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170861-63-9 | 4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]isoxazolidine-3,5-dione
CAS No: 170861-63-9 Catalog No: AG00BA0Z MDL No:
Product Description
Catalog Number:
AG00BA0Z
Chemical Name:
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]isoxazolidine-3,5-dione
CAS Number:
170861-63-9
IUPAC Name:
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione
InChI:
InChI=1S/C22H20N2O5/c1-14-19(23-21(28-14)16-5-3-2-4-6-16)11-12-27-17-9-7-15(8-10-17)13-18-20(25)24-29-22(18)26/h2-10,18H,11-13H2,1H3,(H,24,25)
InChI Key:
QBQLYIISSRXYKL-UHFFFAOYSA-N
Properties
Complexity:
572
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
392.137g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
392.411g/mol
Monoisotopic Mass:
392.137g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
90.7A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
4
Literature
| Title | Journal |
|---|---|
| [Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050201 |
| Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators. | Bioorganic & medicinal chemistry letters 20040705 |
| [Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)]. | Nihon rinsho. Japanese journal of clinical medicine 20020901 |
| [The chemical structure and pharmacological properties of a novel isoxazolidinedione insulin sensitizer, JTT-501]. | Nihon rinsho. Japanese journal of clinical medicine 20011101 |
| Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse. | European journal of endocrinology 20010701 |
| Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle. | European journal of pharmacology 20010629 |
| The PPARs: from orphan receptors to drug discovery. | Journal of medicinal chemistry 20000224 |
| Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative. | European journal of pharmacology 19990108 |
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