200,000+ products from a single source!
sales@angenechem.com
174689-39-5 | 2-Propanol, 1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-, (2S)-, ethanedioate (1:1)
CAS No: 174689-39-5 Catalog No: AG001ZV8 MDL No:
Product Description
Catalog Number:
AG001ZV8
Chemical Name:
2-Propanol, 1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-, (2S)-, ethanedioate (1:1)
CAS Number:
174689-39-5
Molecular Formula:
C23H29NO6
Molecular Weight:
415.4795
IUPAC Name:
(2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propan-2-ol;oxalic acid
InChI:
InChI=1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
InChI Key:
XTBQNQMNFXNGLR-MKSBGGEFSA-N
SMILES:
OC(=O)C(=O)O.CCc1ccccc1OC[C@H](CN[C@H]1CCCc2c1cccc2)O
Properties
Complexity:
433
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
415.199g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
415.486g/mol
Monoisotopic Mass:
415.199g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
116A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. | Biochemical and biophysical research communications 20130816 |
| Blockade of β₁-, β₂- and β₃-adrenoceptors in the temporomandibular joint induces antinociception especially in female rats. | European journal of pain (London, England) 20121001 |
| Two-week treatment with the β₃-adrenoceptor antagonist SR59230A normalizes the increased pancreatic islet blood flow in type 2 diabetic GK rats. | Diabetes, obesity & metabolism 20121001 |
| Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation. | American journal of physiology. Renal physiology 20120901 |
| Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock? | Surgery 20120901 |
| Pharmacological effect of TRK-380, a novel selective human β3-adrenoceptor agonist, on mammalian detrusor strips. | Urology 20120301 |
| Increased thermogenic capacity of brown adipose tissue under low temperature and its contribution to arousal from hibernation in Syrian hamsters. | American journal of physiology. Regulatory, integrative and comparative physiology 20120101 |
| Effects and selectivity of CL 316243, beta-3-adrenoceptor agonist, in term-pregnant rat myometrium. | Gynecologic and obstetric investigation 20120101 |
| Antiangiogenic effects of β2 -adrenergic receptor blockade in a mouse model of oxygen-induced retinopathy. | Journal of neurochemistry 20111201 |
| Modulation of β-adrenergic receptors in the ventromedial hypothalamus influences counterregulatory responses to hypoglycemia. | Diabetes 20111201 |
| Involvement of β3-adrenergic receptors in the control of food intake in rats. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20111101 |
| Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region. | The European journal of neuroscience 20111101 |
| SR59230A, a beta-3 adrenoceptor antagonist, inhibits ultradian brown adipose tissue thermogenesis and interrupts associated episodic brain and body heating. | American journal of physiology. Regulatory, integrative and comparative physiology 20111001 |
| Stress-induced epinephrine levels compromise murine dermal fibroblast activity through β-adrenoceptors. | Experimental dermatology 20110501 |
| Lack of evidence that nebivolol is a β₃-adrenoceptor agonist. | European journal of pharmacology 20110301 |
| Activation of β(3)-adrenoceptor promotes rapid pacing-induced atrial electrical remodeling in rabbits. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| Physiological evidence for β3-adrenoceptor in frog (Rana esculenta) heart. | General and comparative endocrinology 20101101 |
| Activation of β3-adrenergic receptor inhibits ventricular arrhythmia in heart failure through calcium handling. | The Tohoku journal of experimental medicine 20101101 |
| β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist BRL 37344. | The Journal of toxicological sciences 20101001 |
| [Association between beta3-adrenergic receptor and oxidative stress in chronic heart failure rats]. | Zhonghua xin xue guan bing za zhi 20100501 |
| The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin. | Gastroenterology 20100101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-alpha-like effector A, in rat interscapular brown adipose tissue by sympathetically activated beta3-adrenoreceptors. | Biochemical and biophysical research communications 20090918 |
| Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. | British journal of pharmacology 20090901 |
| Reversal of high pancreatic islet and white adipose tissue blood flow in type 2 diabetic GK rats by administration of the beta3-adrenoceptor inhibitor SR-59230A. | American journal of physiology. Endocrinology and metabolism 20090801 |
| Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism. | Comparative medicine 20090601 |
| Effects of a novel beta(3)-adrenoceptor agonist, AJ-9677, on relaxation of the detrusor muscle: an in vitro study. | International journal of urology : official journal of the Japanese Urological Association 20081201 |
| The adrenergic receptor subtypes present in frog (Rana esculenta) skin. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080801 |
| Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. | Life sciences 20080620 |
| Roles of PKA, PI3K, and cPLA2 in the NO-mediated negative inotropic effect of beta2-adrenoceptor agonists in guinea pig right papillary muscles. | American journal of physiology. Cell physiology 20080101 |
