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175131-60-9 | Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1), (1S,2R)-
CAS No: 175131-60-9 Catalog No: AG00205A MDL No:
Product Description
Catalog Number:
AG00205A
Chemical Name:
Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1), (1S,2R)-
CAS Number:
175131-60-9
Molecular Formula:
C15H23ClN2O
Molecular Weight:
282.8089
IUPAC Name:
(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride
InChI:
InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m0./s1
InChI Key:
XNCDYJFPRPDERF-NQQJLSKUSA-N
SMILES:
NC[C@@H]1C[C@]1(c1ccccc1)C(=O)N(CC)CC.Cl
UNII:
371U2ZK31U
Properties
Complexity:
295
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
282.15g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
282.812g/mol
Monoisotopic Mass:
282.15g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
46.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
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| Milnacipran for fibromyalgia: a useful addition to the treatment armamentarium. | Expert opinion on pharmacotherapy 20130501 |
| Effects of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fibre-evoked field potentials in spinal long-term potentiation and neuropathic pain. | British journal of pharmacology 20121001 |
| Excretion and metabolism of milnacipran in humans after oral administration of milnacipran hydrochloride. | Drug metabolism and disposition: the biological fate of chemicals 20120901 |
| Enantioselective synthesis of levomilnacipran. | Chemical communications (Cambridge, England) 20120821 |
| A combination of mirtazapine and milnacipran augments the extracellular levels of monoamines in the rat brain. | Neuropharmacology 20120601 |
| An increase in spinal cord noradrenaline is a major contributor to the antihyperalgesic effect of antidepressants after peripheral nerve injury in the rat. | Pain 20120501 |
| Short-term (2-week) effects of discontinuing milnacipran in patients with fibromyalgia. | Current medical research and opinion 20120501 |
| Possible interaction between milnacipran and warfarin potassium. | Journal of clinical pharmacology 20120501 |
| Plasma levels of milnacipran and its effectiveness for the treatment of chronic pain in the orofacial region. | Human psychopharmacology 20120501 |
| Milnacipran for neuropathic pain and fibromyalgia in adults. | The Cochrane database of systematic reviews 20120101 |
| Relationships among pain, depressed mood, and global status in fibromyalgia patients: post hoc analyses of a randomized, placebo-controlled trial of milnacipran. | Psychosomatics 20120101 |
| Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons. | Molecular pain 20120101 |
| Milnacipran is active in models of irritable bowel syndrome and abdominal visceral pain in rodents. | European journal of pharmacology 20111215 |
| Cardiotoxicity and serotonin syndrome complicating a milnacipran overdose. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20111201 |
| The interaction between antidepressant drugs and the pain-relieving effect of spinal cord stimulation in a rat model of neuropathy. | Anesthesia and analgesia 20111101 |
| Neoteric pharmacotherapeutic targets in fibromyalgia. | Expert opinion on therapeutic targets 20111101 |
| Epidemiological characterization of drug overconsumption: the example of antidepressants. | Journal of addictive diseases 20111001 |
| Prevention of poststroke depression with milnacipran in patients with acute ischemic stroke: a double-blind randomized placebo-controlled trial. | International clinical psychopharmacology 20110901 |
| Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model. | Behavioural pharmacology 20110901 |
| Pharmacotherapy of fibromyalgia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110715 |
| Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran. | Synapse (New York, N.Y.) 20110701 |
| Longterm therapeutic response to milnacipran treatment for fibromyalgia. A European 1-year extension study following a 3-month study. | The Journal of rheumatology 20110701 |
| Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain? | British journal of pharmacology 20110601 |
| Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110601 |
| Correction: milnacipran for treatment of fibromyalgia. | The Annals of pharmacotherapy 20110601 |
| Can milnacipran used for neuropathic pain in patients with advanced cancer cause neuromuscular and somatosensory disorders? | Journal of palliative medicine 20110401 |
| Olanzapine augmentation of milnacipran for stage 2 treatment-resistant major depression: an open study. | Human psychopharmacology 20110401 |
| Fibromyalgia and sleep. | Best practice & research. Clinical rheumatology 20110401 |
| Pharmacotherapy of fibromyalgia. | Best practice & research. Clinical rheumatology 20110401 |
| Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. | European journal of pharmacology 20110325 |
| Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis. | Rheumatology (Oxford, England) 20110301 |
| A pooled analysis of two randomized, double-blind, placebo-controlled trials of milnacipran monotherapy in the treatment of fibromyalgia. | Pain practice : the official journal of World Institute of Pain 20110101 |
| Novel antidepressants and panic disorder: evidence beyond current guidelines. | Neuropsychobiology 20110101 |
| Intranasal administration of milnacipran in rats: evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect. | Biological & pharmaceutical bulletin 20110101 |
| Milnacipran dose-effect study in patients with burning mouth syndrome. | Clinical neuropharmacology 20110101 |
| The dubious effect of milnacipran for the treatment of burning mouth syndrome. | Clinical neuropharmacology 20110101 |
| Milnacipran in panic disorder with agoraphobia and major depressive disorder: a case report. | Clinical neuropharmacology 20110101 |
| Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use. | Texas Heart Institute journal 20110101 |
| Sexual side effects of milnacipran. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine. | Cardiovascular toxicology 20101201 |
| A case of milnacipran-related sweating alleviated by duloxetine substitution. | Journal of clinical psychopharmacology 20101001 |
| Milnacipran-associated urinary retention: a case report. | Journal of clinical psychopharmacology 20101001 |
| Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: results of a randomized, double-blind, placebo-controlled trial. | Arthritis and rheumatism 20100901 |
| Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. | The Journal of pharmacology and experimental therapeutics 20100901 |
| Milnacipran for treatment of fibromyalgia. | The Annals of pharmacotherapy 20100901 |
| Effectiveness and safety of milnacipran treatment for a patient with delusional disorder, somatic type taking multiple medications for concomitant physical diseases. | Clinical neuropharmacology 20100701 |
| Comparative efficacy and harms of duloxetine, milnacipran, and pregabalin in fibromyalgia syndrome. | The journal of pain : official journal of the American Pain Society 20100601 |
| ACS chemical neuroscience molecule spotlight on savella. | ACS chemical neuroscience 20100519 |
| Effectiveness of milnacipran for a patient with pain disorder and long QT syndrome. | Clinical neuropharmacology 20100501 |
| Contributions of change in clinical status parameters to Patient Global Impression of Change (PGIC) scores among persons with fibromyalgia treated with milnacipran. | Pain 20100501 |
| Effects of milnacipran on cardiac repolarization in healthy participants. | Journal of clinical pharmacology 20100401 |
| A European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgia. | The Journal of rheumatology 20100401 |
| [Prediction of antidepressant response to milnacipran and fluvoxamine using pharmacogenetical methods]. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20100401 |
| Management of depression in the presence of pain symptoms. | Psychiatria Danubina 20100301 |
| Serotonin syndrome after administration of milnacipran for fibromyalgia. | Neurology 20100223 |
| Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats. | Neuroscience research 20100201 |
| Durability of therapeutic response to milnacipran treatment for fibromyalgia. Results of a randomized, double-blind, monotherapy 6-month extension study. | Pain medicine (Malden, Mass.) 20100201 |
| [Milnacipram intoxication during multi-intoxication: interest of toxicologic screening]. | Annales francaises d'anesthesie et de reanimation 20100201 |
| New Drugs2010, PART 1. | Nursing 20100201 |
| Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in mice. | Psychopharmacology 20100101 |
| Milnacipran: in fibromyalgia. | Drugs 20100101 |
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| Effectiveness of milnacipran for the treatment of chronic pain in the orofacial region. | Clinical neuropharmacology 20100101 |
| Behavioral despair during a water maze learning task in mice. | Experimental animals 20100101 |
| Milnacipran for chronic pain in the orofacial region. | Clinical neuropharmacology 20100101 |
| Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex. | Naunyn-Schmiedeberg's archives of pharmacology 20091201 |
| [Milnacipran and venlafaxine at flexible doses (up to 200 mg/d) in the outpatient treatment of adults with moderate-to-severe major depressive disorder: a 24-week randomised, double blind exploratory study]. | L'Encephale 20091201 |
| Effects of antidepressants on plasma metabolites of nitric oxide in major depressive disorder: comparison between milnacipran and paroxetine. | Progress in neuro-psychopharmacology & biological psychiatry 20091113 |
