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Home > Sulfanilamide > 174227-18-0
174227-18-0 | N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
CAS No: 174227-18-0 Catalog No: AG00BA7U MDL No:
Product Description
Catalog Number:
AG00BA7U
Chemical Name:
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
CAS Number:
174227-18-0
IUPAC Name:
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
InChI:
InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
InChI Key:
GJPICJJJRGTNOD-UHFFFAOYSA-N
UNII:
XUL93R30K2
Properties
Complexity:
839
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
551.184g/mol
Formal Charge:
0
Heavy Atom Count:
39
Hydrogen Bond Acceptor Count:
11
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
551.618g/mol
Monoisotopic Mass:
551.184g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
154A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8
Literature
| Title | Journal |
|---|---|
| Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. | Archives of toxicology 20180601 |
| X-ray structures of endothelin ET(B) receptor bound to clinical antagonist bosentan and its analog. | Nature structural & molecular biology 20170901 |
| From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells. | Toxicological sciences : an official journal of the Society of Toxicology 20170601 |
| Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. | Chemical research in toxicology 20170515 |
| Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. | Toxicology letters 20161130 |
| In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population. | Chemico-biological interactions 20160625 |
| Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension: a case report. | BMC pulmonary medicine 20160101 |
| Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates? | Journal of applied toxicology : JAT 20150901 |
| Endothelin-1 receptor antagonists in fetal development and pulmonary arterial hypertension. | Reproductive toxicology (Elmsford, N.Y.) 20150815 |
| Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity. | Bioorganic & medicinal chemistry 20150215 |
| Lack of a clinically significant interaction of grapefruit juice with ambrisentan and bosentan in healthy adults. | International journal of clinical pharmacology and therapeutics 20141101 |
| A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. | Toxicological sciences : an official journal of the Society of Toxicology 20140101 |
| Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | Toxicological sciences : an official journal of the Society of Toxicology 20131201 |
| A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. | Toxicological sciences : an official journal of the Society of Toxicology 20131101 |
| Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. | Chemical research in toxicology 20130617 |
| Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. | Journal of clinical pharmacology 20121201 |
| Efficacy of bosentan therapy for segmental pulmonary artery hypertension due to major aortopulmonary collateral arteries in children. | International journal of cardiology 20121101 |
| Development of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study. | Journal of pharmaceutical and biomedical analysis 20121101 |
| Safety and efficacy evaluation of ambrisentan in pulmonary hypertension. | Expert opinion on drug safety 20121101 |
| Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways. | Life sciences 20121015 |
| Endothelin-1 enhances β₂-adrenoceptor gene transcription in human lung fibroblasts. | Life sciences 20121015 |
| Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. | Life sciences 20121015 |
| Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. | Life sciences 20121015 |
| Role of endothelin-1 in renal regulation of acid-base equilibrium in acidotic humans. | American journal of physiology. Renal physiology 20121001 |
| Endothelin receptor antagonists for aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update. | Stroke 20121001 |
| Current strategies for treating infants with severe bronchopulmonary dysplasia. | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20121001 |
| Do companion diagnostics make economic sense for drug developers? | New biotechnology 20120915 |
| β₂-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. | European journal of pharmacology 20120915 |
| The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist. | Journal of medicinal chemistry 20120913 |
| Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20120901 |
| Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds. | Xenobiotica; the fate of foreign compounds in biological systems 20120901 |
| Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20120901 |
| The big clinical trials in idiopathic pulmonary fibrosis. | Current opinion in pulmonary medicine 20120901 |
| Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases. | Frontiers of medicine 20120901 |
| Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body. | High altitude medicine & biology 20120901 |
| Bosentan reduces pulmonary artery pressure in high altitude residents. | High altitude medicine & biology 20120901 |
| Tadalafil for the treatment of pulmonary arterial hypertension: a double-blind 52-week uncontrolled extension study. | Journal of the American College of Cardiology 20120821 |
| Treatment with bosentan in a patient with thalassemia intermedia and pulmonary arterial hypertension. | Blood 20120816 |
| A randomized, double-blind, placebo-controlled, prospective study of bosentan for the treatment of persistent pulmonary hypertension of the newborn. | Journal of perinatology : official journal of the California Perinatal Association 20120801 |
| Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension. | American journal of respiratory cell and molecular biology 20120801 |
| Successful management of plastic bronchitis in a child post Fontan: case report and literature review. | Lung 20120801 |
| Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. | Bioorganic & medicinal chemistry 20120801 |
| Successful shunt closure and improvement of hemodynamics in an ASD patient with severe pulmonary arterial hypertension and small shunt following a long-term use of bosentan. | International journal of cardiology 20120712 |
| Torcetrapib impairs endothelial function in hypertension. | European heart journal 20120701 |
| Purification and characterization of recombinant human endothelin receptor type A. | Protein expression and purification 20120701 |
| Congenital heart disease and pulmonary hypertension. | Heart failure clinics 20120701 |
| Usefulness of intravenous adenosine in idiopathic pulmonary arterial hypertension as a screening agent for identifying long-term responders to calcium channel blockers. | The American journal of cardiology 20120615 |
| Haemodynamic and neuroendocrine effects of tezosentan in chronic experimental pulmonary hypertension. | Intensive care medicine 20120601 |
| [Experience with bosentan in a female patient with systemic lupus erythematosus and livedo racemosa]. | Revista clinica espanola 20120601 |
| Changes by tacrolimus of the rat aortic proteome: involvement of endothelin-1. | Transplant immunology 20120601 |
| Changes of gene expression after bone marrow cell transfusion in rats with monocrotaline-induced pulmonary hypertension. | Journal of Korean medical science 20120601 |
| Inhaled treprostinil for the treatment of pulmonary arterial hypertension. | Expert review of respiratory medicine 20120601 |
| Treatment of pulmonary arterial hypertension in connective tissue disease. | Drugs 20120528 |
| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
| Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry. | Annals of the rheumatic diseases 20120501 |
| Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data. | Drug metabolism and disposition: the biological fate of chemicals 20120501 |
| Long-term effect of bosentan therapy on cardiac function and symptomatic benefits in adult patients with Eisenmenger syndrome. | Journal of cardiac failure 20120501 |
| Endothelin receptor antagonist bosentan improves the dermal sclerosis in a patient with systemic sclerosis. | The Australasian journal of dermatology 20120501 |
| A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. | Internal medicine journal 20120501 |
| Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries. | The European respiratory journal 20120401 |
| Pulmonary arterial hypertension therapy may be safe and effective in patients with systemic sclerosis and borderline pulmonary artery pressure. | Arthritis and rheumatism 20120401 |
| Pulmonary arterial hypertension in the setting of pregnancy: a case series and standard treatment approach. | Lung 20120401 |
| Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model. | The Journal of pharmacology and experimental therapeutics 20120401 |
| Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120401 |
| Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery. | Biochemical pharmacology 20120401 |
| Curing HIV-associated pulmonary arterial hypertension. | The European respiratory journal 20120401 |
| [HIV-related pulmonary arterial hypertension]. | Revue des maladies respiratoires 20120401 |
| Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. | Journal of chemical information and modeling 20120326 |
| Bosentan-sildenafil association in patients with congenital heart disease-related pulmonary arterial hypertension and Eisenmenger physiology. | International journal of cardiology 20120322 |
| Role of angiotensin and endothelin in testicular ischemia reperfusion injury. | International journal of urology : official journal of the Japanese Urological Association 20120301 |
| Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. | The AAPS journal 20120301 |
| The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial. | Diabetologia 20120301 |
| High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices. | Analytical and bioanalytical chemistry 20120301 |
| Agreement with guidelines from a large database for management of systemic sclerosis: results from the Canadian Scleroderma Research Group. | The Journal of rheumatology 20120301 |
| Pulmonary arterial hypertension during systemic lupus. | Joint, bone, spine : revue du rhumatisme 20120301 |
| Ambrisentan and tadalafil synergistically relax endothelin-induced contraction of rat pulmonary arteries. | Hypertension (Dallas, Tex. : 1979) 20120301 |
| [Progress in pharmacotherapy of pulmonary arterial hypertension in children]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301 |
| A pharmacological investigation of the venom extract of the Australian box jellyfish, Chironex fleckeri, in cardiac and vascular tissues. | Toxicology letters 20120225 |
| Development and validation of a fully automated online human dried blood spot analysis of bosentan and its metabolites using the Sample Card And Prep DBS System. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120215 |
| Bosentan effects on hemodynamics and clinical outcome in heart failure patients with pulmonary hypertension awaiting cardiac transplantation. | The Thoracic and cardiovascular surgeon 20120201 |
| Efficacy of low-dose imatinib mesylate for cutaneous involvement in systemic sclerosis: a preliminary report of three cases. | Modern rheumatology 20120201 |
| Effects of bosentan on nondigital ulcers in patients with systemic sclerosis. | The British journal of dermatology 20120201 |
| In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. | Pharmaceutical research 20120201 |
| Monitoring drug safety with registries: useful components of postmarketing pharmacovigilance systems. | Journal of clinical epidemiology 20120201 |
| Differential inhibitory effect of cyclosporin A and bosentan on taurocholate uptake in human and rat hepatocytes as a function of culturing time. | Toxicology in vitro : an international journal published in association with BIBRA 20120201 |
| Usefulness of first-line combination therapy with epoprostenol and bosentan in pulmonary arterial hypertension: an observational study. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120201 |
| Chronic thromboembolic pulmonary hypertension due to upper-extremity deep vein thrombosis caused by thoracic outlet syndrome. | Archivos de bronconeumologia 20120201 |
| Thrombotic microangiopathic nephropathy, pulmonary hypertension and nephromegaly: case report of a patient treated with endothelin receptor antagonist. | Clinical nephrology 20120201 |
| Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1/CXCR2 in mice. | Canadian journal of physiology and pharmacology 20120201 |
| Transcatheter intervention following bosentan-iloprost treatment in a patient with patent ductus arteriosus and pulmonary hypertension. | International journal of cardiology 20120126 |
| Congenital right pulmonary artery agenesis with atrial septal defect and pulmonary hypertension. | Congenital heart disease 20120101 |
| Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. | Chest 20120101 |
| Bosentan for digital ulcers in patients with systemic sclerosis. | The Journal of dermatology 20120101 |
| Advances in the management of meconium aspiration syndrome. | International journal of pediatrics 20120101 |
| [Management of digital ulcers in patients with systemic sclerosis]. | Deutsche medizinische Wochenschrift (1946) 20120101 |
| Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Efficacy and safety of bosentan in adults with simple and complex Eisenmenger's syndrome. | Congenital heart disease 20120101 |
| Cardiovascular magnetic resonance in pulmonary hypertension. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20120101 |
| Inhaled treprostinil: a therapeutic review. | Drug design, development and therapy 20120101 |
| BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. | PloS one 20120101 |
| Treatment of thromboangiitis obliterans (Buerger's disease) with bosentan. | BMC cardiovascular disorders 20120101 |
| Pulmonary arterial hypertension: advances in pathophysiology and management. | Indian journal of pharmacology 20120101 |
| The safety and effects of bosentan in patients with a Fontan circulation. | Congenital heart disease 20120101 |
| Ocular safety of sildenafil citrate when administered chronically for pulmonary arterial hypertension: results from phase III, randomised, double masked, placebo controlled trial and open label extension. | BMJ (Clinical research ed.) 20120101 |
| Homology modeling, active site prediction, and targeting the anti hypertension activity through molecular docking on endothelin - B receptor domain. | Bioinformation 20120101 |
| Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Smoking and idiopathic pulmonary fibrosis. | Pulmonary medicine 20120101 |
| Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts. | Respiratory research 20120101 |
| Clinical significance of serum decoy receptor 3 levels in patients with systemic sclerosis. | European journal of dermatology : EJD 20120101 |
| Relation of bosentan, iloprost, and sildenafil with growth factor levels in monocrotaline-induced pulmonary hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101 |
| Abnormal pulmonary artery stiffness in pulmonary arterial hypertension: in vivo study with intravascular ultrasound. | PloS one 20120101 |
| Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. | PloS one 20120101 |
| Pulmonary hypertension in pulmonary langerhans cell granulomatosis. | Case reports in medicine 20120101 |
| Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications. | Critical care research and practice 20120101 |
| Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders. | Journal of aging research 20120101 |
| Antidiuretic effects of the endothelin receptor antagonist avosentan. | Frontiers in physiology 20120101 |
| Pulmonary hypertension in patients with chronic kidney disease on dialysis and without dialysis: results of the PEPPER-study. | PloS one 20120101 |
| A novel expression of exercise induced pulmonary hypertension in human immunodeficiency virus patients: a pilot study. | The open cardiovascular medicine journal 20120101 |
| Treatment patterns and healthcare system burden of managed care patients with suspected pulmonary arterial hypertension in the United States. | Journal of medical economics 20120101 |
| Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension. | Pulmonary circulation 20120101 |
| Bosentan effects in hypoxic pulmonary vasoconstriction: Preliminary study in subjects with or without high altitude pulmonary edema-history. | Pulmonary circulation 20120101 |
| Estimation of endothelin-mediated vasoconstriction in acute pulmonary thromboembolism. | Pulmonary circulation 20120101 |
| Severe pulmonary hypertension in idiopathic nonspecific interstitial pneumonia. | Pulmonary circulation 20120101 |
| The WHO classification of pulmonary hypertension: A case-based imaging compendium. | Pulmonary circulation 20120101 |
| Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension. | PloS one 20120101 |
| Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans. | Frontiers in immunology 20120101 |
| Distal extremity necrosis as a manifestation of cutaneous polyarteritis nodosa: case report and review of the acute management of a pediatric patient. | Pediatric dermatology 20120101 |
| Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. | PloS one 20120101 |
| Iontophoresis of endothelin receptor antagonists in rats and men. | PloS one 20120101 |
| Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. | PloS one 20120101 |
| Prevention and treatment of Schistosoma mansoni-induced liver fibrosis in mice. | Inflammopharmacology 20111201 |
| Long-term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: the Treprostinil Sodium Inhalation Used in the Management of Pulmonary Arterial Hypertension (TRIUMPH) study open-label extension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20111201 |
| Pregnancy in women with pulmonary hypertension. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20111201 |
| Recent progress in treatment of pulmonary arterial hypertension due to congenital heart disease. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20111201 |
| Pulmonary arterial hypertension: an update. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20111201 |
| Advanced therapy for pulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20111201 |
| [Treatment of pulmonary fibrosis. New substances and new interventions]. | Der Internist 20111201 |
| The management of Eisenmenger syndrome in the modern treatment era: a case report. | European respiratory review : an official journal of the European Respiratory Society 20111201 |
| 'Treat-to-target' in pulmonary arterial hypertension and the use of extracorporeal membrane oxygenation as a bridge to transplantation. | European respiratory review : an official journal of the European Respiratory Society 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Human immunodeficiency virus & cardiovascular risk. | The Indian journal of medical research 20111201 |
| Surgical correction of cor triatriatum associated with pulmonary artery thrombosis in an adult. | The Korean journal of thoracic and cardiovascular surgery 20111201 |
| Efficacy and safety of bosentan for pulmonary arterial hypertension in adults with congenital heart disease. | The American journal of cardiology 20111115 |
| Prevalence of spontaneous portosystemic shunts in patients with portopulmonary hypertension and effect on treatment. | Gastroenterology 20111101 |
| Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A. | Arthritis and rheumatism 20111101 |
| Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition. | The journal of physiological sciences : JPS 20111101 |
| Contemporary management of Raynaud's phenomenon and digital ischaemic complications. | Current opinion in rheumatology 20111101 |
| Adult congenital heart disease and pulmonary arterial hypertension: the Texas Adult Congenital Heart Program experience. | Postgraduate medicine 20111101 |
| Endothelin receptor expression in idiopathic pulmonary arterial hypertension: effect of bosentan and epoprostenol treatment. | The European respiratory journal 20111001 |
| Macitentan: entry-into-humans study with a new endothelin receptor antagonist. | European journal of clinical pharmacology 20111001 |
| Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene. | Modern rheumatology 20111001 |
| Kinetic characterization of rat hepatic uptake of 16 actively transported drugs. | Drug metabolism and disposition: the biological fate of chemicals 20111001 |
| Chronic leg ulceration as the presenting feature of diffuse systemic sclerosis in childhood. | The Journal of pediatrics 20111001 |
| Successful treatment with bosentan for pulmonary hypertension and reduced peripheral circulation in juvenile systemic sclerosis. | Pediatric cardiology 20111001 |
| Effect of a sequential therapy of bosentan and iloprost versus a monotherapy with bosentan in the treatment of scleroderma related digital ulcers. | International angiology : a journal of the International Union of Angiology 20111001 |
| Bosentan is effective against digital ulcerations and hyperkeratosis in systemic sclerosis. | Acta dermato-venereologica 20111001 |
| Effect of Bosentan on systemic sclerosis-associated interstitial lung disease ineligible for cyclophosphamide therapy: a prospective open-label study. | The Journal of rheumatology 20111001 |
| Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm? | The Annals of thoracic surgery 20111001 |
| Inhaled iloprost for patients with precapillary pulmonary hypertension and right-side heart failure. | Journal of cardiac failure 20111001 |
| Pulmonary hypertension presenting with apnea, cyanosis, and failure to thrive in a young child. | Chest 20111001 |
| Endothelin receptor antagonists -- their role in pulmonary medicine. | Revue des maladies respiratoires 20111001 |
| Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? | Journal of the Korean Society of Coloproctology 20111001 |
| [Tuberculous tenosynovitis]. | Presse medicale (Paris, France : 1983) 20110901 |
| Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice. | The American journal of pathology 20110901 |
| Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial. | Wilderness & environmental medicine 20110901 |
| Combination therapy with an endothelin-1 receptor antagonist (bosentan) and a phosphodiesterase V inhibitor (sildenafil) for the management of severe digital ulcerations in systemic sclerosis. | Journal of the American Academy of Dermatology 20110901 |
| [Pulmonary arterial hypertension related to HIV: is inflammation related to IL-6 the cornerstone?]. | Revue de pneumologie clinique 20110901 |
| Advances in the management of pediatric pulmonary hypertension. | Respiratory care 20110901 |
| Transient use of oral bosentan can be an additional option to reduce pulmonary arterial hypertension in a patient with severe pulmonary arterial hypertension associated with atrial septal defect. | Journal of cardiovascular ultrasound 20110901 |
| Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far. | Hematology reports 20110831 |
| Association of anemia and long-term survival in patients with pulmonary hypertension. | International journal of cardiology 20110804 |
| Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma. | Annals of the rheumatic diseases 20110801 |
| Combination therapy for life-threatening pulmonary hypertension in a premature infant: first report on bosentan use. | European journal of pediatrics 20110801 |
| Bosentan in clinical practice for treating digital and other ischemic ulcers in Spanish patients with systemic sclerosis: IBER-DU cohort study. | The Journal of rheumatology 20110801 |
| Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe. | Intensive care medicine 20110801 |
| Long-term (5 years) effects of bosentan in patients with pulmonary arterial hypertension. | Revista espanola de cardiologia 20110801 |
| Bosentan: a novel therapy for leg ulcers in Werner syndrome. | Journal of the American Academy of Dermatology 20110801 |
| Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): a case report. | Dermatology online journal 20110715 |
| Long-term efficacy of bosentan in treatment of pulmonary arterial hypertension in children. | The European respiratory journal 20110701 |
| Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis. | Joint, bone, spine : revue du rhumatisme 20110701 |
| Expert agreement on EULAR/EUSTAR recommendations for the management of systemic sclerosis. | The Journal of rheumatology 20110701 |
| BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. | American journal of respiratory and critical care medicine 20110701 |
| Endothelin receptor antagonists for the treatment of pulmonary arterial hypertension. | Expert opinion on pharmacotherapy 20110701 |
| Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity? | Contemporary clinical trials 20110701 |
| Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110701 |
| Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists. | Bioorganic & medicinal chemistry letters 20110701 |
| [Treatment of idiopathic pulmonary arterial hypertension]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110701 |
| End of an ERA: lessons from negative clinical trials in idiopathic pulmonary fibrosis. | American journal of respiratory and critical care medicine 20110701 |
| Occlusive venopathy phenotype in hereditary pulmonary arterial hypertension. | Arquivos brasileiros de cardiologia 20110701 |
| Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro. | European journal of pharmacology 20110625 |
| Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts. | The Journal of surgical research 20110601 |
| The management of acute pulmonary arterial hypertension. | Cardiovascular therapeutics 20110601 |
| Endothelin receptor antagonists: potential in Alzheimer's disease. | Pharmacological research 20110601 |
| Venous giant post-thrombotic chronic ulcer: successful treatment with Bosentan. | Phlebology 20110601 |
| Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110601 |
| The pressure wire as a diagnostic tool in patients with congenital cardiac disease. | Cardiology in the young 20110601 |
| Pharmacokinetics of bosentan in routinely treated Japanese pediatric patients with pulmonary arterial hypertension. | Drug metabolism and pharmacokinetics 20110601 |
| [Interstitial lung disease]. | Deutsche medizinische Wochenschrift (1946) 20110601 |
| Pharmacoeconomic evidence of bosentan for pulmonary arterial hypertension. | Expert review of pharmacoeconomics & outcomes research 20110601 |
| Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio. | Canadian journal of physiology and pharmacology 20110601 |
| New perspectives for the treatment of pulmonary hypertension. | British journal of pharmacology 20110501 |
| Novel therapeutic approaches for pulmonary fibrosis. | British journal of pharmacology 20110501 |
| Bosentan, a selective and more potent antagonist for Atractaspis envenomation than the specific antivenom. | Toxicon : official journal of the International Society on Toxinology 20110501 |
| Late clinical manifestations of mitral valve disease and severe pulmonary hypertension in a patient diagnosed with premature closure of foramen ovale during fetal life. | World journal of pediatrics : WJP 20110501 |
| Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease. | Current cardiology reviews 20110501 |
| Orthotopic heart transplantation in patients with univentricular physiology. | Current cardiology reviews 20110501 |
| Heart transplantation in biventricular congenital heart disease: indications, techniques, and outcomes. | Current cardiology reviews 20110501 |
| Postoperative care of the transplanted patient. | Current cardiology reviews 20110501 |
| Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow. | Life sciences 20110425 |
| Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors. | The Journal of pharmacology and experimental therapeutics 20110401 |
| Plasma volume and arterial stiffness in the cardiac alterations associated with long-term high sodium feeding in rats. | American journal of hypertension 20110401 |
| Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. | The Journal of clinical investigation 20110401 |
| The initial 18 months of the first multi-disciplinary regional Pulmonary Arterial Hypertension Clinic in Australia. | The Australian journal of rural health 20110401 |
| Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. | Wiener klinische Wochenschrift 20110401 |
| Constrictive-like physiology in severe pulmonary hypertension: the effect of the Valsalva maneuver. | Southern medical journal 20110401 |
| [Combination treatment in pulmonary arterial hypertension]. | Harefuah 20110401 |
| Bosentan improves systemic sclerosis-related peripheral circulation insufficiency. | International journal of cardiology 20110317 |
| The Bosentan Patient Registry: long-term survival in pulmonary arterial hypertension. | Internal medicine journal 20110301 |
| Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure. | The European respiratory journal 20110301 |
| Treprostinil increases the number and angiogenic potential of endothelial progenitor cells in children with pulmonary hypertension. | Angiogenesis 20110301 |
| Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease. | Intensive care medicine 20110301 |
| Survival after the initiation of combination therapy in patients with pulmonary arterial hypertension: an Australian collaborative report. | Internal medicine journal 20110301 |
| Successful bosentan therapy for pulmonary arterial hypertension associated with hereditary hemorrhagic telangiectasia. | Heart and vessels 20110301 |
| Pharmacokinetic evaluation of ambrisentan. | Expert opinion on drug metabolism & toxicology 20110301 |
| The rise and fall of endothelin receptor antagonists in congestive heart failure. | The European respiratory journal 20110301 |
| Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature. | Journal of gastrointestinal and liver diseases : JGLD 20110301 |
| Synthesis and biological evaluation of 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid derivatives. | Archives of pharmacal research 20110301 |
| Comparison of selective versus dual endothelin receptor antagonism on cerebrovascular dysfunction in diabetes. | Neurological research 20110301 |
| [Changes long term prognosis of 17 patients with pulmonary artery hypertension]. | Revista medica de Chile 20110301 |
| Paediatric sickle cell disease: pulmonary hypertension but normal vascular resistance. | Archives of disease in childhood 20110201 |
| Endothelin receptor antagonists as disease modifiers in systemic sclerosis. | Inflammation & allergy drug targets 20110201 |
| [Pulmonary hypertension in pediatric and neonatal intensive care unit. Part II: diagnosis and treatment]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20110201 |
| [The efficacy and safety of bosentan therapy for Chinese patients with idiopathic pulmonary arterial hypertension: an open-label, prospective multicenter study]. | Zhonghua xin xue guan bing za zhi 20110201 |
| Emerging pathogenetic mechanisms of pulmonary arterial hypertension: nitric oxide and more. | Korean circulation journal 20110201 |
| Gene expressions of nitric oxide synthase and matrix metalloproteinase-2 in monocrotaline-induced pulmonary hypertension in rats after bosentan treatment. | Korean circulation journal 20110201 |
| Evaluation of drug formularies for pediatric intensive care. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20110101 |
| Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. | Annals of the rheumatic diseases 20110101 |
| Endothelin-1 antagonism and nitric oxide augmentation prevents cyclosporine-induced vasomotor impairment. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110101 |
| Identification of clinically used drugs that activate pregnane X receptors. | Drug metabolism and disposition: the biological fate of chemicals 20110101 |
| Availability of and access to orphan drugs: an international comparison of pharmaceutical treatments for pulmonary arterial hypertension, Fabry disease, hereditary angioedema and chronic myeloid leukaemia. | PharmacoEconomics 20110101 |
| Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response. | American journal of physiology. Regulatory, integrative and comparative physiology 20110101 |
| Connective tissue diseases: Treatment of digital ulcers in systemic sclerosis. | Nature reviews. Rheumatology 20110101 |
| Bosentan for the treatment of adult pulmonary hypertension. | Future cardiology 20110101 |
| Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. | BMC neuroscience 20110101 |
| Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats. | PloS one 20110101 |
| Systemic sclerosis - a systematic overview: part 2 - immunosuppression, treatment of SSc-associated vasculopathy, and treatment of pulmonary arterial hypertension. | VASA. Zeitschrift fur Gefasskrankheiten 20110101 |
| [A complication of coronary angiography in a female patient with systemic sclerosis]. | Nederlands tijdschrift voor geneeskunde 20110101 |
| Sinus venosus defect: right heart catheterisation and computed tomographic scan. | Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101 |
| Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach. | Molecular cancer 20110101 |
| Survival of geriatric idiopathic pulmonary arterial hypertension patients. | Connecticut medicine 20110101 |
| Pirfenidone treatment of idiopathic pulmonary fibrosis. | Therapeutics and clinical risk management 20110101 |
| Effects of pulmonary vasodilator therapy on ventilatory efficiency during exercise in adults with Eisenmenger syndrome. | Congenital heart disease 20110101 |
| Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension. | Vascular health and risk management 20110101 |
| Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study. | Arthritis research & therapy 20110101 |
| Effect of the dual endothelin receptor antagonist bosentan on untreatable skin ulcers in a patient with diabetes: a case report. | Journal of medical case reports 20110101 |
| Evaluation of the effect of Bosentan treatment on proinflammatory cytokine serum levels in patients affected by Systemic Sclerosis. | International journal of immunopathology and pharmacology 20110101 |
| Right ventricular dysfunction and failure in chronic pressure overload. | Cardiology research and practice 20110101 |
| Pulmonary vascular complications of chronic liver disease: Pathophysiology, imaging, and treatment. | Annals of thoracic medicine 20110101 |
| Therapeutic targets for bone metastases in breast cancer. | Breast cancer research : BCR 20110101 |
| [Pulmonary arterial hypertension: changing approaches to management]. | Kardiologiia 20110101 |
| Successful bosentan therapy in a case of pulmonary arterial hypertention developed during immunosuppressive therapy for lupus nephritis. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20110101 |
| Recent trends in pulmonary arterial hypertension. | Lung India : official organ of Indian Chest Society 20110101 |
| Pulmonary hypertension related to left-sided cardiac pathology. | Pulmonary medicine 20110101 |
| Lengthy diagnostic challenge in a rare case of pulmonary veno-occlusive disease: case report and review of the literature. | Internal medicine (Tokyo, Japan) 20110101 |
| Pricing and reimbursement of orphan drugs: the need for more transparency. | Orphanet journal of rare diseases 20110101 |
| Therapeutic strategies in pulmonary hypertension. | Frontiers in pharmacology 20110101 |
| Prostacyclin: an inflammatory paradox. | Frontiers in pharmacology 20110101 |
| Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice. | Arthritis research & therapy 20110101 |
| Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension. | Respiratory research 20110101 |
| Peptide and non-peptide antagonists targeting endothelin receptors in physiology and pathology. | Current pharmaceutical design 20110101 |
| Bosentan. | Neonatal network : NN 20110101 |
| Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease. | International journal of nephrology 20110101 |
| The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. | Respiratory research 20110101 |
| Evaluation of liver transplant candidates: A pulmonary perspective. | Annals of thoracic medicine 20110101 |
| Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. | PloS one 20110101 |
| Long-term survival in idiopathic pulmonary arterial hypertension associated with massive pulmonary artery dilation. | Canadian respiratory journal 20110101 |
| Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining. | Arthritis research & therapy 20110101 |
| Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure. | European journal of medical research 20110101 |
| Pulmonary medium vessel vasculitis in an 11 year old boy: Hughes Stovin syndrome as a variant of polyarteritis nodosa? | Pediatric rheumatology online journal 20110101 |
| Acute effect of sildenafil is maintained in pulmonary arterial hypertension patients chronically treated with bosentan. | International heart journal 20110101 |
| Efficacy and safety of bosentan treatment for portopulmonary hypertension associated with syncope. | International heart journal 20110101 |
| An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition. | Lung India : official organ of Indian Chest Society 20110101 |
| Cardiovascular disease in systemic sclerosis--an emerging association? | Arthritis research & therapy 20110101 |
| Does market exclusivity hinder the development of Follow-on Orphan Medicinal Products in Europe? | Orphanet journal of rare diseases 20110101 |
| Endothelin antagonism in patients with resistant hypertension and hypertension nephropathy. | Contributions to nephrology 20110101 |
| Funding linked to ongoing research: impact of the bosentan patient registry on pricing in Australia. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110101 |
| Vascular inflammation and endothelial dysfunction in experimental hypertension. | International journal of hypertension 20110101 |
| Diagnosis and management of pulmonary arterial hypertension. | Pulmonary medicine 20110101 |
| Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling. | International journal of inflammation 20110101 |
| Estimating the budget impact of orphan medicines in Europe: 2010 - 2020. | Orphanet journal of rare diseases 20110101 |
| Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. | Respiratory research 20110101 |
| Anaesthesia Management of Caesarean Section in Two Patients with Eisenmenger's Syndrome. | Anesthesiology research and practice 20110101 |
| Pulmonary venous occlusion and death in pulmonary arterial hypertension: survival analyses using radiographic surrogates. | BMC pulmonary medicine 20110101 |
| Management of cardiopulmonary complications of cirrhosis. | International journal of hepatology 20110101 |
| Disproportionate pulmonary hypertension in a patient with early-onset pulmonary emphysema treated with specific drugs for pulmonary arterial hypertension. | Internal medicine (Tokyo, Japan) 20110101 |
| Initial and programmed combination therapy with oral drugs for severe idiopathic pulmonary arterial hypertension. | International heart journal 20110101 |
| Vascular changes in bleomycin-induced scleroderma. | International journal of rheumatology 20110101 |
| VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. | Respiratory research 20110101 |
| Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality. | Pulmonary circulation 20110101 |
| Severe pulmonary artery hypertension following intracardiac repair of tetralogy of Fallot: An unusual finding. | Pulmonary circulation 20110101 |
| Diagnostic and therapeutic algorithm for pulmonary arterial hypertension. | Pulmonary circulation 20110101 |
| Overview of current therapeutic approaches for pulmonary hypertension. | Pulmonary circulation 20110101 |
| Diagnosis and assessment of pulmonary vascular disease by Doppler echocardiography. | Pulmonary circulation 20110101 |
| Lung transplantation for pulmonary hypertension. | Pulmonary circulation 20110101 |
| Synthesis and characterization of novel 2, 2'-bipyrimidine fluorescent derivative for protein binding. | Chemistry Central journal 20110101 |
| Asymptomatic pulmonary hypertension in systemic lupus erythematosus. | Clinical medicine insights. Arthritis and musculoskeletal disorders 20110101 |
| Reduced hypoxia risk in a systemic sclerosis patient with interstitial lung disease after long-term pulmonary rehabilitation. | Clinical medicine insights. Case reports 20110101 |
| Vascular involvement in systemic sclerosis (scleroderma). | Journal of inflammation research 20110101 |
| Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. | PloS one 20110101 |
| Assessment of daily life physical activities in pulmonary arterial hypertension. | PloS one 20110101 |
| Pulmonary thromboendarterectomy after treatment with treprostenil in a chronic thromboembolic pulmonary hypertension patient: a case report. | International journal of general medicine 20110101 |
| Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis. | International journal of rheumatology 20110101 |
| Long-term effects of intravenous iloprost in patients with idiopathic pulmonary arterial hypertension deteriorating on non-parenteral therapy. | BMC pulmonary medicine 20110101 |
| Effect and safety of mycophenolate mofetil in idiopathic pulmonary fibrosis. | Pulmonary medicine 20110101 |
| Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure. | BMC cardiovascular disorders 20110101 |
| The genetics of pulmonary arterial hypertension in the post-BMPR2 era. | Pulmonary circulation 20110101 |
| Primary biliary cirrhosis associated with systemic sclerosis: diagnostic and clinical challenges. | International journal of rheumatology 20110101 |
| Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. | PloS one 20110101 |
| [Digital ulcers in systemic sclerosis: use of endotheline antagonists]. | Acta medica portuguesa 20110101 |
| Donot Ignore Pulmonary Hypertension Any Longer. It's Time to Deal with it! | ARYA atherosclerosis 20110101 |
| Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences. | British journal of pharmacology 20101201 |
| Bosentan improves skin perfusion of hands in patients with systemic sclerosis with pulmonary arterial hypertension. | The Journal of rheumatology 20101201 |
| Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Short and long term anti-inflammatory effects of bosentan therapy in patients with pulmonary arterial hypertension: relation to clinical and hemodynamic responses. | Expert opinion on therapeutic targets 20101201 |
| Early intervention in pulmonary arterial hypertension associated with systemic sclerosis: an essential component of disease management. | European respiratory review : an official journal of the European Respiratory Society 20101201 |
| Sinus venosus atrial septal defect in a 31-year-old female patient: a case for surgical repair. | European respiratory review : an official journal of the European Respiratory Society 20101201 |
| Pulmonary arterial hypertension: combination therapy in the modern management era. | European respiratory review : an official journal of the European Respiratory Society 20101201 |
| Bosentan and improved pulmonary endothelial function in pulmonary arterial hypertension. | The European respiratory journal 20101201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20101201 |
| HIV and pulmonary arterial hypertension: a systematic review. | HIV medicine 20101101 |
| Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension. | Rheumatology (Oxford, England) 20101101 |
| The endothelin axis stimulates the expression of pro-inflammatory cytokines and pro-migratory molecules in breast cancer. | Cancer investigation 20101101 |
| Review on bosentan, a dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension. | Recent patents on cardiovascular drug discovery 20101101 |
| Pulmonary hypertension associated with use of phentermine. | Yonsei medical journal 20101101 |
| Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling. | Journal of cardiovascular pharmacology 20101101 |
| Differences in disability as measured by the Health Assessment Questionnaire between patients with and without digital ulcers in systemic sclerosis: a post hoc analysis of pooled data from two randomised controlled trials in digital ulcers using bosentan. | Annals of the rheumatic diseases 20101101 |
| [PAH and many other indications. Old and new endothelin receptor antagonists.]. | Pharmazie in unserer Zeit 20101101 |
| [Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition]. | Pharmazie in unserer Zeit 20101101 |
| [The ideal dosage form for clinical study. Bosentan in pediatric patients]. | Pharmazie in unserer Zeit 20101101 |
| Long-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings. | The American journal of cardiology 20101101 |
| Drug-induced hepatic injury in children: a case/non-case study of suspected adverse drug reactions in VigiBase. | British journal of clinical pharmacology 20101101 |
| Bosentan - a previously unrecognised cause of facial telangiectasia. | Annals of the Academy of Medicine, Singapore 20101101 |
| The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part II: Medical Treatment - Study Results. | Current cardiology reviews 20101101 |
| Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan. | International journal of cardiology 20101029 |
| Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: a subgroup analysis. | International journal of cardiology 20101029 |
| Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil. | The European respiratory journal 20101001 |
| Long-term outcomes in pulmonary arterial hypertension in the first-line epoprostenol or first-line bosentan era. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20101001 |
| A higher degree of criticism about the effectiveness of bosentan for digital ulcers in scleroderma patients, as for interstitial disease, is also necessary: comment on the article by Seibold et al. | Arthritis and rheumatism 20101001 |
| Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-[beta] type I receptor. | Journal of cardiovascular pharmacology 20101001 |
| Endothelin receptor antagonists are an effective long term treatment option in pulmonary arterial hypertension associated with congenital heart disease with or without trisomy 21. | Heart, lung & circulation 20101001 |
| Development and validity testing of an IPF-specific version of the St George's Respiratory Questionnaire. | Thorax 20101001 |
| [Efficacy of long-term oral monotherapy and additional effect of inhaled iloprost in patients with severe idiopathic pulmonary arterial hypertension]. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20101001 |
| Pulmonary arterial hypertension in women. | Revue des maladies respiratoires 20101001 |
| [Efficacy of combination therapy with bosentan and sildenafil for refractory pulmonary arterial hypertension associated with fibrotic lung in systemic sclerosis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20101001 |
| Childhood idiopathic pulmonary arterial hypertension: a national cohort study. | Heart (British Cardiac Society) 20100901 |
| Sarcoidosis in the aged: review and management. | Current opinion in pulmonary medicine 20100901 |
| Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial meta-analyses. | European heart journal 20100901 |
| Regulation of NO-dependent acetylcholine relaxation by K+ channels and the Na+-K+ ATPase pump in porcine internal mammary artery. | European journal of pharmacology 20100901 |
| Pulmonary vasoreactivity predicts long-term outcome in patients with Eisenmenger syndrome receiving bosentan therapy. | Heart (British Cardiac Society) 20100901 |
| The efficacy of tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease. | Heart and vessels 20100901 |
| The efficacy of treatment for systemic sclerosis interstitial lung disease: results from a meta-analysis. | Medical science monitor : international medical journal of experimental and clinical research 20100901 |
| Gene expression of endothelin-1 and endothelin receptor a on monocrotaline-induced pulmonary hypertension in rats after bosentan treatment. | Korean circulation journal 20100901 |
| Endothelin-1 (ET-1) increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways: role of a phospholipase A(2)(cPLA(2))/cyclooxygenase-2 (COX-2)/prostacyclin receptor-dependent autocrine loop. | The Journal of biological chemistry 20100820 |
| Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. | Annals of the rheumatic diseases 20100801 |
| Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells. | The Journal of general virology 20100801 |
| Primary pulmonary arterial hypertension and autoimmune polyendocrine syndrome in a pediatric patient. | Pediatric cardiology 20100801 |
| Bosentan induces clinical and hemodynamic improvement in candidates for right-sided heart bypass surgery. | The Journal of thoracic and cardiovascular surgery 20100801 |
| Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. | Journal of applied physiology (Bethesda, Md. : 1985) 20100801 |
| NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. | American journal of physiology. Heart and circulatory physiology 20100801 |
| A novel BMPR2 mutation associated with pulmonary arterial hypertension in an octogenarian. | Lung 20100801 |
| [Digital ulcers in systemic sclerosis--an interdisciplinary challenge]. | Medizinische Klinik (Munich, Germany : 1983) 20100801 |
| Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. | Journal of clinical pharmacology 20100701 |
| Bosentan for chronic thromboembolic pulmonary hypertension: findings from a systematic review and meta-analysis. | Thrombosis research 20100701 |
| Oral sildenafil for persistent pulmonary hypertension early after congenital cardiac surgery in children. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20100701 |
| Therapy with sildenafil or bosentan decreases pulmonary vascular resistance in patients ineligible for heart transplantation because of severe pulmonary hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100701 |
| Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial. | Rheumatology (Oxford, England) 20100701 |
| Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. | Arthritis and rheumatism 20100701 |
| Current and future treatment options in idiopathic pulmonary fibrosis. | Inflammation & allergy drug targets 20100701 |
| Meta-analysis of randomized controlled trials on treatment of pulmonary arterial hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20100701 |
| Efficacy of bosentan in digital ischemic ulcers. | Annals of vascular surgery 20100701 |
| Severe pulmonary hypertension in histiocytosis X: long-term improvement with bosentan. | The European respiratory journal 20100701 |
| Efficacy of bosentan in the treatment of a patient with mixed connective tissue disease complicated by pulmonary arterial hypertension. | Clinical rheumatology 20100601 |
| Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20100601 |
| Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100601 |
| Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. | Naunyn-Schmiedeberg's archives of pharmacology 20100601 |
| Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men. | Hypertension (Dallas, Tex. : 1979) 20100601 |
| Irreversible pulmonary hypertension associated with the use of interferon alpha for chronic hepatitis C. | Digestive diseases and sciences 20100601 |
| Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. | Pediatrics 20100601 |
| Bosentan treatment unable to alter the progression of interstitial lung disease in patients with SSc. | Nature reviews. Rheumatology 20100601 |
| Dual endothelin receptor antagonism prevents remodeling of resistance arteries in diabetes. | Canadian journal of physiology and pharmacology 20100601 |
| Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. | Canadian journal of physiology and pharmacology 20100601 |
| Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. | Canadian journal of physiology and pharmacology 20100601 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20100601 |
| Clinical presentations of critical cardiac defects in the newborn: Decision making and initial management. | Korean journal of pediatrics 20100601 |
| Pulmonary hypertension in infants with bronchopulmonary dysplasia. | Korean journal of pediatrics 20100601 |
| Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. | Journal of the American College of Cardiology 20100504 |
| Endothelium-derived endothelin-1. | Pflugers Archiv : European journal of physiology 20100501 |
| Pulmonary hypertension in lung diseases: survey of beliefs and practice patterns. | Respiratory medicine 20100501 |
| Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies. | British journal of haematology 20100501 |
| Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. | Hypertension research : official journal of the Japanese Society of Hypertension 20100501 |
| Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: a randomized, placebo-controlled, double-blinded trial. | European heart journal 20100501 |
| Assessment of endpoints in the pediatric population: congenital heart disease and idiopathic pulmonary arterial hypertension. | Current opinion in pulmonary medicine 20100501 |
| Modelling the time to onset of adverse reactions with parametric survival distributions: a potential approach to signal detection and evaluation. | Drug safety 20100501 |
| Bosentan-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. | The Journal of rheumatology 20100501 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20100501 |
| [The mechanism and pulmonary-protective effects of endothelin-1 receptor antagonist in chronic obstructive pulmonary diseases rat model]. | Zhonghua nei ke za zhi 20100501 |
| Safe treatment of pulmonary hypertension with bosentan in a patient with moyamoya disease and cerebral ischemia. | Journal of child neurology 20100401 |
| Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. | The European respiratory journal 20100401 |
| Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. | Lung 20100401 |
| Bosentan. | Expert opinion on pharmacotherapy 20100401 |
| Successful bosentan and nonnucleoside reverse transcriptase inhibitor-based therapy in a patient with acquired immunodeficiency syndrome and pulmonary arterial hypertension. | Pharmacotherapy 20100401 |
| Chronic thromboembolic pulmonary hypertension. | Current treatment options in cardiovascular medicine 20100401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20100401 |
| Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats. | Journal of neuroimmunology 20100330 |
| Tadalafil: in pulmonary arterial hypertension. | Drugs 20100305 |
| Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects? | Journal of cell communication and signaling 20100301 |
| Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil. | Rheumatology (Oxford, England) 20100301 |
| Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study. | Rheumatology (Oxford, England) 20100301 |
| Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. | Arthritis and rheumatism 20100301 |
| Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. | Korean circulation journal 20100301 |
| Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans. | European journal of clinical investigation 20100301 |
| Hereditary hemorrhagic telangiectasia: rare cause of pulmonary hypertension? | Arquivos brasileiros de cardiologia 20100301 |
| Thymoquinone-induced relaxation of isolated rat pulmonary artery. | Journal of ethnopharmacology 20100203 |
| Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study. | Rheumatology (Oxford, England) 20100201 |
| An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20100201 |
| RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20100201 |
| IL-17 mediates articular hypernociception in antigen-induced arthritis in mice. | Pain 20100201 |
| The 6 minute walk in idiopathic pulmonary fibrosis: longitudinal changes and minimum important difference. | Thorax 20100201 |
| Late-onset pulmonary arterial hypertension after a successful atrial or arterial switch procedure for transposition of the great arteries. | Pediatric cardiology 20100201 |
| Pulmonary hypertension in thoracic surgical patients. | Current opinion in anaesthesiology 20100201 |
| Efficacy, safety and tolerability of bosentan in Chinese patients with pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201 |
| The globalization of clinical trials in pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201 |
| The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. | The European respiratory journal 20100201 |
| [Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. | Revue des maladies respiratoires 20100201 |
| [Guidelines for the diagnosis and treatment of pulmonary hypertension]. | Revue des maladies respiratoires 20100201 |
| [Bosenten and sildenafil in the treatment of Eisenmenger syndrome]. | Kardiologia polska 20100201 |
| Angina in Women without Obstructive Coronary Artery Disease. | Current cardiology reviews 20100201 |
| Improvement of bleomycin-induced pulmonary hypertension and pulmonary fibrosis by the endothelin receptor antagonist Bosentan. | Respiratory physiology & neurobiology 20100131 |
| Renal failure in cirrhosis. | The New England journal of medicine 20100107 |
| Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. | The Journal of thoracic and cardiovascular surgery 20100101 |
| Quality of life and dyspnoea in patients treated with bosentan for idiopathic pulmonary fibrosis (BUILD-1). | The European respiratory journal 20100101 |
| Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure. | Heart failure reviews 20100101 |
| Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. | Ophthalmic research 20100101 |
| Rheumatic manifestations of skin disease. | Current opinion in rheumatology 20100101 |
| Medicinal chemistry of drugs used in diabetic cardiomyopathy. | Current medicinal chemistry 20100101 |
| Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis. | Joint, bone, spine : revue du rhumatisme 20100101 |
| Bosentan: in pediatric patients with pulmonary arterial hypertension. | Paediatric drugs 20100101 |
| Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis. | Respiratory research 20100101 |
| Pulmonary arterial hypertension in connective tissue diseases. | Cardiology in review 20100101 |
| Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy? | BMC cardiovascular disorders 20100101 |
| Warfarin and bosentan interaction in a patient with pulmonary hypertension secondary to bilateral pulmonary emboli. | Clinical therapeutics 20100101 |
| The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. | PloS one 20100101 |
| Initial Experience with Sildenafil, Bosentan, and Nitric Oxide for Pediatric Cardiomyopathy Patients with Elevated Pulmonary Vascular Resistance before and after Orthotopic Heart Transplantation. | Journal of transplantation 20100101 |
| Measurement of pulmonary flow reserve and pulmonary index of microcirculatory resistance for detection of pulmonary microvascular obstruction. | PloS one 20100101 |
| Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20100101 |
| Truncus arteriosus with aortic arch interruption: cardiovascular magnetic resonance findings in the unrepaired adult. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20100101 |
| Novel approaches to treat experimental pulmonary arterial hypertension: a review. | Journal of biomedicine & biotechnology 20100101 |
| A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. | Molecular cancer 20100101 |
| Portopulmonary hypertension. | Annals of thoracic medicine 20100101 |
| Mutual pharmacokinetic interactions between bosentan and lopinavir/ritonavir in healthy participants. | Antiviral therapy 20100101 |
| Pulmonary veno-occlusive disease: a case report. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20100101 |
| Pharmacotherapeutic management of pulmonary arterial hypertension. | Cardiology in review 20100101 |
| Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma. | Arthritis research & therapy 20100101 |
| Recent achievements in the management of Raynaud's phenomenon. | Vascular health and risk management 20100101 |
| Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension. | Journal of cardiopulmonary rehabilitation and prevention 20100101 |
| Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension. | BMC pulmonary medicine 20100101 |
| First report of the successful use of bosentan in refractory vasospastic angina. | Cardiology 20100101 |
| Advances in the treatment of Raynaud's phenomenon. | Vascular health and risk management 20100101 |
| Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | Current chemical genomics 20100101 |
| The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension. | Vascular health and risk management 20100101 |
| Nitric oxide and pulmonary hypertension. | Korean journal of anesthesiology 20100101 |
| Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment. | Fibrogenesis & tissue repair 20100101 |
| Evaluation of treatment with bosentan in patients with carcinoid heart disease: single center study. | Onkologie 20100101 |
| Right ventricular ejection fraction is better reflected by transverse rather than longitudinal wall motion in pulmonary hypertension. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20100101 |
| Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. | Critical care (London, England) 20100101 |
| Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension. | Drug design, development and therapy 20100101 |
| Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET(A)-receptor complexes. | PloS one 20100101 |
| Microalbuminuria versus brain natriuretic peptide in cardiac hypertrophy of hypertensive rats. | Physiological research 20100101 |
| Treatment patterns and resource utilization and costs among patients with pulmonary arterial hypertension in the United States. | Journal of medical economics 20100101 |
| Clinical outcome in Down syndrome patients with congenital heart disease. | Cirugia y cirujanos 20100101 |
| The value of hepatic diffusion-weighted MR imaging in demonstrating hepatic congestion secondary to pulmonary hypertension. | Cardiovascular ultrasound 20100101 |
| The matrix metalloproteases and endothelin-1 in infection-associated preterm birth. | Obstetrics and gynecology international 20100101 |
| Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management. | Arthritis research & therapy 20100101 |
| Post-operative management of endarterectomy. | Annals of cardiac anaesthesia 20100101 |
| Adult patients with pulmonary arterial hypertension due to congenital heart disease: a review on advanced medical treatment with bosentan. | Therapeutics and clinical risk management 20100101 |
| Registry evaluation of digital ulcers in systemic sclerosis. | International journal of rheumatology 20100101 |
| Digital ischemia in scleroderma spectrum of diseases. | International journal of rheumatology 20100101 |
| Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report. | Journal of medical case reports 20100101 |
| What Limits Cardiac Performance during Exercise in Normal Subjects and in Healthy Fontan Patients? | International journal of pediatrics 20100101 |
| Exercise testing and prescription in patients with congenital heart disease. | International journal of pediatrics 20100101 |
| Pulmonary hypertension in hemolytic anemias. | F1000 medicine reports 20100101 |
| Interleukin-6 as a potential therapeutic target for pulmonary arterial hypertension. | International journal of rheumatology 20100101 |
| The usefulness of submaximal exercise gas exchange in pulmonary arterial hypertension: a case series. | Clinical medicine insights. Circulatory, respiratory and pulmonary medicine 20100101 |
| Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis. | Internal medicine (Tokyo, Japan) 20100101 |
| A comparison of two anastomotic techniques in the jejunum of the goat. | Veterinary medicine international 20100101 |
| [A rare cause of pulmonary arterial hypertension diagnosed in an elderly patient]. | Pneumologia (Bucharest, Romania) 20100101 |
| A case of curable pulmonary hypertension. | Archives of cardiovascular diseases 20100101 |
| The cardiovascular physiology and pharmacology of endothelin-1. | Advances in pharmacology (San Diego, Calif.) 20100101 |
| Eisenmenger syndrome due to a large ductus arteriosus. | Archives of cardiovascular diseases 20100101 |
| Treatment of pulmonary hypertension in patients with connective tissue disease and interstitial lung disease. | Canadian respiratory journal 20100101 |
| Developing pulmonary vasculopathy in systemic sclerosis, detected with non-invasive cardiopulmonary exercise testing. | PloS one 20100101 |
| Inhaled treprostinil and pulmonary arterial hypertension. | Vascular health and risk management 20100101 |
| Severe pulmonary hypertension in a young patient with end-stage renal disease on chronic hemodialysis. | Annals of pediatric cardiology 20100101 |
| Bosentan treatment for Raynauds phenomenon and skin fibrosis in patients with Systemic Sclerosis and pulmonary arterial hypertension: an open-label, observational, retrospective study. | International journal of immunopathology and pharmacology 20100101 |
| [Using nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension]. | Terapevticheskii arkhiv 20100101 |
| Endothelin-1 role in human eye: a review. | Journal of ophthalmology 20100101 |
| Phosphodiesterase-5 inhibitors in management of pulmonary hypertension: safety, tolerability, and efficacy. | Drug, healthcare and patient safety 20100101 |
| Thrombotic microangiopathy in haematopoietic cell transplantation: an update. | Mediterranean journal of hematology and infectious diseases 20100101 |
| Cardiac magnetic resonance imaging in systemic sclerosis: a cross-sectional observational study of 52 patients. | Annals of the rheumatic diseases 20091201 |
| Vasodilators in the treatment of acute heart failure: what we know, what we don't. | Heart failure reviews 20091201 |
| No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers. | Journal of pharmaceutical sciences 20091201 |
| Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease. | British journal of haematology 20091201 |
| TNFalpha-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism. | Thorax 20091201 |
| Bosentan for chronic thromboembolic pulmonary hypertension. | Expert review of cardiovascular therapy 20091201 |
| Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study. | British journal of clinical pharmacology 20091201 |
| [Endothelin receptor antagonists - their role in pulmonary medicine]. | Revue des maladies respiratoires 20091201 |
| Eisenmenger syndrome and juvenile rheumatoid arthritis--a case of double diagnosis. | Kardiologia polska 20091201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091201 |
| [Eisenmenger syndrome. Specific treatments]. | Presse medicale (Paris, France : 1983) 20091201 |
| Long-term outcome in pulmonary arterial hypertension: a plea for earlier parenteral prostacyclin therapy. | European respiratory review : an official journal of the European Respiratory Society 20091201 |
| Outcome of pulmonary hypertension subjects transitioned from intravenous prostacyclin to oral bosentan. | Respiratory medicine 20091101 |
| EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia. | American journal of physiology. Lung cellular and molecular physiology 20091101 |
| Acute hemodynamic effects of single-dose sildenafil when added to established bosentan therapy in patients with pulmonary arterial hypertension: results of the COMPASS-1 study. | Journal of clinical pharmacology 20091101 |
| [Pulmonary hypertension in hereditary haemorrhagic teleangiectasia]. | Pneumologie (Stuttgart, Germany) 20091101 |
| Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hypertensive rats. | Journal of hypertension 20091101 |
| Goal-oriented therapy in pulmonary veno-occlusive disease: a word of caution. | The European respiratory journal 20091101 |
| Unilateral absence of a left pulmonary artery: successful therapeutic response to a combination of bosentan and warfarin. | Circulation. Cardiovascular imaging 20091101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091101 |
| Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: time-dependent effects. | European journal of pharmacology 20091025 |
| Low-dose combination therapy of severe digital ulcers in diffuse progressive systemic sclerosis with the endothelin-1 receptor antagonist bosentan and the phosphodiesterase V inhibitor sildenafil. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20091001 |
| Successful treatment of persistent pulmonary hypertension of the newborn with bosentan. | Acta paediatrica (Oslo, Norway : 1992) 20091001 |
| [Effectiveness of bosentan in the management of Latin American patients diagnosed with pulmonary arterial hypertension]. | Archivos de bronconeumologia 20091001 |
| Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. | Bioorganic & medicinal chemistry 20091001 |
| Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis. | Drugs 20091001 |
| Myocardial protective effect of tezosentan, an endothelin receptor antagonist, for ischemia-reperfusion injury in experimental heart failure models. | Journal of Korean medical science 20091001 |
| Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. | Health technology assessment (Winchester, England) 20091001 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091001 |
| [Thrombosed giant proximal pulmonary artery aneurysm]. | Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001 |
| Pulmonary hypertensive medical therapy in chronic thromboembolic pulmonary hypertension before pulmonary thromboendarterectomy. | Circulation 20090929 |
| Bosentan reduces oxidative burst in acid aspiration-induced lung injury in rats. | Injury 20090901 |
| The role of transporters in the pharmacokinetics of orally administered drugs. | Pharmaceutical research 20090901 |
| Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. | Hypertension (Dallas, Tex. : 1979) 20090901 |
| Mechanisms responsible for the altered pharmacokinetics of bosentan: analysis utilizing rats with bile duct ligation-induced liver dysfunction. | Biopharmaceutics & drug disposition 20090901 |
| Can we improve outcome of congenital diaphragmatic hernia? | Pediatric surgery international 20090901 |
| Long-term bosentan treatment of complex congenital heart disease and Eisenmenger's syndrome. | Revista espanola de cardiologia 20090901 |
| Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension. | Advances in therapy 20090901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090901 |
| Long-term efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20090901 |
| Bosentan in pulmonary arterial hypertension: a comparison between congenital heart disease and chronic pulmonary embolism. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20090901 |
| The use of combination therapy in pulmonary arterial hypertension: new developments. | European respiratory review : an official journal of the European Respiratory Society 20090901 |
| Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease. | European respiratory review : an official journal of the European Respiratory Society 20090901 |
| Chronic thromboembolic pulmonary hypertension as a cause of dyspnoea in an older patient with a complex history. | European respiratory review : an official journal of the European Respiratory Society 20090901 |
| Pulmonary veno-occlusive disease misdiagnosed as idiopathic pulmonary arterial hypertension. | European respiratory review : an official journal of the European Respiratory Society 20090901 |
| Endothelial and potassium channel dependent modulation of noradrenergic vasoconstriction in the pig radial artery. | European journal of pharmacology 20090815 |
| [Outcome of oral bosentan in children with congenital heart disease associated pulmonary arterial hypertension]. | Zhonghua yi xue za zhi 20090811 |
| Endothelin-1 contributes to hemoglobin glutamer-200-mediated hepatocellular dysfunction after hemorrhagic shock. | Shock (Augusta, Ga.) 20090801 |
| Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. | Atherosclerosis 20090801 |
| Change in pharmacological effect of endothelin receptor antagonists in rats with pulmonary hypertension: role of ETB-receptor expression levels. | Pulmonary pharmacology & therapeutics 20090801 |
| The effect of bosentan in patients with a failing Fontan circulation. | Cardiology in the young 20090801 |
| Pulmonary arterial hypertension and HIV infection. | Seminars in respiratory and critical care medicine 20090801 |
| Current concepts of mechanisms in drug-induced hepatotoxicity. | Current medicinal chemistry 20090801 |
| [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20090801 |
| Use of inhaled iloprost in an infant with bronchopulmonary dysplasia and pulmonary artery hypertension. | Korean circulation journal 20090801 |
| Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension. | Journal of dermatological science 20090701 |
| No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. | Clinical rheumatology 20090701 |
| Do we need fenestration when performing two-staged total cavopulmonary connection using an extracardiac conduit? | Interactive cardiovascular and thoracic surgery 20090701 |
| The ischemic metabolite lysophosphatidylcholine increases rat coronary arterial tone by endothelium-dependent mechanisms. | Journal of molecular and cellular cardiology 20090701 |
| Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease. | Diabetes/metabolism research and reviews 20090701 |
| Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension. | American journal of physiology. Heart and circulatory physiology 20090701 |
| Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report. | Multiple sclerosis (Houndmills, Basingstoke, England) 20090701 |
| Bosentan for digital ulcers in patients with systemic sclerosis: a prospective 3-year followup study. | The Journal of rheumatology 20090701 |
| Tadalafil therapy for pulmonary arterial hypertension. | Circulation 20090609 |
| Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance. | Acta physiologica (Oxford, England) 20090601 |
| Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. | Chest 20090601 |
| A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade. | European journal of clinical investigation 20090601 |
| Up-regulation of endothelin type a receptor in human and rat radiation proctitis: preclinical therapeutic approach with endothelin receptor blockade. | International journal of radiation oncology, biology, physics 20090601 |
| Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension. | Journal of cardiology 20090601 |
| Skin disease: a cardinal feature of systemic sclerosis. | Rheumatology (Oxford, England) 20090601 |
| Digital ulcers: overt vascular disease in systemic sclerosis. | Rheumatology (Oxford, England) 20090601 |
| Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. | Rheumatology (Oxford, England) 20090601 |
| Vasculopathy and pulmonary arterial hypertension. | Rheumatology (Oxford, England) 20090601 |
| Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. | IDrugs : the investigational drugs journal 20090601 |
| Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition. | Transplantation proceedings 20090601 |
| Improved myocardial perfusion preceding clinical response on bosentan treatment for coronary vasospasm. | Acta cardiologica 20090601 |
| Sarcoidosis-associated pulmonary hypertension: a role for endothelin receptor antagonists? | Therapeutic advances in respiratory disease 20090601 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090601 |
| Down patients with Eisenmenger syndrome: is bosentan treatment an option? | International journal of cardiology 20090529 |
| Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. | Cancer research 20090515 |
| CCL3/MIP-1 alpha is not involved in the LPS-induced fever and its pyrogenic activity depends on CRF. | Brain research 20090507 |
| Effects of bosentan on the skin lesions: an observational study from a single center in Japan. | Rheumatology international 20090501 |
| Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension. | European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20090501 |
| Endothelin-1 modulates angiotensin II in the development of hypertension in fructose-fed rats. | Molecular and cellular biochemistry 20090501 |
| Clinical practice: pulmonary hypertension in children. | European journal of pediatrics 20090501 |
| Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. | Chest 20090501 |
| Endothelin-receptor antagonist/N-acetylcysteine combination in type 1 hepatorenal syndrome. | Journal of hepatology 20090501 |
| Effect of bosentan on exercise capacity and quality of life in adults with pulmonary arterial hypertension associated with congenital heart disease with and without Down's syndrome. | The American journal of cardiology 20090501 |
| Severe pulmonary hypertension and adenotonsillectomy in a child with Trisomy-21 and obstructive sleep apnea. | Paediatric anaesthesia 20090501 |
| [Is there a hope in pharmacological treatment of thromboembolic pulmonary hypertension?]. | Vnitrni lekarstvi 20090501 |
| Heart Disease in Patients with HIV/AIDS-An Emerging Clinical Problem. | Current cardiology reviews 20090501 |
| Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. | Journal of the American College of Cardiology 20090414 |
| Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats. | Neuropeptides 20090401 |
| Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors. | The British journal of dermatology 20090401 |
| Effect of bosentan on plasma markers of endothelial cell activity in patients with secondary pulmonary hypertension related to connective tissue diseases. | The Journal of rheumatology 20090401 |
| Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1. | British journal of pharmacology 20090401 |
