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Home > Fluorides > 174484-41-4
CAS No: 174484-41-4 Catalog No: AG001ZOJ MDL No:MFCD00949098
Title | Journal |
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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. | Chemical research in toxicology 20170515 |
Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | Toxicological sciences : an official journal of the Society of Toxicology 20131201 |
P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. | Antimicrobial agents and chemotherapy 20131001 |
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. | Chemistry & biology 20130919 |
GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro. | Antimicrobial agents and chemotherapy 20130501 |
Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data. | Antimicrobial agents and chemotherapy 20121101 |
Short communication: Phenotypic protease inhibitor resistance and cross-resistance in the clinic from 2006 to 2008 and mutational prevalences in HIV from patients with discordant tipranavir and darunavir susceptibility phenotypes. | AIDS research and human retroviruses 20120901 |
Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing. | Antimicrobial agents and chemotherapy 20120701 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
Tipranavir in highly antiretroviral treatment-experienced patients: Results from a French prospective cohort. | Scandinavian journal of infectious diseases 20120101 |
Boosted tipranavir versus darunavir in treatment-experienced patients: observational data from the randomized POTENT trial. | Drugs in R&D 20111201 |
Tipranavir in the protease inhibitors arena. | Drugs in R&D 20111201 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
In vitro activity of antiretroviral drugs against Plasmodium falciparum. | Antimicrobial agents and chemotherapy 20111101 |
Emerging HIV-1 resistance to tipranavir and darunavir in patients with virological failure to first-generation protease inhibitors in Taiwan. | International journal of STD & AIDS 20111101 |
The higher barrier of darunavir and tipranavir resistance for HIV-1 protease. | Biochemical and biophysical research communications 20110909 |
Effect of tipranavir/ritonavir combination on the pharmacokinetics of tadalafil in healthy volunteers. | Journal of clinical pharmacology 20110701 |
Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone. | The American journal of drug and alcohol abuse 20110701 |
Effects of tipranavir, darunavir, and ritonavir on platelet function, coagulation, and fibrinolysis in healthy volunteers. | Current HIV research 20110601 |
Pharmacokinetic profile in late pregnancy and cord blood concentration of tipranavir and enfuvirtide. | International journal of STD & AIDS 20110501 |
Lack of a pharmacokinetic interaction between steady-state tipranavir/ritonavir and single-dose valacyclovir in healthy volunteers. | European journal of clinical pharmacology 20110301 |
Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects. | PloS one 20110101 |
Efficacy and safety of ritonavir dose reduction based on the tipranavir inhibitory quotient in HIV-infected patients on salvage antiretroviral therapy with tipranavir/ritonavir. | AIDS research and human retroviruses 20101101 |
Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro. | Antimicrobial agents and chemotherapy 20100801 |
Successful virological outcome in an HIV-infected individual with a three-class resistant variant and an insertion in the protease genome with a Tipranavir based regimen. | Irish journal of medical science 20100601 |
A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. | Clinical pharmacology and therapeutics 20100601 |
Susceptibility of HIV-1 to tipranavir and other antiretroviral agents in treatment-experienced patients: The UTILIZE Study. | Current HIV research 20100601 |
Hybrid-genetic algorithm based descriptor optimization and QSAR models for predicting the biological activity of Tipranavir analogs for HIV protease inhibition. | Journal of molecular graphics & modelling 20100601 |
Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. | Drug metabolism and disposition: the biological fate of chemicals 20100501 |
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. | Journal of virology 20100501 |
The benefit of simplification from tipranavir/ritonavir 500/200 bid to 500/100 bid guided by therapeutic drug monitoring. | Therapeutic drug monitoring 20100401 |
Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial. | The Journal of infectious diseases 20100315 |
Trends in uptake of recently approved antiretrovirals within a national healthcare system. | HIV medicine 20100301 |
HIV type 1 antiretroviral resistance mutations in subtypes B, C, and F in the City of São Paulo, Brazil. | AIDS research and human retroviruses 20100301 |
Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials. | AIDS research and human retroviruses 20100301 |
Diagnosis and monitoring of HIV-1 group O-infected patients in Cameroun. | Journal of acquired immune deficiency syndromes (1999) 20100101 |
Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS. | Journal of molecular graphics & modelling 20100101 |
Pharmacokinetic characterization of three doses of tipranavir boosted with ritonavir on highly active antiretroviral therapy in treatment-experienced HIV-1 patients. | HIV clinical trials 20100101 |
[Adverse reactions of atazanavir, fosamprenavir and tipranavir in 'real life']. | Therapie 20100101 |
Do we need genotypic weighted resistance scores for antiretrovirals? The curious case of tipranavir. | Antiviral therapy 20100101 |
Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score. | Antiviral therapy 20100101 |
Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice. | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101 |
In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients. | Antiviral therapy 20100101 |
Pharmacokinetic interactions between buprenorphine/naloxone and tipranavir/ritonavir in HIV-negative subjects chronically receiving buprenorphine/naloxone. | Drug and alcohol dependence 20091201 |
Efficacy and safety of a salvage regimen based on tipranavir, enfuvirtide and three nucleoside analogues in HIV1 infected patients with clinical progression: 96-week evaluation. | Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20091201 |
Drugs in traditional drug classes (nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor/protease inhibitors) with activity against drug-resistant virus (tipranavir, darunavir, etravirine). | Current opinion in HIV and AIDS 20091101 |
Cytotoxicological analysis of a gp120 binding aptamer with cross-clade human immunodeficiency virus type 1 entry inhibition properties: comparison to conventional antiretrovirals. | Antimicrobial agents and chemotherapy 20090701 |
HIV protease inhibitors: recent clinical trials and recommendations on use. | Expert opinion on pharmacotherapy 20090701 |
Clinical validation and applicability of different tipranavir/ritonavir genotypic scores in HIV-1 protease inhibitor-experienced patients. | Current HIV research 20090701 |
Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin. | Proteins 20090515 |
Drug-excipient complexation in lipid based delivery systems: an investigation of the Tipranavir-1,3-dioctanolyglycerol complex. | Journal of pharmaceutical sciences 20090501 |
Provider prescribing of 4 antiretroviral agents after implementation of drug use guidelines in the Department of Veterans Affairs. | Journal of managed care pharmacy : JMCP 20090501 |
Reversal of major genotypic tipranavir mutations under long-term treatment with tipranavir/ritonavir itself with very limited optimized background, during deep salvage antiretroviral therapy. | Current HIV research 20090501 |
Changes in darunavir/r resistance score after previous failure to tipranavir/r in HIV-1-infected multidrug-resistant patients. | Journal of acquired immune deficiency syndromes (1999) 20090201 |
[Tipranavir: therapeutic drug monitoring in a pediatric patient with HIV infection]. | Enfermedades infecciosas y microbiologia clinica 20090201 |
Multidrug-experienced HIV-1-infected women demonstrated similar virological and immunological responses to tipranavir/ritonavir compared with men. | AIDS (London, England) 20090128 |
A 12-year-old boy with multidrug-resistant human immunodeficiency virus type 1 successfully treated with HAART including ritonavir-boosted tipranavir oral solution and enfuvirtide. | European journal of medical research 20090128 |
Hepatic safety of tipranavir plus ritonavir (TPV/r)-based antiretroviral combinations: effect of hepatitis virus co-infection and pre-existing fibrosis. | The Journal of antimicrobial chemotherapy 20090101 |
Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection. | Clinical chemistry 20090101 |
Impact of first-line protease inhibitors on predicted resistance to tipranavir in HIV-1-infected patients with virological failure. | BMC infectious diseases 20090101 |
Comparison of the pharmacokinetics of apricitabine in the presence and absence of ritonavir-boosted tipranavir: a phase I, open-label, controlled, single-centre study. | Clinical drug investigation 20090101 |
Hepatic profile analyses of tipranavir in Phase II and III clinical trials. | BMC infectious diseases 20090101 |
[Desensitization to tipranavir caused by toxicodermia]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101 |
Tipranavir: a new protease inhibitor for the pediatric population. | Expert review of anti-infective therapy 20081201 |
Effects of boosted tipranavir and lopinavir on body composition, insulin sensitivity and adipocytokines in antiretroviral-naive adults. | AIDS (London, England) 20081112 |