| Chronic blocking of beta 3-adrenoceptor ameliorates cardiac function in rat model of heart failure. | Chinese medical journal 20071220 |
| Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? | European journal of pharmacology 20071114 |
| Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists. | Molecular pharmacology 20071101 |
| [Effect of beta3-adrenoceptor antagonist on the cardiac function and expression of endothelial nitric oxide synthase in a rat model of heart failure]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20071101 |
| Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation. | Hypertension (Dallas, Tex. : 1979) 20071001 |
| Existence of beta(3)-adrenoceptors in rat heart: functional implications. | Clinical and experimental pharmacology & physiology 20070801 |
| Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells. | Pharmacological research 20070401 |
| Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats. | Pharmacology 20070101 |
| Beta3-adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO-cGMP-dependent mechanism. | The Journal of experimental biology 20061201 |
| Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells. | Clinical and experimental pharmacology & physiology 20060801 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries. | British journal of pharmacology 20051101 |
| Functional coupling of beta3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes. | The Journal of clinical endocrinology and metabolism 20051001 |
| Chronic effects of AJ-9677 on energy expenditure and energy source utilization in rats. | European journal of pharmacology 20050905 |
| Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery. | Naunyn-Schmiedeberg's archives of pharmacology 20050701 |
| [Effects of beta-adrenergic agonists on alveolar fluid clearance in rat lungs]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20050601 |
| Comparison of the alpha-adrenoceptor-mediated effects of beta3-adrenoceptor ligands in rat pulmonary artery. | Naunyn-Schmiedeberg's archives of pharmacology 20050601 |
| Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]. | The Journal of pharmacology and experimental therapeutics 20050301 |
| beta3-Adrenergic-dependent and -independent mechanisms participate in cold-induced modulation of insulin signal transduction in brown adipose tissue of rats. | Pflugers Archiv : European journal of physiology 20050301 |
| Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists. | British journal of pharmacology 20040601 |
| ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. | British journal of pharmacology 20040601 |
| Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. | The Journal of pharmacology and experimental therapeutics 20040401 |
| Role of lipid-mobilising factor (LMF) in protecting tumour cells from oxidative damage. | British journal of cancer 20040322 |
| Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. | Naunyn-Schmiedeberg's archives of pharmacology 20040201 |
| The functional role of beta-adrenoceptor subtypes in mediating relaxation of pig urethral smooth muscle. | The Journal of urology 20031201 |
| Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. | The Journal of pharmacology and experimental therapeutics 20030501 |
| Inhibitory effect of beta3-adrenoceptor agonist in lower esophageal sphincter smooth muscle: in vitro studies. | The Journal of pharmacology and experimental therapeutics 20030101 |
| High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro. | Neurourology and urodynamics 20030101 |
| Identification of beta-adrenoceptor subtypes in lower urinary tract of the female pig. | The Journal of urology 20021201 |
| Stimulatory effect of D-ephedrine on beta3-adrenoceptors in adipose tissue of rats. | Autonomic neuroscience : basic & clinical 20010412 |
| Agonistic activity of SR59230A at atypical beta-adrenoceptors in guinea pig gastric fundus and duodenum. | European journal of pharmacology 20010323 |
| beta(1)- and beta(3)-adrenoceptor mediated smooth muscle relaxation in hypothyroid rat ileum. | European journal of pharmacology 20010301 |
| Enhancement of memory consolidation in chicks by beta(3)-adrenoceptor agonists. | European journal of pharmacology 20010216 |
| Effect of SR59230A on atypical beta-adrenoceptor mediating relaxation in the Guinea Pig gastric fundus. | Pharmacology 20010201 |
| Functional, biochemical and molecular biological evidence for a possible beta(3)-adrenoceptor in human near-term myometrium. | British journal of pharmacology 20000801 |
| beta(3)-adrenoceptor regulation and relaxation responses in mouse ileum. | British journal of pharmacology 20000301 |
| Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. | Naunyn-Schmiedeberg's archives of pharmacology 19990401 |
| The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. | FEBS letters 19990212 |
| SR59230A blocks beta3-adrenoceptor-linked modulation of upcoupling protein-1 and leptin in rat brown adipocytes. | European journal of pharmacology 19980703 |
| Functional evidence of atypical beta 3-adrenoceptors in the human colon using the beta 3-selective adrenoceptor antagonist, SR 59230A. | British journal of pharmacology 19960401 |
| Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. | Molecular pharmacology 19960101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.