| In vitro inhibition and induction of human liver cytochrome p450 enzymes by milnacipran. | Drug metabolism and disposition: the biological fate of chemicals 20091001 |
| Current progress in the pharmacological therapy of fibromyalgia. | Expert opinion on investigational drugs 20091001 |
| A possible mechanism underlying an antidepressive-like effect of Kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice. | Biological & pharmaceutical bulletin 20091001 |
| The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task: a simple and valid model of impulsive action using rats. | Behavioural pharmacology 20090901 |
| A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran. | Organic & biomolecular chemistry 20090821 |
| Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances. | Behavioural brain research 20090812 |
| Analgesic effect of milnacipran is associated with c-Fos expression in the anterior cingulate cortex in the rat neuropathic pain model. | Neuroscience research 20090801 |
| Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. | Neuroscience research 20090701 |
| Milnacipran (savella) for fibromyalgia. | The Medical letter on drugs and therapeutics 20090615 |
| Functional magnetic resonance imagery (fMRI) in fibromyalgia and the response to milnacipran. | Human psychopharmacology 20090601 |
| Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia. | The Korean journal of internal medicine 20090601 |
| Fibromyalgia: a new treatment option for fibromyalgia. | Nature reviews. Rheumatology 20090401 |
| Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer's disease. | Progress in neuro-psychopharmacology & biological psychiatry 20090317 |
| Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. | Neurochemical research 20090301 |
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| Lower side effects of milnacipran than paroxetine in the treatment of major depression disorder among Han Chinese in Taiwan. | The Chinese journal of physiology 20081231 |
| Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. | Journal of medicinal chemistry 20081127 |
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| The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. | Journal of clinical psychopharmacology 20081001 |
| BNIP-3: a novel candidate for an intrinsic depression-related factor found in NG108-15 cells treated with Hochu-ekki-to, a traditional oriental medicine, or typical antidepressants. | Neuroscience research 20080901 |
| Chiral analysis of milnacipran by a nonchiral HPLC--circular dichroism: improvement of the linearity of dichroic response by temperature control. | Journal of separation science 20080901 |
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| Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors. | Bioorganic & medicinal chemistry letters 20080601 |
| Two cases of burning mouth syndrome treated with olanzapine. | Psychiatry and clinical neurosciences 20080601 |
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| Patient satisfaction with antidepressants: an Internet-based study. | Journal of affective disorders 20080401 |
| Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation. | Anesthesia and analgesia 20080401 |
| No predictors of antidepressant patient response to milnacipran were obtained using the three-factor structures of the Montgomery and Asberg Depression Rating Scale in Japanese patients with major depressive disorders. | Psychiatry and clinical neurosciences 20080401 |
| Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran. | Human psychopharmacology 20080301 |
| Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. | Bioorganic & medicinal chemistry letters 20080215 |
| Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases. | Chirality 20080201 |
| Efficacy and tolerability of milnacipran in the treatment of major depression in comparison with other antidepressants : a systematic review and meta-analysis. | CNS drugs 20080101 |
| Management of phantom limb pain and sensation with milnacipran. | The Journal of neuropsychiatry and clinical neurosciences 20080101 |
| A case of severe parkinsonism associated with short-term treatment with milnacipran. | Clinical neuropharmacology 20080101 |
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| Effects of the serotonin and noradrenaline reuptake inhibitor (SNRI) milnacipran on marble burying behavior in mice. | Biological & pharmaceutical bulletin 20071201 |
| The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine. | Journal of psychopharmacology (Oxford, England) 20070801 |
| Gender differences in the clinical effects of fluvoxamine and milnacipran in Japanese major depressive patients. | Psychiatry and clinical neurosciences 20070801 |
| Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients. | Progress in neuro-psychopharmacology & biological psychiatry 20070630 |
