalonic aciduria. Acta paediatrica (Oslo, Norway : 1992) 20020101
Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. Journal of atherosclerosis and thrombosis 20020101
[Current state of carotenoid biosynthesis in chloroplasts of eucaryotes]. Zhurnal obshchei biologii 20020101
Brassinosteroids. Plant counterparts to animal steroid hormones? Vitamins and hormones 20020101
[Organic acid disorders: cerebral organic acidemia]. Ryoikibetsu shokogun shirizu 20020101
The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. The American journal of Chinese medicine 20020101
Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. The Journal of biological chemistry 20011228
Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. Biochemical pharmacology 20011215
Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. The Journal of biological chemistry 20011214
Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. The Biochemical journal 20011201
Statins and their potential for osteoporosis. Bone 20011201
Biosynthesis of a hopane triterpene and three diterpenes in the liverwort Fossombronia alaskana. Phytochemistry 20011201
Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. European journal of biochemistry 20011201
Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology 20011201
Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. Molecular and cellular biochemistry 20011201
More on pamidronate in Langerhans'-cell histiocytosis. The New England journal of medicine 20011115
Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. Biochemical and biophysical research communications 20011102
Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. FEBS letters 20011102
Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells. Chinese medical journal 20011101
Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. Journal of bacteriology 20011001
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. Current opinion in chemical biology 20011001
Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone 20011001
Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. Plant physiology 20011001
Clinically relevant pleiotropic effects of statins: drug properties or effects of profound cholesterol reduction? Nutrition, metabolism, and cardiovascular diseases : NMCD 20011001
Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatin. Atherosclerosis 20010901
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Leukemia 20010901
Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. Plant physiology 20010901
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression. Japanese journal of cancer research : Gann 20010901
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. Methods and findings in experimental and clinical pharmacology 20010901
Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications 20010825
Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. Archives of disease in childhood 20010801
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). British journal of pharmacology 20010801
In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arteriosclerosis, thrombosis, and vascular biology 20010801
Statins and bone: myth or reality? Calcified tissue international 20010801
Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nature structural biology 20010701
Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. Bioscience, biotechnology, and biochemistry 20010701
[Inhibition of bone resorption by bisphosphonates, heterogeneous group of drugs with different intracellular model of action]. Polskie Archiwum Medycyny Wewnetrznej 20010701
Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. The Journal of biological chemistry 20010629
Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. Biochimica et biophysica acta 20010629
LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS letters 20010615
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. The Journal of biological chemistry 20010601
A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. British journal of pharmacology 20010601
Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. Atherosclerosis 20010601
Metabolism and molecular toxicology of isoprene. Chemico-biological interactions 20010601
HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. Arteriosclerosis, thrombosis, and vascular biology 20010601
Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. Journal of leukocyte biology 20010601
Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor. Bioorganic & medicinal chemistry 20010601
Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. Planta 20010601
Mevalonate kinase deficiency in a child with periodic fever and without hyperimmunoglobulinaemia D. Journal of inherited metabolic disease 20010601
Mevalonic aciduria and hyper-IgD syndrome: two sides of the same coin? Journal of inherited metabolic disease 20010601
Inherited disorders of cholesterol biosynthesis. Neuropediatrics 20010601
NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. British journal of pharmacology 20010501
Biosynthesis of the hemi- and monoterpene moieties of isoprenyl phenyl ethers from the liverwort Trichocolea tomentella. Phytochemistry 20010501
3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. Arteriosclerosis, thrombosis, and vascular biology 20010501
Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology 20010501
The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. Pharmacology 20010501
Clinical and molecular variability in childhood periodic fever with hyperimmunoglobulinaemia D. Rheumatology (Oxford, England) 20010501
High IgD could be a nonpathogenetic diagnostic marker of the hyper-IgD and periodic fever syndrome. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010501
American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. Biochemistry. Biokhimiia 20010501
Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. Japanese journal of pharmacology 20010501
Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. Bioscience, biotechnology, and biochemistry 20010501
Catabolic and anabolic signals in bone: therapeutic implications. Current opinion in clinical nutrition and metabolic care 20010501
Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1. Breast cancer research and treatment 20010501
Metabolic labeling of prenyl and carboxyl-methyl groups. Current protocols in cell biology 20010501
Analysis of protein prenylation and carboxyl-methylation. Current protocols in protein science 20010501
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications 20010425
The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. The Journal of biological chemistry 20010413