Tipranavir resistance associated mutations in protease inhibitor-naïve patients with HIV-1 subtype A/E infection. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20081101 |
Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage? | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081101 |
Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's Adverse Event Reporting System. | AIDS patient care and STDs 20081101 |
[Role of the new molecules in antiretroviral therapy. Position of raltegravir]. | Enfermedades infecciosas y microbiologia clinica 20081101 |
Low trough levels of tipranavir in a combination antiretroviral therapy of tipranavir/ritonavir and tenofovir require therapeutic drug monitoring. | European journal of medical research 20081027 |
Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir. | Journal of acquired immune deficiency syndromes (1999) 20081001 |
Tipranavir trials close unexpectedly. | AIDS patient care and STDs 20081001 |
HIV-protease inhibitors block the enzymatic activity of purified Ste24p. | Biochemical and biophysical research communications 20080919 |
Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen. | AIDS (London, England) 20080912 |
Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents. | AIDS (London, England) 20080912 |
Tipranavir effective and well tolerated in children. | AIDS patient care and STDs 20080901 |
FDA notifications. New tipranavir solution approved. | AIDS alert 20080801 |
Intracranial haemorrhage possibly related to Tipranavir in an HIV-1 patient with cryptococcal meningitis. | The Journal of infection 20080701 |
New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists. | The Journal of infection 20080701 |
New pediatric dosing information for Kaletra. | AIDS patient care and STDs 20080701 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). | Journal of medicinal chemistry 20080612 |
Quality control of protease inhibitors. | Journal of pharmaceutical sciences 20080601 |
Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1. | Current HIV research 20080601 |
New protease inhibitors and non-nucleoside reverse transcriptase inhibitors. | Journal of HIV therapy 20080601 |
Expected response to protease inhibitors of HIV-1 non-B subtype viruses according to resistance algorithms. | AIDS (London, England) 20080531 |
European Commission grants full approval for Aptivus. | AIDS patient care and STDs 20080501 |
[HIV therapy and adherence]. | MMW Fortschritte der Medizin 20080428 |
[Tipranavir optimizes the effect of recent antiretroviral substances. Encouraging options in multiple resistance]. | MMW Fortschritte der Medizin 20080428 |
Pharmacokinetics, safety, and efficacy of tipranavir boosted with ritonavir alone or in combination with other boosted protease inhibitors as part of optimized combination antiretroviral therapy in highly treatment-experienced patients (BI Study 1182.51). | Journal of acquired immune deficiency syndromes (1999) 20080401 |
Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742. | Antimicrobial agents and chemotherapy 20080401 |
Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use. | Chemical biology & drug design 20080401 |
Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes. | AIDS (London, England) 20080312 |
Association between tipranavir plasma levels and virological response in HIV-infected patients. | AIDS research and human retroviruses 20080301 |
High performance liquid chromatographic method for the determination of HIV-1 protease inhibitor tipranavir in plasma of patients during highly active antiretroviral therapy. | European journal of medical research 20080225 |
Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivo. | The Journal of antimicrobial chemotherapy 20080201 |
[New therapeutic options in protracted HIV-infected patients with virological failure]. | Medicina clinica 20080126 |
Tipranavir exhibits different effects on opportunistic pathogenic fungi. | The Journal of infection 20080101 |
Increased risk of bleeding with the use of tipranavir boosted with ritonavir in haemophilic patients. | Haemophilia : the official journal of the World Federation of Hemophilia 20080101 |
Health-related quality of life and tolerability in treatment-experienced HIV-1-infected patients on tipranavir versus comparator regimens. | Antiviral therapy 20080101 |
Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir. | HIV clinical trials 20080101 |
Tipranavir: a review of its use in the management of HIV infection. | Drugs 20080101 |
New resistance score for tipranavir. | AIDS reviews 20080101 |
Cost-effectiveness of tipranavir in treatment-experienced HIV patients in the United States. | HIV clinical trials 20080101 |
Clinically significant drug interaction between tipranavir-ritonavir and phenobarbital in an HIV-infected subject. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215 |
