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176391-41-6 | Acetic acid, 2-[[7,8-dihydro-5-[2-[[(E)-(phenyl-3-pyridinylmethylene)amino]oxy]ethyl]-1-naphthalenyl]oxy]-
CAS No: 176391-41-6 Catalog No: AG0024NA MDL No:
Product Description
Catalog Number:
AG0024NA
Chemical Name:
Acetic acid, 2-[[7,8-dihydro-5-[2-[[(E)-(phenyl-3-pyridinylmethylene)amino]oxy]ethyl]-1-naphthalenyl]oxy]-
CAS Number:
176391-41-6
Molecular Formula:
C26H24N2O4
Molecular Weight:
428.4798
IUPAC Name:
2-[[5-[2-[(E)-[phenyl(pyridin-3-yl)methylidene]amino]oxyethyl]-7,8-dihydronaphthalen-1-yl]oxy]acetic acid
InChI:
InChI=1S/C26H24N2O4/c29-25(30)18-31-24-13-5-11-22-19(9-4-12-23(22)24)14-16-32-28-26(20-7-2-1-3-8-20)21-10-6-15-27-17-21/h1-3,5-11,13,15,17H,4,12,14,16,18H2,(H,29,30)/b28-26+
InChI Key:
WBBLIRPKRKYMTD-BYCLXTJYSA-N
SMILES:
OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1
Properties
Complexity:
671
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
428.174g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
428.488g/mol
Monoisotopic Mass:
428.174g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
81A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.9
Literature
| Title | Journal |
|---|---|
| Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. | Toxicology and applied pharmacology 20171101 |
| A novel prostacyclin agonist protects against airway hyperresponsiveness and remodeling in mice. | American journal of respiratory cell and molecular biology 20120801 |
| Single injection of ONO-1301-loaded PLGA microspheres directly after ischaemia reduces ischaemic damage in rats subjected to middle cerebral artery occlusion. | The Journal of pharmacy and pharmacology 20120301 |
| Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression. | American journal of physiology. Gastrointestinal and liver physiology 20120215 |
| A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury. | European journal of pharmacology 20120115 |
| The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia. | Journal of microencapsulation 20120101 |
| A prostacycline analog prevents chronic myocardial remodeling in murine cardiac allografts. | International heart journal 20120101 |
| Preparation of ONO-1301-loaded poly(lactide-co-glycolide) microspheres and their effect on nerve conduction velocity. | The Journal of pharmacy and pharmacology 20110301 |
| Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model. | Prostaglandins, leukotrienes, and essential fatty acids 20110101 |
| A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100201 |
| [Prostacyclin derivatives]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats. | American journal of respiratory and critical care medicine 20080115 |
| A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart. | Clinical science (London, England : 1979) 20070601 |
| Non-prostanoid prostacyclin agonists for the treatment of pulmonary arterial hypertension. | Expert opinion on investigational drugs 20060301 |
| Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. | American journal of physiology. Lung cellular and molecular physiology 20060101 |
| A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. | American journal of respiratory and critical care medicine 20051215 |
| Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives. | Journal of medicinal chemistry 20050811 |
| Prostaglandins E1 and E2 inhibit lipopolysaccharide-induced interleukin-18 production in monocytes. | European journal of pharmacology 20050711 |
| Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes. | European journal of pharmacology 20050411 |
| Unique regulation profile of prostaglandin e1 on adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics. | British journal of pharmacology 20011201 |
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