Concise synthesis of (+)-2-C-methyl-D-erythritol-4-phosphate. The Journal of organic chemistry 20010406
Synthetic applications of epoxide hydrolases. Current opinion in chemical biology 20010401
Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism: clinical and experimental 20010401
Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. Journal of lipid research 20010401
Isoprene increases thermotolerance of fosmidomycin-fed leaves. Plant physiology 20010401
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. British journal of cancer 20010401
Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. European journal of human genetics : EJHG 20010401
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene. Insect biochemistry and molecular biology 20010315
Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca(2+) homeostasis. European journal of pharmacology 20010301
Biosynthesis of the bicycloalternarenes, mixed terpenoids of Alternaria alternata. Phytochemistry 20010301
Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. European journal of cell biology 20010301
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. The Journal of pharmacology and experimental therapeutics 20010201
Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. Molecular pharmacology 20010201
Deoxyxylulose phosphate pathway to terpenoids. Trends in plant science 20010201
Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. Molecular and cellular neurosciences 20010201
Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. Planta 20010201
Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. Medical hypotheses 20010201
Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. Biochemical and biophysical research communications 20010119
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene 20010110
Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. The Biochemical journal 20010101
Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation. Medical hypotheses 20010101
Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. British journal of pharmacology 20010101
Tracer studies on the incorporation of [2-14C]-DL-mevalonate into chlorophylls a and b, alpha-chaconine, and alpha-solanine of potato sprouts. Journal of agricultural and food chemistry 20010101
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. Clinical cancer research : an official journal of the American Association for Cancer Research 20010101
Investigation of avenacin-deficient mutants of Avena strigosa. Phytochemistry 20010101
In vivo prenylation analysis of Ras and Rho proteins. Methods in enzymology 20010101
Lovastatin controls signal transduction in vascular smooth muscle cells by modulating phosphorylation levels of mevalonate-independent pathways. Basic research in cardiology 20010101
Genetic disorders of cholesterol biosynthesis in mice and humans. Molecular genetics and metabolism 20010101
Identification of a gene cluster for the mevalonate pathway in Lactobacillus helveticus. DNA sequence : the journal of DNA sequencing and mapping 20010101
Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. The Journal of eukaryotic microbiology 20010101
Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circulation research 20000929
Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture. Atherosclerosis 20000601
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochemical and biophysical research communications 20000519
Biosynthesis of avenacins and phytosterols in roots of Avena sativa cv. Image. Phytochemistry 20000501
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. Biochemical and biophysical research communications 20000402
Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. Journal of molecular biology 20000331
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Archives of biochemistry and biophysics 20000101
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. The Journal of pharmacy and pharmacology 19991001
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (New York, N.Y.) 19990903
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research 19990801
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer research 19981201
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401
Hepatic cholesterol metabolism in experimental nephrotic syndrome. Lipids 19980201
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. Journal of lipid research 19971101
Identification of catalytic residues in human mevalonate kinase. The Journal of biological chemistry 19971010
Human multidrug-resistant (MRP,p190) myeloid leukemia HL-60/ADR cells in vitro: resistance to the mevalonate pathway inhibitor lovastatin. Neoplasma 19970101
Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. Journal of medicinal chemistry 19960719
Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells. Biochimica et biophysica acta 19960412
Phenoxypropylamines: a new series of squalene synthase inhibitors. Journal of medicinal chemistry 19951013
In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer research 19950201
ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. The Journal of biological chemistry 19941216
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. The Biochemical journal 19930115
Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia. The Quarterly journal of medicine 19920901
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. Biochimica et biophysica acta 19920709
Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19920106
Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. The Journal of biological chemistry 19901215
The gamma subunit of transducin is farnesylated. Proceedings of the National Academy of Sciences of the United States of America 19901001
[Lipid metabolism in daunomycin-induced nephrotic rats (5)]. Nihon Jinzo Gakkai shi 19900901
Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. Journal of medicinal chemistry 19900101
Plasma mevalonate response in lovastatin-related myopathy. Lancet (London, England) 19891104
Lipid and lipoprotein metabolism in Hep G2 cells. Biochimica et biophysica acta 19880812
The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. Journal of lipid research 19861001
Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. Antimicrobial agents and chemotherapy 19840401
Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. The Biochemical journal 19790701
Effect in vitro of 3-hydroxy-3-methylglutaric acid on the synthesis of mevalonate and its precursors. Archives internationales de physiologie et de biochimie 19770201
The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid. The Biochemical journal 19660401

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