| Effects of co-administration of antidepressants and monoamine oxidase inhibitors on 5-HT-related behavior in rats. | European journal of pharmacology 20070622 |
| Effect of long-term administration of the antidepressant drug milnacipran on serotonergic and noradrenergic neurotransmission in the rat hippocampus. | Life sciences 20070620 |
| Piloerection induced by replacing fluvoxamine with milnacipran. | British journal of clinical pharmacology 20070601 |
| [The clinical efficacy of SNRI milnacipran in the treatment of hot flushes with prostate cancer hormonally treated]. | Hinyokika kiyo. Acta urologica Japonica 20070601 |
| Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters. | Bioorganic & medicinal chemistry letters 20070515 |
| Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice. | American journal of physiology. Regulatory, integrative and comparative physiology 20070501 |
| Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats. | Psychopharmacology 20070501 |
| The efficacy of milnacipran in panic disorder: an open trial. | International clinical psychopharmacology 20070501 |
| A case of adult attention-deficit/hyperactivity disorder alleviated by milnacipran. | Progress in neuro-psychopharmacology & biological psychiatry 20070413 |
| Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran. | Naunyn-Schmiedeberg's archives of pharmacology 20070301 |
| Successful treatment of severe antidepressant-induced nausea with a combination of milnacipran and olanzapine. | Pharmacopsychiatry 20070301 |
| A meta-analysis of clinical trials comparing milnacipran, a serotonin--norepinephrine reuptake inhibitor, with a selective serotonin reuptake inhibitor for the treatment of major depressive disorder. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070101 |
| Hypertension induced by regular doses of milnacipran: a case report. | Pharmacopsychiatry 20070101 |
| Successful treatment of trigeminal neuralgia with milnacipran. | Clinical neuropharmacology 20070101 |
| [Applications and safety of modern antidepressants in patients with liver diseases]. | Wiadomosci lekarskie (Warsaw, Poland : 1960) 20070101 |
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| [Antidepressants with different action mechanisms in the treatment of chronic daily headache]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101 |
| Efficacy of milnacipran in treating anxiety symptoms in schizophrenic patients receiving clozapine: a case series study. | Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20061201 |
| Antidepressants enhance the antinociceptive effects of carbamazepine in the acetic acid-induced writhing test in mice. | European journal of pharmacology 20061121 |
| Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine. | Journal of pharmacological sciences 20061101 |
| Efficacy of milnacipran on cognitive dysfunction with post-stroke depression: preliminary open-label study. | Psychiatry and clinical neurosciences 20061001 |
| Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease. | Progress in neuro-psychopharmacology & biological psychiatry 20060930 |
| Effects of repeated milnacipran administration on brain serotonergic and noradrenergic functions in healthy volunteers. | Psychopharmacology 20060901 |
| Electrophysiological and neurochemical characterization of the effect of repeated treatment with milnacipran on the rat serotonergic and noradrenergic systems. | Journal of psychopharmacology (Oxford, England) 20060701 |
| Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. | The journal of pain : official journal of the American Pain Society 20060701 |
| Clinical potential of milnacipran, a serotonin and norepinephrine reuptake inhibitor, in pain. | Current opinion in investigational drugs (London, England : 2000) 20060701 |
| Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran. | Physiology & behavior 20060615 |
| Lack of pharmacokinetic interaction when switching from fluoxetine to milnacipran. | International clinical psychopharmacology 20060501 |
| Effects of milnacipran in animal models of anxiety and memory. | Neurochemical research 20060401 |
| Is milnacipran effective in treating pain in patients with fibromyalgia? | Nature clinical practice. Rheumatology 20060301 |
| Response rate obtained using milnacipran depending on the severity of depression in the treatment of major depressive patients. | Clinical neuropharmacology 20060101 |
| Remission rates with milnacipran 100 mg/day and 150 mg/day in the long-term treatment of major depression. | Clinical drug investigation 20060101 |
| Efficacy of milnacipran on poststroke depression on inpatient rehabilitation. | Psychiatry and clinical neurosciences 20051201 |
| Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells. | Biochemical pharmacology 20051101 |