FDA notifications. Tentative approval to Aptivus for combination ART. | AIDS alert 20071201 |
Hill A, Moyle G. Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. HIV Med 2007; 8: 259-264. Methodological accuracy in cross-trial comparisons of antiretroviral regimens in multitreated patients. | HIV medicine 20071101 |
Relative antiviral efficacy should not be inferred from cross-trial comparisons. | HIV medicine 20071101 |
Tipranavir: the first nonpeptidic protease inhibitor for the treatment of protease resistance. | Clinical therapeutics 20071101 |
Aptivus capsules granted full FDA approval. | AIDS patient care and STDs 20071101 |
Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores. | AIDS (London, England) 20071018 |
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. | The Journal of biological chemistry 20070928 |
Tipranavir: a new option for the treatment of drug-resistant HIV infection. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070915 |
Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST. | AIDS (London, England) 20070912 |
In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV. | Antimicrobial agents and chemotherapy 20070901 |
Tipranavir/T20-based salvage regimens highly effective and durable against HIV-1 with evidence for genotypic predictability of response in clinical practice. | International journal of STD & AIDS 20070901 |
Biotransformation and mass balance of tipranavir, a nonpeptidic protease inhibitor, when co-administered with ritonavir in Sprague-Dawley rats. | The Journal of pharmacy and pharmacology 20070901 |
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. | Clinical pharmacology and therapeutics 20070801 |
Long-term efficacy and safety of tipranavir boosted with ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2 study. | Journal of acquired immune deficiency syndromes (1999) 20070801 |
Compromised immunologic recovery in patients receiving tipranavir/ritonavir coadministered with tenofovir and didanosine in Randomized Evaluation of Strategic Intervention in multidrug-resiStant patients with tipranavir (RESIST) studies. | Journal of acquired immune deficiency syndromes (1999) 20070801 |
Trial of tipranavir versus darunavir in treatment-experienced patients enrolling. | AIDS patient care and STDs 20070801 |
Tipranavir demonstrates potent and durable treatment response in HIV-positive women. | AIDS patient care and STDs 20070801 |
Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report. | AIDS (London, England) 20070711 |
Mechanisms of pharmacokinetic and pharmacodynamic drug interactions associated with ritonavir-enhanced tipranavir. | Pharmacotherapy 20070601 |
Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. | HIV medicine 20070501 |
A simple and sensitive assay for determining plasma tipranavir concentration in the clinical setting by new HPLC method. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401 |
Tipranavir: a new protease inhibitor for the treatment of antiretroviral-experienced HIV-infected patients. | Expert opinion on pharmacotherapy 20070401 |
When and how to use tipranavir and darunavir. | The AIDS reader 20070401 |
High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications. | Journal of pharmaceutical and biomedical analysis 20070312 |
Modification of tandem mass spectrometric method to permit simultaneous quantification of 17 anti-HIV drugs which include atazanavir and tipranavir. | Clinica chimica acta; international journal of clinical chemistry 20070301 |
Acute pancreatitis caused by tipranavir/ritonavir-induced hypertriglyceridaemia. | AIDS (London, England) 20070219 |
Efficacy and safety of three doses of tipranavir boosted with ritonavir in treatment-experienced HIV type-1 infected patients. | AIDS research and human retroviruses 20070201 |
Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients. | AIDS (London, England) 20070111 |
Anti-HIV agents. Tipranavir for treatment-experienced PHAs. | TreatmentUpdate 20070101 |
Anti-HIV agents. Maraviroc--coming soon. | TreatmentUpdate 20070101 |
SPRING: a new trial to evaluate tipranavir in heterogeneous treatment-experienced HIV populations. | AIDS reviews 20070101 |
Drug interactions of tipranavir, a new HIV protease inhibitor. | Drug metabolism letters 20070101 |
Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model. | Journal of acquired immune deficiency syndromes (1999) 20061215 |
Intracranial hemorrhage with Aptivu. | AIDS patient care and STDs 20061201 |
Efficacy of the protease inhibitors tipranavir plus ritonavir in treatment-experienced patients: 24-week analysis from the RESIST-1 trial. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061115 |