| Bosentan in pediatric patients with pulmonary arterial hypertension. | Current vascular pharmacology 20090401 |
| Substrate-specific pharmacokinetic interaction between endothelin receptor antagonists and phosphodiesterase-5 inhibitors--assembling the clues. | British journal of clinical pharmacology 20090401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090401 |
| Ambrisentan: new drug. Too risky in mildly symptomatic pulmonary hypertension. | Prescrire international 20090401 |
| Bosentan: new indication. Also too risky in mildly symptomatic pulmonary arterial hypertension. No proven tangible benefit in mildly symptomatic patients, and too many adverse effects. | Prescrire international 20090401 |
| Isolated pulmonary arterial hypertension-janus' faces of hyperthyroidism. | Korean circulation journal 20090401 |
| Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. | Circulation research 20090327 |
| Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. | Journal of the American College of Cardiology 20090303 |
| Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French ItinérAIR-Sclérodermie study. | Rheumatology (Oxford, England) 20090301 |
| Delayed hypersensitivity to bosentan. | Allergy 20090301 |
| [Therapy of mild, but symptomatic pulmonary hypertension]. | Der Internist 20090301 |
| Atrial septal defect repair after a 10-month treatment with bosentan in a patient with severe pulmonary arterial hypertension: a case report. | The Journal of thoracic and cardiovascular surgery 20090301 |
| Severe hepatotoxicity in a patient on bosentan upon addition of methotrexate: reversible with resumption of methotrexate without bosentan. | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090301 |
| Endothelin receptor antagonist therapy in congenital heart disease with shunt-associated pulmonary arterial hypertension: a qualitative systematic review. | The Canadian journal of cardiology 20090301 |
| Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090301 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090301 |
| Beneficial and adverse effects of bosentan treatment in korean patients with pulmonary artery hypertension. | Korean circulation journal 20090301 |
| Managing chronic thromboembolic pulmonary hypertension: pharmacological treatment options. | European respiratory review : an official journal of the European Respiratory Society 20090301 |
| Inhaled iloprost for the treatment of pulmonary hypertension. | European respiratory review : an official journal of the European Respiratory Society 20090301 |
| Prophylactic bosentan does not improve exercise capacity or lower pulmonary artery systolic pressure at high altitude. | Respiratory physiology & neurobiology 20090227 |
| Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells. | Digestive diseases and sciences 20090201 |
| Treatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001-2006. | Heart (British Cardiac Society) 20090201 |
| [Pulmonary arterial hypertension related to systemic sclerosis in 2008]. | Journal des maladies vasculaires 20090201 |
| A meta-analysis of randomized controlled trials in pulmonary arterial hypertension. | European heart journal 20090201 |
| Portopulmonary hypertension. | Current gastroenterology reports 20090201 |
| 'End-stage' pulmonary fibrosis in sarcoidosis. | The Mount Sinai journal of medicine, New York 20090201 |
| Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. | Arthritis and rheumatism 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade. | Therapeutic advances in respiratory disease 20090201 |
| Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease. | Therapeutic advances in respiratory disease 20090201 |
| N-terminal pro-brain natriuretic peptide in systemic sclerosis related pulmonary arterial hypertension under bosentan treatment. | Rheumatology international 20090101 |
| Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects. | Investigative ophthalmology & visual science 20090101 |
| Long-term effects of bosentan in patients with HIV-associated pulmonary arterial hypertension. | The European respiratory journal 20090101 |
| Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. | Chest 20090101 |
| [Pulmonary hypertension in a patient on chronic hemodialysis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20090101 |
| WJES: how to review a clinical paper. | World journal of emergency surgery : WJES 20090101 |
| Improvement in right ventricular function during reversibility testing in pulmonary arterial hypertension: a case report. | Cardiovascular ultrasound 20090101 |
| The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan). | Pathology, research and practice 20090101 |
| Bosentan for patients with chronic thromboembolic pulmonary hypertension. | European journal of internal medicine 20090101 |
| [Treatment of Raynaud's phenomenon]. | Revista clinica espanola 20090101 |
| [Pulmonary arterial hypertension: a voyage around the year 2008]. | Archivos de bronconeumologia 20090101 |
| Right-to-left shunt with hypoxemia in pulmonary hypertension. | BMC cardiovascular disorders 20090101 |
| Portopulmonary hypertension associated with congenital absence of the portal vein treated with bosentan. | Internal medicine (Tokyo, Japan) 20090101 |
| Effects and mechanisms of action of sildenafil citrate in human chorionic arteries. | Reproductive biology and endocrinology : RB&E 20090101 |
| Review of inhaled iloprost for the control of pulmonary artery hypertension in children. | Vascular health and risk management 20090101 |
| Bone mineral density and secondary hyperparathyroidism in pulmonary hypertension. | The open respiratory medicine journal 20090101 |
| [Potential role of endothelin in patients with acute pulmonary embolism and chronic thromboembolic pulmonary hypertension]. | Pneumonologia i alergologia polska 20090101 |
| Inhaled iloprost for the control of pulmonary hypertension. | Vascular health and risk management 20090101 |
| Patients with pulmonary hypertension related to congenital systemic-to-pulmonary shunts are characterized by inflammation involving endothelial cell activation and platelet-mediated inflammation. | Congenital heart disease 20090101 |
| Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan. | Modern rheumatology 20090101 |
| Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer. | Breast cancer research : BCR 20090101 |
| Treatment of pediatric pulmonary hypertension. | Vascular health and risk management 20090101 |
| Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20090101 |
| The cost-effectiveness of bosentan in the United Kingdom for patients with pulmonary arterial hypertension of WHO functional class III. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101 |
| Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension. | Vascular pharmacology 20090101 |
| Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells. | BMC cell biology 20090101 |
| [Contemporary methods in the treatment of chronic pulmonary hypertension]. | Casopis lekaru ceskych 20090101 |
| Bosentan in the treatment of pulmonary arterial hypertension with the focus on the mildly symptomatic patient. | Vascular health and risk management 20090101 |
| Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. | BMC cardiovascular disorders 20090101 |
| RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension. | Vascular health and risk management 20090101 |
| Successful tricuspid valve replacement in a patient with severe pulmonary arterial hypertension and preserved right ventricular systolic function. | Case reports in medicine 20090101 |
| Cost-utility of treatments for pulmonary arterial hypertension: a Markov state-transition decision analysis model. | Clinical drug investigation 20090101 |
| Targeted treatment in COPD: a multi-system approach for a multi-system disease. | International journal of chronic obstructive pulmonary disease 20090101 |
| Pulmonary stenosis development and reduction of pulmonary arterial hypertension in atrioventricular septal defect: a case report. | Journal of cardiothoracic surgery 20090101 |
| Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101 |
| Drugs associated with more suicidal ideations are also associated with more suicide attempts. | PloS one 20090101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090101 |
| Update on pulmonary hypertension complicating chronic obstructive pulmonary disease. | International journal of chronic obstructive pulmonary disease 20090101 |
| Rac inhibition reverses the phenotype of fibrotic fibroblasts. | PloS one 20090101 |
| Successful pregnancy in pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report. | Journal of medical case reports 20090101 |
| Graves' disease associated with primary systemic sclerosis. | Orbit (Amsterdam, Netherlands) 20090101 |
| An atypical presentation of liver enzyme elevation resulting from bosentan use. | Canadian respiratory journal 20090101 |
| Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial. | Respiratory research 20090101 |
| Exhaled nitric oxide in diagnosis and management of respiratory diseases. | Annals of thoracic medicine 20090101 |
| Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes. | Vascular health and risk management 20090101 |
| Sarcoidosis-induced pericarditis in a patient with portopulmonary hypertension: a case report. | Cases journal 20090101 |
| Safety and tolerability of bosentan in the management of pulmonary arterial hypertension. | Drug design, development and therapy 20090101 |
| Therapeutic methods used in patients with Eisenmenger syndrome. | Cardiology journal 20090101 |
| No difference in between-country variability in use of newly approved orphan and non- orphan medicinal products--a pilot study. | Orphanet journal of rare diseases 20090101 |
| Novel therapies in sickle cell disease. | Hematology. American Society of Hematology. Education Program 20090101 |
| Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension. | Respiratory research 20090101 |
| Brain natriuretic peptide in pulmonary arterial hypertension: biomarker and potential therapeutic agent. | Drug design, development and therapy 20090101 |
| The right ventricle: biologic insights and response to disease. | Current cardiology reviews 20090101 |
| End-organ damage in hypertensive transgenic Ren-2 rats: influence of early and late endothelin receptor blockade. | Physiological research 20090101 |
| New developments in the therapy of pulmonary fibrosis. | Advances in pharmacology (San Diego, Calif.) 20090101 |
| The role of long-term doxycycline in patients of idiopathic pulmonaryfibrosis: The results of an open prospective trial. | Lung India : official organ of Indian Chest Society 20090101 |
| Use of Bosentan in neonatal post cardiac surgery pulmonary hypertension. | Annals of pediatric cardiology 20090101 |
| Integrated care and optimal management of pulmonary arterial hypertension. | Journal of multidisciplinary healthcare 20090101 |
| Pathophisiology of sickle cell disease and new drugs for the treatment. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report. | BMJ case reports 20090101 |
| Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. | Journal of the American College of Cardiology 20081216 |
| The responsiveness and validity of the CAMPHOR Utility Index. | The European respiratory journal 20081201 |
| Successful treatment with bosentan of non-digital skin ulcers in severe scleroderma. | Annals of the rheumatic diseases 20081201 |
| Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1. | Fundamental & clinical pharmacology 20081201 |
| Sildenafil for pulmonary hypertension: need for evidence generation. | International journal of clinical pharmacology and therapeutics 20081201 |
| Pulmonary arterial hypertension: need to treat. | Inflammation & allergy drug targets 20081201 |
| Bosentan: new indication. Scleroderma and finger ulcers: no tangible efficacy. | Prescrire international 20081201 |
| [Pulmonary arterial hypertension]. | La Revue du praticien 20081130 |
| Venous endotelin-1 (ET-1) and brain natriuretic peptide (BNP) plasma levels during 6-month bosentan treatment for pulmonary arterial hypertension. | Regulatory peptides 20081129 |
| Bosentan in mild pulmonary hypertension. | Lancet (London, England) 20081115 |
| Bosentan in mild pulmonary hypertension. | Lancet (London, England) 20081115 |
| Bosentan: a rapidly expanding role in the management of cardio-thoracic diseases. | Rheumatology international 20081101 |
| Treatment of pulmonary hypertension in children with chronic lung disease with newer oral therapies. | Pediatric cardiology 20081101 |
| Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
| Successful bosentan treatment of critical ischaemia induced by vasculitis in an SCLE patient. | Rheumatology (Oxford, England) 20081101 |
| Pulmonary arterial hypertension in adults with congenital heart disease: distinct differences from other causes of pulmonary arterial hypertension and management implications. | Current opinion in cardiology 20081101 |
| Bosentan for idiopathic pulmonary fibrosis. | Current opinion in investigational drugs (London, England : 2000) 20081101 |
| Role of ambrisentan in the management of pulmonary hypertension. | The Annals of pharmacotherapy 20081101 |
| [Endothelin receptor antagonist]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| [Anticoagulation therapy in pulmonary arterial hypertension]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| [Pulmonary arterial hypertension in pediatric age]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| [Remarkable response of bosentan, an endothelin receptor antagonist, for a patient with Eisenmenger syndrome]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20081010 |
| Size and function of the atria. | The international journal of cardiovascular imaging 20081001 |
| Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival. | Chest 20081001 |
| Thyme extract, but not thymol, inhibits endothelin-induced contractions of isolated rat trachea. | Planta medica 20081001 |
| Endothelin and scleroderma lung disease. | Rheumatology (Oxford, England) 20081001 |
| Digital ulcers and outcomes assessment in scleroderma. | Rheumatology (Oxford, England) 20081001 |
| GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. | The Journal of clinical investigation 20081001 |
| Role of angiotensin II, endothelin-1 and L-type calcium channel in the development of glomerular, tubulointerstitial and perivascular fibrosis. | Journal of hypertension 20081001 |
| [Specific drugs for the treatment of pulmonary arterial hypertension - current status]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| [Combination therapy in patients with pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| [Update in pulmonary hypertension associated with connective tissue diseases - a systematic literature review]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| Salt-induced cardiac hypertrophy is independent of blood pressure and endothelin in obese, heart failure-prone SHHF rats. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001 |
| Platelet-derived growth factor inhibition--a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? | Journal of pediatric surgery 20081001 |
| The drug-drug interaction potential of rifampicin. | Clinical therapeutics 20081001 |
| Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. | Vascular health and risk management 20081001 |
| Arterial pulmonary hypertension in noncardiac intensive care unit. | Vascular health and risk management 20081001 |
| Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension. | Vascular health and risk management 20081001 |
| Long-term effects of bosentan on quality of life, survival, safety and tolerability in pulmonary arterial hypertension related to connective tissue diseases. | Annals of the rheumatic diseases 20080901 |
| A randomised, controlled trial of bosentan in severe COPD. | The European respiratory journal 20080901 |
| Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1. | Journal of leukocyte biology 20080901 |
| Efficacy of the endothelin receptor blocker bosentan for refractory sickle cell leg ulcers. | British journal of haematology 20080901 |
| Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: the role of bosentan. | Expert opinion on therapeutic targets 20080901 |
| New developments in localized scleroderma. | Current opinion in rheumatology 20080901 |
| Bosentan therapy in patients with pulmonary arterial hypertension: the relationship between improvements in 6 minute walk distance and quality of life. | Respirology (Carlton, Vic.) 20080901 |
| Chronic stable angina pectoris. | Disease-a-month : DM 20080901 |
| Pulmonary arterial hypertension: on the way to a manageable disease. | Current opinion in investigational drugs (London, England : 2000) 20080901 |
| Treating pulmonary hypertension in COPD: where do we start? | The European respiratory journal 20080901 |
| Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. | Radiation research 20080901 |
| Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. | Chest 20080901 |
| HIV-related pulmonary arterial hypertension: clinical presentation and management. | AIDS (London, England) 20080901 |
| Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke. | International journal of chronic obstructive pulmonary disease 20080901 |
| Bosentan for pulmonary hypertension and other pulmonary diseases: emerging evidence. | Future cardiology 20080901 |
| The role of endothelin pathway in modulation of airway reactivity to methacholine in C57Bl/6 and BALB/c mice. | European journal of pharmacology 20080820 |
| [Effects of bosentan in treatment of pulmonary arterial hypertension: a pilot study of 21 patients]. | Zhonghua yi xue za zhi 20080805 |
| Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension. | Annals of the rheumatic diseases 20080801 |
| Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program. | Pediatric research 20080801 |
| Changes in exercise haemodynamics during treatment in pulmonary arterial hypertension. | The European respiratory journal 20080801 |
| The effects of endothelin receptor blockade by bosentan on the healing of a bowel anastomosis in an experimental Crohn's disease model. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080801 |
| Late treatment with angiotensin-converting enzyme inhibitors plus endothelin receptor antagonists ameliorates rat tracheal allograft rejection. | Transplant international : official journal of the European Society for Organ Transplantation 20080801 |
| Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? | European heart journal 20080801 |
| [A case of severe pulmonary hypertension associated with COPD treated with epoprostenol]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080801 |
| A case report of successful treatment with immunoadsorption onto protein A in mixed connective tissue disease in childhood. | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20080801 |
| Sitaxsentan sodium for pulmonary hypertension. | Drugs of today (Barcelona, Spain : 1998) 20080801 |
| [Current treatment of systemic sclerosis. Part II. Vascular and antifibrotic treatment]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080801 |
| Role of IL-18 in overt pain-like behaviour in mice. | European journal of pharmacology 20080707 |
| Vaso-active therapy can improve 6-min walk distance in patients with pulmonary hypertension and fibrotic interstitial lung disease. | Respiratory medicine 20080701 |
| Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats. | Clinical and experimental pharmacology & physiology 20080701 |
| The management of pulmonary hypertension in children. | Archives of disease in childhood 20080701 |
| Treprostinil-based therapy in the treatment of moderate-to-severe pulmonary arterial hypertension: long-term efficacy and combination with bosentan. | Chest 20080701 |
| Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20080701 |
| Additional effects of bosentan in patients with idiopathic pulmonary arterial hypertension already treated with high-dose epoprostenol. | Circulation journal : official journal of the Japanese Circulation Society 20080701 |
| Pulmonary veno-occlusive disease: clinical, functional, radiologic, and hemodynamic characteristics and outcome of 24 cases confirmed by histology. | Medicine 20080701 |
| Successful treatment with bosentan for refractory digital ulcers in a patient with systemic lupus erythematosus. | The Journal of dermatology 20080701 |
| Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study. | International journal of cardiology 20080623 |
| Endothelin-receptor antagonism: the future is bright. | Lancet (London, England) 20080621 |
| Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. | Lancet (London, England) 20080621 |
| LPS abolishes extrasplenic vasoconstriction to atrial natriuretic peptide: the role of NO and endothelin 1. | Shock (Augusta, Ga.) 20080601 |
| Effects of oral treatments on exercise capacity in systemic sclerosis related pulmonary arterial hypertension: a meta-analysis of randomised controlled trials. | Annals of the rheumatic diseases 20080601 |
| Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
| Cardiac expression patterns of endothelin-converting enzyme (ECE): implications for conduction system development. | Developmental dynamics : an official publication of the American Association of Anatomists 20080601 |
| Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. | The American journal of cardiology 20080601 |
| Late complete heart block in an adult patient undergoing percutaneous ventricular septal defect closure. | The Journal of invasive cardiology 20080601 |
| Bosentan in systemic sclerosis. | Drugs of today (Barcelona, Spain : 1998) 20080601 |
| Sitaxentan: new drug. Pulmonary hypertension: better to continue to use bosentan. | Prescrire international 20080601 |
| Treprostinil for pulmonary hypertension. | Vascular health and risk management 20080601 |
| Evaluation of bosentan for idiopathic pulmonary fibrosis. | Expert review of respiratory medicine 20080601 |
| N-terminal pro-BNP in sclerodermic patients on bosentan therapy for PAH. | Rheumatology international 20080501 |
| N-terminal probrain natriuretic peptide as a biochemical marker in the evaluation of bosentan treatment in systemic-sclerosis-related pulmonary arterial hypertension. | Clinical rheumatology 20080501 |
| Long-term experience after transition from parenteral prostanoids to oral agents in patients with pulmonary hypertension. | Respiratory medicine 20080501 |
| Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects. | Journal of clinical pharmacology 20080501 |
| Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. | The Journal of clinical investigation 20080501 |
| Treatment for Raynaud's: beyond calcium channel blockers. | Journal of drugs in dermatology : JDD 20080501 |
| [Systemic sclerosis]. | Medizinische Monatsschrift fur Pharmazeuten 20080501 |
| Ambrisentan for the management of pulmonary arterial hypertension. | Clinical therapeutics 20080501 |
| Persistent pulmonary hypertension of the newborn with transposition of the great arteries: successful treatment with bosentan. | European journal of pediatrics 20080401 |
| [Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. | La Revue de medecine interne 20080401 |
| [Digital ulcers in systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20080401 |
| Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients. | Rheumatology (Oxford, England) 20080401 |
| Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats. | American journal of physiology. Heart and circulatory physiology 20080401 |
| Bosentan for the treatment of idiopathic pulmonary fibrosis. | Expert opinion on investigational drugs 20080401 |
| [Pulmonary arterial hypertension in women]. | Revue des maladies respiratoires 20080401 |
| [Long-term therapy with endothelin-1 antagonist for pulmonary hypertension secondary to systemic sclerosis]. | Harefuah 20080401 |
| Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080305 |
| The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? | British journal of pharmacology 20080301 |
| Physiological concentration of 17beta-estradiol on sympathetic reinnervation in ovariectomized infarcted rats. | Endocrinology 20080301 |
| Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats. | American journal of physiology. Heart and circulatory physiology 20080301 |
| Diagnosis of pulmonary arterial hypertension in a patient with systemic sclerosis. | Nature clinical practice. Rheumatology 20080301 |
| Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080301 |
| Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. | Chest 20080301 |
| Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohn's disease. | Journal of clinical biochemistry and nutrition 20080301 |
| Reduced vascular response to phenylephrine during exposure to lipopolysaccharide in vitro involves nitric oxide and endothelin 1. | Shock (Augusta, Ga.) 20080301 |
| Pulmonary hypertension associated with COPD. | International journal of chronic obstructive pulmonary disease 20080301 |
| IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. | Proceedings of the National Academy of Sciences of the United States of America 20080219 |
| Treatment of complications associated with systemic sclerosis. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080215 |
| Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats. | European journal of pharmacology 20080202 |
| Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. | Clinical science (London, England : 1979) 20080201 |
| Pulmonary hypertension: basic concepts and practical management. | The European respiratory journal 20080201 |
| Endothelin receptor antagonists in pulmonary arterial hypertension. | The European respiratory journal 20080201 |
| Central cyanosis due to severe pulmonary hypertension combined with pericarditis as the initial manifestation of systemic lupus erythematosus. | The American journal of emergency medicine 20080201 |
| Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080201 |
| A retrospective study of bosentan in pulmonary arterial hypertension associated with congenital heart disease. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080201 |
| Acute right ventricular failure in the setting of acute pulmonary embolism or chronic pulmonary hypertension: a detailed review of the pathophysiology, diagnosis, and management. | Current cardiology reviews 20080201 |
| Successful treatment of sarcoidosis-associated pulmonary hypertension with bosentan. | Respiration; international review of thoracic diseases 20080101 |
| Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension--a multi-center randomized study. | Cardiology 20080101 |
| BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. | American journal of respiratory and critical care medicine 20080101 |
| Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil. | European journal of clinical pharmacology 20080101 |
| Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes. | Physiological research 20080101 |
| Current status of bosentan for treatment of pulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Sildenafil for pulmonary hypertension: dose-dependent improvement in exercise performance. | Pulmonary pharmacology & therapeutics 20080101 |
| The Italian Network for Tumor Biotherapy (NIBIT): getting together to push the field forward. | Journal of translational medicine 20080101 |
| Prostacyclin among prostanoids. | Pharmacological reports : PR 20080101 |
| Influence of the incremental step size in work rate on exercise response and gas exchange in patients with pulmonary hypertension. | BMC pulmonary medicine 20080101 |
| Inflammatory responses after endothelin B (ETB) receptor activation in human monocytes: new evidence for beneficial anti-inflammatory potency of ETB-receptor antagonism. | Pulmonary pharmacology & therapeutics 20080101 |
| Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia. | BMC infectious diseases 20080101 |
| Treatment of severe pulmonary hypertension secondary to scleroderma: a three-drug approach. | Internal medicine (Tokyo, Japan) 20080101 |
| Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats. | Vascular pharmacology 20080101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20080101 |
| Role of iloprost and bosentan in pulmonary arterial hypertension. | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20080101 |
| Severe liver dysfunction due to bosentan in a patient with mixed connective tissue disease. | European journal of dermatology : EJD 20080101 |
| [Pulmonary hypertension and right ventricular failure. Part XIV. Differentiated therapy of primary (idiopathic) and associated forms of pulmonary arterial hypertension]. | Kardiologiia 20080101 |
| PGE1 nebulisation during caesarean section for Eisenmenger's syndrome: a case report. | Journal of medical case reports 20080101 |
| Pulmonary hypertension associated with sickle cell disease: pathophysiology and rationale for treatment. | Lung 20080101 |
| Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome. | Drugs 20080101 |
| Association of ABCB1 genetic variants with renal function in Africans and in Caucasians. | BMC medical genomics 20080101 |
| Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101 |
| Hidden hazards of Bosentan therapy in pulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Bosentan for the treatment of portopulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. | Scandinavian journal of clinical and laboratory investigation 20080101 |
| Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. | Drugs 20080101 |
| Regression toward the mean--a detection method for unknown population mean based on Mee and Chua's algorithm. | BMC medical research methodology 20080101 |
| Current pharmacological treatment of pulmonary arterial hypertension. | Current clinical pharmacology 20080101 |
| General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. | Clinical pharmacokinetics 20080101 |
| Successful switch from inhaler iloprost to treatment in a patient who initially presented with pulmonary arterial hypertension and diagnosed as SLE. | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20080101 |
| Exhaled and arterial levels of endothelin-1 are increased and correlate with pulmonary systolic pressure in COPD with pulmonary hypertension. | BMC pulmonary medicine 20080101 |
| Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. | Texas Heart Institute journal 20080101 |
| Efficacy of Bosentan in treatment of refractory sclerodermic bone prominences skin ulcers. | La Clinica terapeutica 20080101 |
| Effect of early bosentan administration on the development of esophageal varices in cirrhotic rats: experimental study in Wistar rats. | Journal of gastroenterology 20080101 |
| Addition of sildenafil in patients with pulmonary arterial hypertension with inadequate response to bosentan monotherapy. | Canadian respiratory journal 20080101 |
| Circulating tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) in systemic sclerosis patients with elevated pulmonary arterial pressure. | Mediators of inflammation 20080101 |
| A new model to evaluate the long-term cost effectiveness of orphan and highly specialised drugs following listing on the Australian Pharmaceutical Benefits Scheme: the Bosentan Patient Registry. | Journal of medical economics 20080101 |
| Role of urinary biomarkers in the diagnosis of congenital upper urinary tract obstruction. | Indian journal of urology : IJU : journal of the Urological Society of India 20080101 |
| Pulmonary hypertension: past, present and future. | Annals of thoracic medicine 20080101 |
| Ambrisentan for the treatment of pulmonary arterial hypertension. | Drug design, development and therapy 20080101 |
| Drug therapy: Sildenafil for post-operative pulmonary hypertension and Eisenmenger syndrome - A brief review of literature and survey of expert opinion. | Annals of pediatric cardiology 20080101 |
| The Fontan pathway: What's down the road? | Annals of pediatric cardiology 20080101 |
| Experience with inhaled iloprost and bosentan in portopulmonary hypertension. | The European respiratory journal 20071201 |
| [The treatment of idiopathic pulmonary artery hypertension and its relation to systemic scleroderma]. | La Revue de medecine interne 20071201 |
| Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. | Arthritis and rheumatism 20071201 |
| Caring for the orphan's orphan: treatment of patients with portopulmonary hypertension. | The European respiratory journal 20071201 |
| Endothelin receptor antagonists in cancer therapy. | Cancer investigation 20071201 |
| Bosentan treatment in an adult with pulmonary hypertension due to patent ductus arteriosus permits surgical repair. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20071201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20071201 |
| Review of bosentan in the management of pulmonary arterial hypertension. | Vascular health and risk management 20071201 |
| [Bosentan and chronic thromboembolic pulmonary hypertension]. | Medicina clinica 20071103 |
| Complex multidrug therapy in a patient with pulmonary hypertension before and after orthotopic heart transplantation. A case report. | Journal of cardiovascular medicine (Hagerstown, Md.) 20071101 |
| Selective and mixed endothelin receptor antagonism in cardiovascular disease. | Trends in pharmacological sciences 20071101 |
| Autopsy case of systemic sclerosis with severe pulmonary hypertension. | The Journal of dermatology 20071101 |
| The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy. | Cancer research 20071101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20071101 |
| Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema. | Experimental & molecular medicine 20071031 |
| Bosentan therapy for chronic thromboembolic pulmonary hypertension. A national open label study assessing the effect of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (BOCTEPH-Study). | Swiss medical weekly 20071020 |
| The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. | Cardiovascular research 20071001 |
| Lupus-associated pulmonary hypertension: long-term response to vasoactive therapy. | Respiratory medicine 20071001 |
| The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1. | British journal of pharmacology 20071001 |
| Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. | Matrix biology : journal of the International Society for Matrix Biology 20071001 |
| Systematic review of randomised, double-blind clinical trials of oral agents conducted in patients with pulmonary arterial hypertension. | International journal of clinical practice 20071001 |
| Bosentan therapy for patients with severe Raynaud's phenomenon in systemic sclerosis. | Annals of the rheumatic diseases 20071001 |
| Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist? | American heart journal 20071001 |
| Clinical management of portopulmonary hypertension. | Hepatobiliary & pancreatic diseases international : HBPD INT 20071001 |
| Expert opinion on available options treating pulmonary arterial hypertension. | Expert opinion on pharmacotherapy 20071001 |
| Severe pulmonary hypertension due to chronic echinococcal pulmonary emboli treated with targeted pulmonary vascular therapy and hepatic resection. | Chest 20071001 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20071001 |
| Evidence-based pharmacologic management of pulmonary arterial hypertension. | Clinical therapeutics 20071001 |
| The Swiss registry for pulmonary arterial hypertension: the paediatric experience. | Swiss medical weekly 20070908 |
| Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis. | Annals of the rheumatic diseases 20070901 |
| Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070901 |
| Survival of patients with idiopathic pulmonary arterial hypertension after listing for transplantation: impact of iloprost and bosentan treatment. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070901 |
| Therapeutic challenges for systemic sclerosis: facts and future targets. | Annals of the New York Academy of Sciences 20070901 |
| Pulmonary hypertension and granulomatous vasculitis in sarcoidosis. | Current opinion in pulmonary medicine 20070901 |
| Pulmonary hypertension and chronic cor pulmonale in COPD. | International journal of chronic obstructive pulmonary disease 20070901 |
| [Two patients with Eisenmenger syndrome treated with novel agents that target vasodilation of the pulmonary capillary bed]. | Nederlands tijdschrift voor geneeskunde 20070811 |
| Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B. | World journal of gastroenterology 20070807 |
| Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
| Results of European post-marketing surveillance of bosentan in pulmonary hypertension. | The European respiratory journal 20070801 |
| Successful treatment with bosentan for severe digital ischaemia in limited cutaneous systemic sclerosis. | Annals of the rheumatic diseases 20070801 |
| Long-term safety, tolerability and efficacy of bosentan in adults with pulmonary arterial hypertension associated with congenital heart disease. | Heart (British Cardiac Society) 20070801 |
| [Warfarin-bosentan interaction. Risk of big INR changes]. | Lakartidningen 20070801 |
| Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy. | Diabetes/metabolism research and reviews 20070701 |
| Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. | Brain, behavior, and immunity 20070701 |
| Long-term outcome and effects of oral bosentan therapy in Taiwanese patients with advanced idiopathic pulmonary arterial hypertension. | Respiratory medicine 20070701 |
| Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701 |
| Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients. | Chest 20070701 |
| A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma. | Investigational new drugs 20070601 |
| Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20070601 |
| Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Treatment of patients with Eisenmenger's syndrome with Bosentan. | Cardiology in the young 20070601 |
| Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis. | Arthritis and rheumatism 20070601 |
| [An initial experience of endotherine-1 dual-receptor blockade in the treatment of sustained pulmonary hypertension early after congenital cardiac surgery in infancy]. | Kyobu geka. The Japanese journal of thoracic surgery 20070601 |
| [Bosentan for treatment of heart failure]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| Long term effects of bosentan treatment in adult patients with pulmonary arterial hypertension related to congenital heart disease (Eisenmenger physiology): safety, tolerability, clinical, and haemodynamic effect. | Heart (British Cardiac Society) 20070501 |
| The impact of treatment of portopulmonary hypertension on survival following liver transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070501 |
| Polyarteritis nodosa resistant to conventional treatment in a pediatric patient. | The Annals of pharmacotherapy 20070501 |
| Management of pulmonary arterial hypertension with a focus on combination therapies. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070501 |
| [Treatment of a leg ulcer with bosentan in a female patient with progressive systemic scleroderma]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20070501 |
| Endothelin-1 accentuates the proatherosclerotic effects associated with C-reactive protein. | The Journal of thoracic and cardiovascular surgery 20070501 |
| Does endothelin play a role in chemoreception during acute hypoxia in normal men? | Chest 20070501 |
| Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body. | American journal of physiology. Lung cellular and molecular physiology 20070501 |
| [Alveolar capillary dysplasia and persistent pulmonary hypertension of the newborn]. | Archives des maladies du coeur et des vaisseaux 20070501 |
| Combined endothelin receptor antagonist and transcatheter interventional therapy of patent ductus arteriosus with severe pulmonary artery hypertension. | International journal of cardiology 20070404 |
| Therapeutic profile of orphan medicines. | Pharmacoepidemiology and drug safety 20070401 |
| Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study. | The European respiratory journal 20070401 |
| Long-term follow-up after conversion from intravenous epoprostenol to oral therapy with bosentan or sildenafil in 13 patients with pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070401 |
| Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors. | The Tohoku journal of experimental medicine 20070401 |
| The effect of nonsteroidal anti-inflammatory drugs on rat gastric mucosa. The role of endothelin. | Saudi medical journal 20070401 |
| [Treatment with sildenafil, bosentan, or both in children and young people with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome]. | Revista espanola de cardiologia 20070401 |
| [Long-term experience with trerpostinil infusion treatment in patients with pulmonary arterial hypertension in the Czech Republic]. | Vnitrni lekarstvi 20070401 |
| [Therapeutic management of acral manifestations of systemic sclerosis]. | Medizinische Klinik (Munich, Germany : 1983) 20070315 |
| Long-term oral bosentan treatment in patients with pulmonary arterial hypertension related to congenital heart disease: a 2-year study. | Heart (British Cardiac Society) 20070301 |
| Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension. | The European respiratory journal 20070301 |
| Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts. | Biochimica et biophysica acta 20070301 |
| Inhibitory and inductive effects of rifampin on the pharmacokinetics of bosentan in healthy subjects. | Clinical pharmacology and therapeutics 20070301 |
| Cyclophosphamide for scleroderma interstitial lung disease. Tashkin DP, Elashoff R, Clements PJ et al.: Cyclophosphamide versus placebo in scleroderma lung disease. N. Engl. J. Med. (2006) 354(25):2655-2666. | Expert opinion on investigational drugs 20070301 |
| Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension. | Pediatric research 20070301 |
| Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20070301 |
| Observational trials in pulmonary arterial hypertension: low scientific evidence but high clinical value. | The European respiratory journal 20070301 |
| Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070301 |
| Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. | Clinics in chest medicine 20070301 |
| Combination therapy and new types of agents for pulmonary arterial hypertension. | Clinics in chest medicine 20070301 |
| Chronic thromboembolic pulmonary hypertension. | Clinics in chest medicine 20070301 |
| [Pulmonary hypertension treatment: future prospects]. | Archivos de bronconeumologia 20070301 |
| [Digital necrosis in scleroderma]. | La Revue du praticien 20070227 |
| Sitaxsentan in the management of pulmonary arterial hypertension. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070215 |
| Assessment of digital vascular structure and function in response to bosentan in patients with systemic sclerosis-related Raynaud's phenomenon. | Rheumatology (Oxford, England) 20070201 |
| Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. | Kidney international 20070201 |
| Bosentan and sildenafil: should the combination therapy be a valid alternative in childhood to prostacyclin infusion? | Pediatric transplantation 20070201 |
| Quality of life in pulmonary arterial hypertension: improvement and maintenance with bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070201 |
| Long-term trial of bosentan monotherapy for pulmonary arterial hypertension in Japanese patients. | Current medical research and opinion 20070201 |
| A review of pulmonary arterial hypertension: role of ambrisentan. | Vascular health and risk management 20070201 |
| A review of sitaxsentan sodium in patients with pulmonary arterial hypertension. | Vascular health and risk management 20070201 |
| [Role of bosentan in patients with chronic venous thromboembolic pulmonary hypertension]. | Medicina clinica 20070113 |
| Renal nerves participation in the effects of nitric oxide and ET(A)/ET(B) receptor inhibition in spontaneously hypertensive rats. | Physiological research 20070101 |
| Long-term bosentan in chronic thromboembolic pulmonary hypertension. | Respiration; international review of thoracic diseases 20070101 |
| Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release. | Vascular pharmacology 20070101 |
| Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2. | Biopharmaceutics & drug disposition 20070101 |
| Sitaxsentan for treatment of pulmonary hypertension. | The Annals of pharmacotherapy 20070101 |
| Assessment and treatment of pulmonary arterial hypertension: an Australian perspective in 2006. | Internal medicine journal 20070101 |
| Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat. | BMC neuroscience 20070101 |
| Bosentan as a rescue therapy in scleroderma refractory digital ulcers. | Archives of dermatology 20070101 |
| Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101 |
| Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. | BMC genomics 20070101 |
| The diagnosis and treatment of Raynaud's phenomenon: a practical approach. | Drugs 20070101 |
| Bosentan use in systemic lupus erythematosus patients with pulmonary arterial hypertension. | Lupus 20070101 |
| Endothelin-1 induces NF-kappaB via two independent pathways in human renal tubular epithelial cells. | American journal of nephrology 20070101 |
| [Pulmonary arterial hypertension--experience of Centro Hospitalar de Vila Nova de Gaia]. | Revista portuguesa de pneumologia 20070101 |
| Increased endothelin-1 levels of BAL fluid in patients with Behçet's disease. | Mediators of inflammation 20070101 |
| [Chronic thromboembolic pulmonary hypertension]. | Cirugia y cirujanos 20070101 |
| Bosentan for increased pulmonary vascular resistance in a patient with single ventricle physiology and a bidirectional Glenn shunt. | Pediatric cardiology 20070101 |
| Pulmonary arterial hypertension among Filipino patients with connective tissue diseases. | Modern rheumatology 20070101 |
| [Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan)]. | Reumatismo 20070101 |
| Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | Canadian journal of physiology and pharmacology 20070101 |
| Hepatopulmonary syndrome and portopulmonary hypertension: what's new? | Acta gastro-enterologica Belgica 20070101 |
| Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease. | Arthritis research & therapy 20070101 |
| How does endothelial cell injury start? The role of endothelin in systemic sclerosis. | Arthritis research & therapy 20070101 |
| Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis. | Arthritis research & therapy 20070101 |
| Therapeutic targets in systemic sclerosis. | Arthritis research & therapy 20070101 |
| Clinical trials in systemic sclerosis: lessons learned and outcomes. | Arthritis research & therapy 20070101 |
| Pulmonary hypertension associated with sarcoidosis. | Arthritis research & therapy 20070101 |
| Vasculitis: mechanisms involved and clinical manifestations. | Arthritis research & therapy 20070101 |
| Interrelated modulation of endothelial function in Behcet's disease by clinical activity and corticosteroid treatment. | Arthritis research & therapy 20070101 |
| [Digital ulcers in a cohort of 333 scleroderma patients]. | Reumatismo 20070101 |
| High-dose bosentan in the prevention and treatment of subarachnoid hemorrhage-induced cerebral vasospasm: an open-label feasibility study. | Neurocritical care 20070101 |
| Consecutive use of sildenafil and bosentan for the treatment of pulmonary arterial hypertension associated with collagen vascular disease: sildenafil as reliever and bosentan as controller. | Lupus 20070101 |
| [Observational study of the efficacy and tolerability of bosentan for the treatment of pulmonary hypertension in a tertiary referral hospital]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101 |
| Sustained success of therapy with inhaled iloprost for severe pulmonary arterial hypertension associated with systemic sclerosis and pulmonary fibrosis. | Clinical and experimental rheumatology 20070101 |
| [Two-years therapy with bosentan of pulmonary arterial hypertension related to connective tissue diseases]. | Reumatismo 20070101 |
| Should right ventricle dilatation during exercise have clinical implications in patients with chronic thromboembolic pulmonary hypertension? Case report. | Cardiovascular ultrasound 20070101 |
| [Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. | Kardiologiia 20070101 |
| Management of pulmonary arterial hypertension associated with congenital heart disease. | Romanian journal of internal medicine = Revue roumaine de medecine interne 20070101 |
| [Treatment of pulmonary hypertension]. | Wiadomosci lekarskie (Warsaw, Poland : 1960) 20070101 |
| [Pharmacological treatment of pulmonary arterial hypertension]. | Archivos de cardiologia de Mexico 20070101 |
| Tadalafil: the evidence for its clinical potential in the treatment of pulmonary arterial hypertension. | Core evidence 20070101 |
| Platelet-derived growth factor as a therapeutic target for systemic autoimmune diseases. | Drug target insights 20070101 |
| [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Pulmonary hypertension in HIV patients]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Pulmonary arterial hypertension following pulmonary thromboembolism]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Drug combination treatment for pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil. | The European respiratory journal 20061201 |
| Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20061201 |
| Does cyclically iloprost infusion prevent severe isolated pulmonary hypertension in systemic sclerosis? Preliminary results. | Rheumatology international 20061201 |
| [Chronic pulmonary thromboembolism revealing beta-thalassemia intermedia after splenectomy]. | La Revue de medecine interne 20061201 |
| Bosentan increases myocardial perfusion and function in systemic sclerosis: a magnetic resonance imaging and Tissue-Doppler echography study. | The Journal of rheumatology 20061201 |
| Short-term and long-term FK506 treatment alters the vascular reactivity of renal and mesenteric vascular beds. | Journal of pharmacological sciences 20061201 |
| Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children. | The Journal of rheumatology 20061201 |
| [Systemic sclerosis: paths into the future]. | Presse medicale (Paris, France : 1983) 20061201 |
| [Pulmonary arterial hypertension and systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20061201 |
| Sildenafil 20 mg. Pulmonary arterial hypertension: for oral treatment, no better than bosentan. | Prescrire international 20061201 |
| [Long-term outcomes of treatment with bosentan in pulmonary hypertension]. | Archivos de bronconeumologia 20061201 |
| [Porto-pulmonary hypertension]. | Revue des maladies respiratoires 20061201 |
| Formulary implications of management of pulmonary arterial Hypertension: Part II--Payer and provider perspectives on new therapeutic options. | Managed care interface 20061201 |
| Sildenafil in the treatment of pulmonary hypertension. | Vascular health and risk management 20061201 |
| Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension. | Hypertension (Dallas, Tex. : 1979) 20061101 |
| Comparison and validation of three measures of quality of life in patients with pulmonary hypertension. | Internal medicine journal 20061101 |
| Pharmacologic treatment for pulmonary arterial hypertension. | Current opinion in cardiology 20061101 |
| Effects of blockade of the renin-angiotensin and endothelin systems on experimental bronchiolitis obliterans. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20061101 |
| Conversion to bosentan from prostacyclin infusion therapy in pulmonary arterial hypertension: a pilot study. | Chest 20061101 |