| Characterization and consequences of pain variability in individuals with fibromyalgia. | Arthritis and rheumatism 20051101 |
| alpha2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice. | Behavioural brain research 20051014 |
| Efficacy of milnacipran in patients with fibromyalgia. | The Journal of rheumatology 20051001 |
| Subchronic milnacipran treatment increases basal extracellular noradrenaline concentrations in the medial prefrontal cortex of rats. | European journal of pharmacology 20050927 |
| SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. | CNS spectrums 20050901 |
| Comparison of efficacy and safety of milnacipran and fluoxetine in Korean patients with major depression. | Current medical research and opinion 20050901 |
| Effectiveness of milnacipran for SSRI-intolerant patients with premenstrual dysphoric disorder. | Journal of clinical psychopharmacology 20050801 |
| Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action. | Pharmacology, biochemistry, and behavior 20050701 |
| Effect of milnacipran on extracellular monoamine concentrations in the medial prefrontal cortex of rats pre-treated with lithium. | European journal of pharmacology 20050615 |
| Milnacipran for the drastic improvement of refractory pain in a patient without depressive symptoms: a case report. | European psychiatry : the journal of the Association of European Psychiatrists 20050601 |
| Chronic treatment with milnacipran reverses the impairment of synaptic plasticity induced by conditioned fear stress. | Psychopharmacology 20050501 |
| The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain. | Anesthesia and analgesia 20050501 |
| Remarkable effect of milnacipran, a serotonin-noradrenalin reuptake inhibitor (SNRI), on depressive symptoms in patients with Parkinson's disease who have insufficient response to selective serotonin reuptake inhibitors (SSRIs): two case reports. | Progress in neuro-psychopharmacology & biological psychiatry 20050201 |
| Lithium augmentation in milnacipran-refractory depression for the prevention of relapse following electroconvulsive therapy. | The Australian and New Zealand journal of psychiatry 20050101 |
| [Effects of milnacipran on neuronal excitability and synaptic transmission in neurons of the rat locus coeruleus]. | No to hattatsu = Brain and development 20050101 |
| Peripheral circulatory disturbance induced by milnacipran. | The Journal of neuropsychiatry and clinical neurosciences 20050101 |
| The effect of milnacipran (serotonin noradrenaline reuptake inhibitor) on memory in Korsakoff's syndrome after encephalitis. | General hospital psychiatry 20050101 |
| Lack of interaction of milnacipran with the cytochrome p450 isoenzymes frequently involved in the metabolism of antidepressants. | Clinical pharmacokinetics 20050101 |
| [Depression and pain: novel clinical, neurobiological and psychopharmacological data]. | Psychiatria polska 20050101 |
| A comparative study of milnacipran and paroxetine in outpatients with major depression. | Journal of affective disorders 20041201 |
| Post-treatment emergent adverse events in depressed patients following treatment with milnacipran and paroxetine. | Human psychopharmacology 20041201 |
| Acute effect of milnacipran on the relationship between the locus coeruleus noradrenergic and dorsal raphe serotonergic neuronal transmitters. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201 |
| [Review of antidepressants from the TCAs to the third generation drugs]. | Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20041201 |
| Characterization of the anxiolytic-like effects of fluvoxamine, milnacipran and risperidone in mice using the conditioned fear stress paradigm. | European journal of pharmacology 20041103 |
| Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. | The Journal of pharmacology and experimental therapeutics 20041101 |
| Controlled comparison of two different doses of milnacipran in major depressive outpatients. | International clinical psychopharmacology 20041101 |
| Differential effects of milnacipran, fluvoxamine and paroxetine for inhibited and agitated depression. | European psychiatry : the journal of the Association of European Psychiatrists 20041101 |
| A double-blind placebo-controlled trial of milnacipran in the treatment of fibromyalgia. | Human psychopharmacology 20041001 |
| Clinical experience with dual action antidepressants in different chronic pain syndromes. | Human psychopharmacology 20041001 |
| The effectiveness of lithium augmentation of milnacipran: preliminary data using the modified Japanese Psychopharmacology Algorithm. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20041001 |
| Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats. | European journal of pharmacology 20040913 |
| In vitro inhibition of recombinant ligand-gated ion channels by high concentrations of milnacipran. | Psychopharmacology 20040901 |
| Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms. | The American journal of psychiatry 20040901 |
| Prevalence of induced mania in patients treated with milnacipran: a comparison with paroxetine. | European psychiatry : the journal of the Association of European Psychiatrists 20040801 |
| Differential effects of fluvoxamine, paroxetine and milnacipran for depression, especially with regard to age. | Human psychopharmacology 20040801 |
| Milnacipran treatment of a terminally ill cancer patient with major depressive disorder. | Human psychopharmacology 20040801 |
| Determination of milnacipran, a serotonin and noradrenaline reuptake inhibitor, in human plasma using liquid chromatography with spectrofluorimetric detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705 |
| Subjective and polysomnographic effects of milnacipran on sleep in depressed patients. | Human psychopharmacology 20040701 |
| A case of temporo-mandibular disorder with fibromyalgia treated with the antidepressant, milnacipran. | Human psychopharmacology 20040701 |
| A comparative study of milnacipran and imipramine in the treatment of major depressive disorder. | Current medical research and opinion 20040601 |
| The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats. | Anesthesia and analgesia 20040501 |
| Efficacy of milnacipran for depressive symptoms in schizophrenia spectrum disorders. | Psychiatry and clinical neurosciences 20040401 |
| Milnacipran, a serotonin and noradrenaline reuptake inhibitor, suppresses long-term potentiation in the rat hippocampal CA1 field via 5-HT1A receptors and alpha 1-adrenoceptors. | Neuroscience letters 20040304 |
| Augmentation of milnacipran by risperidone in treatment for major depression. | The international journal of neuropsychopharmacology 20040301 |
| Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran. | Anesthesiology 20040301 |
| Milnacipran: a dual norepinephrine and serotonin reuptake pump inhibitor. | Journal of psychiatric practice 20040301 |
| Associations between baseline plasma MHPG (3-methoxy-4-hydroxyphenylglycol) levels and clinical responses with respect to milnacipran versus paroxetine treatment. | Journal of clinical psychopharmacology 20040201 |
| Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. | Biological psychiatry 20040201 |
| [Acute hepatitis associated with milnacipran treatment]. | Gastroenterologie clinique et biologique 20040201 |
| Double-blind comparative study of the action of repeated administration of milnacipran versus placebo on cognitive functions in healthy volunteers. | Human psychopharmacology 20040101 |
| Reboxetine: a norepinephrine selective reuptake pump inhibitor. | Journal of psychiatric practice 20040101 |
| Effectiveness of milnacipran for the treatment of chronic pain: a case series. | Clinical neuropharmacology 20040101 |
| Ejaculation after defecation without orgasm induced by milnacipran. | The Journal of neuropsychiatry and clinical neurosciences 20040101 |
| Effects of milnacipran on the inhibitory postsynaptic potential in neurons of the rat locus coeruleus. | The Kurume medical journal 20040101 |
| Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats. | Neuropharmacology 20031201 |
| Differential effects of milnacipran, fluvoxamine and paroxetine for depression, especially in gender. | European psychiatry : the journal of the Association of European Psychiatrists 20031201 |
| Milnacipran and pindolol: a randomized trial of reduction of antidepressant latency. | Human psychopharmacology 20031201 |
| Effect of pindolol and milnacipran versus milnacipran and placebo on plasma prolactin and adrenocorticotrophic hormone in depressed subjects. | Human psychopharmacology 20031001 |
| Milnacipran for the treatment of chronic pain. | Human psychopharmacology 20031001 |
| Differential period of onset of action of fluvoxamine, paroxetine and milnacipran for depression. | Human psychopharmacology 20030801 |
| Therapeutic effects of milnacipran (serotonin noradrenalin reuptake inhibitor) on depression following mild and moderate traumatic brain injury. | Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20030801 |
| Milnacipran plasma levels and antidepressant response in Japanese major depressive patients. | Human psychopharmacology 20030601 |
| Dual action antidepressants and some important considerations. | The Australian and New Zealand journal of psychiatry 20030401 |
| Milnacipran in the treatment of bulimia nervosa: a report of 16 cases. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030301 |
| The clinical use of milnacipran for depression. | European psychiatry : the journal of the Association of European Psychiatrists 20030201 |
| Parkinsonism associated with a serotonin and noradrenaline reuptake inhibitor, milnacipran. | Journal of neurology, neurosurgery, and psychiatry 20030101 |