Ritonavir-boosted tipranavir demonstrates superior efficacy to ritonavir-boosted protease inhibitors in treatment-experienced HIV-infected patients: 24-week results of the RESIST-2 trial. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061115 |
Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide. | AIDS (London, England) 20061003 |
Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials. | Lancet (London, England) 20060805 |
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma. | Biomedical chromatography : BMC 20060801 |
An update and review of antiretroviral therapy. | Pharmacotherapy 20060801 |
Determination of tipranavir in human plasma by reverse phase liquid chromatography with UV detection using photodiode array. | Therapeutic drug monitoring 20060801 |
New black box warning for ritonavir-boosted tipranavir. | AIDS clinical care 20060801 |
Severe hepatotoxicity associated with the combination of enfuvirtide and tipranavir/ritonavir: case report. | AIDS (London, England) 20060713 |
Prevention of mother-to-child transmission of multi-drug resistant HIV-1 using maternal therapy with both enfuvirtide and tipranavir. | AIDS (London, England) 20060626 |
Susceptibility to protease inhibitors in HIV-2 primary isolates from patients failing antiretroviral therapy. | The Journal of antimicrobial chemotherapy 20060401 |
Tipranavir (Aptivus) for HIV. | Obstetrics and gynecology 20060401 |
A simple high performance liquid chromatography assay for monitoring plasma concentrations of tipranavir in HIV infected patients. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307 |
Determination of the novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217 |
Practical perspectives on the use of tipranavir in combination with other medications: lessons learned from pharmacokinetic studies. | Journal of clinical pharmacology 20060201 |
Quantification of tipranavir in human plasma by high-performance liquid chromatography with UV detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102 |
Tipranavir: a protease inhibitor for multi-drug resistant HIV-1. | Expert opinion on investigational drugs 20060101 |
[Tipranavir (used with ritonavir)]. | Revue de l'infirmiere 20060101 |
New drugs: ramelteon, tipranavir, nepafenac, and deferasirox. | Journal of the American Pharmacists Association : JAPhA 20060101 |
Tipranavir: PNU 140690, tipranivir. | Drugs in R&D 20060101 |
48-weeks of the RESIST trials. | AIDS reviews 20060101 |
Three-year final results of the NEFA simplification trial. | AIDS reviews 20060101 |
Tipranavir: a protease inhibitor for HIV salvage therapy. | The Annals of pharmacotherapy 20060101 |
Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: recent data and consensus recommendations. | HIV clinical trials 20060101 |
Tipranavir: a novel nonpeptidic protease inhibitor of HIV. | Clinical pharmacokinetics 20060101 |
New protease inhibitor offers clinicians hope for better salvage therapy. | HIV clinician 20060101 |
Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG. | Antiviral therapy 20060101 |
Detection of HIV protease inhibitors in alveolar epithelial lining fluid: relevance for modulation of pneumocystis infection in the course of HAART. | The Journal of eukaryotic microbiology 20060101 |
The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line. | The Journal of eukaryotic microbiology 20060101 |
Drug interactions. Unexpected interaction between T-20 and some protease inhibitors. | TreatmentUpdate 20060101 |
48-week RESIST data confirms TPV benefit. | IAPAC monthly 20060101 |
Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir drug product. | Magnetic resonance in chemistry : MRC 20051201 |
Tipranavir. | Nature reviews. Drug discovery 20051201 |
Protease inhibitors: the current status. | Journal of HIV therapy 20051201 |
FDA notifications. Accelerated approval of tipranavir. | AIDS alert 20051101 |
Tipranavir. | Drugs of today (Barcelona, Spain : 1998) 20051101 |
Tipranavir (Aptivus) for HIV. | The Medical letter on drugs and therapeutics 20051010 |
Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir. | Antiviral research 20051001 |
New drugs and dosage forms. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050915 |
Tipranavir gets approved. | AIDS patient care and STDs 20050901 |
Boehringer drug for resistant HIV approved. | The AIDS reader 20050801 |
Protease inhibitor get nod from panel. | AIDS patient care and STDs 20050801 |
FDA approval: tipranavir. | AIDS clinical care 20050801 |
New drugs. | HIV medicine 20050701 |
FDA approves Aptivus (tipranavir). | The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20050701 |
FDA approves tipranavir. | IAPAC monthly 20050701 |
Tipranavir (Aptivus): approval cautiously recommended. | AIDS treatment news 20050527 |
[Perspectives: hope for therapy experienced patients. Tipranavir shows superior effectiveness with comparable safety]. | MMW Fortschritte der Medizin 20050425 |