| Treatment of pulmonary arterial hypertension. | Jornal de pediatria 20061101 |
| Formulary implications of management of pulmonary arterial hypertension: Part I--An overview of existing and new pharmacological treatment options. | Managed care interface 20061101 |
| HIV-related pulmonary hypertension. | The Mount Sinai journal of medicine, New York 20061101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20061101 |
| European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts. | European journal of pediatrics 20061101 |
| Bosentan improved syncope in a hemodialysis patient with pulmonary hypertension and mild aortic stenosis. | International heart journal 20061101 |
| [Treatment of systemic sclerosis]. | Reumatologia clinica 20061101 |
| Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension. | Journal of the American College of Cardiology 20061003 |
| Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20061001 |
| Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions. | Annals of the rheumatic diseases 20061001 |
| Efficiency and safety of bosentan in child C cirrhosis with portopulmonary hypertension and renal insufficiency. | European journal of gastroenterology & hepatology 20061001 |
| [Raynaud phenomenon in dermatology : Part 2: therapy]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20061001 |
| Successful treatment of patients with severe secondary Raynaud's phenomenon with the endothelin receptor antagonist bosentan. | Rheumatology (Oxford, England) 20061001 |
| Weaning of epoprostenol in a small infant receiving concomitant bosentan for severe pulmonary arterial hypertension secondary to bronchopulmonary dysplasia. | Minerva pediatrica 20061001 |
| Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. | The European respiratory journal 20061001 |
| The current treatment of pulmonary arterial hypertension: time to redefine success. | Chest 20061001 |
| [Beneficial effect of sildenafil following surgery for mitral stenosis complicated by pre-capillary pulmonary hypertension: report of two cases]. | Annales de cardiologie et d'angeiologie 20061001 |
| Combination therapy with sildenafil and bosentan reverts severe pulmonary hypertension and allows heart transplantation: case report. | Transplantation proceedings 20061001 |
| Treprostinil: new drug. Pulmonary artery hypertension: just another (disappointing) prostacycline analogue. | Prescrire international 20061001 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20061001 |
| Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. | Circulation 20060926 |
| Endothelin-1 and the pulmonary vascular response to altitude: a new therapeutic target? | Circulation 20060926 |
| Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes. | The Journal of pharmacology and experimental therapeutics 20060901 |
| Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. | The Journal of pharmacology and experimental therapeutics 20060901 |
| Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats. | Vascular pharmacology 20060901 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060901 |
| Dual endothelin receptor antagonism in pulmonary arterial hypertension. | European journal of clinical investigation 20060901 |
| Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension. | European journal of clinical investigation 20060901 |
| Survival in patients with pulmonary arterial hypertension treated with first-line bosentan. | European journal of clinical investigation 20060901 |
| Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan. | European journal of clinical investigation 20060901 |
| Bosentan for the treatment of pulmonary arterial hypertension associated with congenital heart defects. | European journal of clinical investigation 20060901 |
| First experience with an oral combination therapy using bosentan and sildenafil for pulmonary arterial hypertension. | European journal of clinical investigation 20060901 |
| Bosentan in Eisenmenger syndrome and chronic thromboembolic pulmonary hypertension. | European journal of clinical investigation 20060901 |
| Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease. | European journal of clinical investigation 20060901 |
| Bosentan therapy of pulmonary arterial hypertension in connective tissue diseases. | European journal of clinical investigation 20060901 |
| Endothelin and endothelin receptor antagonism in portopulmonary hypertension. | European journal of clinical investigation 20060901 |
| Successful treatment of portopulmonary hypertension with bosentan: case report. | European journal of clinical investigation 20060901 |
| Bosentan treatment of portopulmonary hypertension related to liver cirrhosis owing to hepatitis C. | European journal of clinical investigation 20060901 |
| Bosentan therapy for pulmonary arterial hypertension associated with hereditary haemorrhagic telangiectasia. | European journal of clinical investigation 20060901 |
| Clinical outcomes of bosentan in pulmonary arterial hypertension do not correlate with levels of TIMPs. | European journal of clinical investigation 20060901 |
| Bosentan improves functional class, pulmonary artery systolic pressure, and DLCO in scleroderma patients with pulmonary hypertension: a possible synergy with iloprost. | The Journal of rheumatology 20060901 |
| Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm. | Proceedings of the American Thoracic Society 20060901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060901 |
| Portopulmonary hypertension. | Journal of gastroenterology 20060901 |
| [Pulmonary arterial hypertension in connective tissue disease]. | Revue des maladies respiratoires 20060901 |
| Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathy. | Transplantation 20060815 |
| Highly active antiretroviral therapy compared with HAART and bosentan in combination in patients with HIV-associated pulmonary hypertension. | Heart (British Cardiac Society) 20060801 |
| Bosentan for the treatment of systemic sclerosis-associated pulmonary arterial hypertension, pulmonary fibrosis and digital ulcers. | Expert opinion on pharmacotherapy 20060801 |
| Blocking ET-1 receptors does not correct subnormal retinal oxygenation response in experimental diabetic retinopathy. | Investigative ophthalmology & visual science 20060801 |
| Long-term results after addition of sildenafil in idiopathic PAH patients on bosentan. | Southern medical journal 20060801 |
| Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic rats. | Endocrine 20060801 |
| Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. | Circulation 20060725 |
| Endothelin receptor antagonists for pulmonary arterial hypertension. | The Cochrane database of systematic reviews 20060719 |
| Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. | Circulation 20060704 |
| Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. | Circulation 20060704 |
| Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease. | International journal of colorectal disease 20060701 |
| Systemic sclerosis associated pulmonary hypertension: improved survival in the current era. | Heart (British Cardiac Society) 20060701 |
| Treatment of severe Raynaud's phenomenon with bosentan in a patient with systemic sclerosis. | Rheumatology (Oxford, England) 20060701 |
| Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. | Pain 20060701 |
| The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study. | The European respiratory journal 20060701 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060701 |
| [Pulmonary arterial hypertension in collagenoses: clinical features, epidemiology, pathogenesis, diagnosis and treatment]. | Zeitschrift fur Rheumatologie 20060701 |
| [Evidence-based therapy of Raynaud's syndrome]. | Zeitschrift fur Rheumatologie 20060701 |
| Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. | Microbes and infection 20060701 |
| [Pulmonary arterial hypertension. Therapy with the endothelin-1 receptor antagonist bosentan]. | Medizinische Monatsschrift fur Pharmazeuten 20060701 |
| [Endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20060701 |
| [Transition from prostacyclin to bosentan in five patients with severe pulmonary hypertension: the switch is possible]. | Revista espanola de cardiologia 20060701 |
| IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin. | Proceedings of the National Academy of Sciences of the United States of America 20060620 |
| Atrial septal defect closure in a patient with 'irreversible' pulmonary hypertensive arteriopathy. | International journal of cardiology 20060607 |
| Endothelin receptor antagonists. | Pharmacology & therapeutics 20060601 |
| Cardioprotective effects of bosentan, a mixed endothelin type A and B receptor antagonist, during myocardial ischaemia and reperfusion in rats. | Basic & clinical pharmacology & toxicology 20060601 |
| Does rapid dose titration affect the hepatic safety profile of Bosentan? | Vascular pharmacology 20060601 |
| Bosentan for the treatment of pulmonary arterial hypertension associated with congenital cardiac disease. | Cardiology in the young 20060601 |
| Current understanding of the role of bosentan in inoperable chronic thromboembolic pulmonary hypertension. | Expert opinion on pharmacotherapy 20060601 |
| Current perspectives on the treatment of idiopathic pulmonary fibrosis. | Proceedings of the American Thoracic Society 20060601 |
| Profile of past and current clinical trials involving endothelin receptor antagonists: the novel '-sentan' class of drug. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Clinical trials of endothelin antagonists in heart failure: a question of dose? | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Endothelins: regulators of extracellular matrix protein production in diabetes. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Endothelin ET(B) receptor antagonist reduces mechanical allodynia in rats with trigeminal neuropathic pain. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060601 |
| Valsartan in the treatment of heart attack survivors. | Vascular health and risk management 20060601 |
| Systemic sclerosis: hypothesis-driven treatment strategies. | Lancet (London, England) 20060520 |
| Drug-related hepatotoxicity. | The New England journal of medicine 20060518 |
| Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. | Journal of the American College of Cardiology 20060516 |
| [Bosentan: a new pillar in the treatment of pulmonary hypertension?]. | Deutsche medizinische Wochenschrift (1946) 20060505 |
| Long-term bosentan treatment in children with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20060502 |
| Response to bosentan in children with pulmonary hypertension. | Heart (British Cardiac Society) 20060501 |
| Chronic exercise does not prevent hypoxia-induced increased aortic sensitivity to endothelin in rats. | Vascular pharmacology 20060501 |
| Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. | Brain research 20060501 |
| Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate. | Annals of the rheumatic diseases 20060501 |
| Successful treatment of systemic sclerosis-related digital ulcers and sarcoidosis with endothelin receptor antagonist (bosentan) therapy. | The British journal of dermatology 20060501 |
| Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations. | The Journal of pharmacy and pharmacology 20060501 |
| Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. | Expert review of cardiovascular therapy 20060501 |
| Management and therapeutic options in pediatric pulmonary hypertension. | Expert review of cardiovascular therapy 20060501 |
| Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo. | Journal of cardiovascular pharmacology 20060501 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060501 |
| [The effect of an endothelin receptor antagonist in Eisenmenger syndrome: a single-center experience of 11 patients]. | Archives des maladies du coeur et des vaisseaux 20060501 |
| [Pulmonary fibrosis--a therapeutic dilemma?]. | Medizinische Klinik (Munich, Germany : 1983) 20060415 |
| Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060401 |
| Preliminary experience with bosentan as initial therapy in childhood idiopathic pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060401 |
| Efficacy of bosentan in a small cohort of adult patients with pulmonary arterial hypertension related to congenital heart disease. | Chest 20060401 |
| [Bosentan for treatment of active digital ulcers in patients with systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20060401 |
| [Intestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of Endothelin-1 blockade]. | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20060401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060401 |
| [Diagnosis and treatment of pulmonary hypertension]. | Deutsche medizinische Wochenschrift (1946) 20060324 |
| Bosentan preserves endothelial function in mice overexpressing APP. | Neurobiology of aging 20060301 |
| Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension. | European heart journal 20060301 |
| Therapeutic management of idiopathic pulmonary fibrosis: an evidence-based approach. | Clinics in chest medicine 20060301 |
| Pharmacokinetic interaction between bosentan and the oral contraceptives norethisterone and ethinyl estradiol. | International journal of clinical pharmacology and therapeutics 20060301 |
| Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. | Shock (Augusta, Ga.) 20060301 |
| Influence of renal denervation on renal effects of acute nitric oxide and ETA/ETB receptor inhibition in conscious normotensive rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060301 |
| Renal effects of acute nitric oxide and ET(A)/ET(B) receptor inhibition in conscious spontaneously hypertensive rats. | Acta physiologica Hungarica 20060301 |
| Long-term experience with oral or inhaled vasodilator combination therapy in patients with pulmonary hypertension. | Swiss medical weekly 20060218 |
| Endothelin-induced increased nitric oxide mediates augmented distal nephron acidification as a result of dietary protein. | Journal of the American Society of Nephrology : JASN 20060201 |
| Successful switch from long-term intravenous iloprost to non-invasive combination therapy in idiopathic pulmonary arterial hypertension. | Wiener klinische Wochenschrift 20060201 |
| Central endothelin ET(B) receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat. | American journal of physiology. Regulatory, integrative and comparative physiology 20060101 |
| Improvement in cardiac function of diabetic rats by bosentan is not associated with changes in the activation of PKC isoforms. | Molecular and cellular biochemistry 20060101 |
| Role of endothelins and nitric oxide in the pulmonary circulation of perinatal lambs during hyperoxia and hypoxia. | Pediatric research 20060101 |
| Heart rate responses during the 6-minute walk test in pulmonary arterial hypertension. | The European respiratory journal 20060101 |
| Bosentan in pulmonary arterial hypertension secondary to scleroderma. | The Journal of rheumatology 20060101 |
| Use of myocardial performance index in pediatric patients with idiopathic pulmonary arterial hypertension. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20060101 |
| The influence of sex hormones on pulmonary vascular reactivity: possible vasodilator therapies for the treatment of pulmonary hypertension. | Current vascular pharmacology 20060101 |
| Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension. | Pulmonary pharmacology & therapeutics 20060101 |
| Pharmacotherapy for idiopathic pulmonary arterial hypertension during the past 25 years. | Pharmacotherapy 20060101 |
| Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi. | BMC pulmonary medicine 20060101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060101 |
| Initial experience with bosentan therapy in patients considered ineligible for heart transplantation because of severe pulmonary hypertension. | Clinical transplantation 20060101 |
| Persistent painful indurated erythema secondary to bosentan. | Acta dermato-venereologica 20060101 |
| Role of endothelin-1 on the enhanced carotid body activity induced by chronic intermittent hypoxia. | Advances in experimental medicine and biology 20060101 |
| Clinical features and endothelin receptor antagonist in primary Sjögren's syndrome with pulmonary arterial hypertension. | Scandinavian journal of rheumatology 20060101 |
| Drug eruption due to bosentan in a patient with systemic sclerosis. | Modern rheumatology 20060101 |
| Scar wars: is TGFbeta the phantom menace in scleroderma? | Arthritis research & therapy 20060101 |
| Bosentan: a review of its use in pulmonary arterial hypertension and systemic sclerosis. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101 |
| Pulmonary hypertension in older children: new approaches and therapies. | Paediatric respiratory reviews 20060101 |
| NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. | Arthritis research & therapy 20060101 |
| Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. | Clinical & experimental metastasis 20060101 |
| Interaction of endothelin with renal nerves modulates kidney function in spontaneously hypertensive rats. | Kidney & blood pressure research 20060101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060101 |
| Public funding of bosentan for the treatment of pulmonary artery hypertension in Australia: cost effectiveness and risk sharing. | PharmacoEconomics 20060101 |
| Systemic and localized scleroderma. | Clinics in dermatology 20060101 |
| Endothelin. | Handbook of experimental pharmacology 20060101 |
| Pulmonary arterial hypertension and women. | Cardiology in review 20060101 |
| Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. | Canadian journal of physiology and pharmacology 20060101 |
| Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. | BMC musculoskeletal disorders 20060101 |
| An open-label, multicentre pilot study of bosentan in pulmonary arterial hypertension related to congenital heart disease. | Canadian respiratory journal 20060101 |
| Pulmonary involvement in systemic sclerosis. | Treatments in respiratory medicine 20060101 |
| What role does the right side of the heart play in circulation? | Critical care (London, England) 20060101 |
| The effect of Bosentan on healing of colonic anastomosis. | World journal of emergency surgery : WJES 20060101 |
| Pulmonary hypertension: pathogenesis and management. | The Central African journal of medicine 20060101 |
| PHARMAC responds on treatments for pulmonary arterial hypertension. | The New Zealand medical journal 20051216 |
| Acute and chronic effects of sildenafil in patients with pulmonary arterial hypertension. | Respiratory medicine 20051201 |
| Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia. | American journal of physiology. Lung cellular and molecular physiology 20051201 |
| Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol. | Thorax 20051201 |
| New therapeutic agents for pulmonary vascular disease. | Paediatric respiratory reviews 20051201 |
| Improving survival in idiopathic pulmonary arterial hypertension: revisiting the 'kingdom of the near-dead'. | Thorax 20051201 |
| Possible reduction in indinavir serum concentrations by bosentan. | Therapeutic drug monitoring 20051201 |
| Effect of chronic endothelin blockade on PKC isoform distribution in mesenteric arteries from diabetic rats. | Molecular and cellular biochemistry 20051201 |
| Endothelins: pathophysiology and treatment implications in chronic heart failure. | Current heart failure reports 20051201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20051201 |
| [Pharmacological characteristics and clinical efficacy of bosentan]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20051201 |
| Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases. | Nature clinical practice. Rheumatology 20051201 |
| PHARMAC not funding some treatments for rare, life-threatening diseases: bosentan as an example. | The New Zealand medical journal 20051125 |
| Images in cardiovascular medicine. Medical treatment of varicose veins. | Circulation 20051108 |
| [Treatment of pulmonary arterial hypertension]. | Presse medicale (Paris, France : 1983) 20051105 |
| [Treatment for pulmonary arterial hypertension under the new French hospital financing system. Recommendations of the Pulmonary Vascular Diseases Working Group of the French Society of Pulmonary Medicine]. | Presse medicale (Paris, France : 1983) 20051105 |
| Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease. | Heart (British Cardiac Society) 20051101 |
| Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. | The European respiratory journal 20051101 |
| Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats. | Hypertension (Dallas, Tex. : 1979) 20051001 |
| Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy. | American heart journal 20051001 |
| Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001 |
| Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management. | Hematology/oncology clinics of North America 20051001 |
| [A role for combination therapy in pulmonary arterial hypertension]. | Pneumologie (Stuttgart, Germany) 20051001 |
| Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension. | Chest 20051001 |
| Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension. | Chest 20051001 |
| Endothelin-1 and human platelets. | Current vascular pharmacology 20051001 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20051001 |
| Treatment of pulmonary hypertension secondary to alveolar microlithiasis with Bosentan: a case report. | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20051001 |
| Chronicles in drug discovery. | Drug news & perspectives 20051001 |
| [The therapeutic effects of bosentan and valsartan on renal interstitial fibrosis of chronic aristolochic acid nephropathy]. | Zhonghua yi xue za zhi 20050928 |
| Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade. | Journal of hypertension 20050901 |
| Late-onset pulmonary arterial hypertension in association with graft-versus-host disease after allogeneic stem-cell transplantation. | American journal of hematology 20050901 |
| Initial experience with bosentan (Tracleer) as treatment for pulmonary arterial hypertension (PAH) due to congenital heart disease in infants and young children. | Zeitschrift fur Kardiologie 20050901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050901 |
| [Pulmonary arterial hypertension]. | Revue des maladies respiratoires 20050901 |
| New therapeutic strategies for systemic sclerosis--a critical analysis of the literature. | Clinical & developmental immunology 20050901 |
| Effects of long-term bosentan in children with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20050816 |
| Improving the outcome of childhood pulmonary arterial hypertension: the effect of bosentan in the setting of a dedicated pulmonary hypertension clinic. | Journal of the American College of Cardiology 20050816 |
| Decreased exhaled nitric oxide in pulmonary arterial hypertension: response to bosentan therapy. | American journal of respiratory and critical care medicine 20050801 |
| A urinary test for pulmonary arterial hypertension? | American journal of respiratory and critical care medicine 20050801 |
| Bosentan in inoperable chronic thromboembolic pulmonary hypertension. | Thorax 20050801 |
| Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy. | Chest 20050801 |
| Bosentan induces clinical, exercise and hemodynamic improvement in a pre-transplant patient with plastic bronchitis after Fontan operation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050801 |
| Endothelin antagonism in pulmonary arterial hypertension. | Seminars in respiratory and critical care medicine 20050801 |
| Changing the prognosis of pulmonary arterial hypertension: impact of medical therapy. | Seminars in respiratory and critical care medicine 20050801 |
| [Endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20050801 |
| Combination therapy for portopulmonary hypertension with intravenous iloprost and oral bosentan. | Wiener medizinische Wochenschrift (1946) 20050801 |
| The role of endothelin in FK506-induced vascular reactivity changes in rat perfused kidney. | European journal of pharmacology 20050704 |
| Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20050701 |
| Endothelin-induced increased aldosterone activity mediates augmented distal nephron acidification as a result of dietary protein. | Journal of the American Society of Nephrology : JASN 20050701 |
| Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension. | British journal of clinical pharmacology 20050701 |
| Combination therapy with bosentan and phosphodiesterase-5 inhibitor in pulmonary arterial hypertension. | The European respiratory journal 20050701 |
| [Portopulmonary hypertension]. | Zeitschrift fur Gastroenterologie 20050701 |
| Treatment of pulmonary arterial hypertension with bosentan: from pathophysiology to clinical evidence. | Expert opinion on pharmacotherapy 20050701 |
| Bosentan, the mixed ETA-ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion. | Molecular and cellular biochemistry 20050701 |
| [Pulmonary hypertension in hereditary haemorrhagic teleangiectasia (Rendu-Osler-Weber disease). Progression over 10 years]. | Deutsche medizinische Wochenschrift (1946) 20050610 |
| Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. | American journal of respiratory and critical care medicine 20050601 |
| Pulmonary arterial hypertension: the race for the most effective treatment. | American journal of respiratory and critical care medicine 20050601 |
| Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050601 |
| [Emerging therapies for the treatment of pulmonary arterial hypertension]. | Herz 20050601 |
| [Treatment algorithm for pulmonary arterial hypertension]. | Herz 20050601 |
| Effect of bosentan treatment on surrogate markers in pulmonary arterial hypertension. | Current medical research and opinion 20050601 |
| Pulmonary hypertension: its diagnosis and management, a multidisciplinary approach. | The Netherlands journal of medicine 20050601 |