| New hope in the treatment of painful symptoms in depression. | Current opinion in investigational drugs (London, England : 2000) 20030101 |
| Favorable effect of milnacipran on depression induced by interferon-alpha. | The Journal of neuropsychiatry and clinical neurosciences 20030101 |
| [Adverse effects of antidepressants and antimanics]. | Ryoikibetsu shokogun shirizu 20030101 |
| [Pharmacokinetics and drug interaction of antidepressants and anti-manic drugs]. | Ryoikibetsu shokogun shirizu 20030101 |
| [Serotonin syndrome]. | Ryoikibetsu shokogun shirizu 20030101 |
| Addition of a dopamine agonist, cabergoline, to a serotonin-noradrenalin reuptake inhibitor, milnacipran as a therapeutic option in the treatment of refractory depression: two case reports. | Clinical neuropharmacology 20030101 |
| [Experience with ixel (milnacipran hydrochloride) use in the treatment of patients with post-stroke depression]. | Terapevticheskii arkhiv 20030101 |
| Elevation of blood pressure induced by high-dose milnacipran. | Human psychopharmacology 20021201 |
| In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs. | Behavioural brain research 20021115 |
| Effect of chronic treatment with milnacipran on sleep architecture in rats compared with paroxetine and imipramine. | Pharmacology, biochemistry, and behavior 20021001 |
| A randomised, double-blind comparison of milnacipran and imipramine in the treatment of depression. | Journal of affective disorders 20021001 |
| Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors. | Journal of psychopharmacology (Oxford, England) 20020901 |
| Partial response and nonresponse to antidepressant therapy: current approaches and treatment options. | The Journal of clinical psychiatry 20020901 |
| Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats. | Psychopharmacology 20020701 |
| Conformational analysis of the NMDA receptor antagonist (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) designed by a novel conformational restriction method based on the structural feature of cyclopropane ring. | Chemical & pharmaceutical bulletin 20020701 |
| Pharmacology and pharmacokinetics of milnacipran. | International clinical psychopharmacology 20020601 |
| Japanese experience with dual-action antidepressants. | International clinical psychopharmacology 20020601 |
| Clinical utility of milnacipran in comparison with other antidepressants. | International clinical psychopharmacology 20020601 |
| Remarkable effect of milnacipran in the treatment of Japanese major depressive patients. | Human psychopharmacology 20020601 |
| Therapeutic effects of milnacipran, a serotonin and noradrenaline reuptake inhibitor, on post-stroke depression. | International clinical psychopharmacology 20020501 |
| Differential effects of milnacipran and fluvoxamine, especially in patients with severe depression and agitated depression: a case-control study. | International clinical psychopharmacology 20020301 |
| Blood concentration of milnacipran in a case of a fatal automobile accident. | Journal of analytical toxicology 20020301 |
| Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype? | Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20020101 |
| Silent thyroiditis associated with short-term lithium therapy. | General hospital psychiatry 20020101 |
| [Serotonin-noradrenaline reuptake inhibitors(SNRIs)]. | Nihon rinsho. Japanese journal of clinical medicine 20010801 |
| [Pharmacokinetics and drug interactions of antidepressive agents]. | Nihon rinsho. Japanese journal of clinical medicine 20010801 |
| Antidepressant efficacy and tolerability of milnacipran, a dual serotonin and noradrenaline reuptake inhibitor: a comparison with fluvoxamine. | International clinical psychopharmacology 20010501 |
| Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401 |
| (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC), a new class of NMDA-receptor antagonist: molecular design by a novel conformational restriction strategy. | Japanese journal of pharmacology 20010301 |
| [Amenorrhea and galactorrhea after acute overdose with milnacipran]. | Therapie 20010101 |
| Does combined treatment with novel antidepressants and a dopamine D3 receptor agonist reproduce cocaine discrimination in rats? | Polish journal of pharmacology 20010101 |
| Which bioequivalence study for a racemic drug? Application to milnacipran. | European journal of drug metabolism and pharmacokinetics 19980101 |
| Long-term efficacy and safety of milnacipran compared to clomipramine in patients with major depression. | Acta psychiatrica Scandinavica 19971201 |
| Preclinical pharmacology of milnacipran. | International clinical psychopharmacology 19960901 |
| Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. | Neuropharmacology 19851201 |
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