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170230-39-4 | N-(3-(2-(Dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide
CAS No: 170230-39-4 Catalog No: AG003U7E MDL No:
Product Description
Catalog Number:
AG003U7E
Chemical Name:
N-(3-(2-(Dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide
CAS Number:
170230-39-4
Molecular Formula:
C28H30N4O4
Molecular Weight:
486.5622
IUPAC Name:
N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide
InChI:
InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33)
InChI Key:
JRNUKVFYILMMLX-UHFFFAOYSA-N
SMILES:
COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C
UNII:
ZM4360761C
Properties
Complexity:
687
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
486.227g/mol
Formal Charge:
0
Heavy Atom Count:
36
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
486.572g/mol
Monoisotopic Mass:
486.227g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
89.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5
Literature
| Title | Journal |
|---|---|
| The effect of serotonin 5HT1B receptor ligands on amphetamine self-administration in rats. | European journal of pharmacology 20120227 |
| Neonatal DSP-4 treatment impairs 5-HT(1B) receptor reactivity in adult rats. Behavioral and biochemical studies. | Pharmacological reports : PR 20100101 |
| Regulation of serotonin 1B receptor by glycogen synthase kinase-3. | Molecular pharmacology 20091201 |
| 5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro. | Neuroscience 20080219 |
| Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats. | Pharmacological reports : PR 20080101 |
| Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats. | European journal of pharmacology 20070322 |
| Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice. | Psychopharmacology 20060901 |
| Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. | European journal of pharmacology 20060710 |
| Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. | Brain research 20051026 |
| Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. | European journal of pharmacology 20050523 |
| Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol. | European journal of pharmacology 20050321 |
| Role of 5-HT1A and 5-HT1B receptors in the hypophagic effect of 5-HT on the structure of feeding behavior. | Medical science monitor : international medical journal of experimental and clinical research 20050301 |
| The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action. | The Journal of pharmacy and pharmacology 20050201 |
| Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. | Behavioural pharmacology 20041201 |
| Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. | Brain research 20040917 |
| Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. | Naunyn-Schmiedeberg's archives of pharmacology 20040701 |
| Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test. | European journal of pharmacology 20040308 |
| 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus. | Neuroscience research 20040301 |
| Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. | American journal of physiology. Gastrointestinal and liver physiology 20030701 |
| The role of 5-HT1A/B autoreceptors in the antinociceptive effect of systemic administration of acetaminophen. | Anesthesiology 20030301 |
| Triptans reduce the inflammatory response in bacterial meningitis. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020801 |
| Parabrachial infusion of D-fenfluramine reduces food intake. Blockade by the 5-HT(1B) antagonist SB-216641. | Pharmacology, biochemistry, and behavior 20020401 |
| Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices. | Journal of neurochemistry 20011101 |
| Role of 5-HT(1B) receptors in the sensitization to amphetamine in mice. | European journal of pharmacology 20010622 |
| Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei. | Neuropharmacology 20010301 |
| The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. | Journal of medicinal chemistry 19980409 |
| SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. | Naunyn-Schmiedeberg's archives of pharmacology 19970901 |
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