| [PAH in congenital heart defects--therapeutic experiences with children and adults]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20050601 |
| [Drug treatments for idiopathic pulmonary fibrosis]. | Revue de pneumologie clinique 20050601 |
| Resolution of severe digital ulceration during a course of Bosentan therapy. | Annals of internal medicine 20050503 |
| Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. | American journal of physiology. Lung cellular and molecular physiology 20050501 |
| Hemodynamic observations in two pulmonary hypertensive patients changing treatment from inhaled iloprost to the oral endothelin-antagonist bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050501 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050501 |
| Bosentan therapy for pulmonary arterial hypertension. | Future cardiology 20050501 |
| The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans. | Clinical science (London, England : 1979) 20050401 |
| New hope for systemic sclerosis patients with digital ulcers. | Current rheumatology reports 20050401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050401 |
| Endothelin receptor antagonists: an overview of their synthesis and structure-activity relationship. | Mini reviews in medicinal chemistry 20050401 |
| Bosentan: new preparation. Pulmonary hypertension: an option before epoprostenol infusion. | Prescrire international 20050401 |
| Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits. | American journal of physiology. Heart and circulatory physiology 20050301 |
| Role of the endothelin-1 system in the luteolytic process of pseudopregnant rabbits. | Endocrinology 20050301 |
| Involvement of endothelin and nitric oxide in cyclosporine A-induced contractions in guinea pig isolated gallbladder strips. | Pharmacological research 20050301 |
| Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. | British journal of pharmacology 20050301 |
| [Therapy of pulmonary arterial hypertension]. | Der Internist 20050301 |
| Bosentan therapy for portopulmonary hypertension. | The European respiratory journal 20050301 |
| When cure is care: diagnosis and management of pulmonary arterial hypertension. | Journal of the American Academy of Nurse Practitioners 20050301 |
| The effect of bosentan on matrix metalloproteinase-9 levels in patients with systemic sclerosis-induced pulmonary hypertension. | Current medical research and opinion 20050301 |
| Iloprost for idiopathic pulmonary arterial hypertension. | Expert review of cardiovascular therapy 20050301 |
| Eisenmenger's syndrome in a 27 week pregnancy--management with bosentan and sildenafil. | Irish medical journal 20050301 |
| Endothelin A and B receptor antagonist bosentan reduces postischemic myocardial injury in the rat: critical timing of administration. | Canadian journal of physiology and pharmacology 20050301 |
| Eisenmenger syndrome in the adult--experience with new drugs for the treatment of pulmonary hypertension. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20050301 |
| [Cytokine antagonists and endothelin antagonists for therapy of heart failure]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210 |
| Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20050201 |
| Effect of bosentan (ETA/ETB receptor antagonist) on metabolic changes during stress and diabetes. | Pharmacological research 20050201 |
| The right ventricle in pulmonary hypertension. | Coronary artery disease 20050201 |
| Initial experience with Bosentan therapy in patients with the Eisenmenger syndrome: Tetralogy of Fallot? | The American journal of cardiology 20050201 |
| Effects of the endothelin receptor antagonist bosentan on hemodynamics, symptoms and functional capacity in Japanese patients with severe pulmonary hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20050201 |
| Improving survival in pulmonary arterial hypertension. | The European respiratory journal 20050201 |
| Survival with first-line bosentan in patients with primary pulmonary hypertension. | The European respiratory journal 20050201 |
| Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study. | Journal of cardiac failure 20050201 |
| The impact of finally publishing a negative study: new conclusions about endothelin antagonists. | Journal of cardiac failure 20050201 |
| Combination of sildenafil and bosentan for nitric oxide withdrawal. | European journal of anaesthesiology 20050201 |
| [Bosentan]. | Revue de l'infirmiere 20050201 |
| [New choice of therapy of pulmonary hypertension: endothelin receptor antagonist]. | Zhonghua yi xue za zhi 20050126 |
| Endothelin receptor antagonists for pulmonary arterial hypertension. | The Cochrane database of systematic reviews 20050125 |
| A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1. | American journal of physiology. Renal physiology 20050101 |
| Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate. | American journal of physiology. Renal physiology 20050101 |
| Comparative investigation of the pharmacokinetics of bosentan in Caucasian and Japanese healthy subjects. | Journal of clinical pharmacology 20050101 |
| Use of a mixed endothelin receptor antagonist in portopulmonary hypertension: a safe and effective therapy? | Gastroenterology 20050101 |
| Safety and tolerability of bosentan in adults with Eisenmenger physiology. | International journal of cardiology 20050101 |
| Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes. | Xenobiotica; the fate of foreign compounds in biological systems 20050101 |
| Cold hands--strained heart? Advances in the management of Raynaud's phenomenon and pulmonary hypertension. | Arthritis research & therapy 20050101 |
| Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. | Annals of medicine 20050101 |
| Successful therapy of bosentan-refractory pulmonary arterial hypertension (PAH) with inhalative iloprost. | Clinical and experimental rheumatology 20050101 |
| Inhaled iloprost in pulmonary arterial hypertension. | The Annals of pharmacotherapy 20050101 |
| Drug treatment of pulmonary arterial hypertension: current and future agents. | Drugs 20050101 |
| Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. | Critical care (London, England) 20050101 |
| [A child with pulmonary hypertension: from etiological study to therapeutic decisions]. | Revista portuguesa de pneumologia 20050101 |
| Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. | Respiratory research 20050101 |
| Health-related quality of life in patients with pulmonary arterial hypertension. | Respiratory research 20050101 |
| Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. | Proceedings of the American Thoracic Society 20050101 |
| Renal blood flow in sepsis. | Critical care (London, England) 20050101 |
| [Course of pulmonary artery hypertension disease]. | Krankenpflege Journal 20050101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050101 |
| Pulmonary arterial hypertension associated to connective tissue diseases. | Lupus 20050101 |
| Risk management strategies in the postmarketing period : safety experience with the US and European bosentan surveillance programmes. | Drug safety 20050101 |
| Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration. | Respiratory research 20050101 |
| Combination drug therapy in the management of pulmonary arterial hypertension. | Progress in cardiovascular nursing 20050101 |
| Functional and metabolic recovery of the right ventricle during Bosentan therapy in idiopathic pulmonary arterial hypertension. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20050101 |
| Secondary pulmonary arterial hypertension: treated with endothelin receptor blockade. | Texas Heart Institute journal 20050101 |
| [Endothelin receptor antagonism in routine clinical care]. | Krankenpflege Journal 20050101 |
| Advances in the medical treatment of pulmonary hypertension. | Kidney & blood pressure research 20050101 |
| Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein. | Transactions of the American Clinical and Climatological Association 20050101 |
| [Endothelin receptor antagonist bosentan. Breakthrough in the treatment of pulmonary hypertension]. | MMW Fortschritte der Medizin 20041209 |
| Endothelin receptor antagonist bosentan improves survival in a murine caecal ligation and puncture model of septic shock. | European journal of pharmacology 20041203 |
| Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20041201 |
| Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. | Toxicology in vitro : an international journal published in association with BIBRA 20041201 |
| Zebrafish IRX1b in the embryonic cardiac ventricle. | Developmental dynamics : an official publication of the American Association of Anatomists 20041201 |
| Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. | The European respiratory journal 20041201 |
| High-altitude pulmonary edema in children with underlying cardiopulmonary disorders and pulmonary hypertension living at altitude. | Archives of pediatrics & adolescent medicine 20041201 |
| Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. | Arthritis and rheumatism 20041201 |
| [Treatment of pulmonary arterial hypertension (PAH) with oral endothelin-receptor antagonist bosentan in systemic sclerosis: BREATHE-1 trial and clinical experience]. | Zeitschrift fur Rheumatologie 20041201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20041201 |
| Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. | American journal of respiratory and critical care medicine 20041115 |
| Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis. | Laboratory investigation; a journal of technical methods and pathology 20041101 |
| Sitaxsentan, a selective endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. | Expert opinion on investigational drugs 20041101 |
| Successful treatment of severe Raynaud's phenomenon with bosentan in four patients with systemic sclerosis. | Rheumatology (Oxford, England) 20041101 |
| Endothelin-receptor antagonist treatment of portopulmonary hypertension. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20041101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20041101 |
| YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction. | Journal of cardiovascular pharmacology 20041101 |
| Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist. | Journal of cardiovascular pharmacology 20041101 |
| Reverse cardiac remodelling in patients with primary pulmonary hypertension after isolated lung transplantation. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041001 |
| [Treatments for pulmonary arterial hypertension]. | La Revue de medecine interne 20041001 |
| Pulmonary hypertension. | Current problems in cardiology 20041001 |
| Idiopathic- and scleroderma-related pulmonary arterial hypertension: outcomes and QOL on bosentan. | Expert review of pharmacoeconomics & outcomes research 20041001 |
| Successful switch from inhalative iloprost to oral bosentan in portopulmonary hypertension associated with liver cirrhosis. | Wiener klinische Wochenschrift 20040930 |
| Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. | European journal of pharmacology 20040913 |
| A new era in the management of pulmonary arterial hypertension related to scleroderma: endothelin receptor antagonism. | Annals of the rheumatic diseases 20040901 |
| Endothelin upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. | Metabolism: clinical and experimental 20040901 |
| Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein. | Journal of the American Society of Nephrology : JASN 20040901 |
| Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. | The European respiratory journal 20040901 |
| Transition from epoprostenol and treprostinil to the oral endothelin receptor antagonist bosentan in patients with pulmonary hypertension. | Chest 20040901 |
| [Pathophysiological significance of endothelin in pulmonary hypertension]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| [Septic shock and endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| [Prospects for endothelin-related drugs]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040901 |
| Severe necrotising leucocytoclastic vasculitis in a patient taking bosentan. | BMJ (Clinical research ed.) 20040821 |
| The orally active nonpeptide selective endothelin ETA receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats. | European journal of pharmacology 20040802 |
| [Treatment of pulmonary arterial hypertension in children]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20040801 |
| Endothelin and pulmonary arterial hypertension. | Seminars in arthritis and rheumatism 20040801 |
| Initial experience with bosentan therapy in patients with the Eisenmenger syndrome. | The American journal of cardiology 20040715 |
| Pulmonary arterial hypertension in children. | Pediatric pulmonology 20040701 |
| Blood flow alterations in TNBS-induced colitis: role of endothelin receptors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701 |
| [Bosentán, hope or reality for the treatment of pulmonary arterial hypertension]. | Medicina clinica 20040626 |
| Endothelin receptor antagonists in pulmonary arterial hypertension. | Journal of the American College of Cardiology 20040616 |
| Endothelin-3 induced mesenteric vasoconstriction and PMN infiltration in the rat small intestine: role of endothelin receptors. | Regulatory peptides 20040615 |
| Successful treatment of severe portopulmonary hypertension after liver transplantation by bosentan. | Transplantation 20040615 |
| Use of oral endothelin-receptor antagonist bosentan in the treatment of portopulmonary hypertension. | Transplantation 20040615 |
| Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. | Clinical science (London, England : 1979) 20040601 |
| Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells. | The Journal of surgical research 20040601 |
| Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. | Acta physiologica Scandinavica 20040601 |
| Influence of nonselective ET(A)/ET(B) receptor blockade on renal function in conscious rats: effects of renal denervation. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040601 |
| New answers raise new questions in pulmonary arterial hypertension. | The European respiratory journal 20040601 |
| End points in pulmonary arterial hypertension: the way forward. | The European respiratory journal 20040601 |
| Bosentan therapy for pulmonary arterial hypertension. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040601 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040601 |
| Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists. | Journal of medicinal chemistry 20040520 |
| Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion. | American journal of physiology. Heart and circulatory physiology 20040501 |
| Role of endogenous endothelin-1 in transplant obliterative airway disease in the rat. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040501 |
| Treatment of secondary pulmonary hypertension with bosentan and its pharmacokinetic monitoring in ESRD. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20040501 |
| Experimental approaches to evaluate endothelin-A receptor antagonists. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Intergenic enhancers with distinct activities regulate Dlx gene expression in the mesenchyme of the branchial arches. | Developmental biology 20040415 |
| Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. | Journal of medicinal chemistry 20040408 |
| Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan. | The American journal of cardiology 20040401 |
| What you should know about pulmonary hypertension. | The Nurse practitioner 20040401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040401 |
| Physiological involvement of placental endothelin-1 and prostaglandin F2alpha in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress. | Canadian journal of physiology and pharmacology 20040401 |
| Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Current medical treatment of pulmonary arterial hypertension. | The Mount Sinai journal of medicine, New York 20040301 |
| [Treatment of pulmonary arterial hypertension associated to systemic sclerosis]. | La Revue de medecine interne 20040301 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040301 |
| Bosentan. | Expert review of cardiovascular therapy 20040301 |
| [Involvement of endothelin in the pathogenesis of hypertension and hypertensive target-organ damage]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20040215 |
| [The preliminary studies on the cross action between endothelin-1 and angiotensin II in kidney tissue of rats with diabetic nephropathy]. | Zhonghua yi xue za zhi 20040202 |
| The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release. | Journal of cardiovascular pharmacology 20040201 |
| New combined treatments avoided transplantation in a child with severe pulmonary hypertension. | Heart (British Cardiac Society) 20040201 |
| The endothelin system in pulmonary arterial hypertension. | Cardiovascular research 20040201 |
| Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. | British journal of pharmacology 20040201 |
| Endothelins regulate astrocyte gap junctions in rat hippocampal slices. | The European journal of neuroscience 20040201 |
| Role of membrane potential and expression of endothelial factors in restenosis after angioplasty in SHR. | Hypertension (Dallas, Tex. : 1979) 20040101 |
| Coxsackievirus B3 infection compromises endothelial-dependent vasodilation of coronary resistance arteries. | Journal of cardiovascular pharmacology 20040101 |
| Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040101 |
| Oncofetal fibronectin in diabetic retinopathy. | Investigative ophthalmology & visual science 20040101 |
| [Therapeutic implications of endothelin antagonists for cardiovascular diseases]. | Harefuah 20040101 |
| Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. | Drugs 20040101 |
| Bosentan: a novel agent for the treatment of pulmonary arterial hypertension. | International journal of clinical practice 20040101 |
| Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats. | Kidney & blood pressure research 20040101 |
| Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs. | Critical care (London, England) 20040101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040101 |
| [Treatment of pulmonary hypertension]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101 |
| [Updated treatment of primary pulmonary hypertension -- the role of endothelin receptor antagonists]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101 |
| Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. | BMC pharmacology 20040101 |
| New hope for patients with pulmonary hypertension: endothelin receptor antagonists: update for the clinical nurse specialist. | Clinical nurse specialist CNS 20040101 |
| Effects of lornoxicam on the physiology of severe sepsis. | Critical care (London, England) 20040101 |
| Clinical pharmacology of bosentan, a dual endothelin receptor antagonist. | Clinical pharmacokinetics 20040101 |
| Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats. | Physiological research 20040101 |
| Pulmonary arterial hypertension in systemic sclerosis: clinical manifestations, pathophysiology, evaluation, and management. | Treatments in respiratory medicine 20040101 |
| Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. | Circulation research 20031212 |
| Bosentan and overcirculation-induced experimental pulmonary arterial hypertension. | Circulation 20031209 |
| Endothelium-dependent, vasopressin-induced contractions in rabbit renal arteries. | Journal of cardiovascular pharmacology 20031201 |
| Nephroprotective effect of bosentan in diabetic rats. | Journal of cardiovascular pharmacology 20031201 |
| Drug therapy for pulmonary arterial hypertension: what's on the menu today? | Chest 20031201 |
| Treatment of pulmonary arterial hypertension: a preliminary decision analysis. | Chest 20031201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20031201 |
| Reinduction of T-type calcium channels by endothelin-1 in failing hearts in vivo and in adult rat ventricular myocytes in vitro. | Circulation 20031118 |
| Endothelin receptor blockers in cardiovascular disease. | Circulation 20031104 |
| Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. | Toxicological sciences : an official journal of the Society of Toxicology 20031101 |
| Scleroderma: a treatable disease. | Cleveland Clinic journal of medicine 20031101 |
| Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure. | American journal of physiology. Heart and circulatory physiology 20031001 |
| Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. | Hypertension (Dallas, Tex. : 1979) 20031001 |
| Protective skeletal muscle arteriolar vasomotion during critical perfusion conditions of osteomyocutaneous flaps is not mediated by nitric oxide and endothelins. | Langenbeck's archives of surgery 20031001 |
| Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock. | Acta pharmacologica Sinica 20031001 |
| Endothelin receptor antagonists in the treatment of prostate cancer. | Seminars in oncology 20031001 |
| [Endothelin-1 receptor antagonists in heart failure]. | Archives des maladies du coeur et des vaisseaux 20031001 |
| Pharmacological characterization of YM598, an orally active and highly potent selective endothelin ET(A) receptor antagonist. | European journal of pharmacology 20030930 |
| Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo. | American journal of physiology. Heart and circulatory physiology 20030901 |
| Effects of bosentan on neointimal response following coronary angioplasty. | European journal of clinical investigation 20030901 |
| Attenuation of renal vasopressin V2 receptor upregulation by bosentan, an ETA/ETB receptor antagonist. | Metabolism: clinical and experimental 20030901 |
| Expression of the serotonin 1b receptor in experimental pulmonary hypertension. | The European respiratory journal 20030901 |
| Bosentan for pulmonary arterial hypertension. | Drug and therapeutics bulletin 20030901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20030901 |
| [Dyspnea. When is it pulmonary hypertension?]. | MMW Fortschritte der Medizin 20030821 |
| Endothelin receptor antagonists in heart failure--a refutation of a bold conjecture? | European journal of heart failure 20030801 |
| Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids. | The European respiratory journal 20030801 |
| Endothelin-1 is a potent regulator in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells. | Peptides 20030801 |
| [Blockade of endothelin receptor with bosentan--a new principle of treatment in pulmonary arterial hypertension]. | Ugeskrift for laeger 20030714 |
| Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat. | Journal of cardiovascular pharmacology 20030701 |
| Treatment of pulmonary arterial hypertension: a step forward. | Chest 20030701 |
| Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study. | Chest 20030701 |
| Endothelin receptor blockade and exacerbation of heart failure. | Circulation 20030610 |
| Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. | American journal of physiology. Endocrinology and metabolism 20030601 |
| Endothelin receptor blockade in canine oleic acid-induced lung injury. | Intensive care medicine 20030601 |
| The endothelin system in pulmonary hypertension. | Canadian journal of physiology and pharmacology 20030601 |
| Endothelin-1 directly modulates its own secretion: studies utilising the cell immunoblot technique. | Regulatory peptides 20030515 |
| Endothelin and endothelin receptor antagonists in systemic rheumatic disease. | Arthritis and rheumatism 20030501 |
| Pulmonary hypertension in systemic sclerosis. | Rheumatic diseases clinics of North America 20030501 |
| Update on disease-modifying antirheumatic drugs in the treatment of systemic sclerosis. | Rheumatic diseases clinics of North America 20030501 |
| Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20030416 |
| Endothelin-I receptor antagonist for the treatment of pulmonary arterial hypertension in systemic sclerosis. | Current rheumatology reports 20030401 |
| Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. | Clinical pharmacology and therapeutics 20030401 |
| Therapy for primary pulmonary hypertension. | Canadian respiratory journal 20030401 |
| Pulmonary arterial hypertension--the primary pulmonary hypertension syndromes. | The Israel Medical Association journal : IMAJ 20030401 |
| [Renoprotective effects of nonselective endothelin receptor antagonist bosentan on rats with interstitial fibrosis following unilateral ureteral obstruction]. | Zhonghua yi xue za zhi 20030325 |
| Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. | Circulation 20030311 |
| Bis-sulfonamides as endothelin receptor antagonists. | Bioorganic & medicinal chemistry letters 20030310 |
| The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. | Bioorganic & medicinal chemistry letters 20030310 |
| Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. | British journal of cancer 20030310 |
| Advances in the treatment of secondary pulmonary hypertension. | Current opinion in pulmonary medicine 20030301 |
| Chronic endothelin antagonism restores cerebrovascular function in diabetes. | Neurosurgery 20030301 |
| Inhibition of in vivo constriction of fetal ductus arteriosus by endothelin receptor blockade in rats. | Pediatric research 20030301 |
| Endothelium and the lipid metabolism: the current understanding. | International journal of cardiology 20030301 |
| Will endothelin receptor antagonists have a role in heart failure? | The Medical clinics of North America 20030301 |
| Current status of endothelin blockade for the treatment of cardiovascular and pulmonary vascular disease. | Current opinion in investigational drugs (London, England : 2000) 20030301 |
| Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II. | Journal of the American College of Cardiology 20030219 |
| Altered myocardial thin-filament function in the failing Dahl salt-sensitive rat heart: amelioration by endothelin blockade. | Circulation 20030204 |