Design of HIV-1 protease inhibitors active on multidrug-resistant virus. | Journal of medicinal chemistry 20050324 |
Tipranavir: FDA advisory committee will meet May 19, hear experts, public comment. | AIDS treatment news 20050225 |
Estimated extent of cross-resistance to ritonavir-boosted protease inhibitors among protease inhibitors-experienced patients: implications for tipranavir use. | AIDS patient care and STDs 20050201 |
Tipranavir: a novel second-generation nonpeptidic protease inhibitor. | Expert review of anti-infective therapy 20050201 |
Molecular significance of tipranavir related codon 33 protease gene mutations. | AIDS (London, England) 20050128 |
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties. | Bioorganic & medicinal chemistry letters 20050103 |
RESIST-1 results released. | AIDS patient care and STDs 20050101 |
Updates on developments in HIV therapeutics. | The AIDS reader 20050101 |
Tipranavir favored in RESIST-2. | AIDS patient care and STDs 20050101 |
Meeting notes from ICAAC. Ritonavir-boosted tipranavir proves beneficial in treatment-experienced patients. | AIDS clinical care 20050101 |
Tipranavir: a ritonavir-boosted protease inhibitor. | Drugs 20050101 |
A lame duck, a dark horse, and a goat. | GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101 |
Aptivus in the hotseat. Excerpts from the FDA hearings. | GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101 |
Salvage therapy update. | Survival news (Atlanta, Ga.) 20050101 |
New therapy for advanced HIV. | FDA consumer 20050101 |
Anti-HIV agents. Tipranavir in treatment-experienced PHAs. | TreatmentUpdate 20050101 |
A combined QM/MM approach to protein--ligand interactions: polarization effects of the HIV-1 protease on selected high affinity inhibitors. | Journal of medicinal chemistry 20041230 |
Approval application for tipranavir. | AIDS patient care and STDs 20041201 |
Codevelopment of new antiretrovirals in very treatment-experienced HIV-infected individuals. | Lancet (London, England) 20040901 |
Management of HIV-infected patients with multidrug-resistant virus. | Current HIV/AIDS reports 20040901 |
The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients. | Antiviral therapy 20040601 |
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040525 |
[New protease inhibitor for PI pretreated patients. Tipranavir targets also multiresistant viruses]. | MMW Fortschritte der Medizin 20040426 |
A 14-day dose-response study of the efficacy, safety, and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naive HIV-1-infected patients. | Journal of acquired immune deficiency syndromes (1999) 20040401 |
Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates. | The Journal of antimicrobial chemotherapy 20040301 |
How flexible is tipranavir in complex with the HIV-1 protease active site? | AIDS (London, England) 20040220 |
Tipranavir: the first nonpeptidic protease inhibitor. | BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation 20040101 |
Initial therapy for human immunodeficiency virus: broadening the options. | HIV clinical trials 20040101 |
Non-peptidic HIV protease inhibitors. | Current topics in medicinal chemistry 20040101 |
Strategies for overcoming resistance in HIV-1 infected patients receiving HAART. | AIDS reviews 20040101 |
Pharmacokinetic characterization of different dose combinations of coadministered tipranavir and ritonavir in healthy volunteers. | HIV clinical trials 20040101 |
The RESIST trials--superiority of tipranavir over other PIs. | AIDS reviews 20040101 |
Anti-HIV agents. Unexpected results from a tipranavir study. | TreatmentUpdate 20040101 |
Tipranavir: a novel non-peptidic protease inhibitor for the treatment of HIV infection. | Expert opinion on investigational drugs 20031101 |
Tipranavir: a protease inhibitor from a new class with distinct antiviral activity. | Journal of acquired immune deficiency syndromes (1999) 20030901 |
Reviving protease inhibitors: new data and more options. | Journal of acquired immune deficiency syndromes (1999) 20030601 |
[Treatment outcome with anti-HIV agent Tipranavir]. | Deutsche medizinische Wochenschrift (1946) 20030509 |
[Non-peptide protease inhibitor in phase III study. Tipranavir--control of multidrug resistant viruses]. | MMW Fortschritte der Medizin 20030428 |
Tipranavir. | Drugs 20030101 |
Tipranavir. | Drugs 20030101 |
Tipranavir. | Drugs 20030101 |
Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: a concise synthesis of tipranavir. | Journal of the American Chemical Society 20021204 |
Tipranavir reduces viral load. | AIDS patient care and STDs 20020901 |
In vitro antiviral interaction of lopinavir with other protease inhibitors. | Antimicrobial agents and chemotherapy 20020701 |
New antiretroviral may help failing PI regimens. | AIDS alert 20010901 |
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