| High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1. | American journal of physiology. Cell physiology 20030201 |
| Endothelin in unilateral ureteral obstruction: vascular and cellular effects. | The Journal of urology 20030201 |
| Endothelin-1 suppresses plasma membrane Ca++-ATPase, concomitant with contraction of hepatic sinusoidal endothelial fenestrae. | The American journal of pathology 20030201 |
| [New expansion of endothelin research: perspectives for clinical application of endothelin-receptor antagonists]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030201 |
| [Therapy of pulmonary involvement of rheumatic diseases]. | Zeitschrift fur Rheumatologie 20030201 |
| No influence of the endothelin receptor antagonist bosentan on basal and indomethacin-induced reduction of cerebral blood flow in pigs. | Acta anaesthesiologica Scandinavica 20030201 |
| Endothelin-1: a multifunctional molecule in cancer. | British journal of cancer 20030127 |
| Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. | Glia 20030115 |
| Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. | Journal of medicinal chemistry 20030102 |
| ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. | Journal of cardiovascular pharmacology 20030101 |
| Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan. | Rheumatology (Oxford, England) 20030101 |
| Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts. | Hypertension (Dallas, Tex. : 1979) 20030101 |
| Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | Journal of clinical pharmacology 20030101 |
| Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock. | Critical care medicine 20030101 |
| Vascular endothelial growth factor induced functional and morphologic signs of endothelial dysfunction in isolated arteries from normal pregnant women. | American journal of obstetrics and gynecology 20030101 |
| Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction. | The European respiratory journal 20030101 |
| Pulmonary arterial hypertension in children. | The European respiratory journal 20030101 |
| Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin. | Clinical pharmacokinetics 20030101 |
| Increased salt sensitivity secondary to leptin resistance in SHHF rats is mediated by endothelin. | Molecular and cellular biochemistry 20030101 |
| Understanding primary pulmonary hypertension. | Critical care nursing quarterly 20030101 |
| Bosentan. | Heart disease (Hagerstown, Md.) 20030101 |
| Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps. | Rapid communications in mass spectrometry : RCM 20030101 |
| Pulmonary hypertension: new perspectives. | Congestive heart failure (Greenwich, Conn.) 20030101 |
| Bosentan and warfarin interaction. | The Annals of pharmacotherapy 20030101 |
| Bosentan for the treatment of pulmonary arterial hypertension. | The Annals of pharmacotherapy 20030101 |
| Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus report. | Lupus 20030101 |
| Sickle cell crisis and endothelin antagonists. | Critical care nursing quarterly 20030101 |
| [From basic research to clinical results. The OVERTURE, ENABLE, and RENEWAL studies]. | Archivos de cardiologia de Mexico 20030101 |
| [What is new in the treatment of pulmonary artery hypertension?]. | Archivos de cardiologia de Mexico 20030101 |
| Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. | Nephron. Experimental nephrology 20030101 |
| The role of endogenous endothelin in the regulation of uteroplacental and renal blood flow during pregnancy in conscious rats. | Placenta 20030101 |
| [Endothelin receptor blockers--one more agent for the treatment of pulmonary hypertension]. | Kardiologiia 20030101 |
| Augmented contractile response of vascular smooth muscle in a diabetic mouse model. | Journal of vascular research 20030101 |
| Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit? | Annals of medicine 20030101 |
| The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. | Advances in experimental medicine and biology 20030101 |
| Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy. | American journal of physiology. Heart and circulatory physiology 20021201 |
| Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver. | Hepatology (Baltimore, Md.) 20021201 |
| Effects of endothelin-1 (ET-1) and thrombin antagonism on cardiovascular and respiratory dysfunctions during endotoxic shock in pig. | Prostaglandins, leukotrienes, and essential fatty acids 20021201 |
| Endothelin-induced vascular and bronchial effects in pig airways: role in acute allergic responses. | Journal of applied physiology (Bethesda, Md. : 1985) 20021101 |
| Targeting mediators of vascular injury in scleroderma. | Current opinion in rheumatology 20021101 |
| Scleroderma in children. | Current opinion in rheumatology 20021101 |
| Intestinal nitric oxide in the normal and endotoxemic pig. | Shock (Augusta, Ga.) 20021101 |
| The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system. | Expert opinion on investigational drugs 20021101 |
| [Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure]. | Pneumologie (Stuttgart, Germany) 20021101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20021101 |
| [Young patient with stress dyspnea of uncertain origin. Evaluate for pulmonary hypertension!]. | MMW Fortschritte der Medizin 20021017 |
| Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? | International journal of cardiology 20021001 |
| Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. | The Journal of endocrinology 20021001 |
| The new clinical trials on pharmacological treatment in pulmonary arterial hypertension. | The European respiratory journal 20021001 |
| Exaggerated coronary reactivity to endothelin-1 in diabetes: reversal with bosentan. | Canadian journal of physiology and pharmacology 20021001 |
| [Antihypertensive treatment in patients with diabetes mellitus]. | Polskie Archiwum Medycyny Wewnetrznej 20021001 |
| Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis. | Life sciences 20020906 |
| Current and emerging therapy for primary pulmonary hypertension. | The Annals of pharmacotherapy 20020901 |
| Different mechanism of LPS-induced vasodilation in resistance and conductance arteries from SHR and normotensive rats. | British journal of pharmacology 20020901 |
| Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. | European journal of pharmacology 20020823 |
| Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan. | Journal of hepatology 20020801 |
| Endothelin-1-induced arachidonic acid release by cytosolic phospholipase A2 activation in rat vascular smooth muscle via extracellular signal-regulated kinases pathway. | Biochemical pharmacology 20020801 |
| Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. | Clinical science (London, England : 1979) 20020801 |
| Bosentan for pulmonary hypertension. | The New England journal of medicine 20020725 |
| Bosentan for pulmonary hypertension. | The New England journal of medicine 20020725 |
| Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension. | Cardiovascular research 20020701 |
| Bosentan: a dual endothelin receptor antagonist. | Expert opinion on investigational drugs 20020701 |
| Endothelin receptor antagonists prevent parathyroid cell proliferation caused by hypocalcemia in rats. | Current opinion in nephrology and hypertension 20020701 |
| Influence of severe renal dysfunction on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | International journal of clinical pharmacology and therapeutics 20020701 |
| Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes. | Chinese medical journal 20020701 |
| The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses. | Heart and vessels 20020701 |
| [Treatment of heart failure: an update]. | Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20020701 |
| New drugs 2002, part III. | Nursing 20020701 |
| Endothelin induced cerebral vasoconstriction in rainbow trout, detected in a novel in vitro preparation. | Neuroscience letters 20020614 |
| Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole. | British journal of clinical pharmacology 20020601 |
| Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. | The Journal of thoracic and cardiovascular surgery 20020601 |
| Ease symptoms of pulmonary hypertension with bosentan. | The Nurse practitioner 20020601 |
| Developments in therapeutics for pulmonary arterial hypertension. | Minerva cardioangiologica 20020601 |
| Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): approaching the asymptote of efficacy? | Journal of cardiac failure 20020601 |
| Gateways to Clinical Trials. June 2002. | Methods and findings in experimental and clinical pharmacology 20020601 |
| Endothelin B receptor-mediated regulation of endothelin-1 content and release in cultured porcine aorta endothelial cell. | Journal of cardiovascular pharmacology 20020501 |
| Early intervention with a potent endothelin-A/endothelin-B receptor antagonist aggravates left ventricular remodeling after myocardial infarction in rats. | Basic research in cardiology 20020501 |
| Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. | Circulation 20020423 |
| [2 studies for heart failure therapy. Endothelin receptor antagonist does not improve prognosis]. | MMW Fortschritte der Medizin 20020404 |
| Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes. | Journal of hypertension 20020401 |
| Bosentan (Tracleer) for pulmonary arterial hypertension. | The Medical letter on drugs and therapeutics 20020401 |
| In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide. | Clinical pharmacology and therapeutics 20020401 |
| Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. | The Annals of thoracic surgery 20020401 |
| Bosentan therapy for pulmonary arterial hypertension. | The New England journal of medicine 20020321 |
| Treatment of primary pulmonary hypertension -- the next generation. | The New England journal of medicine 20020321 |
| Bosentan enters market with risk management program. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020315 |
| Influence of food intake and formulation on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | Journal of clinical pharmacology 20020301 |
| Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure. | Cardiovascular research 20020301 |
| [Bosentan in pulmonary hypertension]. | Medizinische Monatsschrift fur Pharmazeuten 20020301 |
| Modulation of noradrenaline-induced vasoconstriction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin. | Canadian journal of physiology and pharmacology 20020301 |
| Endothelin receptor antagonism attenuates cardiomyocyte apoptosis after induction of ischemia in rats. | Scandinavian cardiovascular journal : SCJ 20020301 |
| Pulmonary hypertension and HIV. | Project Inform perspective 20020301 |
| Crosstalk of endothelin-1 and platelet-derived growth factor in cardiac allograft arteriosclerosis. | Journal of the American College of Cardiology 20020220 |
| Endothelin antagonists and heart failure. | Current hypertension reports 20020201 |
| Medical management of primary pulmonary hypertension. | Expert opinion on pharmacotherapy 20020201 |
| Tracleer. Tablets ease symptoms of rare lung disorder. | Nursing 20020201 |
| [Physical endurance improves markedly. New therapy approach in pulmonary hypertension]. | MMW Fortschritte der Medizin 20020117 |
| [The effects of endothelin blockade on renal expression of angiotensin II type 1 receptor in diabetic hypertensive rats]. | Zhonghua yi xue za zhi 20020110 |
| Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists. | Bioorganic & medicinal chemistry letters 20020107 |
| Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys. | Journal of cardiovascular pharmacology 20020101 |
| Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelins. | Nephron 20020101 |
| Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure. | Gut 20020101 |
| Growth factors in idiopathic pulmonary fibrosis: relative roles. | Respiratory research 20020101 |
| Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways. | Pflugers Archiv : European journal of physiology 20020101 |
| Tracleer (bosentan). | Journal of clinical hypertension (Greenwich, Conn.) 20020101 |
| Human endothelin subtype A receptor enhancement during tissue culture via de novo transcription. | Neurosurgery 20020101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20020101 |
| Medication approved to treat rare lung disorder. | FDA consumer 20020101 |
| MS3 using the collision cell of a tandem mass spectrometer system. | Rapid communications in mass spectrometry : RCM 20020101 |
| Endothelin in health and disease: endothelin receptor antagonists in the management of pulmonary artery hypertension. | Journal of cardiovascular pharmacology and therapeutics 20020101 |
| Levels of endothelin-1 in embryos from control and neonatal streptozotocin-induced diabetic rats, and their relationship with nitric oxide generation. | Reproduction, fertility, and development 20020101 |
| Endothelin antagonism with bosentan: current status and future perspectives. | Cardiovascular drug reviews 20020101 |
| Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Primary pulmonary hypertension and cor pulmonale. | Cardiology in review 20020101 |
| Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. | Diabetes/metabolism research and reviews 20020101 |
| Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. | International journal of experimental diabetes research 20020101 |
| Emerging medical therapies for pulmonary arterial hypertension. | Progress in cardiovascular diseases 20020101 |
| Bosentan. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101 |
| Coronary and aortic vasoreactivity protection with endothelin receptor antagonist, bosentan, after ischemia and hypoxia in aged rats. | European journal of pharmacology 20011207 |
| Therapeutic role of bosentan in hypertension: lessons from the model of perinephritic hypertension. | Heart failure reviews 20011201 |
| Endothelin antagonism in experimental ischemic heart failure: hemodynamic, structural and neurohumoral effects. | Heart failure reviews 20011201 |
| Hemodynamic effects of bosentan in patients with chronic heart failure. | Heart failure reviews 20011201 |
| Endothelin and heart failure. | Heart failure reviews 20011201 |
| Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat. | American journal of physiology. Renal physiology 20011201 |
| Endothelin antagonist reduces hemodynamic responses to vasopressin in DOCA-salt hypertension. | American journal of physiology. Heart and circulatory physiology 20011201 |
| Role of endogenous endothelin on coronary reflow after cardioplegic arrest. | The Journal of thoracic and cardiovascular surgery 20011201 |
| Angiotensin II activates collagen type I gene in the renal cortex and aorta of transgenic mice through interaction with endothelin and TGF-beta. | Journal of the American Society of Nephrology : JASN 20011201 |
| Small bowel review: diseases of the small intestine. | Digestive diseases and sciences 20011201 |
| Endothelin blockade in angiotensin II hypertension: prevention and treatment studies in the rat. | Clinical and experimental pharmacology & physiology 20011201 |
| General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. | Journal of pharmacokinetics and pharmacodynamics 20011201 |
| Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes. | American journal of physiology. Cell physiology 20011101 |
| Renal tubulointerstitial damage caused by persistent proteinuria is attenuated in AT1-deficient mice: role of endothelin-1. | The American journal of pathology 20011101 |
| Effects of the endothelin receptor antagonist bosentan on cardiac performance during porcine endotoxin shock. | Acta anaesthesiologica Scandinavica 20011101 |
| Rationale and perspective of endothelin-1 antagonism in acute heart failure. | Journal of cardiovascular pharmacology 20011101 |
| [Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomized placebo-controlled study]. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20011101 |
| Endothelin receptor blockade in congestive heart failure. | Circulation 20011030 |
| Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. | Journal of medicinal chemistry 20011011 |
| Report from the 93rd Cardiovascular and Renal Drugs Advisory Committee Meeting, August 9-10, 2001. | Circulation 20011009 |
| Endothelin-receptor antagonists in pulmonary hypertension. | Lancet (London, England) 20011006 |
| Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. | Lancet (London, England) 20011006 |
| Endothelin mediates phospholipase C stimulation in the proximal tubule during initiation of compensatory renal growth in adult rats. | Croatian medical journal 20011001 |
| Chronic blockade of endothelin receptors improves ischemia-induced angiogenesis in rat hindlimbs through activation of vascular endothelial growth factor-no pathway. | Arteriosclerosis, thrombosis, and vascular biology 20011001 |
| Endothelin receptor blockade and nitric oxide bioactivity. | Cardiovascular research 20011001 |
| Endogenous endothelins mediate increased acidification in remnant kidneys. | Journal of the American Society of Nephrology : JASN 20010901 |
| Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20010901 |
| Endothelin involvement in respiratory centre activity. | Prostaglandins, leukotrienes, and essential fatty acids 20010901 |
| Report From the 93rd Cardiovascular and Renal Drugs Advisory Committee Meeting, August 9-10, 2001. | Circulation 20010828 |
| Endothelin receptor blockade reduces ventricular dysfunction and injury after reoxygenation. | The Annals of thoracic surgery 20010801 |
| The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure. | International journal of cardiology 20010801 |
| Improvement of respiratory function by bosentan during endotoxic shock in the pig. | Prostaglandins, leukotrienes, and essential fatty acids 20010801 |
| Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure. | Circulation 20010731 |
| Effects of the endothelin receptor antagonist Bosentan on ischaemia/reperfusion injury in rat skeletal muscle. | European journal of pharmacology 20010713 |
| Influence of nitric oxide synthase inhibition and endothelin-1 receptor blockade on acetylcholine-induced coronary artery contraction in vitro in dilated and ischemic cardiomyopathies. | Journal of cardiovascular pharmacology 20010701 |
| Endothelin mediates some of the renal actions of acutely administered angiotensin II. | Hypertension (Dallas, Tex. : 1979) 20010701 |
| Long-term endothelin receptor blockade improves cardiovascular function in diabetes. | American journal of hypertension 20010701 |
| New pharmacological strategies for the treatment of heart failure. | Current opinion in investigational drugs (London, England : 2000) 20010701 |
| Aminoethyl-isothiourea inhibits the increase in plasma endothelin-1 caused by serogroup A streptococci and prolongs survival in rat peritoneal sepsis. | Shock (Augusta, Ga.) 20010601 |
| Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro. | Japanese journal of pharmacology 20010601 |
| Effect of angiotensin II receptor antagonist and endothelin receptor antagonist on nitroglycerin tolerance in rats. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20010601 |
| Acute endothelin a receptor blockade in heart failure. | Circulation 20010508 |
| Neurogenic inflammation in the context of migraine. | Microscopy research and technique 20010501 |
| Combined angiotensin and endothelin receptor blockade attenuates adverse cardiac remodeling post-myocardial infarction in the rat: possible role of transforming growth factor beta(1). | Journal of molecular and cellular cardiology 20010501 |
| Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? | Journal of the American College of Cardiology 20010501 |
| Blockade of the renin-angiotensin and endothelin systems on progressive renal injury. | Hypertension (Dallas, Tex. : 1979) 20010501 |
| Update in pharmacologic treatment of hypertension. | Cardiology clinics 20010501 |
| Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation. | American journal of physiology. Lung cellular and molecular physiology 20010401 |
| Role of endothelin and vasopressin in DOCA-salt hypertension. | British journal of pharmacology 20010401 |
| Role of endothelin in the circulatory changes associated with small bowel strangulation obstruction in pigs: effects of the endothelin receptor antagonist bosentan. | The Journal of surgical research 20010401 |
| Pharmacologic characterization of S-1255, a highly potent and orally active endothelin A receptor antagonist. | Journal of cardiovascular pharmacology 20010401 |
| Activation of NF-kappaB in tubular epithelial cells of rats with intense proteinuria: role of angiotensin II and endothelin-1. | Hypertension (Dallas, Tex. : 1979) 20010401 |
| The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. | Clinical pharmacology and therapeutics 20010401 |
| Chronic bosentan treatment improves renal artery vascular function in diabetes. | Journal of hypertension 20010401 |
| The timing of endothelin and nitric oxide inhibition affects survival in a mice model of septic shock. | European journal of pharmacology 20010302 |
| A new era in the treatment of primary pulmonary hypertension. | Heart (British Cardiac Society) 20010301 |
| Subarachnoid haemorrhage-induced sympathoexcitation in rats is reversed by bosentan or sodium nitroprusside. | Clinical and experimental pharmacology & physiology 20010301 |
| Perceived benefit after participating in positive or negative/neutral heart failure trials: the patients' perspective. | European journal of heart failure 20010301 |
| Pressure overload increases GATA4 binding activity via endothelin-1. | Circulation 20010206 |
| Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits. | Journal of neurosurgery 20010201 |
| Endothelin antagonism uncovers insulin-mediated vasorelaxation in vitro and in vivo. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Regression of renal vascular fibrosis by endothelin receptor antagonism. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Endothelin receptor blockade improves endothelial function in human internal mammary arteries. | Cardiovascular research 20010101 |
| Endothelin receptor antagonist prevents parathyroid cell proliferation of low calcium diet-induced hyperparathyroidism in rats. | Endocrinology 20010101 |
| Combined blockade of endothelin-1 and thromboxane A(2) receptors against postischaemic contractile dysfunction in rat hearts. | British journal of pharmacology 20010101 |
| Important role for endothelins in acute hepatic ischemia/reperfusion injury. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20010101 |
| Endothelin synthesis and receptors in porcine kidney. | Acta physiologica Scandinavica 20010101 |
| Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20010101 |
| The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101 |
| Endothelin receptor antagonist activity of (R)-(-)-2-(benzo[1,3]dioxol-5-yl)-N-(4-isopropylphenylsulfonyl)-2-(6-methyl- 2-propylpyridin-3-yloxy)acetamide hydrochloride (PABSA) in rat aortic smooth muscle cells and isolated rat thoracic aorta. | Arzneimittel-Forschung 20010101 |
| Pharmacological regulation of postischemic sinusoidal diameters in rats--a new approach for reducing hepatic ischemia/reperfusion injury. | Clinical hemorheology and microcirculation 20010101 |
| Current management of primary pulmonary hypertension. | Drugs 20010101 |
| Pulmonary hypertension associated with COPD. | Critical care (London, England) 20010101 |
| Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane. | Journal of vascular research 20010101 |
| Influence of several methodological procedures utilized to obtain in vitro vascular preparations on endothelial activity. | Endothelium : journal of endothelial cell research 20010101 |
| Acute treatments: some blind alleys. | Current medical research and opinion 20010101 |
| Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. | Molecular pharmacology 20001201 |
| Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release. | Naunyn-Schmiedeberg's archives of pharmacology 20000801 |
| Angiotensin II receptor blockade unmasks a depressor response to endothelin antagonists in rats. | Fundamental & clinical pharmacology 20000101 |
| Bosentan reduces blood pressure and the target-organ damage induced by a high-fructose diet in rats. | Journal of hypertension 19991201 |
| Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan. | Clinical and experimental pharmacology & physiology 19990801 |
| Endothelin antagonism with bosentan: a review of potential applications. | Journal of molecular medicine (Berlin, Germany) 19990401 |
| Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives. | Development (Cambridge, England) 19981201 |
| Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. | Cardiovascular research 19980901 |
| The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. | The New England journal of medicine 19980319 |
| Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension. | Hypertension (Dallas, Tex. : 1979) 19970301 |
| Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. | Hypertension (Dallas, Tex. : 1979) 19960901 |
| Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney. | American journal of kidney diseases : the official journal of the National Kidney Foundation 19960301 |
| [Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats]. | Archives des maladies du coeur et des vaisseaux 19950801 |
| The role of endothelin in experimental cerebral vasospasm. | Neurosurgery 19950701 |
| Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. | Hypertension (Dallas, Tex. : 1979) 19950401 |
| In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats. | Circulation 19950201 |
| Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. | Hypertension (Dallas, Tex. : 1979) 19940801 |
| Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. | The Journal of pharmacology and experimental therapeutics 19940701 |
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